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The map label for this gene is trx [H]

Identifier: 57237155

GI number: 57237155

Start: 150472

End: 150786

Strand: Reverse

Name: trx [H]

Synonym: CJE0143

Alternate gene names: 57237155

Gene position: 150786-150472 (Counterclockwise)

Preceding gene: 57237156

Following gene: 57237154

Centisome position: 8.48

GC content: 34.6

Gene sequence:

>315_bases
ATGGGAAAATATATTGAATTAACAAGTGATAATTTTGCTCAAGCAAAAGAAGGTGTAGCTTTAGTTGATTTTTGGGCTCC
ATGGTGCGGACCTTGTAGAATGCTTGCTCCAGTTATTGATGAACTTGCAAATGACTTCGATGGTAAAGCTAAAATTTGCA
AAGTAAATACAGATGAACAAGGTGATTTAGCAGCTGAATTTGGTGTTCGCTCTATTCCTACGCTTATTTTCTTTAAAAAT
GGTGAAGTTGTAGATCAACTCGTTGGTGCACAATCTAAACAAGCAATTAGTGATAAACTAAACTCTTTACTATAA

Upstream 100 bases:

>100_bases
TTAAAAATGATGTGATACAATTTTGCGAAAATATAAGTTTTTAAGCTGATATTTAAAAAAATAAAATACAATTAGACAAA
AATTAAAGAAAGGAAAAATT

Downstream 100 bases:

>100_bases
ACTAAAGGCTAGTATAACTAGCCTTCTTCTTAAAAATTTCAAATTTATACTAAATAATAATTTTTATTAACTACTATTAA
GAATAATTTTTATATCATTA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MGKYIELTSDNFAQAKEGVALVDFWAPWCGPCRMLAPVIDELANDFDGKAKICKVNTDEQGDLAAEFGVRSIPTLIFFKN
GEVVDQLVGAQSKQAISDKLNSLL

Sequences:

>Translated_104_residues
MGKYIELTSDNFAQAKEGVALVDFWAPWCGPCRMLAPVIDELANDFDGKAKICKVNTDEQGDLAAEFGVRSIPTLIFFKN
GEVVDQLVGAQSKQAISDKLNSLL
>Mature_103_residues
GKYIELTSDNFAQAKEGVALVDFWAPWCGPCRMLAPVIDELANDFDGKAKICKVNTDEQGDLAAEFGVRSIPTLIFFKNG
EVVDQLVGAQSKQAISDKLNSLL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=88, Percent_Identity=38.6363636363636, Blast_Score=76, Evalue=4e-15,
Organism=Homo sapiens, GI42794771, Length=94, Percent_Identity=36.1702127659575, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI20070125, Length=82, Percent_Identity=40.2439024390244, Blast_Score=69, Evalue=8e-13,
Organism=Homo sapiens, GI224493972, Length=94, Percent_Identity=36.1702127659575, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI21361657, Length=101, Percent_Identity=33.6633663366337, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=46.6666666666667, Blast_Score=104, Evalue=9e-25,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=50, Blast_Score=99, Evalue=8e-23,
Organism=Escherichia coli, GI87081747, Length=84, Percent_Identity=35.7142857142857, Blast_Score=66, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=80, Percent_Identity=40, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980565, Length=76, Percent_Identity=43.421052631579, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71980562, Length=77, Percent_Identity=42.8571428571429, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=84, Percent_Identity=36.9047619047619, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=79, Percent_Identity=40.5063291139241, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=73, Percent_Identity=42.4657534246575, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=95, Percent_Identity=36.8421052631579, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=83, Percent_Identity=33.7349397590361, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=43.1818181818182, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=83, Percent_Identity=44.578313253012, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=70, Percent_Identity=34.2857142857143, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639826, Length=90, Percent_Identity=41.1111111111111, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573567, Length=81, Percent_Identity=37.037037037037, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17648013, Length=83, Percent_Identity=38.5542168674699, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=83, Percent_Identity=38.5542168674699, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=77, Percent_Identity=40.2597402597403, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647799, Length=95, Percent_Identity=40, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24658597, Length=79, Percent_Identity=40.5063291139241, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921434, Length=80, Percent_Identity=41.25, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859803, Length=94, Percent_Identity=31.9148936170213, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11337; Mature: 11206

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKYIELTSDNFAQAKEGVALVDFWAPWCGPCRMLAPVIDELANDFDGKAKICKVNTDEQ
CCCEEEECCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
GDLAAEFGVRSIPTLIFFKNGEVVDQLVGAQSKQAISDKLNSLL
CCHHHHCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
GKYIELTSDNFAQAKEGVALVDFWAPWCGPCRMLAPVIDELANDFDGKAKICKVNTDEQ
CCEEEECCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
GDLAAEFGVRSIPTLIFFKNGEVVDQLVGAQSKQAISDKLNSLL
CCHHHHCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]