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The map label for this gene is lctP [H]

Identifier: 57237084

GI number: 57237084

Start: 86025

End: 87722

Strand: Reverse

Name: lctP [H]

Synonym: CJE0072

Alternate gene names: 57237084

Gene position: 87722-86025 (Counterclockwise)

Preceding gene: 57237085

Following gene: 57237083

Centisome position: 4.93

GC content: 34.92

Gene sequence:

>1698_bases
TTGGAACAAATTTTAACATGGCAACAAATTTATGACCCTTTTTCAAACATTTGGCTAAGTGCTTTAGTGGCATTTTTACC
TATACTATGTTTTTTAGTTTGTTTGGTTGTTTTAAAACTTAAAGGCTATCAAGCAGGTTTTTTAACTGTTATACTTGCTA
CTTTGGTAGCTTTATTTGCCTATAAAATGCCTTGGAATTTAGTGGGTGCAAGTTTTATTCAAGGCTTTACAAATGGTATG
TGGCCTATAGCTTGGATTATCATCGCGGCAATCTTTCTTTACAAACTTTCTATCAAGTCAGGTTCTTTTGAAATCATTAA
AAAAAGCGTGATGAGCATTACTCCAGATCATAGAATTCAAGTGATTTTAATAGGTTTTTGTTTTGGTTCATTTTTAGAGG
GTGCTATAGGTTTTGGTGGCCCTGTGGCTATAACCGCTGCACTTTTAGTAGGACTTGGCTTGCGTCCTTTACAAGCTGCA
GGGCTTTGTCTTATCGCAAATACCGCTCCTGTTGCTTTTGGTGCGGTGGGAATTCCTATTATTGCTATGGCAAATCTTGT
CGGCATAGAACAGCATTCAGTTTCTGCCATGGTAGGTAGAATGCTAGTTCCTTTAAGCCTTACTATACCTTTTTTCATAG
TTTTTTTAATGGATGGATTTAAAGGTATTAAAGAAACTTTTCCAGCTATTTTAGTTGCGGCGCTAAGTTTTACAACTACT
CAATTTTTAAGCTCAAATCACCTAGGAGCGGAATTACCTGATATTATTTCAGCTGTGGTTTCTTTAGCAGTTACGACTGT
ATTTTTGAAATTTTGGAAACCAAAAAATATTTTTAGATTTGACAATGAAAGCAATTTCACTCAAGATAACACCTTAAGTT
TTAATCAAATTTTAAAAGCTTGGTCACCTTTTATTTTACTCATTGTTTGTATTATCATTTGGACACAACCTTGGTTTAAA
GCTCTCTTTGATAAGGACGGAATTTTAAGCTATACAAGTATTACTTTACAATTTAGCAATATCACAACTGGAATTTTAAG
CCCTTCTATCACAGGCATAGGAGAAGCTAAGCCTTTATCTTTGGCCTTGGGTGTAGATTTAATCAATGGAAAAACCGTAG
CTCAAGCAGGAACAGCGATTTTACTTGCCGCTTTTCTAACTATAGCTATTTTAAAAATCAAAGCCGAAGATGCTGCAGAA
TGCTTTTGGGTTACCTTAAAAGAAATGGCTATACCTTGTATCACCATAGGTTTGGTTGTGGCCTTTGCTTTTATCTCTAA
AAATAGTGGTATGAGCACTACTTTAGGACTTGCTTTTGCACACACAGGTGATGCTTTTTCTTTCTTTTCACCAATCATTG
GCTGGATAGGGGTATTTTTAACAGGCTCTGATACAAGTGCTAATTTACTTTTTGGAACCTTGCAACAAGTAAGCGCTCAA
AAACTAGGTATTAGCGAAGCTTTATTTTTAGCAGCTAATTCAGTAGGTGGGGTTGTTGGAAAGATGATCAGTCCACAAAG
CATTGCTATAGCTTGTGCAGCGGTTGGACTTGTGGGAAAAGAATCTGATCTTTTCAAATTCACATTAAAATATTCTGTAG
CTTTTATTATTTTAATAGGAATTTGGACTTGCATTATAGCTTTTTTCTTACAAGGAATCATCCCTGAAGTTATTAGTGAA
ATAATTAAAAAAAATTAA

Upstream 100 bases:

>100_bases
TAATAATACAATGTAATTTACCTTACTCTATAATTCTTTTATTTTAATTTAATTTTTTGTTACAATAAATTTATACATAA
TAATTATCAAGGAGGAAAAA

Downstream 100 bases:

>100_bases
GTTTTATTTCAACAAATATTCGTTTTTAGAATATTTGTTAGAAATTTTACTTTGCTTTTATTTTTACAGGATTAGAATAT
TTATCCTAAATTATCCTAAA

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MEQILTWQQIYDPFSNIWLSALVAFLPILCFLVCLVVLKLKGYQAGFLTVILATLVALFAYKMPWNLVGASFIQGFTNGM
WPIAWIIIAAIFLYKLSIKSGSFEIIKKSVMSITPDHRIQVILIGFCFGSFLEGAIGFGGPVAITAALLVGLGLRPLQAA
GLCLIANTAPVAFGAVGIPIIAMANLVGIEQHSVSAMVGRMLVPLSLTIPFFIVFLMDGFKGIKETFPAILVAALSFTTT
QFLSSNHLGAELPDIISAVVSLAVTTVFLKFWKPKNIFRFDNESNFTQDNTLSFNQILKAWSPFILLIVCIIIWTQPWFK
ALFDKDGILSYTSITLQFSNITTGILSPSITGIGEAKPLSLALGVDLINGKTVAQAGTAILLAAFLTIAILKIKAEDAAE
CFWVTLKEMAIPCITIGLVVAFAFISKNSGMSTTLGLAFAHTGDAFSFFSPIIGWIGVFLTGSDTSANLLFGTLQQVSAQ
KLGISEALFLAANSVGGVVGKMISPQSIAIACAAVGLVGKESDLFKFTLKYSVAFIILIGIWTCIIAFFLQGIIPEVISE
IIKKN

Sequences:

>Translated_565_residues
MEQILTWQQIYDPFSNIWLSALVAFLPILCFLVCLVVLKLKGYQAGFLTVILATLVALFAYKMPWNLVGASFIQGFTNGM
WPIAWIIIAAIFLYKLSIKSGSFEIIKKSVMSITPDHRIQVILIGFCFGSFLEGAIGFGGPVAITAALLVGLGLRPLQAA
GLCLIANTAPVAFGAVGIPIIAMANLVGIEQHSVSAMVGRMLVPLSLTIPFFIVFLMDGFKGIKETFPAILVAALSFTTT
QFLSSNHLGAELPDIISAVVSLAVTTVFLKFWKPKNIFRFDNESNFTQDNTLSFNQILKAWSPFILLIVCIIIWTQPWFK
ALFDKDGILSYTSITLQFSNITTGILSPSITGIGEAKPLSLALGVDLINGKTVAQAGTAILLAAFLTIAILKIKAEDAAE
CFWVTLKEMAIPCITIGLVVAFAFISKNSGMSTTLGLAFAHTGDAFSFFSPIIGWIGVFLTGSDTSANLLFGTLQQVSAQ
KLGISEALFLAANSVGGVVGKMISPQSIAIACAAVGLVGKESDLFKFTLKYSVAFIILIGIWTCIIAFFLQGIIPEVISE
IIKKN
>Mature_565_residues
MEQILTWQQIYDPFSNIWLSALVAFLPILCFLVCLVVLKLKGYQAGFLTVILATLVALFAYKMPWNLVGASFIQGFTNGM
WPIAWIIIAAIFLYKLSIKSGSFEIIKKSVMSITPDHRIQVILIGFCFGSFLEGAIGFGGPVAITAALLVGLGLRPLQAA
GLCLIANTAPVAFGAVGIPIIAMANLVGIEQHSVSAMVGRMLVPLSLTIPFFIVFLMDGFKGIKETFPAILVAALSFTTT
QFLSSNHLGAELPDIISAVVSLAVTTVFLKFWKPKNIFRFDNESNFTQDNTLSFNQILKAWSPFILLIVCIIIWTQPWFK
ALFDKDGILSYTSITLQFSNITTGILSPSITGIGEAKPLSLALGVDLINGKTVAQAGTAILLAAFLTIAILKIKAEDAAE
CFWVTLKEMAIPCITIGLVVAFAFISKNSGMSTTLGLAFAHTGDAFSFFSPIIGWIGVFLTGSDTSANLLFGTLQQVSAQ
KLGISEALFLAANSVGGVVGKMISPQSIAIACAAVGLVGKESDLFKFTLKYSVAFIILIGIWTCIIAFFLQGIIPEVISE
IIKKN

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=556, Percent_Identity=53.9568345323741, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1789347, Length=564, Percent_Identity=49.822695035461, Blast_Score=518, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 60706; Mature: 60706

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]