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The map label for this gene is lpxA [H]

Identifier: 57237330

GI number: 57237330

Start: 287343

End: 288134

Strand: Direct

Name: lpxA [H]

Synonym: CJE0323

Alternate gene names: 57237330

Gene position: 287343-288134 (Clockwise)

Preceding gene: 57237329

Following gene: 57237331

Centisome position: 16.16

GC content: 34.22

Gene sequence:

>792_bases
ATGAAAAAAATTCATCCAAGTGCGGTGATTGAAGAGGGTGCACAACTTGGTGACGATGTTGTAGTAGAAGCTTATGCTTA
TGTAAGCAAAGATGCTAAAATAGGTAATAATGTTGTCATCAAACAAGGTGCTCGAATTCTTTCAGATACAACTATAGGTG
ATCATTCTCGTGTATTTTCTTATGCTATAGTAGGCGATATTCCTCAGGACATATCTTATAAAGAAGAGCAAAAAAGCGGT
GTTGTTATAGGGAAAAATGCAACTATTAGAGAATTTGCAACGATAAATTCAGGTACAGCTAAAGGAGATGGTTTTACTCG
TATAGGCGATAATGCTTTTATTATGGCTTATTGTCATATTGCTCATGATTGTCTTTTAGGTAATAATATTATTTTAGCTA
ATAATGCAACTTTGGCAGGACATGTAGAGCTTGGAGATTTTACGGTTGTAGGCGGGCTTACACCTATTCATCAATTTGTC
AAAGTAGGTGAGGGTTGTATGATAGCAGGAGCAAGTGCACTTTCTCAGGATATAGTACCGTTTTGTTTAGCAGAAGGAAA
TCGTGCAAGTATTAGAAGTTTAAATTTAGTAGGTACTCGTCGTCGTTTTGATAAAGATGAAGTAGATAGACTTAGTAGAG
CTTTTAAAACTTTATTTAGACAAGGAGATTTAAAAGAAAATGCTAAAAATTTGCTTGAAAATCAAGAAAGTGAAAATGTT
AAAAAAATGTGCCATTTTATATTAGAAACAAAGCGTGGAATTCCTGTCTATAGGGGTAAAAATAATGCCTAG

Upstream 100 bases:

>100_bases
TTAAAAATCGTGGTAATATGTGGATTTTTAAAGGGCAAGCTTTTGTAGATGGAAATTTAGTTGCAGAGGCCGAGCTTAAA
GCTATGATAGTGGATAAATA

Downstream 100 bases:

>100_bases
AAAATGTAGTTTTTGCAATGAAGTGGAGAATCCACAAAGAAGAATTTTAGCAAATGAAAATGATGATGCTTTTATTTGTG
AATATTGCGTTGAAGGTGCT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKKIHPSAVIEEGAQLGDDVVVEAYAYVSKDAKIGNNVVIKQGARILSDTTIGDHSRVFSYAIVGDIPQDISYKEEQKSG
VVIGKNATIREFATINSGTAKGDGFTRIGDNAFIMAYCHIAHDCLLGNNIILANNATLAGHVELGDFTVVGGLTPIHQFV
KVGEGCMIAGASALSQDIVPFCLAEGNRASIRSLNLVGTRRRFDKDEVDRLSRAFKTLFRQGDLKENAKNLLENQESENV
KKMCHFILETKRGIPVYRGKNNA

Sequences:

>Translated_263_residues
MKKIHPSAVIEEGAQLGDDVVVEAYAYVSKDAKIGNNVVIKQGARILSDTTIGDHSRVFSYAIVGDIPQDISYKEEQKSG
VVIGKNATIREFATINSGTAKGDGFTRIGDNAFIMAYCHIAHDCLLGNNIILANNATLAGHVELGDFTVVGGLTPIHQFV
KVGEGCMIAGASALSQDIVPFCLAEGNRASIRSLNLVGTRRRFDKDEVDRLSRAFKTLFRQGDLKENAKNLLENQESENV
KKMCHFILETKRGIPVYRGKNNA
>Mature_263_residues
MKKIHPSAVIEEGAQLGDDVVVEAYAYVSKDAKIGNNVVIKQGARILSDTTIGDHSRVFSYAIVGDIPQDISYKEEQKSG
VVIGKNATIREFATINSGTAKGDGFTRIGDNAFIMAYCHIAHDCLLGNNIILANNATLAGHVELGDFTVVGGLTPIHQFV
KVGEGCMIAGASALSQDIVPFCLAEGNRASIRSLNLVGTRRRFDKDEVDRLSRAFKTLFRQGDLKENAKNLLENQESENV
KKMCHFILETKRGIPVYRGKNNA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=254, Percent_Identity=37.007874015748, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1786376, Length=233, Percent_Identity=26.1802575107296, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28625; Mature: 28625

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIHPSAVIEEGAQLGDDVVVEAYAYVSKDAKIGNNVVIKQGARILSDTTIGDHSRVFS
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCEEECCCCCCCCHHHEE
YAIVGDIPQDISYKEEQKSGVVIGKNATIREFATINSGTAKGDGFTRIGDNAFIMAYCHI
EEEECCCCCCCCCCHHHCCCEEEECCCCCHHHEECCCCCCCCCCCEEECCCEEEEEHHHH
AHDCLLGNNIILANNATLAGHVELGDFTVVGGLTPIHQFVKVGEGCMIAGASALSQDIVP
HHHHHCCCCEEEECCCEEEEEEEECCEEEECCCHHHHHHHHHCCCEEEECHHHHHHCCHH
FCLAEGNRASIRSLNLVGTRRRFDKDEVDRLSRAFKTLFRQGDLKENAKNLLENQESENV
HHHCCCCCCHHEEEEEEHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
KKMCHFILETKRGIPVYRGKNNA
HHHHHHHHHHCCCCCEECCCCCC
>Mature Secondary Structure
MKKIHPSAVIEEGAQLGDDVVVEAYAYVSKDAKIGNNVVIKQGARILSDTTIGDHSRVFS
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCEEECCCCCCCCHHHEE
YAIVGDIPQDISYKEEQKSGVVIGKNATIREFATINSGTAKGDGFTRIGDNAFIMAYCHI
EEEECCCCCCCCCCHHHCCCEEEECCCCCHHHEECCCCCCCCCCCEEECCCEEEEEHHHH
AHDCLLGNNIILANNATLAGHVELGDFTVVGGLTPIHQFVKVGEGCMIAGASALSQDIVP
HHHHHCCCCEEEECCCEEEEEEEECCEEEECCCHHHHHHHHHCCCEEEECHHHHHHCCHH
FCLAEGNRASIRSLNLVGTRRRFDKDEVDRLSRAFKTLFRQGDLKENAKNLLENQESENV
HHHCCCCCCHHEEEEEEHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
KKMCHFILETKRGIPVYRGKNNA
HHHHHHHHHHCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA