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The map label for this gene is glmU [H]

Identifier: 57235022

GI number: 57235022

Start: 197662

End: 198372

Strand: Direct

Name: glmU [H]

Synonym: DET0205

Alternate gene names: 57235022

Gene position: 197662-198372 (Clockwise)

Preceding gene: 57235023

Following gene: 57235014

Centisome position: 13.45

GC content: 48.95

Gene sequence:

>711_bases
ATGCAGGCGGTAATACTTTGCGGCGGTTTGGCTACCAGACTAAGACCCATAACTGAAAACATTCCCAAGTGTCTTTTGCC
CATGGCCGGGCGTCCTTTTCTGCACCACCAGTTTCGCTTGCTGAAATCACAGGGCTTTGACCGGGTGGTTTTGTGCATAG
GCCATCTGGGTGAAATGGTCAAAGATTGTTTCGGGTCGGGAGATGAATACGGCCTTAAGCTGGCCTACAGTCAGGAAACC
GAAAAACTGCTGGGTACGGCCGGGGCTTTGAAAAATGCCGAAGATTACCTGGAAGAAGAGTTTTTTGTAATAAACGGGGA
TACCTATCTGGATATGGATTACCGGCAGGCCTGGCAGACCTATTCTCAAAATAATTGTGATGCCCTTATGACAGTTTATG
ATAACAGGCATGGGCGTATAAATGCCCGCAATGACGTGGCACTGGATGAAAATATGCTGGTCAGCTGTTATGAAAAAGAC
AGCCACCTGCCGGAACTGAAGTTTGTAAATGCCGGGGCTCTTATTCTCCGGAAGAGCCTGTTTGCCACCCTGGAAAAGGA
CAAACCTTATTCGCTGGAGAGGGCTATTCTGCCGGTGCTGGCTCACAACCAGCGGATGCTGGCCTATCCGGTAAAGGAAT
GTTTCTATGATGTGGGTACGGTAGAGGGCATATATACCTTTTGCAACTATCTGGAGAACCAGCCGGTATGA

Upstream 100 bases:

>100_bases
TTGATATCAGCCGTATCCGCACTTTGGGCTTTAAACCTAAGTTTACTTCACTTCAAGCCGTCAAACTGGCAATCAAAGAA
ACTCTGAAGGAGATTTGACT

Downstream 100 bases:

>100_bases
TTATCAGCCGTACACCATTCCGGATAAGCTTTGCGGGGGGCGGCACAGACCTTAAGGCTTTTTATTCCCTTAAAGCAGGT
GAGGTGGTAAGCACCGCCAT

Product: D-glycero-D-manno-heptose 1-phosphate guanosyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MQAVILCGGLATRLRPITENIPKCLLPMAGRPFLHHQFRLLKSQGFDRVVLCIGHLGEMVKDCFGSGDEYGLKLAYSQET
EKLLGTAGALKNAEDYLEEEFFVINGDTYLDMDYRQAWQTYSQNNCDALMTVYDNRHGRINARNDVALDENMLVSCYEKD
SHLPELKFVNAGALILRKSLFATLEKDKPYSLERAILPVLAHNQRMLAYPVKECFYDVGTVEGIYTFCNYLENQPV

Sequences:

>Translated_236_residues
MQAVILCGGLATRLRPITENIPKCLLPMAGRPFLHHQFRLLKSQGFDRVVLCIGHLGEMVKDCFGSGDEYGLKLAYSQET
EKLLGTAGALKNAEDYLEEEFFVINGDTYLDMDYRQAWQTYSQNNCDALMTVYDNRHGRINARNDVALDENMLVSCYEKD
SHLPELKFVNAGALILRKSLFATLEKDKPYSLERAILPVLAHNQRMLAYPVKECFYDVGTVEGIYTFCNYLENQPV
>Mature_236_residues
MQAVILCGGLATRLRPITENIPKCLLPMAGRPFLHHQFRLLKSQGFDRVVLCIGHLGEMVKDCFGSGDEYGLKLAYSQET
EKLLGTAGALKNAEDYLEEEFFVINGDTYLDMDYRQAWQTYSQNNCDALMTVYDNRHGRINARNDVALDENMLVSCYEKD
SHLPELKFVNAGALILRKSLFATLEKDKPYSLERAILPVLAHNQRMLAYPVKECFYDVGTVEGIYTFCNYLENQPV

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=242, Percent_Identity=28.099173553719, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI11761619, Length=242, Percent_Identity=28.099173553719, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI133931050, Length=241, Percent_Identity=30.2904564315353, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320148, Length=227, Percent_Identity=30.8370044052863, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355443, Length=238, Percent_Identity=31.9327731092437, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644084, Length=238, Percent_Identity=31.9327731092437, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653912, Length=272, Percent_Identity=25.7352941176471, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26836; Mature: 26836

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAVILCGGLATRLRPITENIPKCLLPMAGRPFLHHQFRLLKSQGFDRVVLCIGHLGEMV
CCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KDCFGSGDEYGLKLAYSQETEKLLGTAGALKNAEDYLEEEFFVINGDTYLDMDYRQAWQT
HHHHCCCCCCCEEEEECHHHHHHHHHHHHHCCHHHHHCCCEEEECCCEEECCHHHHHHHH
YSQNNCDALMTVYDNRHGRINARNDVALDENMLVSCYEKDSHLPELKFVNAGALILRKSL
HCCCCCCEEEEEEECCCCCCCCCCCCEECCCCEEEEECCCCCCCCEEEECCCHHHHHHHH
FATLEKDKPYSLERAILPVLAHNQRMLAYPVKECFYDVGTVEGIYTFCNYLENQPV
HHHHCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQAVILCGGLATRLRPITENIPKCLLPMAGRPFLHHQFRLLKSQGFDRVVLCIGHLGEMV
CCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KDCFGSGDEYGLKLAYSQETEKLLGTAGALKNAEDYLEEEFFVINGDTYLDMDYRQAWQT
HHHHCCCCCCCEEEEECHHHHHHHHHHHHHCCHHHHHCCCEEEECCCEEECCHHHHHHHH
YSQNNCDALMTVYDNRHGRINARNDVALDENMLVSCYEKDSHLPELKFVNAGALILRKSL
HCCCCCCEEEEEEECCCCCCCCCCCCEECCCCEEEEECCCCCCCCEEEECCCHHHHHHHH
FATLEKDKPYSLERAILPVLAHNQRMLAYPVKECFYDVGTVEGIYTFCNYLENQPV
HHHHCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]