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The map label for this gene is hepT [H]

Identifier: 57234813

GI number: 57234813

Start: 369797

End: 370771

Strand: Direct

Name: hepT [H]

Synonym: DET0389

Alternate gene names: 57234813

Gene position: 369797-370771 (Clockwise)

Preceding gene: 57234814

Following gene: 57234802

Centisome position: 25.16

GC content: 49.64

Gene sequence:

>975_bases
TTGTTGAAACTTAGCTCTATCTACGCACCTATAAATGAGGGCCTCAAAGGGGTTGAGGACGAGTTTAAGCTGGTATCCGA
AAGCCGGAAGCAGTCTTTTCCCGAAATGGCGGAAATGCTGGATTATATTCTGGTGGGGGGCAAGGTACTCAGACCGGCCC
TTTCCATGTTGTCGGCCATGTGTTTCGGTACGGGTATAAAAAAAGTGTTGCCTTTGGCCACTTCTTCCGAAATGCTGCAC
ATAGCAACCCTGGTGCATGATGATGCCATTGACAAGGCTGATACCCGCCGCAGCCGCCGCACTGTCAATTCCGTATGGGG
GCTGGAAAAGGCTATACTCCTGGGTGATTTCCTGTTTGCCCATGCCGCCGAAGTAGCGGCAGAGACCGACAATATGCGTA
TAGTTACCCTGTTTGCCCAGACTCTGCAGATAATTGCCTCAGGGGAGCTGAAACAGGCTTATGCCAGTTTCAACCCTGAC
CAGAGCTATGAAAATTATCTTGAAAGGATATCCGGCAAGACGGCCGCCCTTTTTGTAATGGCTACCAAGGGCGGGGCTAT
ACTGGCAGACGCTTCGCCCTCTGATGAGGAAATAATGCGTTCTTACGGCTATAATCTGGGTTTAAGTTTCCAGATAGTAG
ATGATATACTGGATTTTGTGGGCAACGCCAAAGATATGGGCAAACCGGTAGGTTCAGACCTGAATAACGGCACAGTTACC
CTGCCGGCGCTTCTCCTGATGGACCGTTATCCGGAAAATAACCCTATCAAAGACATGCTGGGGGCTACAGACCGTTCCGC
TCATGTGGCCAGAGCGGTGGAGATGATAAATTCGTCAGACATCATAGACCTTAGCTACAAAGAAGCTAAACGCTATGCTG
ATTTAGCCTGCCAAGATTTGTCAAAGCTCCCCAAAACGGCTGCCCGCGAATCTCTCTACCAGCTGGCTGAATTTATAGTT
GAACGCAAGAACTGA

Upstream 100 bases:

>100_bases
AATGATACCGCCGGAGCCGCTTTTCAAGAAACTGGAAGATTCGGTTGTAGAAGAAGAAACCGCCCGCATGGGGCTTTAGT
ATTTACCAGGAGGCAAGGTC

Downstream 100 bases:

>100_bases
CAAGGAGGTTCAACGTGAAACTTTTTATAAATATTATCGGCATTATTCTGGTTATTTTTGTCCTTACCCATTTGCGTGAA
GTCTGGCACTGGCTGGAAGG

Product: heptaprenyl diphosphate synthase component II

Products: diphosphate; all-trans-heptaprenyl diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MLKLSSIYAPINEGLKGVEDEFKLVSESRKQSFPEMAEMLDYILVGGKVLRPALSMLSAMCFGTGIKKVLPLATSSEMLH
IATLVHDDAIDKADTRRSRRTVNSVWGLEKAILLGDFLFAHAAEVAAETDNMRIVTLFAQTLQIIASGELKQAYASFNPD
QSYENYLERISGKTAALFVMATKGGAILADASPSDEEIMRSYGYNLGLSFQIVDDILDFVGNAKDMGKPVGSDLNNGTVT
LPALLLMDRYPENNPIKDMLGATDRSAHVARAVEMINSSDIIDLSYKEAKRYADLACQDLSKLPKTAARESLYQLAEFIV
ERKN

Sequences:

>Translated_324_residues
MLKLSSIYAPINEGLKGVEDEFKLVSESRKQSFPEMAEMLDYILVGGKVLRPALSMLSAMCFGTGIKKVLPLATSSEMLH
IATLVHDDAIDKADTRRSRRTVNSVWGLEKAILLGDFLFAHAAEVAAETDNMRIVTLFAQTLQIIASGELKQAYASFNPD
QSYENYLERISGKTAALFVMATKGGAILADASPSDEEIMRSYGYNLGLSFQIVDDILDFVGNAKDMGKPVGSDLNNGTVT
LPALLLMDRYPENNPIKDMLGATDRSAHVARAVEMINSSDIIDLSYKEAKRYADLACQDLSKLPKTAARESLYQLAEFIV
ERKN
>Mature_324_residues
MLKLSSIYAPINEGLKGVEDEFKLVSESRKQSFPEMAEMLDYILVGGKVLRPALSMLSAMCFGTGIKKVLPLATSSEMLH
IATLVHDDAIDKADTRRSRRTVNSVWGLEKAILLGDFLFAHAAEVAAETDNMRIVTLFAQTLQIIASGELKQAYASFNPD
QSYENYLERISGKTAALFVMATKGGAILADASPSDEEIMRSYGYNLGLSFQIVDDILDFVGNAKDMGKPVGSDLNNGTVT
LPALLLMDRYPENNPIKDMLGATDRSAHVARAVEMINSSDIIDLSYKEAKRYADLACQDLSKLPKTAARESLYQLAEFIV
ERKN

Specific function: Possible role in synthesis of the nonaprenyl side chain of plastoquinone or in synthesis of other prenyl chains such as undekaprenyl pyrophosphate [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=317, Percent_Identity=32.4921135646688, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1789578, Length=292, Percent_Identity=33.5616438356164, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786623, Length=233, Percent_Identity=30.4721030042918, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17505681, Length=313, Percent_Identity=33.2268370607029, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319475, Length=333, Percent_Identity=29.4294294294294, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24651612, Length=324, Percent_Identity=31.1728395061728, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR014120
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: 2.5.1.30

Molecular weight: Translated: 35590; Mature: 35590

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLSSIYAPINEGLKGVEDEFKLVSESRKQSFPEMAEMLDYILVGGKVLRPALSMLSAM
CCCCHHHHCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
CFGTGIKKVLPLATSSEMLHIATLVHDDAIDKADTRRSRRTVNSVWGLEKAILLGDFLFA
HHHCCHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAAEVAAETDNMRIVTLFAQTLQIIASGELKQAYASFNPDQSYENYLERISGKTAALFVM
HHHHHHHCCCCCEEHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEE
ATKGGAILADASPSDEEIMRSYGYNLGLSFQIVDDILDFVGNAKDMGKPVGSDLNNGTVT
EECCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHH
LPALLLMDRYPENNPIKDMLGATDRSAHVARAVEMINSSDIIDLSYKEAKRYADLACQDL
HHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
SKLPKTAARESLYQLAEFIVERKN
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKLSSIYAPINEGLKGVEDEFKLVSESRKQSFPEMAEMLDYILVGGKVLRPALSMLSAM
CCCCHHHHCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
CFGTGIKKVLPLATSSEMLHIATLVHDDAIDKADTRRSRRTVNSVWGLEKAILLGDFLFA
HHHCCHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAAEVAAETDNMRIVTLFAQTLQIIASGELKQAYASFNPDQSYENYLERISGKTAALFVM
HHHHHHHCCCCCEEHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEE
ATKGGAILADASPSDEEIMRSYGYNLGLSFQIVDDILDFVGNAKDMGKPVGSDLNNGTVT
EECCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCHH
LPALLLMDRYPENNPIKDMLGATDRSAHVARAVEMINSSDIIDLSYKEAKRYADLACQDL
HHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
SKLPKTAARESLYQLAEFIVERKN
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: all-trans-hexaprenyl diphosphate; isopentenyl diphosphate

Specific reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]