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The map label for this gene is tlpA [H]

Identifier: 57237319

GI number: 57237319

Start: 276479

End: 278467

Strand: Reverse

Name: tlpA [H]

Synonym: CJE0312

Alternate gene names: 57237319

Gene position: 278467-276479 (Counterclockwise)

Preceding gene: 57237321

Following gene: 57237318

Centisome position: 15.66

GC content: 30.52

Gene sequence:

>1989_bases
ATGCAAAAAATGGATTCAGGCAAATCCGTTGGAGTTTCAGTCAAACTTACGCTGTGGGTTGGAATTTTAGTTGTATTAAT
TTTAGCAATCACAAGTACCGTTAGTTACTTTGATGCCAAAAATCACACATATGAATTGCTAAAAGAAAATCAATTAAAAA
CTATGGATGATGTTAAAGTAACTTTTGAAAACTATTCCAAAAGCAAGCAAAAAGCTATAGAGGTTCTAGCATATGAAAGT
GCTAAAAAATTAGAAGATGAAAATATTTCACTGCTTCTAGATTCTTTTAAGAAGGCGTTTGATTTTGATATTGTTTTTAT
TGCGTTTGATAAAAACAACAAAATGCTTTTGTCAAATGGAACAATTTTAGATAAAAAATCAAATTTTGACATTACAAAAC
AAATTTGGTATCAAGAAGCAAAAAATAACAAAGGCATCACAATAACTCAACCATATAAATCCCCTATAGATCAAGAGATT
GGTATAACTTATGTTTTCCCTATTTATAAAAATAATCAACTTATAGCTTTCGTTGGAGGCGATTACAATCTAGATAAATT
TTCCAAAGATGTATTATCTTTAGGACACTCATCAACTACTTATGCTGCTGTTTATGACTCTGAAGGAAGAATTATTTTTC
ACGAAGTGCTTGATAGAATTTTAACAAAAAACACTTTAAGCGTTAATATTGCTAACGCCATAAAAGAAAACCCTGAATAT
ATAGATCCAAATAAGAGAGATATTCTTTTTCCTGTATTTGATGATAAAGGTATCAAATATGAAACAATGTGCGATACAAG
TTCCAATGGATTATATCGTATTTGTGCTGTAACTTTAGATAGTAACTATACTTCCGCTGTTAATTCCATTTTAATGAAAC
AAGTTATAGTTGGTATTATAGCTATAATCATAGCTTTAATCTTGATTAGATTTTTAATCAGCAGAAGCCTCTCCCCACTT
GCAGCTATCCAAACAGGTTTAACTTCATTCTTTGATTTTATCAACTATAAAACAAAAAATGTTTCTACTATAGAAGTAAA
AAGCAATGATGAATTTGGACAAATCTCAAATGCTATCAATGAAAACATTCTTGCTACTAAAAGAGGCTTAGAACAAGACA
ATCAAGCCGTTAAAGAATCAGTTCAAACCGTATCAGTTGTAGAAGGTGGTAATTTAACAGCAAGAATTACTGCTAATCCA
AGAAACCCACAGCTTATTGAACTTAAAAATGTTCTAAATAAACTTCTTGATGTTTTACAAGCTAGAGTAGGTTCTGATAT
GAATGCTATTCATAAAATTTTTGAAGAATACAAAAGCTTAGACTTTAGAAATAAATTAGAAAATGCTAGCGGTAGTGTAG
AATTAACTACTAATGCTTTAGGTGATGAAATAGTTAAAATGCTAAAACAAAGTTCAGACTTTGCTAATGCCTTAGCTAAT
GAAAGTGGAAAATTACAAACTGCTGTTCAAAGCTTAACCACTTCTTCAAATTCTCAAGCTCAATCTTTAGAAGAAACTGC
AGCAGCTTTAGAAGAGATCACTTCTTCTATGCAAAATGTTTCAGTTAAAACTAGTGATGTTATCACTCAATCTGAAGAGA
TTAAAAATGTTACAGGTATTATAGGTGATATTGCAGATCAAATCAATCTTCTAGCTTTAAATGCAGCTATTGAAGCAGCT
CGTGCTGGAGAACATGGTAGAGGCTTTGCAGTGGTAGCTGATGAAGTTAGAAAGTTAGCTGAAAGAACTCAAAAGTCTTT
ATCAGAAATTGAAGCTAATACTAATTTACTTGTTCAATCTATCAATGATATGGCAGAAAGTATTAAAGAACAAACTGCAG
GTATCACTCAAATCAATGATAGCGTAGCTCAAATTGATCAAACTACTAAAGATAATGTTGAAATTGCTAATGAATCAGCT
ATTATTTCTAGTACAGTAAGTGATATAGCTAATAATATCTTAGAAGATGTTAAGAAGAAGAGGTTTTAA

