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The map label for this gene is tlpA [H]

Identifier: 57237321

GI number: 57237321

Start: 279637

End: 281616

Strand: Reverse

Name: tlpA [H]

Synonym: CJE0314

Alternate gene names: 57237321

Gene position: 281616-279637 (Counterclockwise)

Preceding gene: 57237322

Following gene: 57237319

Centisome position: 15.84

GC content: 31.16

Gene sequence:

>1980_bases
ATGAAAAGTGTAAAATTGAAGGTTTCACTGATTGCAAATTTAATCGCAGTAGTGTGTTTGATAATTTTAGGTGTTGTAAC
ATTTATATTTGTAAAGCAAGCAATTTTTCATGAAGTTGTGAATGCTGAAATAAATTATGTTAAAACGGCTAAAAATTCTA
TAGAGTCTTTTAAGGCAAGAAATTCTTTAGCTCTTGAAAGTTTAGCTAAAAGTATTTTAAAGCATCCTATAGAACAGTTA
GATAGTCAAGATGCTTTAATGCATTATGTTGGAAAAGATTTAAAGAATTTTAGAGATGCTGGAAGATTCTTAGCAGTTTA
TATTGCTCAACCAAATGGCGAACTTGTTGTAAGCGATCCAGACTCTGATGCTAAAAATTTAGATTTTGGAACTTATGGAA
AAGCTGATAATTATAATGCTAGAACAAGAGAGTATTATATAGAAGCAGTTAAAACAAATAAACTTTATATTACCCCATCT
TATATTGATGTAACTACAAATTTACCTTGCTTTACATATTCTATTCCGCTTTATAAAGATGGTAAATTTATAGGGGTTTT
GGCTGTAGATATTCTTGCGGCAGATTTGCAAGCTGAATTTGAAAATTTACCAGGTAGAACTTTTGTATTTGATGAAGAAA
ATAAAGTATTTGTTTCTACAGACAAAACTCTTTTGCAACAAGGTTATGATATTAGTACTATTGCAAATCTTGCTAAAACT
AAAGAGGATCTTGAACCTTTTGAGTATACTAGACCAAAAGATGGTAATGAAAGATTTGCTGTATGCACAAAGGTTTCTGG
AATTTATACTGCTTGCGTTGGAGAGCCAATAGAACAAATAGAAGCTCCAGTTTATAAAATTGCATTTATACAAACTGTGA
TTGTTGTTTTTGCAAGCATTCTTAGCGTCATCCTCCTTTATTTCATCGTATCAAAATACCTCTCCCCACTTGCAGCTATC
CAAACAGGTTTAACTTCATTCTTTGATTTTATCAACTATAAAACAAAAAATGTTTCTACTATAGAAGTAAAAAGCAATGA
TGAATTTGGACAAATCTCAAATGCTATCAATGAAAACATTCTTGCTACTAAAAGAGGCTTAGAACAAGACAATCAAGCCG
TTAAAGAATCAGTTCAAACCGTATCAGTTGTAGAAGGTGGTAATTTAACAGCAAGAATTACTGCTAATCCAAGAAACCCA
CAGCTTATTGAACTTAAAAATGTTCTAAATAAACTTCTTGATGTTTTACAAGCTAGAGTAGGTTCTGATATGAATGCTAT
TCATAAAATTTTTGAAGAATACAAAAGCTTAGACTTTAGAAATAAATTAGAAAATGCTAGCGGTAGTGTAGAATTAACTA
CTAATGCTTTAGGTGATGAAATAGTTAAAATGCTAAAACAAAGTTCAGACTTTGCTAATGCCTTAGCTAATGAAAGTGGA
AAATTACAAACTGCTGTTCAAAGCTTAACCACTTCTTCAAATTCTCAAGCTCAATCTTTAGAAGAAACTGCAGCAGCTTT
AGAAGAGATCACTTCTTCTATGCAAAATGTTTCAGTTAAAACTAGTGATGTTATCACTCAATCTGAAGAGATTAAAAATG
TTACAGGTATTATAGGTGATATTGCAGATCAAATCAATCTTCTAGCTTTAAATGCAGCTATTGAAGCAGCTCGTGCTGGA
GAACATGGTAGAGGCTTTGCAGTGGTAGCTGATGAAGTTAGAAAGTTAGCTGAAAGAACTCAAAAGTCTTTATCAGAAAT
TGAAGCTAATACTAATTTACTTGTTCAATCTATCAATGATATGGCAGAAAGTATTAAAGAACAAACTGCAGGTATCACTC
AAATCAATGATAGCGTAGCTCAAATTGATCAAACTACTAAAGATAATGTTGAAATTGCTAATGAATCAGCTATTATTTCT
AGTACAGTAAGTGATATAGCTAATAATATCTTAGAAGATGTTAAGAAGAAGAGGTTTTAA

Upstream 100 bases:

>100_bases
ACTTTTATATTTAAGTAAAAATCTAGATTTTTTAATTTATAATTCTAAAACTTTATGTAGATATCTCTATAAAATAATAT
TAGAAAGGAGCGCTTAAATT

Downstream 100 bases:

