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The map label for this gene is 57234162

Identifier: 57234162

GI number: 57234162

Start: 961200

End: 962606

Strand: Direct

Name: 57234162

Synonym: DET1061

Alternate gene names: NA

Gene position: 961200-962606 (Clockwise)

Preceding gene: 57234163

Following gene: 57234195

Centisome position: 65.4

GC content: 47.83

Gene sequence:

>1407_bases
ATGAGTATAGAAATACAGTTTTTAGGGGCAGCCCGAAATGTTACCGGCTCAAGATACCTGATTAAAACAGACCATACCCA
GTTGCTGGTGGATTGCGGGCTTTATCAGGAACGGCGGCTGCAAGACCGGAACTGGCAGCCTTTTGAGATACCCCCCCAAA
GCTTAAGTGCTGTAATCATCAGCCATGCCCATATTGACCACTGCGGGTTGCTGCCAAAGCTGGTAAAGGAAGGTTTTGCC
GGGCCGGTTTTTGCAACAGAAGCCACCGCAGAAATTGCCCGTATCTCCCTGACAGATGCCGGTAAACTTCAGGAAGAAGA
TGCCGCTTTTAAAAAGAAACGCCATGAACGCGAAGGCCGAAAAACCAAGTATCCCGAAATACCCCTTTACACCGCCGAAG
ACGCCAGAGCCGTATCTCCCCTTTTTAAAACAGTGGAATACAGCCGGGAAATAGCCGTAACAGAAGATATCACTGCCACA
TTTCATAATGCCGGGCATGTTTTCGGTTCGGCCAGCATAGAGCTGAAAATACAGGAAAACCACCGGCAGAAAGTGATAGT
TTTTTCAGGTGATTTGGGAAACTGGGACAGACCGATTTTGAAAAACCCTGACCTTGTAAATCAGGCAGATTACGTGGTCA
TAGAGTCCACTTACGGAGACCGCACCCACCAGGACATAAATGAGGCTTCCCTGAAACTGGCCGAGATAATAAACCAGACT
GTTAAACTGGGCGGGAATATCGTTATTCCCAGTTTCGCTCTGGAACGCACTCAGGACCTGCTGTTTTTCCTTAACCGCTT
TATGTCAGAGGGCAAAATACCCAGCTTGAAAGTTTTTGTAGACAGCCCCATGGCTATCAGCATTACTAAAATATTTAAAG
AACACCCGGAACTGTATGACCGCGAAACCAGCGGCTGGGTGAACAACGGAAGCTCCCCGTTTGAATTTGAAGGTCTTCAC
TTTACCAACAAAGCGGCGGATTCTAAAGCCATTCTGGCTGAAAAAGACCCCTGCATAATTATAGCCGGTTCGGGTATGTG
TACCGGCGGCAGGATAAAACACCATCTGGTAAATAACATTAGCCGCCCCGAATCAACTATCCTGTTTGTGGGCTTTCAGG
CAACCGGGACTCTGGGCAGGCTGATAACTGACGGAGCAAAAGAAGTACGGATACTTGGCCAGCACTATCCGGTACAAGCC
CGCATAGAGGAACTCAGGGCTTTTTCGGCACACGCAGATCAGCCTACCCTGCTGCGCTGGCTAAAGGGGTTTAAAAATAA
ACCTGAAATGGTATTTGTAACCCATGGCGAGCCGGAAACAAGCGCCCGGTTTACAGAAACTATAAAAAATACTTTGGGCT
GGCAGGCAAAAGCACCCGAATACCAAGAAAAATTTATTTTAGATTAA

Upstream 100 bases:

>100_bases
CCGGACTAACATCTATATACTCAACTTTATTTACCCCATTTATCCCCCTATTTTTAGTAATTAGGGTATAATGGGAAAAA
TTAAGTGGGAGCATATCTGG

Downstream 100 bases:

>100_bases
AGGCAAATAAAAAACCGCTCTGAGAGCGGCAAGCTTTATAAATATACCCGAACTTGGGGGGGTAGCCATAAATCTAGGCT
TTATTTTCTTCTGCCCCGCC

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSIEIQFLGAARNVTGSRYLIKTDHTQLLVDCGLYQERRLQDRNWQPFEIPPQSLSAVIISHAHIDHCGLLPKLVKEGFA
GPVFATEATAEIARISLTDAGKLQEEDAAFKKKRHEREGRKTKYPEIPLYTAEDARAVSPLFKTVEYSREIAVTEDITAT
FHNAGHVFGSASIELKIQENHRQKVIVFSGDLGNWDRPILKNPDLVNQADYVVIESTYGDRTHQDINEASLKLAEIINQT
VKLGGNIVIPSFALERTQDLLFFLNRFMSEGKIPSLKVFVDSPMAISITKIFKEHPELYDRETSGWVNNGSSPFEFEGLH
FTNKAADSKAILAEKDPCIIIAGSGMCTGGRIKHHLVNNISRPESTILFVGFQATGTLGRLITDGAKEVRILGQHYPVQA
RIEELRAFSAHADQPTLLRWLKGFKNKPEMVFVTHGEPETSARFTETIKNTLGWQAKAPEYQEKFILD

Sequences:

>Translated_468_residues
MSIEIQFLGAARNVTGSRYLIKTDHTQLLVDCGLYQERRLQDRNWQPFEIPPQSLSAVIISHAHIDHCGLLPKLVKEGFA
GPVFATEATAEIARISLTDAGKLQEEDAAFKKKRHEREGRKTKYPEIPLYTAEDARAVSPLFKTVEYSREIAVTEDITAT
FHNAGHVFGSASIELKIQENHRQKVIVFSGDLGNWDRPILKNPDLVNQADYVVIESTYGDRTHQDINEASLKLAEIINQT
VKLGGNIVIPSFALERTQDLLFFLNRFMSEGKIPSLKVFVDSPMAISITKIFKEHPELYDRETSGWVNNGSSPFEFEGLH
FTNKAADSKAILAEKDPCIIIAGSGMCTGGRIKHHLVNNISRPESTILFVGFQATGTLGRLITDGAKEVRILGQHYPVQA
RIEELRAFSAHADQPTLLRWLKGFKNKPEMVFVTHGEPETSARFTETIKNTLGWQAKAPEYQEKFILD
>Mature_467_residues
SIEIQFLGAARNVTGSRYLIKTDHTQLLVDCGLYQERRLQDRNWQPFEIPPQSLSAVIISHAHIDHCGLLPKLVKEGFAG
PVFATEATAEIARISLTDAGKLQEEDAAFKKKRHEREGRKTKYPEIPLYTAEDARAVSPLFKTVEYSREIAVTEDITATF
HNAGHVFGSASIELKIQENHRQKVIVFSGDLGNWDRPILKNPDLVNQADYVVIESTYGDRTHQDINEASLKLAEIINQTV
KLGGNIVIPSFALERTQDLLFFLNRFMSEGKIPSLKVFVDSPMAISITKIFKEHPELYDRETSGWVNNGSSPFEFEGLHF
TNKAADSKAILAEKDPCIIIAGSGMCTGGRIKHHLVNNISRPESTILFVGFQATGTLGRLITDGAKEVRILGQHYPVQAR
IEELRAFSAHADQPTLLRWLKGFKNKPEMVFVTHGEPETSARFTETIKNTLGWQAKAPEYQEKFILD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=447, Percent_Identity=25.503355704698, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI33300633, Length=481, Percent_Identity=24.7401247401247, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32564696, Length=473, Percent_Identity=24.7357293868922, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32566029, Length=450, Percent_Identity=24.2222222222222, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323307, Length=458, Percent_Identity=24.0174672489083, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24648013, Length=451, Percent_Identity=26.8292682926829, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21358523, Length=479, Percent_Identity=25.0521920668058, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52495; Mature: 52364

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEIQFLGAARNVTGSRYLIKTDHTQLLVDCGLYQERRLQDRNWQPFEIPPQSLSAVII
CEEEEEEECCCCCCCCCEEEEEECCCEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHH
SHAHIDHCGLLPKLVKEGFAGPVFATEATAEIARISLTDAGKLQEEDAAFKKKRHEREGR
HHCCCCHHHHHHHHHHCCCCCCEEECCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHCCC
KTKYPEIPLYTAEDARAVSPLFKTVEYSREIAVTEDITATFHNAGHVFGSASIELKIQEN
CCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCEEECEEEEEEEECC
HRQKVIVFSGDLGNWDRPILKNPDLVNQADYVVIESTYGDRTHQDINEASLKLAEIINQT
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
VKLGGNIVIPSFALERTQDLLFFLNRFMSEGKIPSLKVFVDSPMAISITKIFKEHPELYD
HHHCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHCHHHHC
RETSGWVNNGSSPFEFEGLHFTNKAADSKAILAEKDPCIIIAGSGMCTGGRIKHHLVNNI
CCCCCCCCCCCCCCEECCEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCHHHHHHHCC
SRPESTILFVGFQATGTLGRLITDGAKEVRILGQHYPVQARIEELRAFSAHADQPTLLRW
CCCCCEEEEEEEECCCCHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHH
LKGFKNKPEMVFVTHGEPETSARFTETIKNTLGWQAKAPEYQEKFILD
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCC
>Mature Secondary Structure 
SIEIQFLGAARNVTGSRYLIKTDHTQLLVDCGLYQERRLQDRNWQPFEIPPQSLSAVII
EEEEEEECCCCCCCCCEEEEEECCCEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHH
SHAHIDHCGLLPKLVKEGFAGPVFATEATAEIARISLTDAGKLQEEDAAFKKKRHEREGR
HHCCCCHHHHHHHHHHCCCCCCEEECCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHCCC
KTKYPEIPLYTAEDARAVSPLFKTVEYSREIAVTEDITATFHNAGHVFGSASIELKIQEN
CCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCEEECEEEEEEEECC
HRQKVIVFSGDLGNWDRPILKNPDLVNQADYVVIESTYGDRTHQDINEASLKLAEIINQT
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
VKLGGNIVIPSFALERTQDLLFFLNRFMSEGKIPSLKVFVDSPMAISITKIFKEHPELYD
HHHCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHCHHHHC
RETSGWVNNGSSPFEFEGLHFTNKAADSKAILAEKDPCIIIAGSGMCTGGRIKHHLVNNI
CCCCCCCCCCCCCCEECCEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCHHHHHHHCC
SRPESTILFVGFQATGTLGRLITDGAKEVRILGQHYPVQARIEELRAFSAHADQPTLLRW
CCCCCEEEEEEEECCCCHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHH
LKGFKNKPEMVFVTHGEPETSARFTETIKNTLGWQAKAPEYQEKFILD
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA