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The map label for this gene is folK

Identifier: 57237075

GI number: 57237075

Start: 77786

End: 78259

Strand: Reverse

Name: folK

Synonym: CJE0062

Alternate gene names: 57237075

Gene position: 78259-77786 (Counterclockwise)

Preceding gene: 57237076

Following gene: 57237074

Centisome position: 4.4

GC content: 30.59

Gene sequence:

>474_bases
ATGCTAAAAATTCAAGGAGTAAAACACTTTGAAAAAAGTCGTTTTTTTCCTTTTTTTAGTCAAAATATACGATCTTTTAA
ATATTTAGCTCTTATAGGCTTAGGAAGCAATATAGAGCCCGAAAAAAAAAGATTTGATATGCTTTTTCGAGTAATGATGG
ATGATAAAAGATTTAAAATTTTATCCACATCTCCTATGTTGATAAATGAAGCCTTTGGTTTTAAAGAGCAAAAAGATTTT
ACCAATGCTGTTATGTTGATACAAACTAATTTGCATGCACGAGCACTTTTGAAAGTTTTACTTTATTATGAAGTAAAATT
TAAACGCAAGAGAACTTTCAAAAACGCTCCTAGAACGCTTGATTTAGATCTTTTATACTTTTCACAAAAAGTCAAGCGTG
ATAAGTGGTGTGAGGTGCCTCATAAAGGGGCTAAAGAAAGAGTGAGTGTAATTTTGCCTTTAGGCATGATATAA

Upstream 100 bases:

>100_bases
CTTTTGGCTATCACTTGGCTTTAATGGGTATAATTCAAATTTGCGAACAAATAAAAAATTTGCGTGCGATGCAACAAGCA
CAACAAACGAATAAATAATA

Downstream 100 bases:

>100_bases
GGAATATAAATGGGACAACTTATACATACTTTTACTGTTGAAGATACAGAACAAATTATACCCAAAGTAAAAGAAGATTA
CGGAGATAAAGCTTTAATTA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MLKIQGVKHFEKSRFFPFFSQNIRSFKYLALIGLGSNIEPEKKRFDMLFRVMMDDKRFKILSTSPMLINEAFGFKEQKDF
TNAVMLIQTNLHARALLKVLLYYEVKFKRKRTFKNAPRTLDLDLLYFSQKVKRDKWCEVPHKGAKERVSVILPLGMI

Sequences:

>Translated_157_residues
MLKIQGVKHFEKSRFFPFFSQNIRSFKYLALIGLGSNIEPEKKRFDMLFRVMMDDKRFKILSTSPMLINEAFGFKEQKDF
TNAVMLIQTNLHARALLKVLLYYEVKFKRKRTFKNAPRTLDLDLLYFSQKVKRDKWCEVPHKGAKERVSVILPLGMI
>Mature_157_residues
MLKIQGVKHFEKSRFFPFFSQNIRSFKYLALIGLGSNIEPEKKRFDMLFRVMMDDKRFKILSTSPMLINEAFGFKEQKDF
TNAVMLIQTNLHARALLKVLLYYEVKFKRKRTFKNAPRTLDLDLLYFSQKVKRDKWCEVPHKGAKERVSVILPLGMI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPK_CAMJE (Q9PJ54)

Other databases:

- EMBL:   AL111168
- PIR:   E81422
- RefSeq:   YP_002343529.1
- ProteinModelPortal:   Q9PJ54
- SMR:   Q9PJ54
- IntAct:   Q9PJ54
- GeneID:   904396
- GenomeReviews:   AL111168_GR
- KEGG:   cje:Cj0065c
- HOGENOM:   HBG662565
- OMA:   VFYIERR
- ProtClustDB:   CLSK878626
- BioCyc:   CJEJ192222:CJ0065C-MONOMER
- BRENDA:   2.7.6.3
- InterPro:   IPR000550
- Gene3D:   G3DSA:3.30.70.560
- TIGRFAMs:   TIGR01498

Pfam domain/function: PF01288 HPPK; SSF55083 Hppk

EC number: =2.7.6.3

Molecular weight: Translated: 18629; Mature: 18629

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIQGVKHFEKSRFFPFFSQNIRSFKYLALIGLGSNIEPEKKRFDMLFRVMMDDKRFKI
CEEECCCCHHHHCCCCCHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEE
LSTSPMLINEAFGFKEQKDFTNAVMLIQTNLHARALLKVLLYYEVKFKRKRTFKNAPRTL
EECCCCEEHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
DLDLLYFSQKVKRDKWCEVPHKGAKERVSVILPLGMI
EHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MLKIQGVKHFEKSRFFPFFSQNIRSFKYLALIGLGSNIEPEKKRFDMLFRVMMDDKRFKI
CEEECCCCHHHHCCCCCHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEE
LSTSPMLINEAFGFKEQKDFTNAVMLIQTNLHARALLKVLLYYEVKFKRKRTFKNAPRTL
EECCCCEEHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
DLDLLYFSQKVKRDKWCEVPHKGAKERVSVILPLGMI
EHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204