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The map label for this gene is clpP [H]

Identifier: 57237197

GI number: 57237197

Start: 185563

End: 186147

Strand: Reverse

Name: clpP [H]

Synonym: CJE0185

Alternate gene names: 57237197

Gene position: 186147-185563 (Counterclockwise)

Preceding gene: 57237198

Following gene: 57237196

Centisome position: 10.47

GC content: 32.48

Gene sequence:

>585_bases
ATGTTTATTCCTTATGTTATTGAAAAATCTAGTCGTGGTGAAAGAAGTTATGACATTTATTCACGCCTTTTAAAAGATAG
AATTATTATGCTAAGTGGTGAAATTCATGATGAACTTGCCGCTTCTATCGTAGCACAACTTCTTTTTTTAGAAGCTGAAG
ATCCTACAAAAGATATTTATCTTTATATCAATTCTCCAGGTGGTGTAATTACAAGTGGTTTTAGTATTTATGATACTATG
AACTATATCAAACCTGATGTTTGTACGATTTGCATAGGACAAGCTGCTTCTATGGGAGCATTTTTGCTTAGTTGTGGCGC
AGAAGGAAAACGTTTTGCTTTGCCTAATTCACGCATTATGATTCATCAACCTTTAGGTGGAGCTAGAGGTCAAGCCACAG
ATATTGAAATTCAAGCCAAAGAAATTTTAAGACTCAAAACTATACTTAATGATATTTTGGCAAAAAATACTAAGCAAAAA
GTTGCAAAAATAGCAAAAGATACAGAAAGAGATTTTTTCATGTCAGCACAAGAAGCTAAAGAATATGGGCTGATTGATAA
GGTTTTGGAAAAAAGTTTTAAATGA

Upstream 100 bases:

>100_bases
TGAAAATGGCTTTAATTGAAGAAAAACTTTTTAATGATATTTTTATACCAAAAACAGAAAAATCGGAAAAAGTGAGCAAA
AAAGAGAAAGAAGATAAATA

Downstream 100 bases:

>100_bases
TTTCTTTGGAGATCATTTAAAACAAAGGTTTTTTAATGGTTAGAAAAATTATCACCTATCCCAATCCTAGACTTTTTTTA
AACTCTGAAATTGTAAATAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MFIPYVIEKSSRGERSYDIYSRLLKDRIIMLSGEIHDELAASIVAQLLFLEAEDPTKDIYLYINSPGGVITSGFSIYDTM
NYIKPDVCTICIGQAASMGAFLLSCGAEGKRFALPNSRIMIHQPLGGARGQATDIEIQAKEILRLKTILNDILAKNTKQK
VAKIAKDTERDFFMSAQEAKEYGLIDKVLEKSFK

Sequences:

>Translated_194_residues
MFIPYVIEKSSRGERSYDIYSRLLKDRIIMLSGEIHDELAASIVAQLLFLEAEDPTKDIYLYINSPGGVITSGFSIYDTM
NYIKPDVCTICIGQAASMGAFLLSCGAEGKRFALPNSRIMIHQPLGGARGQATDIEIQAKEILRLKTILNDILAKNTKQK
VAKIAKDTERDFFMSAQEAKEYGLIDKVLEKSFK
>Mature_194_residues
MFIPYVIEKSSRGERSYDIYSRLLKDRIIMLSGEIHDELAASIVAQLLFLEAEDPTKDIYLYINSPGGVITSGFSIYDTM
NYIKPDVCTICIGQAASMGAFLLSCGAEGKRFALPNSRIMIHQPLGGARGQATDIEIQAKEILRLKTILNDILAKNTKQK
VAKIAKDTERDFFMSAQEAKEYGLIDKVLEKSFK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=59.5744680851064, Blast_Score=243, Evalue=9e-65,
Organism=Escherichia coli, GI1786641, Length=188, Percent_Identity=68.6170212765958, Blast_Score=283, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.2258064516129, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=57.1428571428571, Blast_Score=239, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21650; Mature: 21650

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIPYVIEKSSRGERSYDIYSRLLKDRIIMLSGEIHDELAASIVAQLLFLEAEDPTKDIY
CCCCEEEECCCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVITSGFSIYDTMNYIKPDVCTICIGQAASMGAFLLSCGAEGKRFALPNSRIM
EEEECCCCEEECCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCEEE
IHQPLGGARGQATDIEIQAKEILRLKTILNDILAKNTKQKVAKIAKDTERDFFMSAQEAK
EECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
EYGLIDKVLEKSFK
HCCHHHHHHHHCCC
>Mature Secondary Structure
MFIPYVIEKSSRGERSYDIYSRLLKDRIIMLSGEIHDELAASIVAQLLFLEAEDPTKDIY
CCCCEEEECCCCCCCHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVITSGFSIYDTMNYIKPDVCTICIGQAASMGAFLLSCGAEGKRFALPNSRIM
EEEECCCCEEECCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCEEE
IHQPLGGARGQATDIEIQAKEILRLKTILNDILAKNTKQKVAKIAKDTERDFFMSAQEAK
EECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
EYGLIDKVLEKSFK
HCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA