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The map label for this gene is ydgK [H]

Identifier: 57237049

GI number: 57237049

Start: 51656

End: 52858

Strand: Reverse

Name: ydgK [H]

Synonym: CJE0034

Alternate gene names: 57237049

Gene position: 52858-51656 (Counterclockwise)

Preceding gene: 57237051

Following gene: 57237048

Centisome position: 2.97

GC content: 35.74

Gene sequence:

>1203_bases
ATGCAAAAACACACCAAAATTCACGGCTTTGCTAAATTTAAACTCATCGTTATCCTTGCCTTGATGTCAAGCATAGCACC
ACTTTCTACAGATATGTATTTGCCTGCACTTTCTCATGTGGAGCAAAGTTTTCAAACTAATTCTTTTTTAACCCAACTTA
GTATCGCAAGTTTTTTTATCGCTTTTGCTTTAGGACAGCTTATATATGGGCCTTTAAGTGATATTTTTGGGCGTAAAATT
CCAGCTTTGGTGGGGATATTTTTCTTCATCGTTTCGAGTTTGTTTTGTGTGATTATCGATGATATTTATGCTTTTATCGC
TTTGAGATTTTTTGAAGCACTTGGGGGTTGTGCAGGTGTGGTTATCGCAAGGGCTATTGTCAATGACTTGTTTGAGATCA
AAGAAGCTGCAGGGATTTTTGCTTTGATGATGGTTTTTAGTTCTCTTGCTCCTATGCTTTCGCCAACTTTTGGGGGAATT
TTGCTAGAGTATTTTTCATGGCATAGTATTTTTGCGACTTTGTTTGCTTTAGGAATTTTACTTTTTTTGATGATACTTTT
TGGTTTAAAAGAGTCCGCACCTCATCTTAAAAACAAAAAATTTTCCCATCATGAAGCGATGAAAAGCTACAAATTTGTTT
TAAGCGATAAACGCTTTTTAGTTTATATACTATGTGCTTCTTTTGCTTTGGCGGCGATGTTTGCTTATATCACAGGATCA
AGCTTTGTTTTTACGCAGTTTTTTAGCTTAAGTGAGCAAAAATTTGCTTTGCTTTTTGGGGCAAATGCTTTAGGTTTTGT
CGTCTGTGCAAATATCAATGCAAGATTGGTTTTAAAATACGAAAGCGAAAAAATTTTGGCAAAAGCTTTGATGATAATGT
TTATATCGACTGTGATTTTACTTGCAAATGCCTTTTTTCACCCAAATTTCTTGCTTTTTGAACTTAGTATTTTTACAAGT
ATCGCTATGCTTGGTTTCATCGCACCCAATACCACGACTTTGGCTATGGCAAGGTTTAAAGAACATAGCGGAACTGCTTC
TGGGGTGCTTGGAACGGTGCAATTTGGTTTTGCAGGGCTTATTTCTTTTGTGGTTGGGGCTATTAACGCAAATACGCCGA
TAATCCTTGCTTTTGTAATGTGTGCTTGCGTATTGGTTGCAAATATGATATATTTTCTAATCAAAATAAAGGAGAAAAAA
TGA

Upstream 100 bases:

>100_bases
AATTTCCTTAGAATTTTTCCCTAAATTTAACATAGAAAAACAAAGATTATTCTAAGATTGACTTGTTAAAATCATTCTTT
TAGAATAATTAGGATTACAA

Downstream 100 bases:

>100_bases
AAACAAATAATATCTTTATGGCTTTAGCCATAGTTTTGGCAAGTTTGATTCTAGCTTTTGGATTTAACAAGGCTTTAAGT
GATTTTAAAACACTTGAAAG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MQKHTKIHGFAKFKLIVILALMSSIAPLSTDMYLPALSHVEQSFQTNSFLTQLSIASFFIAFALGQLIYGPLSDIFGRKI
PALVGIFFFIVSSLFCVIIDDIYAFIALRFFEALGGCAGVVIARAIVNDLFEIKEAAGIFALMMVFSSLAPMLSPTFGGI
LLEYFSWHSIFATLFALGILLFLMILFGLKESAPHLKNKKFSHHEAMKSYKFVLSDKRFLVYILCASFALAAMFAYITGS
SFVFTQFFSLSEQKFALLFGANALGFVVCANINARLVLKYESEKILAKALMIMFISTVILLANAFFHPNFLLFELSIFTS
IAMLGFIAPNTTTLAMARFKEHSGTASGVLGTVQFGFAGLISFVVGAINANTPIILAFVMCACVLVANMIYFLIKIKEKK

Sequences:

>Translated_400_residues
MQKHTKIHGFAKFKLIVILALMSSIAPLSTDMYLPALSHVEQSFQTNSFLTQLSIASFFIAFALGQLIYGPLSDIFGRKI
PALVGIFFFIVSSLFCVIIDDIYAFIALRFFEALGGCAGVVIARAIVNDLFEIKEAAGIFALMMVFSSLAPMLSPTFGGI
LLEYFSWHSIFATLFALGILLFLMILFGLKESAPHLKNKKFSHHEAMKSYKFVLSDKRFLVYILCASFALAAMFAYITGS
SFVFTQFFSLSEQKFALLFGANALGFVVCANINARLVLKYESEKILAKALMIMFISTVILLANAFFHPNFLLFELSIFTS
IAMLGFIAPNTTTLAMARFKEHSGTASGVLGTVQFGFAGLISFVVGAINANTPIILAFVMCACVLVANMIYFLIKIKEKK
>Mature_400_residues
MQKHTKIHGFAKFKLIVILALMSSIAPLSTDMYLPALSHVEQSFQTNSFLTQLSIASFFIAFALGQLIYGPLSDIFGRKI
PALVGIFFFIVSSLFCVIIDDIYAFIALRFFEALGGCAGVVIARAIVNDLFEIKEAAGIFALMMVFSSLAPMLSPTFGGI
LLEYFSWHSIFATLFALGILLFLMILFGLKESAPHLKNKKFSHHEAMKSYKFVLSDKRFLVYILCASFALAAMFAYITGS
SFVFTQFFSLSEQKFALLFGANALGFVVCANINARLVLKYESEKILAKALMIMFISTVILLANAFFHPNFLLFELSIFTS
IAMLGFIAPNTTTLAMARFKEHSGTASGVLGTVQFGFAGLISFVVGAINANTPIILAFVMCACVLVANMIYFLIKIKEKK

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=402, Percent_Identity=29.1044776119403, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI48994889, Length=393, Percent_Identity=32.0610687022901, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1790146, Length=361, Percent_Identity=22.7146814404432, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787065, Length=259, Percent_Identity=27.4131274131274, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082312, Length=337, Percent_Identity=24.3323442136499, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790794, Length=293, Percent_Identity=21.5017064846416, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319480, Length=201, Percent_Identity=20.8955223880597, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319657, Length=145, Percent_Identity=25.5172413793103, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44058; Mature: 44058

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]