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The map label for this gene is ygcA [C]

Identifier: 57234195

GI number: 57234195

Start: 967110

End: 968297

Strand: Direct

Name: ygcA [C]

Synonym: DET1065

Alternate gene names: 57234195

Gene position: 967110-968297 (Clockwise)

Preceding gene: 57234162

Following gene: 57234194

Centisome position: 65.8

GC content: 49.58

Gene sequence:

>1188_bases
ATGAACGAAATTACACCTGAAATCATTGAAAATGTCTGCCTGGAAAAAGGCGCTAACTCCGGGCTTACCAAAGTAACCCT
GACTGACCGTACCCTGGAAATTTTCGGGGGTATTCCGGGAGAAACGGCAGATATCCGCCTTTTTACCCATAAAGCCGGAC
GCGGCTATGCTCAGGTAATAAAAGTGCATAACCCCTCTGCCGAAAGGGTCCCTCCTGCCTGCCCGTATTTTGGTGATTGT
ACCGGCTGCACCTTCCAGCATATAAGCTATCCCCACCAGCTGAAACTAAAGCACCAGATTATCTTGGCCGAATTTGAAAA
AGCAGGGCTGGACAGCACTTATATCTCAGAGGTAATACCCTCAGCAGCCGAATATGGCTACCGCAATCATGCCCGTTTTT
CCATATATCACGCCAAGCTGGGTTTTGTAAACCGGTTTTCACGCCGCCATGTACAGGTAGACCACTGCCGTATAATGAAC
TCCGGCATAAATAAAGTCCTGGCAGAACTGCAAGATAAATGCGGAGAGACCCGCCAGCTTTCCATCCGCCACGCAAGCAA
TAAAGACAGTTATCTTATCCAGCCTAAACTGACAAAAGCCGATATAAGCATTGAAAGCGGGCAGAAAGAGTACCATGACC
TGCTGCTGGGGCATGATTTTTGCATATCTGCCGCTTCGTTTTTTCAGGTAAACAACCCCCAGGCCGAAAAAATGGCCGGA
CTCATAAAAAAACACCTGAACCTTAGCGGCGGGGAAACGCTGGTAGATGCCTATGCCGGAGTGGGTACATTTGCAGTCCT
GCTCAGCCCTGACTGCAACAGGGTAATAGCCATTGAGGAATCTGCCGCCGCCATCAAGGATGCCCGCCTGAATATTGCAG
GCATAGATAATATTGAACTTATCCAGTCTAAAACAGAGGACGTTATCAGCCAGTTTCAGGGGCAAATGGACGCACTTATA
CTTGACCCGTCACGTAGCGGAGCCCACCCGTCTGTCTTAGCCAGCATATGCCAAAACCCGCCCCGTAACCTGGTATATGT
GGCTTGTGACCCGTCTTCACTGGCCAGAGACCTCAAAATACTGCTTGGCGGCCCGTTTGAACTTTCACAGGTAATACCGG
TGGATATGTTCCCCCAGACTTACCATGTCGAGACGGTCTGCTTGATGTCAAGGGTCGAAGGAAAATAG

Upstream 100 bases:

>100_bases
GCTATAAGTAAACGGGTAACAAGACATTTTTTAAGCTGATGAATGCACCCGCCCCGGACTGAACGCCAAATCTTCATTTA
TGATACAATTCCCTCTGCAT

Downstream 100 bases:

>100_bases
GCGCGAAAGCCCTTGATTTCAGGCACTTTTCGACTTTAGGTAGCTTCGAGCAGGTGGAGACGGTAATAGTTCTGTGGTAA
CTTATCTATGGTGGCTTGGC

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNEITPEIIENVCLEKGANSGLTKVTLTDRTLEIFGGIPGETADIRLFTHKAGRGYAQVIKVHNPSAERVPPACPYFGDC
TGCTFQHISYPHQLKLKHQIILAEFEKAGLDSTYISEVIPSAAEYGYRNHARFSIYHAKLGFVNRFSRRHVQVDHCRIMN
SGINKVLAELQDKCGETRQLSIRHASNKDSYLIQPKLTKADISIESGQKEYHDLLLGHDFCISAASFFQVNNPQAEKMAG
LIKKHLNLSGGETLVDAYAGVGTFAVLLSPDCNRVIAIEESAAAIKDARLNIAGIDNIELIQSKTEDVISQFQGQMDALI
LDPSRSGAHPSVLASICQNPPRNLVYVACDPSSLARDLKILLGGPFELSQVIPVDMFPQTYHVETVCLMSRVEGK

Sequences:

>Translated_395_residues
MNEITPEIIENVCLEKGANSGLTKVTLTDRTLEIFGGIPGETADIRLFTHKAGRGYAQVIKVHNPSAERVPPACPYFGDC
TGCTFQHISYPHQLKLKHQIILAEFEKAGLDSTYISEVIPSAAEYGYRNHARFSIYHAKLGFVNRFSRRHVQVDHCRIMN
SGINKVLAELQDKCGETRQLSIRHASNKDSYLIQPKLTKADISIESGQKEYHDLLLGHDFCISAASFFQVNNPQAEKMAG
LIKKHLNLSGGETLVDAYAGVGTFAVLLSPDCNRVIAIEESAAAIKDARLNIAGIDNIELIQSKTEDVISQFQGQMDALI
LDPSRSGAHPSVLASICQNPPRNLVYVACDPSSLARDLKILLGGPFELSQVIPVDMFPQTYHVETVCLMSRVEGK
>Mature_395_residues
MNEITPEIIENVCLEKGANSGLTKVTLTDRTLEIFGGIPGETADIRLFTHKAGRGYAQVIKVHNPSAERVPPACPYFGDC
TGCTFQHISYPHQLKLKHQIILAEFEKAGLDSTYISEVIPSAAEYGYRNHARFSIYHAKLGFVNRFSRRHVQVDHCRIMN
SGINKVLAELQDKCGETRQLSIRHASNKDSYLIQPKLTKADISIESGQKEYHDLLLGHDFCISAASFFQVNNPQAEKMAG
LIKKHLNLSGGETLVDAYAGVGTFAVLLSPDCNRVIAIEESAAAIKDARLNIAGIDNIELIQSKTEDVISQFQGQMDALI
LDPSRSGAHPSVLASICQNPPRNLVYVACDPSSLARDLKILLGGPFELSQVIPVDMFPQTYHVETVCLMSRVEGK

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=203, Percent_Identity=34.4827586206897, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI51173878, Length=203, Percent_Identity=34.4827586206897, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI269784680, Length=208, Percent_Identity=30.2884615384615, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI269784676, Length=208, Percent_Identity=30.2884615384615, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI20149688, Length=208, Percent_Identity=30.2884615384615, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI269784678, Length=208, Percent_Identity=30.2884615384615, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789148, Length=412, Percent_Identity=28.1553398058252, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1790403, Length=187, Percent_Identity=26.7379679144385, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24666579, Length=211, Percent_Identity=32.2274881516588, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 43475; Mature: 43475

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEITPEIIENVCLEKGANSGLTKVTLTDRTLEIFGGIPGETADIRLFTHKAGRGYAQVI
CCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCCCCCCCEEEEEEECCCCCEEEEE
KVHNPSAERVPPACPYFGDCTGCTFQHISYPHQLKLKHQIILAEFEKAGLDSTYISEVIP
EEECCCCCCCCCCCCCCCCCCCCCHHHCCCCHHEEHHHHEEEEHHHHCCCCHHHHHHHCC
SAAEYGYRNHARFSIYHAKLGFVNRFSRRHVQVDHCRIMNSGINKVLAELQDKCGETRQL
HHHHCCCCCCCEEEEEEEHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SIRHASNKDSYLIQPKLTKADISIESGQKEYHDLLLGHDFCISAASFFQVNNPQAEKMAG
EEEECCCCCCEEECCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHH
LIKKHLNLSGGETLVDAYAGVGTFAVLLSPDCNRVIAIEESAAAIKDARLNIAGIDNIEL
HHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEEECCCHHHHHHCEEEEECCCCHHH
IQSKTEDVISQFQGQMDALILDPSRSGAHPSVLASICQNPPRNLVYVACDPSSLARDLKI
HHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHH
LLGGPFELSQVIPVDMFPQTYHVETVCLMSRVEGK
EECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNEITPEIIENVCLEKGANSGLTKVTLTDRTLEIFGGIPGETADIRLFTHKAGRGYAQVI
CCCCCHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCCCCCCCEEEEEEECCCCCEEEEE
KVHNPSAERVPPACPYFGDCTGCTFQHISYPHQLKLKHQIILAEFEKAGLDSTYISEVIP
EEECCCCCCCCCCCCCCCCCCCCCHHHCCCCHHEEHHHHEEEEHHHHCCCCHHHHHHHCC
SAAEYGYRNHARFSIYHAKLGFVNRFSRRHVQVDHCRIMNSGINKVLAELQDKCGETRQL
HHHHCCCCCCCEEEEEEEHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SIRHASNKDSYLIQPKLTKADISIESGQKEYHDLLLGHDFCISAASFFQVNNPQAEKMAG
EEEECCCCCCEEECCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHEEECCCHHHHHHH
LIKKHLNLSGGETLVDAYAGVGTFAVLLSPDCNRVIAIEESAAAIKDARLNIAGIDNIEL
HHHHHCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEEECCCHHHHHHCEEEEECCCCHHH
IQSKTEDVISQFQGQMDALILDPSRSGAHPSVLASICQNPPRNLVYVACDPSSLARDLKI
HHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHH
LLGGPFELSQVIPVDMFPQTYHVETVCLMSRVEGK
EECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]