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The map label for this gene is htrA [H]

Identifier: 57234204

GI number: 57234204

Start: 940140

End: 940955

Strand: Direct

Name: htrA [H]

Synonym: DET1036

Alternate gene names: 57234204

Gene position: 940140-940955 (Clockwise)

Preceding gene: 57234212

Following gene: 57234203

Centisome position: 63.97

GC content: 50.37

Gene sequence:

>816_bases
ATGAAAAAATTTTCCAAGAATTTCTTCGGTCTGTTTATTTCAATCAGCTTGGTGGTATCCATGCTGTTGGCTCAGGGCTG
TGACCTGCTTCAGGAGTTCAGCAATTCTCCTGAAGATGACACCCAAAACCAGAGTAATAACCAAAATCTGTCTGACGGCA
GTGATGAGCTGGGCAGTGTGCCCAGCCCGGTTAATTTCGTAAATGCCGTAAAAGCGGTAAAACCTTCAGTAGTGGCTATA
AATGTAGAGCTGGTCACCCGTGATATTTTCGGGCGGACAGTAGTAGAACAGGCTGCCGGCTCCGGCTGGATTATAGATTC
AAACGGGATTATCGTAACTAATAACCACGTGGTGGAGGACGCCACCAGCATAACAGTAACCCTGGATGACGGGCGCACTT
TCAATGCGGTAGCGGTACGCACTTATCCGGCCAACGACCTGGCGGTGATAAAGATAGATGCCACCAATCTGCCCGCAGTC
AAGCTAGGTGATGCATCTAAACTGGCGGTAGGAGAACCGGTGGCCGCTATAGGTAATGCGCTGGGTATGGGTATTTCCAT
GACCGGCGGCTGGATAAGCCGGTTAAATACCACTGTTCAGTTCAGCGATACCGAAAGCCTGACCGGGCTGATAGAAACCG
ATGCCGCCATAAATCCGGGTAACTCCGGCGGACCGCTGGTAAACTATCAGGGTGAAGTTATCGGCATAACCAGCGCCAAA
ATACAGGAGGTAGGGGTGGAGGGCATCGGCTATGCTATCAGCCTGTATATAGCTTTGCCCATTATCAATAACCTTATCTC
CCAGCTGCCGGCTTGA

Upstream 100 bases:

>100_bases
TCACAAGGGAGGGGCAAAAAACCCCTCCCTTTAGTTTATAAATAATTTCTACACAATTTCCTGCTATAATAAAACCAATA
ACTCCATACAGGAAGAGGCT

Downstream 100 bases:

>100_bases
GCAAAACTATGAAAAAGAAACAAAAATTATTAAGTCTGTTTCTGGGCATAGTACTTGTTGTTAGTGTTCTCAGCGGAGGC
TGTGATTACTTATCCCAGCC

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKKFSKNFFGLFISISLVVSMLLAQGCDLLQEFSNSPEDDTQNQSNNQNLSDGSDELGSVPSPVNFVNAVKAVKPSVVAI
NVELVTRDIFGRTVVEQAAGSGWIIDSNGIIVTNNHVVEDATSITVTLDDGRTFNAVAVRTYPANDLAVIKIDATNLPAV
KLGDASKLAVGEPVAAIGNALGMGISMTGGWISRLNTTVQFSDTESLTGLIETDAAINPGNSGGPLVNYQGEVIGITSAK
IQEVGVEGIGYAISLYIALPIINNLISQLPA

Sequences:

>Translated_271_residues
MKKFSKNFFGLFISISLVVSMLLAQGCDLLQEFSNSPEDDTQNQSNNQNLSDGSDELGSVPSPVNFVNAVKAVKPSVVAI
NVELVTRDIFGRTVVEQAAGSGWIIDSNGIIVTNNHVVEDATSITVTLDDGRTFNAVAVRTYPANDLAVIKIDATNLPAV
KLGDASKLAVGEPVAAIGNALGMGISMTGGWISRLNTTVQFSDTESLTGLIETDAAINPGNSGGPLVNYQGEVIGITSAK
IQEVGVEGIGYAISLYIALPIINNLISQLPA
>Mature_271_residues
MKKFSKNFFGLFISISLVVSMLLAQGCDLLQEFSNSPEDDTQNQSNNQNLSDGSDELGSVPSPVNFVNAVKAVKPSVVAI
NVELVTRDIFGRTVVEQAAGSGWIIDSNGIIVTNNHVVEDATSITVTLDDGRTFNAVAVRTYPANDLAVIKIDATNLPAV
KLGDASKLAVGEPVAAIGNALGMGISMTGGWISRLNTTVQFSDTESLTGLIETDAAINPGNSGGPLVNYQGEVIGITSAK
IQEVGVEGIGYAISLYIALPIINNLISQLPA

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=208, Percent_Identity=38.9423076923077, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI24308541, Length=204, Percent_Identity=37.7450980392157, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI22129776, Length=213, Percent_Identity=36.6197183098592, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI7019477, Length=192, Percent_Identity=36.4583333333333, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786356, Length=175, Percent_Identity=46.2857142857143, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1789629, Length=216, Percent_Identity=36.1111111111111, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789630, Length=225, Percent_Identity=36.4444444444444, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646839, Length=196, Percent_Identity=38.7755102040816, Blast_Score=107, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 28351; Mature: 28351

Theoretical pI: Translated: 4.10; Mature: 4.10

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFSKNFFGLFISISLVVSMLLAQGCDLLQEFSNSPEDDTQNQSNNQNLSDGSDELGSV
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCC
PSPVNFVNAVKAVKPSVVAINVELVTRDIFGRTVVEQAAGSGWIIDSNGIIVTNNHVVED
CCCHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHHCCCCCEEEECCCEEEECCEEEEC
ATSITVTLDDGRTFNAVAVRTYPANDLAVIKIDATNLPAVKLGDASKLAVGEPVAAIGNA
CCEEEEEECCCCEEEEEEEEEECCCCEEEEEEECCCCCEEEECCCCCEECCCCHHHHHHH
LGMGISMTGGWISRLNTTVQFSDTESLTGLIETDAAINPGNSGGPLVNYQGEVIGITSAK
HCCCEEECCHHHHHCCCEEEECCCCHHEEEEECCCCCCCCCCCCCEEEECCCEEEECHHH
IQEVGVEGIGYAISLYIALPIINNLISQLPA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKFSKNFFGLFISISLVVSMLLAQGCDLLQEFSNSPEDDTQNQSNNQNLSDGSDELGSV
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCC
PSPVNFVNAVKAVKPSVVAINVELVTRDIFGRTVVEQAAGSGWIIDSNGIIVTNNHVVED
CCCHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHHCCCCCEEEECCCEEEECCEEEEC
ATSITVTLDDGRTFNAVAVRTYPANDLAVIKIDATNLPAVKLGDASKLAVGEPVAAIGNA
CCEEEEEECCCCEEEEEEEEEECCCCEEEEEEECCCCCEEEECCCCCEECCCCHHHHHHH
LGMGISMTGGWISRLNTTVQFSDTESLTGLIETDAAINPGNSGGPLVNYQGEVIGITSAK
HCCCEEECCHHHHHCCCEEEECCCCHHEEEEECCCCCCCCCCCCCEEEECCCEEEECHHH
IQEVGVEGIGYAISLYIALPIINNLISQLPA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]