Upstream 100 bases:

>100_bases
AAGAATATTTATGTAAAAAAGTTCATTTTTATGCATTTCTTTCTCTATATTTCTGCTATAATAATAATTTTATTTCCAAA
ATATAAATATAGGAGTTATA

Downstream 100 bases:

>100_bases
TTAATCATTCAAGCCCTTTCTTTGGGCTTGAATTTTAAAAATTTATGCTATGATTTTGTATATTTTATCAAGGAAAATAT
ATGAATTTATGGGATAAAAA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MQKMDSGKSVGVSVKLTLWVGILVVLILAITSTVSYFDAKNHTYELLKENQLKTMDDVKVTFENYSKSKQKAIEVLAYES
AKKLEDENISLLLDSFKKAFDFDIVFIAFDKNNKMLLSNGTILDKKSNFDITKQIWYQEAKNNKGITITQPYKSPIDQEI
GITYVFPIYKNNQLIAFVGGDYNLDKFSKDVLSLGHSSTTYAAVYDSEGRIIFHEVLDRILTKNTLSVNIANAIKENPEY
IDPNKRDILFPVFDDKGIKYETMCDTSSNGLYRICAVTLDSNYTSAVNSILMKQVIVGIIAIIIALILIRFLISRSLSPL
AAIQTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAINENILATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANP
RNPQLIELKNVLNKLLDVLQARVGSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALAN
ESGKLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGIIGDIADQINLLALNAAIEAA
RAGEHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQSINDMAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESA
IISSTVSDIANNILEDVKKKRF

Sequences:

>Translated_662_residues
MQKMDSGKSVGVSVKLTLWVGILVVLILAITSTVSYFDAKNHTYELLKENQLKTMDDVKVTFENYSKSKQKAIEVLAYES
AKKLEDENISLLLDSFKKAFDFDIVFIAFDKNNKMLLSNGTILDKKSNFDITKQIWYQEAKNNKGITITQPYKSPIDQEI
GITYVFPIYKNNQLIAFVGGDYNLDKFSKDVLSLGHSSTTYAAVYDSEGRIIFHEVLDRILTKNTLSVNIANAIKENPEY
IDPNKRDILFPVFDDKGIKYETMCDTSSNGLYRICAVTLDSNYTSAVNSILMKQVIVGIIAIIIALILIRFLISRSLSPL
AAIQTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAINENILATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANP
RNPQLIELKNVLNKLLDVLQARVGSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALAN
ESGKLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGIIGDIADQINLLALNAAIEAA
RAGEHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQSINDMAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESA
IISSTVSDIANNILEDVKKKRF
>Mature_662_residues
MQKMDSGKSVGVSVKLTLWVGILVVLILAITSTVSYFDAKNHTYELLKENQLKTMDDVKVTFENYSKSKQKAIEVLAYES
AKKLEDENISLLLDSFKKAFDFDIVFIAFDKNNKMLLSNGTILDKKSNFDITKQIWYQEAKNNKGITITQPYKSPIDQEI
GITYVFPIYKNNQLIAFVGGDYNLDKFSKDVLSLGHSSTTYAAVYDSEGRIIFHEVLDRILTKNTLSVNIANAIKENPEY
IDPNKRDILFPVFDDKGIKYETMCDTSSNGLYRICAVTLDSNYTSAVNSILMKQVIVGIIAIIIALILIRFLISRSLSPL
AAIQTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAINENILATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANP
RNPQLIELKNVLNKLLDVLQARVGSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALAN
ESGKLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGIIGDIADQINLLALNAAIEAA
RAGEHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQSINDMAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESA
IISSTVSDIANNILEDVKKKRF

