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The map label for this gene is 57234929

Identifier: 57234929

GI number: 57234929

Start: 314201

End: 315226

Strand: Direct

Name: 57234929

Synonym: DET0330

Alternate gene names: NA

Gene position: 314201-315226 (Clockwise)

Preceding gene: 57234930

Following gene: 57234910

Centisome position: 21.38

GC content: 52.73

Gene sequence:

>1026_bases
ATGGCAGTGGGGCTGGTTTATAACCATATATATTTGAACCACGAAACGGGTACCCATGTGGAAAACCCTGACCGCCTGCT
GGCGATTATGGAATACATAAATACGCATGGGCTGAAAGACCGTCTGGTACATGTTGAGCCGAAACGGGTGGGTTTGGGTG
AACTGGAGGGTTTTCATACCCGCAAGTATATCAGCCGGGTGGAGGAAGTGGGTTTCAGCGGCGGCGGCTGGCTGGACCAG
GATACGGTGATTTCGGTGGATAGCTACGAAACAGCCCTGTACGCGGTGGGCGGGGTGCTTGAGGGGGTGGACAAGGTGCT
TTCAGGTGAACTGGAGAGTGCTTTTGTAATGTGCCGCCCGCCGGGTCACCATGCCCTGCCGGAGGCTTCCATGGGTTTCT
GTATTTTTAATAATGTGGCTTTAGGGGCTTTGCATGCCCTTAATAAACATAGACTCAAGCGGGTGGCGGTGGTGGATTTT
GATGTTCACCATGGCAATGGCATTCAGCATGTCTGCCTGAATGACCCGCGGGTGACCTATATTTCCACCCACCAGATTCA
CCATTTCCCCTTTACGGGGGACAGCTGTGAAGACGGCCCGTTTCAGAATATTTTAAATATCCCCCTGCCTGCCGGCTGCG
GGGACAGCCATTACCAGAAAGTATTTGACCAGCTGATTTGCCCGTACCTTCGGAAACTATCACCTGAGCTGATACTGGTA
TGTGCCGGTTATGATGCCCATTTTGCTGATGATATGGGTGAGATGTGCCTTTCACAGCAGGGTTTTGCCGGTATAACCCG
TGCCCTGAAAAAGACGGCGGATGAGGTCTGCGGGGGAAAAATGGTTTTCAGTCTGGAGGGCGGCTACCATTATCTGGGTC
TGGCAGAGAGCGTGGGGGCTAGCCTTGCGGTTTTATTAGATGAGGCTTTGCCTCCCCCTAATACCAAAGCCCCCGAAGAG
ACTGCGGATACGCCTGATATCAGCGGGCTGATTCTGGAGTTACGGGGTATTTTCGGGATTAGCTAA

Upstream 100 bases:

>100_bases
TAGGCTGCGGGTTGTTGCTTGCGGCTTTCGGGGTGTATTTCATTGTTTCCGGGCTGAAGCTGTGGCTTTAGCGGTATCTT
AATACGGAGAAGGTATTTTA

Downstream 100 bases:

>100_bases
GTCCGAAGGGCGTTTCTTACAGTTTATCTGGCATTCGGGGCAGTTTTCCTCGGTGCAGGGTTCTACGTGGATAGTCACGT
AGTCTATTTTCAGTTTATCT

Product: histone deacetylase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MAVGLVYNHIYLNHETGTHVENPDRLLAIMEYINTHGLKDRLVHVEPKRVGLGELEGFHTRKYISRVEEVGFSGGGWLDQ
DTVISVDSYETALYAVGGVLEGVDKVLSGELESAFVMCRPPGHHALPEASMGFCIFNNVALGALHALNKHRLKRVAVVDF
DVHHGNGIQHVCLNDPRVTYISTHQIHHFPFTGDSCEDGPFQNILNIPLPAGCGDSHYQKVFDQLICPYLRKLSPELILV
CAGYDAHFADDMGEMCLSQQGFAGITRALKKTADEVCGGKMVFSLEGGYHYLGLAESVGASLAVLLDEALPPPNTKAPEE
TADTPDISGLILELRGIFGIS

Sequences:

>Translated_341_residues
MAVGLVYNHIYLNHETGTHVENPDRLLAIMEYINTHGLKDRLVHVEPKRVGLGELEGFHTRKYISRVEEVGFSGGGWLDQ
DTVISVDSYETALYAVGGVLEGVDKVLSGELESAFVMCRPPGHHALPEASMGFCIFNNVALGALHALNKHRLKRVAVVDF
DVHHGNGIQHVCLNDPRVTYISTHQIHHFPFTGDSCEDGPFQNILNIPLPAGCGDSHYQKVFDQLICPYLRKLSPELILV
CAGYDAHFADDMGEMCLSQQGFAGITRALKKTADEVCGGKMVFSLEGGYHYLGLAESVGASLAVLLDEALPPPNTKAPEE
TADTPDISGLILELRGIFGIS
>Mature_340_residues
AVGLVYNHIYLNHETGTHVENPDRLLAIMEYINTHGLKDRLVHVEPKRVGLGELEGFHTRKYISRVEEVGFSGGGWLDQD
TVISVDSYETALYAVGGVLEGVDKVLSGELESAFVMCRPPGHHALPEASMGFCIFNNVALGALHALNKHRLKRVAVVDFD
VHHGNGIQHVCLNDPRVTYISTHQIHHFPFTGDSCEDGPFQNILNIPLPAGCGDSHYQKVFDQLICPYLRKLSPELILVC
AGYDAHFADDMGEMCLSQQGFAGITRALKKTADEVCGGKMVFSLEGGYHYLGLAESVGASLAVLLDEALPPPNTKAPEET
ADTPDISGLILELRGIFGIS

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=332, Percent_Identity=35.8433734939759, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI13128864, Length=306, Percent_Identity=38.562091503268, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI226529806, Length=308, Percent_Identity=34.0909090909091, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI17158039, Length=353, Percent_Identity=30.8781869688385, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI30795202, Length=353, Percent_Identity=30.8781869688385, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI30795204, Length=353, Percent_Identity=30.8781869688385, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI153085395, Length=354, Percent_Identity=30.7909604519774, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI62750347, Length=352, Percent_Identity=30.6818181818182, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI62750349, Length=352, Percent_Identity=30.6818181818182, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI148539870, Length=352, Percent_Identity=30.1136363636364, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI169234807, Length=356, Percent_Identity=29.7752808988764, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI13128862, Length=313, Percent_Identity=25.8785942492013, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI13128860, Length=314, Percent_Identity=23.5668789808917, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI8923769, Length=313, Percent_Identity=24.2811501597444, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI293336691, Length=265, Percent_Identity=24.5283018867925, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=24.6636771300448, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25154020, Length=344, Percent_Identity=32.8488372093023, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17540334, Length=330, Percent_Identity=31.2121212121212, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17540332, Length=347, Percent_Identity=30.5475504322767, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI193206283, Length=347, Percent_Identity=30.5475504322767, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25154022, Length=344, Percent_Identity=31.9767441860465, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17537347, Length=326, Percent_Identity=30.6748466257669, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193209491, Length=343, Percent_Identity=30.3206997084548, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17534739, Length=319, Percent_Identity=27.5862068965517, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508561, Length=265, Percent_Identity=27.9245283018868, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17561978, Length=308, Percent_Identity=25, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324307, Length=343, Percent_Identity=28.5714285714286, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323999, Length=314, Percent_Identity=28.6624203821656, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325325, Length=152, Percent_Identity=30.2631578947368, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6321244, Length=308, Percent_Identity=25.3246753246753, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325141, Length=294, Percent_Identity=24.1496598639456, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281360899, Length=325, Percent_Identity=34.1538461538462, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24642146, Length=325, Percent_Identity=34.1538461538462, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24642142, Length=325, Percent_Identity=34.1538461538462, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24642144, Length=325, Percent_Identity=34.1538461538462, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24641720, Length=357, Percent_Identity=30.5322128851541, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281360801, Length=357, Percent_Identity=30.5322128851541, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281360799, Length=357, Percent_Identity=30.5322128851541, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24644244, Length=322, Percent_Identity=25.776397515528, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24657891, Length=269, Percent_Identity=25.2788104089219, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37173; Mature: 37042

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVGLVYNHIYLNHETGTHVENPDRLLAIMEYINTHGLKDRLVHVEPKRVGLGELEGFHT
CEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHCCCHHH
RKYISRVEEVGFSGGGWLDQDTVISVDSYETALYAVGGVLEGVDKVLSGELESAFVMCRP
HHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
PGHHALPEASMGFCIFNNVALGALHALNKHRLKRVAVVDFDVHHGNGIQHVCLNDPRVTY
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCEEEEEECCCEEEE
ISTHQIHHFPFTGDSCEDGPFQNILNIPLPAGCGDSHYQKVFDQLICPYLRKLSPELILV
EEECEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
CAGYDAHFADDMGEMCLSQQGFAGITRALKKTADEVCGGKMVFSLEGGYHYLGLAESVGA
EECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHHH
SLAVLLDEALPPPNTKAPEETADTPDISGLILELRGIFGIS
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVGLVYNHIYLNHETGTHVENPDRLLAIMEYINTHGLKDRLVHVEPKRVGLGELEGFHT
EEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHCCCHHH
RKYISRVEEVGFSGGGWLDQDTVISVDSYETALYAVGGVLEGVDKVLSGELESAFVMCRP
HHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
PGHHALPEASMGFCIFNNVALGALHALNKHRLKRVAVVDFDVHHGNGIQHVCLNDPRVTY
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCEEEEEECCCEEEE
ISTHQIHHFPFTGDSCEDGPFQNILNIPLPAGCGDSHYQKVFDQLICPYLRKLSPELILV
EEECEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
CAGYDAHFADDMGEMCLSQQGFAGITRALKKTADEVCGGKMVFSLEGGYHYLGLAESVGA
EECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHHH
SLAVLLDEALPPPNTKAPEETADTPDISGLILELRGIFGIS
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]