Click here to switch to the map view.

The map label for this gene is yhfN [H]

Identifier: 57237025

GI number: 57237025

Start: 757050

End: 758237

Strand: Reverse

Name: yhfN [H]

Synonym: CJE0823

Alternate gene names: 57237025

Gene position: 758237-757050 (Counterclockwise)

Preceding gene: 57237027

Following gene: 57237024

Centisome position: 42.65

GC content: 28.03

Gene sequence:

>1188_bases
ATGACTTTAATTGCAATTTTATGTCTTTACACAGCACTTTTATCTTGGATTTCCTATGCTCAAATTCGTTTCTTAGAAAG
AGAAAAAGACAAACAAGCTCAAATTTTAAGCGAAAAAGACTATCAAAATGCAGCAGATATTGCCATCGAAAATGAAAAAT
TTAAACTATTTTCCAATTTTTATAATTTAATCATCAATATTGCATGGATAGGTTTTGGATTTTTATATCTTAAAGAATTG
CTTATCTTAAACAACACTCGTTTTGAAAATACTTTATTTTTATTATCTTTTTTAATAATCACAAGTATTTTAAATCTACC
TTTAAGTATTTATGAAAGTTTTATCAAAGATAAAGCCCATGGTTTTTCAAATATGACTGTAAAACTTTTTATCAAAGACA
CTATGAAAAGTCTTATTTTAACTTTAATATTTGGATTTTTAATCCTTTATGCTTTGCTTTTTTGCTATGATTTTTTTGGA
ACTTTTTGGTGGATTGCGGCCTTTATTTTTGCCTTTTGTATTATAGTGATTATAAATCTCATCTACCCTACCTTAATAGC
ACCTATTTTTAATAAAATGAAAAAACTAGACGATGAAAATTTATTGAAAAAAATCAGCTCTTTAATGAAACAATGCGGGT
TTAGTGCAAATGGGATTTATGTTATTGATGCAAGCAAAAGAGATAAGCGTTTAAATGCTTATTTTGGTGGACTTTTTAAA
AGCAAAAGAGTGGTGCTTTTTGATACATTATTAAAAGCCTTAAATGAAAGAGAACTTTTAGCTGTTTTAGGACACGAGCT
TGGACATTTTGTTCATAAGGATATTATCAAAGCTTTATTTAACGGCGCTATAACTATGTTTTTACTTTTTTTTGTTTTTG
CAAATTTACCTGAATTTGTTTACTTAGAAAGTCATCTAGAAGGAGTAAATGGCGGTGTGTTTGCTCTTTTATTTATCTTG
GCAAATATTTTTAACTTTTTAATCTCTCCTATGCTTAATGCCTTAAGTAGAAAAAATGAATTTGCGGCTGATCAACACGG
AGCTAAAGTTACAAGCAAAGAAGATATGAAAAATGCATTGATAGCCCTAGCAAGAGAAAATAAAGCTTTTATCAAAACAA
GTAAAATATATGCATTTTTTTATCTCAGCCATCCAAGTATTAGTGATAGAATCAAGGCTCTTTCTTGA

Upstream 100 bases:

>100_bases
ACCAACTTAGTTGAAAAGAATATTATTTTAGATTTTAAACTATTAACTTTATTTCATTATTTTAAGCTAGAATTCGCAAA
AAACCAATCAAGGAAAAATA

Downstream 100 bases:

>100_bases
CTATAAAAAATGCTCTTATGGAAGCTAAATCTAGCTTAAAAGGTTATGAAAATGAAGCAGTATTTATACTCTGTGAATAT
CTAAAAAAAGATAAAGCTTG

Product: M48 family peptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTLIAILCLYTALLSWISYAQIRFLEREKDKQAQILSEKDYQNAADIAIENEKFKLFSNFYNLIINIAWIGFGFLYLKEL
LILNNTRFENTLFLLSFLIITSILNLPLSIYESFIKDKAHGFSNMTVKLFIKDTMKSLILTLIFGFLILYALLFCYDFFG
TFWWIAAFIFAFCIIVIINLIYPTLIAPIFNKMKKLDDENLLKKISSLMKQCGFSANGIYVIDASKRDKRLNAYFGGLFK
SKRVVLFDTLLKALNERELLAVLGHELGHFVHKDIIKALFNGAITMFLLFFVFANLPEFVYLESHLEGVNGGVFALLFIL
ANIFNFLISPMLNALSRKNEFAADQHGAKVTSKEDMKNALIALARENKAFIKTSKIYAFFYLSHPSISDRIKALS