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=277, Percent_Identity=28.8808664259928, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1787690, Length=222, Percent_Identity=31.5315315315315, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788194, Length=218, Percent_Identity=33.0275229357798, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788195, Length=253, Percent_Identity=30.8300395256917, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789453, Length=210, Percent_Identity=31.4285714285714, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 73113; Mature: 73113

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKMDSGKSVGVSVKLTLWVGILVVLILAITSTVSYFDAKNHTYELLKENQLKTMDDVKV
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHEE
TFENYSKSKQKAIEVLAYESAKKLEDENISLLLDSFKKAFDFDIVFIAFDKNNKMLLSNG
EHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEECC
TILDKKSNFDITKQIWYQEAKNNKGITITQPYKSPIDQEIGITYVFPIYKNNQLIAFVGG
EEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEECCEEEEEECC
DYNLDKFSKDVLSLGHSSTTYAAVYDSEGRIIFHEVLDRILTKNTLSVNIANAIKENPEY
CCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCCEEEEEHHHHHCCCCC
IDPNKRDILFPVFDDKGIKYETMCDTSSNGLYRICAVTLDSNYTSAVNSILMKQVIVGII
CCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
AIIIALILIRFLISRSLSPLAAIQTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAIN
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHH
ENILATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANPRNPQLIELKNVLNKLLDVLQ
HHHHHHHCCCCHHHHHHHHHHHEEEEEECCCEEEEEEECCCCCCEEHHHHHHHHHHHHHH
ARVGSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALAN
HHHCCCHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHC
ESGKLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGI
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHH
IGDIADQINLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQS
HHHHHHHHHHEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
INDMAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESAIISSTVSDIANNILEDVKKK
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHC
RF
CC
>Mature Secondary Structure
MQKMDSGKSVGVSVKLTLWVGILVVLILAITSTVSYFDAKNHTYELLKENQLKTMDDVKV
CCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHEE
TFENYSKSKQKAIEVLAYESAKKLEDENISLLLDSFKKAFDFDIVFIAFDKNNKMLLSNG
EHHHHCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEECC
TILDKKSNFDITKQIWYQEAKNNKGITITQPYKSPIDQEIGITYVFPIYKNNQLIAFVGG
EEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEECCEEEEEECC
DYNLDKFSKDVLSLGHSSTTYAAVYDSEGRIIFHEVLDRILTKNTLSVNIANAIKENPEY
CCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCCEEEEEHHHHHCCCCC
IDPNKRDILFPVFDDKGIKYETMCDTSSNGLYRICAVTLDSNYTSAVNSILMKQVIVGII
CCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
AIIIALILIRFLISRSLSPLAAIQTGLTSFFDFINYKTKNVSTIEVKSNDEFGQISNAIN
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHH
ENILATKRGLEQDNQAVKESVQTVSVVEGGNLTARITANPRNPQLIELKNVLNKLLDVLQ
HHHHHHHCCCCHHHHHHHHHHHEEEEEECCCEEEEEEECCCCCCEEHHHHHHHHHHHHHH
ARVGSDMNAIHKIFEEYKSLDFRNKLENASGSVELTTNALGDEIVKMLKQSSDFANALAN
HHHCCCHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHC
ESGKLQTAVQSLTTSSNSQAQSLEETAAALEEITSSMQNVSVKTSDVITQSEEIKNVTGI
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHH
IGDIADQINLLALNAAIEAARAGEHGRGFAVVADEVRKLAERTQKSLSEIEANTNLLVQS
HHHHHHHHHHEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
INDMAESIKEQTAGITQINDSVAQIDQTTKDNVEIANESAIISSTVSDIANNILEDVKKK
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHC
RF
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]