Click here to switch to the map view.

The map label for this gene is nrdA [H]

Identifier: 57236936

GI number: 57236936

Start: 27857

End: 30226

Strand: Direct

Name: nrdA [H]

Synonym: CJE0024

Alternate gene names: 57236936

Gene position: 27857-30226 (Clockwise)

Preceding gene: 57236935

Following gene: 57236939

Centisome position: 1.57

GC content: 33.59

Gene sequence:

>2370_bases
ATGAAAGTTATTAAAAGAAATGGTCGTACAGAAGAATTGGATGTTTCTAAGATCAAAAAATGCACCTCTGATGCTGTAAA
AGATTTAGAAGGTGTGAATTTAAGCGAACTTGAACTCGATGCAAAGATTCAATTTCGTGATGGAATTTCAACTGAAGAAA
TTCAAAAAACTTTAATTAAAACTGCAGTAGATAAGATAGATATTGATTGTCCAAATTGGACCTTTGTTGCAGCTAGACTT
TTTTTATTTGATTTATATAAAAAAGTTAATGGTATGAATCGCTATAATCATTTGCGTGAGTATTTTGAAAAGGGCGAAAA
AGAAGGAAGAATCTTACTTGGTCTTAAAGAAAAATACGATTTAGATGATTTAAATGCTTATATTAAACCTGAACGCGATA
TGCAATTTACTTATCTTGGTATTAAAACTTTATATGATAGATACTTGATTAAAGATAGTAAAGGTATGCCTATAGAACTT
CCTCAACAAATGTTTATGGCCATTGCGATGTTTTTAGCGCAGAATGAATTTAATCCTCAAGAATGGGCGAAGAAATTTTA
TGATTTAATTTCTAAATTTGAACTCATGCTTGCAACTCCGACTTTATCTAATGCAAGAACAACGCGCCATCAGCTTAGTT
CTTGTTATATAGGATCAACCCCTGATAATATTGAAGGTATTTTTGATTCTTACCAAGAAATGGCTTTGCTTTCTAAATTT
GGTGGCGGTATAGGTTGGGATTGGTCTAAAGTGCGTGCTATGGGTGGAAGCATAGATGGGCATAAAAATGCCGCAGGAGG
GATTATACCTTTCTTGAAAATTACTAATGATATTGCCGTGGCAGTAGATCAGCTAGGAACCAGAAAAGGAGCTATAGCTG
TTTATATAGAACCTTGGCACATGGATATAAGTGATTTTATTGATTTGCGTAAAAATTCAGGTGAAGAAAGACGCCGTGCT
CATGAACTTTTCCCTGCTTTATGGATCAATGATCTTTTTATGAAGAGAGTAAGAGCTAATGATAAATGGACTCTTTTTGA
TCCTGCAGATACAGCAGATTTATGTGATTTATATGGCGAGGCTTTTGAAAAACGCTATGAAGAATATGAAAAAGATGAAA
GCATTACCAAAGAAATCGTAGAAGCTAAAGAGCTTTGGAAGAAAATTTTGCTAAATTATTTTGAAACAGGCTTGCCATTT
TTATGTTTTAAGGATAGTGCTAATAGAGCAAATCCAAATGCTCATGTAGGAATTATTAGAAGTTCAAATTTATGTACTGA
AATTTTTCAAAATACCGAGCCAAATTATTATCAAATTAAAGTAGTTTTTGAAAATGGAGATGAACTTCATTTTGATGAAG
AACAAAAAGTTGCGATCGATGGGGGATATGAAAAACCAGCCAAAAAAATCTCAACTTTAGATAGTATTGATGGTAATAAA
GTTTATATAGTAGAAAAATATAAAAATGATGGAAAAACAGCCGTTTGTAATCTAGCAAGTATAAATCTTAGCAAAGTATA
TACTAAAGAAGATATAGAGCGTGTTGTGCCAACGGCTATTCGTATGCTTGATAATGTGATAGATTTAAATTTTTATCCTC
ATAGAAAAGTAAAAGATACAAATTTAAAATCTCGCGCCATAGGTCTTGGAGTCATGGGTGAGGCACAAATGCTTGCTGAA
GCTAAGATTTATTGGGGAAGCGATGAGCATTTAAATAAAATCGATGAGATTATGGAACAAATTAGCTTTGAGGCTATTAA
TGCGAGTTCAAATTTAGCTCTTGAAAAAGGTTCTTATGAGGATTTTGAAGGATCAAATTGGAGCAAGGGGATTTTTCCTA
TTGATGTAGCAAGTCCTAAGGCTAAAGCTTTAACTTTAAGAGAGGGCTTATTTGATCAAAGTGAATGCGACTGGGTTAAA
CTTAGAGAAAAAGTTAAAAAAGATGGTATGAGAAATGGTTATTTGATGGCCATTGCACCTACTTCTTCTATTTCTATTTT
GGTGGGTACTACGCAGACTATAGAACCTGTTTACAAAAGAAAGTGGTTTGAACAAAATTTAAGTGGTATGATACCTGTTG
TTGTGCCAAATTTAAGCCTTGATACTTGGCAATACTATACTCCAGCCTACGAACTTGATCAAAAAATTCTTGTAAAGGCT
GCTGCTGTGCGTGGTAAATGGATCGATCAAGGGCAGAGTTTAAATATCTTTTTATCGCTTGATAAAGCAAGTGGGGGATA
TTTAAATGAAATTTATCAACTCGCTTGGGAGCTTGGAGTAAAATCTACTTATTATCTAAGAAGCGAAAGCCCTGATAGTG
AAAAAGTCAATGTTGCAGATCGTAGCATAGAATGTGAAGGTTGCCAATAA

Upstream 100 bases:

>100_bases
GAGCGAAGAGGATGTAAGAAAATGTTTCGATTATAACTACTATACAAAAAATGTTGATGTAATTTTTAAAAGAACATTTA
AATAAAAAGCAAGGAAGGCA

Downstream 100 bases:

>100_bases
ATACTAAAACCCAATGAAAAATATTGGGTTTTAAGAGATTAAGAATTGTAAATTTCTTTATCTAGGGCTTTTAGATTTTT
TGCAGTACAAAGTGCCGAAG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 789; Mature: 789

Protein sequence:

>789_residues
MKVIKRNGRTEELDVSKIKKCTSDAVKDLEGVNLSELELDAKIQFRDGISTEEIQKTLIKTAVDKIDIDCPNWTFVAARL
FLFDLYKKVNGMNRYNHLREYFEKGEKEGRILLGLKEKYDLDDLNAYIKPERDMQFTYLGIKTLYDRYLIKDSKGMPIEL
PQQMFMAIAMFLAQNEFNPQEWAKKFYDLISKFELMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYQEMALLSKF
GGGIGWDWSKVRAMGGSIDGHKNAAGGIIPFLKITNDIAVAVDQLGTRKGAIAVYIEPWHMDISDFIDLRKNSGEERRRA
HELFPALWINDLFMKRVRANDKWTLFDPADTADLCDLYGEAFEKRYEEYEKDESITKEIVEAKELWKKILLNYFETGLPF
LCFKDSANRANPNAHVGIIRSSNLCTEIFQNTEPNYYQIKVVFENGDELHFDEEQKVAIDGGYEKPAKKISTLDSIDGNK
VYIVEKYKNDGKTAVCNLASINLSKVYTKEDIERVVPTAIRMLDNVIDLNFYPHRKVKDTNLKSRAIGLGVMGEAQMLAE
AKIYWGSDEHLNKIDEIMEQISFEAINASSNLALEKGSYEDFEGSNWSKGIFPIDVASPKAKALTLREGLFDQSECDWVK
LREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKRKWFEQNLSGMIPVVVPNLSLDTWQYYTPAYELDQKILVKA
AAVRGKWIDQGQSLNIFLSLDKASGGYLNEIYQLAWELGVKSTYYLRSESPDSEKVNVADRSIECEGCQ

Sequences:

>Translated_789_residues
MKVIKRNGRTEELDVSKIKKCTSDAVKDLEGVNLSELELDAKIQFRDGISTEEIQKTLIKTAVDKIDIDCPNWTFVAARL
FLFDLYKKVNGMNRYNHLREYFEKGEKEGRILLGLKEKYDLDDLNAYIKPERDMQFTYLGIKTLYDRYLIKDSKGMPIEL
PQQMFMAIAMFLAQNEFNPQEWAKKFYDLISKFELMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYQEMALLSKF
GGGIGWDWSKVRAMGGSIDGHKNAAGGIIPFLKITNDIAVAVDQLGTRKGAIAVYIEPWHMDISDFIDLRKNSGEERRRA
HELFPALWINDLFMKRVRANDKWTLFDPADTADLCDLYGEAFEKRYEEYEKDESITKEIVEAKELWKKILLNYFETGLPF
LCFKDSANRANPNAHVGIIRSSNLCTEIFQNTEPNYYQIKVVFENGDELHFDEEQKVAIDGGYEKPAKKISTLDSIDGNK
VYIVEKYKNDGKTAVCNLASINLSKVYTKEDIERVVPTAIRMLDNVIDLNFYPHRKVKDTNLKSRAIGLGVMGEAQMLAE
AKIYWGSDEHLNKIDEIMEQISFEAINASSNLALEKGSYEDFEGSNWSKGIFPIDVASPKAKALTLREGLFDQSECDWVK
LREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKRKWFEQNLSGMIPVVVPNLSLDTWQYYTPAYELDQKILVKA
AAVRGKWIDQGQSLNIFLSLDKASGGYLNEIYQLAWELGVKSTYYLRSESPDSEKVNVADRSIECEGCQ
>Mature_789_residues
MKVIKRNGRTEELDVSKIKKCTSDAVKDLEGVNLSELELDAKIQFRDGISTEEIQKTLIKTAVDKIDIDCPNWTFVAARL
FLFDLYKKVNGMNRYNHLREYFEKGEKEGRILLGLKEKYDLDDLNAYIKPERDMQFTYLGIKTLYDRYLIKDSKGMPIEL
PQQMFMAIAMFLAQNEFNPQEWAKKFYDLISKFELMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYQEMALLSKF
GGGIGWDWSKVRAMGGSIDGHKNAAGGIIPFLKITNDIAVAVDQLGTRKGAIAVYIEPWHMDISDFIDLRKNSGEERRRA
HELFPALWINDLFMKRVRANDKWTLFDPADTADLCDLYGEAFEKRYEEYEKDESITKEIVEAKELWKKILLNYFETGLPF
LCFKDSANRANPNAHVGIIRSSNLCTEIFQNTEPNYYQIKVVFENGDELHFDEEQKVAIDGGYEKPAKKISTLDSIDGNK
VYIVEKYKNDGKTAVCNLASINLSKVYTKEDIERVVPTAIRMLDNVIDLNFYPHRKVKDTNLKSRAIGLGVMGEAQMLAE
AKIYWGSDEHLNKIDEIMEQISFEAINASSNLALEKGSYEDFEGSNWSKGIFPIDVASPKAKALTLREGLFDQSECDWVK
LREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKRKWFEQNLSGMIPVVVPNLSLDTWQYYTPAYELDQKILVKA
AAVRGKWIDQGQSLNIFLSLDKASGGYLNEIYQLAWELGVKSTYYLRSESPDSEKVNVADRSIECEGCQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=820, Percent_Identity=33.2926829268293, Blast_Score=377, Evalue=1e-104,
Organism=Escherichia coli, GI2367133, Length=811, Percent_Identity=28.4833538840937, Blast_Score=318, Evalue=9e-88,
Organism=Escherichia coli, GI1789030, Length=670, Percent_Identity=28.8059701492537, Blast_Score=241, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17555242, Length=813, Percent_Identity=33.210332103321, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320914, Length=813, Percent_Identity=32.8413284132841, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322123, Length=814, Percent_Identity=31.6953316953317, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI17352481, Length=816, Percent_Identity=32.2303921568627, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 90038; Mature: 90038

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIKRNGRTEELDVSKIKKCTSDAVKDLEGVNLSELELDAKIQFRDGISTEEIQKTLIK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEECEEEEECCCCCHHHHHHHHHH
TAVDKIDIDCPNWTFVAARLFLFDLYKKVNGMNRYNHLREYFEKGEKEGRILLGLKEKYD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECCCCC
LDDLNAYIKPERDMQFTYLGIKTLYDRYLIKDSKGMPIELPQQMFMAIAMFLAQNEFNPQ
CCCCHHHCCCCCCCEEEEEHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCCHH
EWAKKFYDLISKFELMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYQEMALLSKF
HHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
GGGIGWDWSKVRAMGGSIDGHKNAAGGIIPFLKITNDIAVAVDQLGTRKGAIAVYIEPWH
CCCCCCCHHHHHHCCCCCCCCCCCCCCCEEHEEECCHHHHHHHHHCCCCCEEEEEEECCC
MDISDFIDLRKNSGEERRRAHELFPALWINDLFMKRVRANDKWTLFDPADTADLCDLYGE
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
AFEKRYEEYEKDESITKEIVEAKELWKKILLNYFETGLPFLCFKDSANRANPNAHVGIIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEE
SSNLCTEIFQNTEPNYYQIKVVFENGDELHFDEEQKVAIDGGYEKPAKKISTLDSIDGNK
CCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCE
VYIVEKYKNDGKTAVCNLASINLSKVYTKEDIERVVPTAIRMLDNVIDLNFYPHRKVKDT
EEEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NLKSRAIGLGVMGEAQMLAEAKIYWGSDEHLNKIDEIMEQISFEAINASSNLALEKGSYE
CCCHHHEEEECCCCHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
DFEGSNWSKGIFPIDVASPKAKALTLREGLFDQSECDWVKLREKVKKDGMRNGYLMAIAP
CCCCCCCCCCEEEEECCCCCHHEEEHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
TSSISILVGTTQTIEPVYKRKWFEQNLSGMIPVVVPNLSLDTWQYYTPAYELDQKILVKA
CCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHH
AAVRGKWIDQGQSLNIFLSLDKASGGYLNEIYQLAWELGVKSTYYLRSESPDSEKVNVAD
HHHCCCHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECC
RSIECEGCQ
CEEECCCCC
>Mature Secondary Structure
MKVIKRNGRTEELDVSKIKKCTSDAVKDLEGVNLSELELDAKIQFRDGISTEEIQKTLIK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEECEEEEECCCCCHHHHHHHHHH
TAVDKIDIDCPNWTFVAARLFLFDLYKKVNGMNRYNHLREYFEKGEKEGRILLGLKEKYD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECCCCC
LDDLNAYIKPERDMQFTYLGIKTLYDRYLIKDSKGMPIELPQQMFMAIAMFLAQNEFNPQ
CCCCHHHCCCCCCCEEEEEHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCCHH
EWAKKFYDLISKFELMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYQEMALLSKF
HHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
GGGIGWDWSKVRAMGGSIDGHKNAAGGIIPFLKITNDIAVAVDQLGTRKGAIAVYIEPWH
CCCCCCCHHHHHHCCCCCCCCCCCCCCCEEHEEECCHHHHHHHHHCCCCCEEEEEEECCC
MDISDFIDLRKNSGEERRRAHELFPALWINDLFMKRVRANDKWTLFDPADTADLCDLYGE
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
AFEKRYEEYEKDESITKEIVEAKELWKKILLNYFETGLPFLCFKDSANRANPNAHVGIIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEE
SSNLCTEIFQNTEPNYYQIKVVFENGDELHFDEEQKVAIDGGYEKPAKKISTLDSIDGNK
CCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCE
VYIVEKYKNDGKTAVCNLASINLSKVYTKEDIERVVPTAIRMLDNVIDLNFYPHRKVKDT
EEEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
NLKSRAIGLGVMGEAQMLAEAKIYWGSDEHLNKIDEIMEQISFEAINASSNLALEKGSYE
CCCHHHEEEECCCCHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
DFEGSNWSKGIFPIDVASPKAKALTLREGLFDQSECDWVKLREKVKKDGMRNGYLMAIAP
CCCCCCCCCCEEEEECCCCCHHEEEHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
TSSISILVGTTQTIEPVYKRKWFEQNLSGMIPVVVPNLSLDTWQYYTPAYELDQKILVKA
CCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEECCHHHHHHHHHHHH
AAVRGKWIDQGQSLNIFLSLDKASGGYLNEIYQLAWELGVKSTYYLRSESPDSEKVNVAD
HHHCCCHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECC
RSIECEGCQ
CEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]