Sequences:

>Translated_395_residues
MTLIAILCLYTALLSWISYAQIRFLEREKDKQAQILSEKDYQNAADIAIENEKFKLFSNFYNLIINIAWIGFGFLYLKEL
LILNNTRFENTLFLLSFLIITSILNLPLSIYESFIKDKAHGFSNMTVKLFIKDTMKSLILTLIFGFLILYALLFCYDFFG
TFWWIAAFIFAFCIIVIINLIYPTLIAPIFNKMKKLDDENLLKKISSLMKQCGFSANGIYVIDASKRDKRLNAYFGGLFK
SKRVVLFDTLLKALNERELLAVLGHELGHFVHKDIIKALFNGAITMFLLFFVFANLPEFVYLESHLEGVNGGVFALLFIL
ANIFNFLISPMLNALSRKNEFAADQHGAKVTSKEDMKNALIALARENKAFIKTSKIYAFFYLSHPSISDRIKALS
>Mature_394_residues
TLIAILCLYTALLSWISYAQIRFLEREKDKQAQILSEKDYQNAADIAIENEKFKLFSNFYNLIINIAWIGFGFLYLKELL
ILNNTRFENTLFLLSFLIITSILNLPLSIYESFIKDKAHGFSNMTVKLFIKDTMKSLILTLIFGFLILYALLFCYDFFGT
FWWIAAFIFAFCIIVIINLIYPTLIAPIFNKMKKLDDENLLKKISSLMKQCGFSANGIYVIDASKRDKRLNAYFGGLFKS
KRVVLFDTLLKALNERELLAVLGHELGHFVHKDIIKALFNGAITMFLLFFVFANLPEFVYLESHLEGVNGGVFALLFILA
NIFNFLISPMLNALSRKNEFAADQHGAKVTSKEDMKNALIALARENKAFIKTSKIYAFFYLSHPSISDRIKALS

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=458, Percent_Identity=27.0742358078603, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17505484, Length=436, Percent_Identity=28.6697247706422, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322577, Length=434, Percent_Identity=30.4147465437788, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19922414, Length=433, Percent_Identity=27.0207852193995, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24654305, Length=325, Percent_Identity=23.3846153846154, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI78707252, Length=392, Percent_Identity=22.9591836734694, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI78707254, Length=392, Percent_Identity=22.9591836734694, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 45328; Mature: 45197

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIAILCLYTALLSWISYAQIRFLEREKDKQAQILSEKDYQNAADIAIENEKFKLFSNF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCEEECCHHHHHHHHH
YNLIINIAWIGFGFLYLKELLILNNTRFENTLFLLSFLIITSILNLPLSIYESFIKDKAH
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GFSNMTVKLFIKDTMKSLILTLIFGFLILYALLFCYDFFGTFWWIAAFIFAFCIIVIINL
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYPTLIAPIFNKMKKLDDENLLKKISSLMKQCGFSANGIYVIDASKRDKRLNAYFGGLFK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHH
SKRVVLFDTLLKALNERELLAVLGHELGHFVHKDIIKALFNGAITMFLLFFVFANLPEFV
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
YLESHLEGVNGGVFALLFILANIFNFLISPMLNALSRKNEFAADQHGAKVTSKEDMKNAL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHH
IALARENKAFIKTSKIYAFFYLSHPSISDRIKALS
HHHHHCCCHHHEHHHEEEEEEECCCCHHHHHHCCC
>Mature Secondary Structure 
TLIAILCLYTALLSWISYAQIRFLEREKDKQAQILSEKDYQNAADIAIENEKFKLFSNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCEEECCHHHHHHHHH
YNLIINIAWIGFGFLYLKELLILNNTRFENTLFLLSFLIITSILNLPLSIYESFIKDKAH
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GFSNMTVKLFIKDTMKSLILTLIFGFLILYALLFCYDFFGTFWWIAAFIFAFCIIVIINL
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYPTLIAPIFNKMKKLDDENLLKKISSLMKQCGFSANGIYVIDASKRDKRLNAYFGGLFK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHH
SKRVVLFDTLLKALNERELLAVLGHELGHFVHKDIIKALFNGAITMFLLFFVFANLPEFV
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
YLESHLEGVNGGVFALLFILANIFNFLISPMLNALSRKNEFAADQHGAKVTSKEDMKNAL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHH
IALARENKAFIKTSKIYAFFYLSHPSISDRIKALS
HHHHHCCCHHHEHHHEEEEEEECCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]