>100_bases
TTAATCATTCAAGCCCTTTCTTTGGGCTTGAATTTTAAAAATTTATGCTATGATTTTGTATATTTTATAAATAAACACTT
AACAACAAAAAATAATTTTC

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MKSVKLKVSLIANLIAVVCLIILGVVTFIFVKQAIFHEVVNAEINYVKTAKNSIESFKARNSLALESLAKSILKHPIEQL
DSQDALMHYVGKDLKNFRDAGRFLAVYIAQPNGELVVSDPDSDAKNLDFGTYGKADNYNARTREYYIEAVKTNKLYITPS
YIDVTTNLPCFTYSIPLYKDGKFIGVLAVDILAADLQAEFENLPGRTFVFDEENKVFVSTDKTLLQQGYDISTIANLAKT
KEDLEPFEYTRPKDGNERFAVCTKVSGIYTACVGEPIEQIEAPVYKIAFIQTVIVVFASILSVILLYFIVSKYLSPLAAI
QTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAINENILATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANPRNP
QLIELKNVLNKLLDVLQARVGSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALANESG
KLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGIIGDIADQINLLALNAAIEAARAG
EHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQSINDMAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESAIIS
STVSDIANNILEDVKKKRF

Sequences:

>Translated_659_residues
MKSVKLKVSLIANLIAVVCLIILGVVTFIFVKQAIFHEVVNAEINYVKTAKNSIESFKARNSLALESLAKSILKHPIEQL
DSQDALMHYVGKDLKNFRDAGRFLAVYIAQPNGELVVSDPDSDAKNLDFGTYGKADNYNARTREYYIEAVKTNKLYITPS
YIDVTTNLPCFTYSIPLYKDGKFIGVLAVDILAADLQAEFENLPGRTFVFDEENKVFVSTDKTLLQQGYDISTIANLAKT
KEDLEPFEYTRPKDGNERFAVCTKVSGIYTACVGEPIEQIEAPVYKIAFIQTVIVVFASILSVILLYFIVSKYLSPLAAI
QTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAINENILATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANPRNP
QLIELKNVLNKLLDVLQARVGSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALANESG
KLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGIIGDIADQINLLALNAAIEAARAG
EHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQSINDMAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESAIIS
STVSDIANNILEDVKKKRF
>Mature_659_residues
MKSVKLKVSLIANLIAVVCLIILGVVTFIFVKQAIFHEVVNAEINYVKTAKNSIESFKARNSLALESLAKSILKHPIEQL
DSQDALMHYVGKDLKNFRDAGRFLAVYIAQPNGELVVSDPDSDAKNLDFGTYGKADNYNARTREYYIEAVKTNKLYITPS
YIDVTTNLPCFTYSIPLYKDGKFIGVLAVDILAADLQAEFENLPGRTFVFDEENKVFVSTDKTLLQQGYDISTIANLAKT
KEDLEPFEYTRPKDGNERFAVCTKVSGIYTACVGEPIEQIEAPVYKIAFIQTVIVVFASILSVILLYFIVSKYLSPLAAI
QTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAINENILATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANPRNP
QLIELKNVLNKLLDVLQARVGSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALANESG
KLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGIIGDIADQINLLALNAAIEAARAG
EHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQSINDMAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESAIIS
STVSDIANNILEDVKKKRF

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=277, Percent_Identity=28.8808664259928, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787690, Length=222, Percent_Identity=31.5315315315315, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788194, Length=218, Percent_Identity=33.0275229357798, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788195, Length=253, Percent_Identity=30.8300395256917, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789453, Length=210, Percent_Identity=31.4285714285714, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 72406; Mature: 72406

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVKLKVSLIANLIAVVCLIILGVVTFIFVKQAIFHEVVNAEINYVKTAKNSIESFKAR
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
NSLALESLAKSILKHPIEQLDSQDALMHYVGKDLKNFRDAGRFLAVYIAQPNGELVVSDP
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECC
DSDAKNLDFGTYGKADNYNARTREYYIEAVKTNKLYITPSYIDVTTNLPCFTYSIPLYKD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHEEECCEEEEECCEEEEECCCCEEEEECCEEEC
GKFIGVLAVDILAADLQAEFENLPGRTFVFDEENKVFVSTDKTLLQQGYDISTIANLAKT
CCEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCHHHHHCCCCHHHHHHHHHH
KEDLEPFEYTRPKDGNERFAVCTKVSGIYTACVGEPIEQIEAPVYKIAFIQTVIVVFASI
HHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHH
LSVILLYFIVSKYLSPLAAIQTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAINENI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHH
LATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANPRNPQLIELKNVLNKLLDVLQARV
HHHHCCCCHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHH
GSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALANESG
CCCHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHCCCC
KLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGIIGD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IADQINLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQSIND
HHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESAIISSTVSDIANNILEDVKKKRF
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSVKLKVSLIANLIAVVCLIILGVVTFIFVKQAIFHEVVNAEINYVKTAKNSIESFKAR
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
NSLALESLAKSILKHPIEQLDSQDALMHYVGKDLKNFRDAGRFLAVYIAQPNGELVVSDP
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEECC
DSDAKNLDFGTYGKADNYNARTREYYIEAVKTNKLYITPSYIDVTTNLPCFTYSIPLYKD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHEEECCEEEEECCEEEEECCCCEEEEECCEEEC
GKFIGVLAVDILAADLQAEFENLPGRTFVFDEENKVFVSTDKTLLQQGYDISTIANLAKT
CCEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCHHHHHCCCCHHHHHHHHHH
KEDLEPFEYTRPKDGNERFAVCTKVSGIYTACVGEPIEQIEAPVYKIAFIQTVIVVFASI
HHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHH
LSVILLYFIVSKYLSPLAAIQTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAINENI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHH
LATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANPRNPQLIELKNVLNKLLDVLQARV
HHHHCCCCHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHH
GSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALANESG
CCCHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHCCCC
KLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGIIGD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IADQINLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQSIND
HHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESAIISSTVSDIANNILEDVKKKRF
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]