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The map label for this gene is tsaA [H]

Identifier: 57237385

GI number: 57237385

Start: 338216

End: 338812

Strand: Direct

Name: tsaA [H]

Synonym: CJE0379

Alternate gene names: 57237385

Gene position: 338216-338812 (Clockwise)

Preceding gene: 57237378

Following gene: 57237386

Centisome position: 19.02

GC content: 34.67

Gene sequence:

>597_bases
ATGATAGTTACTAAAAAAGCTTTAGATTTTACTGCTCCAGCAGTATTGGGAAACAATGAAATTGTTCAAGATTTTAATCT
TTATAAAAACATAGGTCCAAAAGGAGCGGTAGTATTCTTTTATCCAAAAGATTTTACTTTTGTTTGTCCTTCAGAAATTA
TAGCTTTTGACAAAAGATATCAAGAATTTAAAAATCGTGGCATTGAAGTAATTGGAATTTCAGGAGATAATGAATTTTCA
CATTTTGCTTGGAAAAATACTCCAGTAAATCAAGGTGGTATTGGTCAGGTTAAATTTCCGCTTGTTGCTGACTTAACTAA
GCAGATTGCTAGAAATTTTGATGTACTTTATGCAGAAGCAGTTGCCCTTCGTGGTTCGTTCTTGCTTGATGCTGATGGAA
CAGTTCGCCATGCTGTGGTTAATGATTTACCACTAGGTAGAAATATAGATGAAATGTTAAGAATGGTTGATACTATGCTT
TTTACAAATGAGCATGGTGAAGTTTGTCCTGCAGGATGGAATAAGGGCGATGAAGGTATGAAAGCTAACCCTAAAGGCGT
GGCTGAATATCTTGGCAAAAACGAAGCTAAACTTTAA

Upstream 100 bases:

>100_bases
CTTTCTTAAATTTTTAATATTATTTTAGATATTTAAAAAAAAATAAAGATTTAAACGATATAATTTCGTTATCAATAAAA
TTTATTATTTAGGAGAAAAT

Downstream 100 bases:

>100_bases
TTTCTTAGTATAAAGCCTCTTTACGAGGCTTTTTCTTCATTTTTATTCTTTAATTGAAATTCATAAATTTTCTACTATAA
TTTTACACACATATTAAAAT

Product: anti-oxidant AhpCTSA family protein

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MIVTKKALDFTAPAVLGNNEIVQDFNLYKNIGPKGAVVFFYPKDFTFVCPSEIIAFDKRYQEFKNRGIEVIGISGDNEFS
HFAWKNTPVNQGGIGQVKFPLVADLTKQIARNFDVLYAEAVALRGSFLLDADGTVRHAVVNDLPLGRNIDEMLRMVDTML
FTNEHGEVCPAGWNKGDEGMKANPKGVAEYLGKNEAKL

Sequences:

>Translated_198_residues
MIVTKKALDFTAPAVLGNNEIVQDFNLYKNIGPKGAVVFFYPKDFTFVCPSEIIAFDKRYQEFKNRGIEVIGISGDNEFS
HFAWKNTPVNQGGIGQVKFPLVADLTKQIARNFDVLYAEAVALRGSFLLDADGTVRHAVVNDLPLGRNIDEMLRMVDTML
FTNEHGEVCPAGWNKGDEGMKANPKGVAEYLGKNEAKL
>Mature_198_residues
MIVTKKALDFTAPAVLGNNEIVQDFNLYKNIGPKGAVVFFYPKDFTFVCPSEIIAFDKRYQEFKNRGIEVIGISGDNEFS
HFAWKNTPVNQGGIGQVKFPLVADLTKQIARNFDVLYAEAVALRGSFLLDADGTVRHAVVNDLPLGRNIDEMLRMVDTML
FTNEHGEVCPAGWNKGDEGMKANPKGVAEYLGKNEAKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=46.1139896373057, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI4505591, Length=190, Percent_Identity=47.3684210526316, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI32455266, Length=190, Percent_Identity=47.3684210526316, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI32455264, Length=190, Percent_Identity=47.3684210526316, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI5453549, Length=194, Percent_Identity=43.8144329896907, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI5802974, Length=192, Percent_Identity=45.3125, Blast_Score=172, Evalue=1e-43,
Organism=Homo sapiens, GI32483377, Length=161, Percent_Identity=47.2049689440994, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=47.5609756097561, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=27.8947368421053, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1786822, Length=151, Percent_Identity=34.4370860927152, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=46.7741935483871, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI193204376, Length=193, Percent_Identity=43.5233160621762, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32565831, Length=193, Percent_Identity=43.5233160621762, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25153706, Length=178, Percent_Identity=26.9662921348315, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=190, Percent_Identity=40.5263157894737, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320661, Length=190, Percent_Identity=40, Blast_Score=144, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319407, Length=162, Percent_Identity=30.2469135802469, Blast_Score=91, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=47.4226804123711, Blast_Score=187, Evalue=4e-48,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=47.4226804123711, Blast_Score=187, Evalue=4e-48,
Organism=Drosophila melanogaster, GI17738015, Length=183, Percent_Identity=45.9016393442623, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI17157991, Length=184, Percent_Identity=45.6521739130435, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24641739, Length=184, Percent_Identity=45.6521739130435, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=41.0526315789474, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24581278, Length=163, Percent_Identity=29.4478527607362, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24652436, Length=177, Percent_Identity=29.3785310734463, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17975518, Length=160, Percent_Identity=29.375, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24652434, Length=160, Percent_Identity=29.375, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21947; Mature: 21947

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVTKKALDFTAPAVLGNNEIVQDFNLYKNIGPKGAVVFFYPKDFTFVCPSEIIAFDKRY
CCCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEECCHHHHHHHHHH
QEFKNRGIEVIGISGDNEFSHFAWKNTPVNQGGIGQVKFPLVADLTKQIARNFDVLYAEA
HHHHHCCEEEEEECCCCCCCCEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCHHHHHHH
VALRGSFLLDADGTVRHAVVNDLPLGRNIDEMLRMVDTMLFTNEHGEVCPAGWNKGDEGM
HHHCCCEEECCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
KANPKGVAEYLGKNEAKL
CCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIVTKKALDFTAPAVLGNNEIVQDFNLYKNIGPKGAVVFFYPKDFTFVCPSEIIAFDKRY
CCCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEECCHHHHHHHHHH
QEFKNRGIEVIGISGDNEFSHFAWKNTPVNQGGIGQVKFPLVADLTKQIARNFDVLYAEA
HHHHHCCEEEEEECCCCCCCCEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCHHHHHHH
VALRGSFLLDADGTVRHAVVNDLPLGRNIDEMLRMVDTMLFTNEHGEVCPAGWNKGDEGM
HHHCCCEEECCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
KANPKGVAEYLGKNEAKL
CCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]