Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 57237365

GI number: 57237365

Start: 320117

End: 321325

Strand: Direct

Name: lysA [H]

Synonym: CJE0359

Alternate gene names: 57237365

Gene position: 320117-321325 (Clockwise)

Preceding gene: 57237364

Following gene: 57237366

Centisome position: 18.01

GC content: 32.34

Gene sequence:

>1209_bases
ATGGATTATAAACAATTAAAGCAAGAATTTAATACTCCTTTTTATATTTACAATTTTGATTTCATAAAAGAGTGTTTTTT
AAATCTCAAAGAGGCTTTTAAGGCTAGAAAATCTCAAATTTTTTACGCTGTAAAAGCCAATTCAAATTTAAGTTTGTTGC
AAATGCTTGCAAATTTAGATAGTGGATTTGATTGTGTAAGTATAGGCGAGGTAAAGCGTGCCTTAAAAGCAGGAGCAAAA
GCTTATAAGATTATTTTTAGTGGAGTAGGAAAAACCAAAGAAGAGTTAAGACAAGCTTTAGAATATGATATTTTATATAT
TAACCTTGAAAGCGAAGCTGAAATGATGCTTTTAGAAAGTGTGGCTAAAGAACTTAATCTAAAGGCAAGAATCAGTATTC
GTGTTAATCCAAATGTTGATGCAAAAACTCATCCTTATATTTCTACAGGATTAAATGAAAATAAATTTGGTGTCGAAATT
GATATAGCAAGAAAAATGTATCTTTATGCAAAAAATTCATCTTTTTTAGAGCCCGTTGGAGTGCATTTTCATATAGGTTC
GCAACTTTTAGATATTTCTCCCATTCATGAAGCAGCAGGCATCGTTGCAAAACTTGTAAGAGAGTTAAAAGCCTTGCAAA
TCGATCTTAAATTTTTTGATATAGGCGGTGGTTTGGGTGTGGCTTATGAAAAAGATGAGTGTGAATCTGATCTTTATGAT
TATGCACAAGGTATATTAGCACAACTTCATGGGCTTGATTTAACTATAGGAATGGAGCCTGGAAGGTATTTAGTTGCTAA
AAGTGGAGAATTTGTTTGTTCAGTGCTTTATGAAAAACAAAATAAAACCAAGCGTTTTGTTGTAGTAGATGGAGCGATGA
ATGATCTTATACGCCCAAGTTTATACGAGGCTTATCATGAAATAATCTTACCTTATAATCAAGCCCAAGAGAGTTTATGT
GATGTTGTAGGTGGAATTTGTGAGAGTGGAGACTTTTTTGCTAAAGCAAGGTCTTTACCTAGCACTCAAAGTGGCGATAT
AATGGTTATTAAAAATACTGGAGCTTATGGTTTTAGCATGAGTAGTAATTACAATACTCGTAATAAAGTTTGCGAATTAG
CTCTTGAAGAAGGACAGGTAAGATTGATCCGTCAAAGAGAAAATTTTGAAAATCAAATCGCTTTAGAAGAGAAATTTTTA
AAGGCTTAA

Upstream 100 bases:

>100_bases
GTGCCTATTATAATTTTGGGTTGTTTAAGTGCTTATATGTATTATAAGCATCGATAAATTAAGCTTTGTGTAGTAAAATT
ATAAAAATTAAAGGTTAAAT

Downstream 100 bases:

>100_bases
AATGTTTTTTTTAGATGTTCAAGGGACTTTAATTTCTGATCATGATAAGAGTTTAATCCATGGCGCTAAAGAATTGATCG
ATTTTTTAAATGCAAAAAAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDYKQLKQEFNTPFYIYNFDFIKECFLNLKEAFKARKSQIFYAVKANSNLSLLQMLANLDSGFDCVSIGEVKRALKAGAK
AYKIIFSGVGKTKEELRQALEYDILYINLESEAEMMLLESVAKELNLKARISIRVNPNVDAKTHPYISTGLNENKFGVEI
DIARKMYLYAKNSSFLEPVGVHFHIGSQLLDISPIHEAAGIVAKLVRELKALQIDLKFFDIGGGLGVAYEKDECESDLYD
YAQGILAQLHGLDLTIGMEPGRYLVAKSGEFVCSVLYEKQNKTKRFVVVDGAMNDLIRPSLYEAYHEIILPYNQAQESLC
DVVGGICESGDFFAKARSLPSTQSGDIMVIKNTGAYGFSMSSNYNTRNKVCELALEEGQVRLIRQRENFENQIALEEKFL
KA

Sequences:

>Translated_402_residues
MDYKQLKQEFNTPFYIYNFDFIKECFLNLKEAFKARKSQIFYAVKANSNLSLLQMLANLDSGFDCVSIGEVKRALKAGAK
AYKIIFSGVGKTKEELRQALEYDILYINLESEAEMMLLESVAKELNLKARISIRVNPNVDAKTHPYISTGLNENKFGVEI
DIARKMYLYAKNSSFLEPVGVHFHIGSQLLDISPIHEAAGIVAKLVRELKALQIDLKFFDIGGGLGVAYEKDECESDLYD
YAQGILAQLHGLDLTIGMEPGRYLVAKSGEFVCSVLYEKQNKTKRFVVVDGAMNDLIRPSLYEAYHEIILPYNQAQESLC
DVVGGICESGDFFAKARSLPSTQSGDIMVIKNTGAYGFSMSSNYNTRNKVCELALEEGQVRLIRQRENFENQIALEEKFL
KA
>Mature_402_residues
MDYKQLKQEFNTPFYIYNFDFIKECFLNLKEAFKARKSQIFYAVKANSNLSLLQMLANLDSGFDCVSIGEVKRALKAGAK
AYKIIFSGVGKTKEELRQALEYDILYINLESEAEMMLLESVAKELNLKARISIRVNPNVDAKTHPYISTGLNENKFGVEI
DIARKMYLYAKNSSFLEPVGVHFHIGSQLLDISPIHEAAGIVAKLVRELKALQIDLKFFDIGGGLGVAYEKDECESDLYD
YAQGILAQLHGLDLTIGMEPGRYLVAKSGEFVCSVLYEKQNKTKRFVVVDGAMNDLIRPSLYEAYHEIILPYNQAQESLC
DVVGGICESGDFFAKARSLPSTQSGDIMVIKNTGAYGFSMSSNYNTRNKVCELALEEGQVRLIRQRENFENQIALEEKFL
KA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=381, Percent_Identity=24.6719160104987, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI16506287, Length=382, Percent_Identity=26.4397905759162, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=31.3868613138686, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1789307, Length=294, Percent_Identity=24.4897959183673, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562780, Length=378, Percent_Identity=24.8677248677249, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322664, Length=381, Percent_Identity=24.4094488188976, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24586472, Length=339, Percent_Identity=26.5486725663717, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24586474, Length=344, Percent_Identity=24.1279069767442, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45254; Mature: 45254

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKQLKQEFNTPFYIYNFDFIKECFLNLKEAFKARKSQIFYAVKANSNLSLLQMLANLD
CCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHCC
SGFDCVSIGEVKRALKAGAKAYKIIFSGVGKTKEELRQALEYDILYINLESEAEMMLLES
CCCCEEEHHHHHHHHHCCCHHEEHHHHCCCCCHHHHHHHHCEEEEEEEECCCHHHHHHHH
VAKELNLKARISIRVNPNVDAKTHPYISTGLNENKFGVEIDIARKMYLYAKNSSFLEPVG
HHHHCCCEEEEEEEECCCCCCCCCCCEECCCCCCCCCEEEEEEEEEEEEECCCCCCCCCC
VHFHIGSQLLDISPIHEAAGIVAKLVRELKALQIDLKFFDIGGGLGVAYEKDECESDLYD
EEEEECCCEECCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEECCHHHHHHHHH
YAQGILAQLHGLDLTIGMEPGRYLVAKSGEFVCSVLYEKQNKTKRFVVVDGAMNDLIRPS
HHHHHHHHHCCCEEEEECCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEECCHHHHCCHH
LYEAYHEIILPYNQAQESLCDVVGGICESGDFFAKARSLPSTQSGDIMVIKNTGAYGFSM
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCCCCEEEE
SSNYNTRNKVCELALEEGQVRLIRQRENFENQIALEEKFLKA
CCCCCHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDYKQLKQEFNTPFYIYNFDFIKECFLNLKEAFKARKSQIFYAVKANSNLSLLQMLANLD
CCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHCC
SGFDCVSIGEVKRALKAGAKAYKIIFSGVGKTKEELRQALEYDILYINLESEAEMMLLES
CCCCEEEHHHHHHHHHCCCHHEEHHHHCCCCCHHHHHHHHCEEEEEEEECCCHHHHHHHH
VAKELNLKARISIRVNPNVDAKTHPYISTGLNENKFGVEIDIARKMYLYAKNSSFLEPVG
HHHHCCCEEEEEEEECCCCCCCCCCCEECCCCCCCCCEEEEEEEEEEEEECCCCCCCCCC
VHFHIGSQLLDISPIHEAAGIVAKLVRELKALQIDLKFFDIGGGLGVAYEKDECESDLYD
EEEEECCCEECCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCEEECCHHHHHHHHH
YAQGILAQLHGLDLTIGMEPGRYLVAKSGEFVCSVLYEKQNKTKRFVVVDGAMNDLIRPS
HHHHHHHHHCCCEEEEECCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEECCHHHHCCHH
LYEAYHEIILPYNQAQESLCDVVGGICESGDFFAKARSLPSTQSGDIMVIKNTGAYGFSM
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCCCCEEEE
SSNYNTRNKVCELALEEGQVRLIRQRENFENQIALEEKFLKA
CCCCCHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]