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The map label for this gene is galE [C]

Identifier: 57235023

GI number: 57235023

Start: 196721

End: 197659

Strand: Direct

Name: galE [C]

Synonym: DET0204

Alternate gene names: 57235023

Gene position: 196721-197659 (Clockwise)

Preceding gene: 57235024

Following gene: 57235022

Centisome position: 13.38

GC content: 50.91

Gene sequence:

>939_bases
ATGCCTGAAGTGTTAGTCACCGGCGGGTGCGGTTTTATCGGCAGTCATCTGGTAGATGCCCTGCTGTCACAGGGATTTAA
GGTAAGGGTAATGGACAACCTTTCAAACGGTTCACTCGAAAACCTTAAGTGCGGCCAAAGGGATAAACTGGAAATAATAA
ACGGAAACCTTACGGACAAATTTCTGCTGGATTCAGCCGTAAAAGGCTGCGAAACGGTATTTCACCTGGCTGCCCATGCC
AATGTCCAGAATAGCGCCAAAGATACCGGCATAGACCTTGAGAATAATACTCTGGCTACCCATAACCTGCTGGAAGCCAT
GCGCCGAAACCGGGTGGACAGGCTGGTATTTGCTTCCAGTGCGGCGGTGTACGGGGAGAGCGGTCTGACGGTACTGGATG
AGGATTACGGGCCGCTTTTGCCTATTTCCCTGTATGGTGCCAGCAAACTGGCAGGCGAAGGGCTGATAAGTGCTTACAGC
CATCTCTACGGGCTGAAAGCCACCATGTTCCGCTTTGCCAATATTGTGGGCAGCAGACGGCACAGCGGGGTGATATATGA
TTTTGTCAGCCGTCTTCGCCAGAACCCGTCCAGTCTGTTAGTGCTGGGTGACGGAAGCCAGAGCAAGCCTTATCTGCACG
TTAGTGACTGTGTTGCCGGTATGTTGCTGGGGTTTGAAAAATCAACCAAAAATTTGGGTTTATATAATCTGGGTACGCCT
GATTCGGTGGCAGTCAGGGATATTGCCTGTCTGGTCGCCTCGGAAATGGGGCTTAAGAATGTTTGCTACAGCTATAGCGG
TGGGGAACGCGGCTGGCAGGGGGATGCCCCTCAGGTACGCTTTGATATCAGCCGTATCCGCACTTTGGGCTTTAAACCTA
AGTTTACTTCACTTCAAGCCGTCAAACTGGCAATCAAAGAAACTCTGAAGGAGATTTGA

Upstream 100 bases:

>100_bases
TTAACTATTCTGACCACCTTAAATATTCTGGGTTCTACCGGCTGGGGTTATATACGCGGAATGGCCTCAGCCAGATTTAT
ATCAGTCAAGGAGGCGGTAA

Downstream 100 bases:

>100_bases
CTATGCAGGCGGTAATACTTTGCGGCGGTTTGGCTACCAGACTAAGACCCATAACTGAAAACATTCCCAAGTGTCTTTTG
CCCATGGCCGGGCGTCCTTT

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MPEVLVTGGCGFIGSHLVDALLSQGFKVRVMDNLSNGSLENLKCGQRDKLEIINGNLTDKFLLDSAVKGCETVFHLAAHA
NVQNSAKDTGIDLENNTLATHNLLEAMRRNRVDRLVFASSAAVYGESGLTVLDEDYGPLLPISLYGASKLAGEGLISAYS
HLYGLKATMFRFANIVGSRRHSGVIYDFVSRLRQNPSSLLVLGDGSQSKPYLHVSDCVAGMLLGFEKSTKNLGLYNLGTP
DSVAVRDIACLVASEMGLKNVCYSYSGGERGWQGDAPQVRFDISRIRTLGFKPKFTSLQAVKLAIKETLKEI

Sequences:

>Translated_312_residues
MPEVLVTGGCGFIGSHLVDALLSQGFKVRVMDNLSNGSLENLKCGQRDKLEIINGNLTDKFLLDSAVKGCETVFHLAAHA
NVQNSAKDTGIDLENNTLATHNLLEAMRRNRVDRLVFASSAAVYGESGLTVLDEDYGPLLPISLYGASKLAGEGLISAYS
HLYGLKATMFRFANIVGSRRHSGVIYDFVSRLRQNPSSLLVLGDGSQSKPYLHVSDCVAGMLLGFEKSTKNLGLYNLGTP
DSVAVRDIACLVASEMGLKNVCYSYSGGERGWQGDAPQVRFDISRIRTLGFKPKFTSLQAVKLAIKETLKEI
>Mature_311_residues
PEVLVTGGCGFIGSHLVDALLSQGFKVRVMDNLSNGSLENLKCGQRDKLEIINGNLTDKFLLDSAVKGCETVFHLAAHAN
VQNSAKDTGIDLENNTLATHNLLEAMRRNRVDRLVFASSAAVYGESGLTVLDEDYGPLLPISLYGASKLAGEGLISAYSH
LYGLKATMFRFANIVGSRRHSGVIYDFVSRLRQNPSSLLVLGDGSQSKPYLHVSDCVAGMLLGFEKSTKNLGLYNLGTPD
SVAVRDIACLVASEMGLKNVCYSYSGGERGWQGDAPQVRFDISRIRTLGFKPKFTSLQAVKLAIKETLKEI

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=322, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI7657641, Length=318, Percent_Identity=28.3018867924528, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786974, Length=315, Percent_Identity=28.2539682539683, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI48994969, Length=259, Percent_Identity=28.957528957529, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790049, Length=257, Percent_Identity=26.0700389105058, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17539532, Length=291, Percent_Identity=26.8041237113402, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI115532424, Length=267, Percent_Identity=28.0898876404494, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17568069, Length=251, Percent_Identity=29.4820717131474, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71982035, Length=281, Percent_Identity=28.1138790035587, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982038, Length=284, Percent_Identity=29.5774647887324, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=270, Percent_Identity=29.6296296296296, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356223, Length=302, Percent_Identity=28.8079470198675, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI19923002, Length=287, Percent_Identity=28.9198606271777, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 33797; Mature: 33666

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEVLVTGGCGFIGSHLVDALLSQGFKVRVMDNLSNGSLENLKCGQRDKLEIINGNLTDK
CCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCHH
FLLDSAVKGCETVFHLAAHANVQNSAKDTGIDLENNTLATHNLLEAMRRNRVDRLVFASS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCC
AAVYGESGLTVLDEDYGPLLPISLYGASKLAGEGLISAYSHLYGLKATMFRFANIVGSRR
HHEECCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HSGVIYDFVSRLRQNPSSLLVLGDGSQSKPYLHVSDCVAGMLLGFEKSTKNLGLYNLGTP
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHHCCCCCCCCCCEEECCCC
DSVAVRDIACLVASEMGLKNVCYSYSGGERGWQGDAPQVRFDISRIRTLGFKPKFTSLQA
CCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCHHHH
VKLAIKETLKEI
HHHHHHHHHHCC
>Mature Secondary Structure 
PEVLVTGGCGFIGSHLVDALLSQGFKVRVMDNLSNGSLENLKCGQRDKLEIINGNLTDK
CCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCHH
FLLDSAVKGCETVFHLAAHANVQNSAKDTGIDLENNTLATHNLLEAMRRNRVDRLVFASS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHCCC
AAVYGESGLTVLDEDYGPLLPISLYGASKLAGEGLISAYSHLYGLKATMFRFANIVGSRR
HHEECCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HSGVIYDFVSRLRQNPSSLLVLGDGSQSKPYLHVSDCVAGMLLGFEKSTKNLGLYNLGTP
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHHCCCCCCCCCCEEECCCC
DSVAVRDIACLVASEMGLKNVCYSYSGGERGWQGDAPQVRFDISRIRTLGFKPKFTSLQA
CCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCHHHH
VKLAIKETLKEI
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]