Click here to switch to the map view.

The map label for this gene is aspC [H]

Identifier: 57233923

GI number: 57233923

Start: 1212644

End: 1213840

Strand: Direct

Name: aspC [H]

Synonym: DET1342

Alternate gene names: 57233923

Gene position: 1212644-1213840 (Clockwise)

Preceding gene: 57233924

Following gene: 57233912

Centisome position: 82.51

GC content: 51.04

Gene sequence:

>1197_bases
ATGACATCACAGGTGGAAACGGACAAAGGTTTTATCTCAGACAGAGCCAAAGAGCTCAAGCCTTCTGGCATACGCAAATT
CTTTGACCTGGCCGCCAAGATGGGCAGCGGAGCTATATCTCTGGGTGTGGGTGAACCTGACTTTACAACCCCGTGGCATA
TCCGCGAATCTGCCATTTACGCTCTGGAAAAGGGCTACACCATGTATACCTCTAACGCCGGGCTTTTGGAACTCCGCCAG
GAGATAGCCAAATACCTGTACCAAACCTACAAACTGGAGTACAACCCCGAAACCGAAATCTTAATAACCGTGGGCTCAAG
TGAGGCTTTGGACCTGGTTATGCGGGCTACCCTGAACCCCGGTGACGAAGTGCTTATGACTGACCCGGCTTATGTAGCTT
ATCCTTCCTGTGTCTTTATGGCATACGGCAACCCGGTCCAGATACCCACTTTTGAAGCTAATAATTTTGAAATAAGTGCG
GCAGATATTGCCCCCAGAATTACCCCCAAGACCCGTTCAATTTTGCTGGGGTATCCTTCAAACCCCACCGGGGCGGTTAT
GCCCAAGGCCAAACTGGCCGAGATTGCCAAGCTAGCGTGCGAGAAGAACCTGCTGGTGGTATCTGACGAGATATATGACA
AGATTATCTACTCCGGTTTTGAACATACCTGCTTTGCCACTTTGCCGGGTATGCGCGAACGGAGTGTAATTATCAACGGC
TTTTCCAAAACATATGCCATGACCGGCTGGCGGATTGGCTATGCGGCCGGTCCGGCGGATATTATTCAGGCTATGACCAA
GATACATCAGCATACCATGCTGTGTGCTCCCATTGCTGCCCAGAAAGCCGCCCTGGAAGCCCTGAAGAATGGTCATGATG
ACGTGCGGCTGATGGTAGAGGAATATGACCGCCGCCGCCGGTTTATAGTAAAAAGTTTCAACGATATGGGGCTGTCCTGC
TTTGAGCCCAAAGGCGCTTTTTACACCTTTCCTTCAGTCAAAAAAACCGGACTGAGTTCAGCCGAATTTGCCGAAAAGCT
GCTCCTGGAAGAAACGGTGGCCGCCGTACCCGGCACTGCTTTTGGTGATAGCGGCGAGGGTTACCTGCGCTGCTGTTACG
CTACCTCCATGAAAGATCTAGAAGAAGCCATGAAGCGTTTCCGCCACTTTTTAAAGCACAACTGCCCCGGGATGTAA

Upstream 100 bases:

>100_bases
CTGCTTAAGCGGTTCAAAGAAGACGACGAAATAATTGACGGCAATGATGATATCAAACGCGAGCCGGTAGTCCTTTAATA
AATATTCAGAGGTTTAGGCC

Downstream 100 bases:

>100_bases
GCCGCTTATCTATACTGTAAAACTAAAGCCCCGCCAAAAGCGGGGCTTATTTTATAACCTTAAATTTGCTAGTGATTGGA
ATCAGCGGAGATTCATTTTC

Product: aspartate aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTSQVETDKGFISDRAKELKPSGIRKFFDLAAKMGSGAISLGVGEPDFTTPWHIRESAIYALEKGYTMYTSNAGLLELRQ
EIAKYLYQTYKLEYNPETEILITVGSSEALDLVMRATLNPGDEVLMTDPAYVAYPSCVFMAYGNPVQIPTFEANNFEISA
ADIAPRITPKTRSILLGYPSNPTGAVMPKAKLAEIAKLACEKNLLVVSDEIYDKIIYSGFEHTCFATLPGMRERSVIING
FSKTYAMTGWRIGYAAGPADIIQAMTKIHQHTMLCAPIAAQKAALEALKNGHDDVRLMVEEYDRRRRFIVKSFNDMGLSC
FEPKGAFYTFPSVKKTGLSSAEFAEKLLLEETVAAVPGTAFGDSGEGYLRCCYATSMKDLEEAMKRFRHFLKHNCPGM

Sequences:

>Translated_398_residues
MTSQVETDKGFISDRAKELKPSGIRKFFDLAAKMGSGAISLGVGEPDFTTPWHIRESAIYALEKGYTMYTSNAGLLELRQ
EIAKYLYQTYKLEYNPETEILITVGSSEALDLVMRATLNPGDEVLMTDPAYVAYPSCVFMAYGNPVQIPTFEANNFEISA
ADIAPRITPKTRSILLGYPSNPTGAVMPKAKLAEIAKLACEKNLLVVSDEIYDKIIYSGFEHTCFATLPGMRERSVIING
FSKTYAMTGWRIGYAAGPADIIQAMTKIHQHTMLCAPIAAQKAALEALKNGHDDVRLMVEEYDRRRRFIVKSFNDMGLSC
FEPKGAFYTFPSVKKTGLSSAEFAEKLLLEETVAAVPGTAFGDSGEGYLRCCYATSMKDLEEAMKRFRHFLKHNCPGM
>Mature_397_residues
TSQVETDKGFISDRAKELKPSGIRKFFDLAAKMGSGAISLGVGEPDFTTPWHIRESAIYALEKGYTMYTSNAGLLELRQE
IAKYLYQTYKLEYNPETEILITVGSSEALDLVMRATLNPGDEVLMTDPAYVAYPSCVFMAYGNPVQIPTFEANNFEISAA
DIAPRITPKTRSILLGYPSNPTGAVMPKAKLAEIAKLACEKNLLVVSDEIYDKIIYSGFEHTCFATLPGMRERSVIINGF
SKTYAMTGWRIGYAAGPADIIQAMTKIHQHTMLCAPIAAQKAALEALKNGHDDVRLMVEEYDRRRRFIVKSFNDMGLSCF
EPKGAFYTFPSVKKTGLSSAEFAEKLLLEETVAAVPGTAFGDSGEGYLRCCYATSMKDLEEAMKRFRHFLKHNCPGM

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=402, Percent_Identity=24.3781094527363, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI169881279, Length=402, Percent_Identity=24.3781094527363, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI56713256, Length=395, Percent_Identity=27.8481012658228, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI56713254, Length=395, Percent_Identity=27.8481012658228, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI169881281, Length=302, Percent_Identity=22.8476821192053, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4507369, Length=386, Percent_Identity=24.6113989637306, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI7705897, Length=428, Percent_Identity=22.6635514018692, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI33469970, Length=428, Percent_Identity=22.6635514018692, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI215599424, Length=370, Percent_Identity=20.8108108108108, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI19263340, Length=370, Percent_Identity=20.5405405405405, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1788722, Length=365, Percent_Identity=30.4109589041096, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786816, Length=356, Percent_Identity=28.3707865168539, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788627, Length=374, Percent_Identity=32.0855614973262, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1787710, Length=184, Percent_Identity=27.1739130434783, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790797, Length=379, Percent_Identity=21.6358839050132, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=288, Percent_Identity=31.25, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71994476, Length=288, Percent_Identity=31.25, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17567369, Length=394, Percent_Identity=26.3959390862944, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17567663, Length=381, Percent_Identity=25.1968503937008, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322401, Length=424, Percent_Identity=23.5849056603774, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320317, Length=337, Percent_Identity=22.2551928783383, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573069, Length=413, Percent_Identity=27.8450363196126, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24646114, Length=413, Percent_Identity=27.8450363196126, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28573067, Length=413, Percent_Identity=27.8450363196126, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28573065, Length=413, Percent_Identity=27.8450363196126, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI18859735, Length=377, Percent_Identity=22.5464190981432, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 44100; Mature: 43969

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQVETDKGFISDRAKELKPSGIRKFFDLAAKMGSGAISLGVGEPDFTTPWHIRESAIY
CCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHH
ALEKGYTMYTSNAGLLELRQEIAKYLYQTYKLEYNPETEILITVGSSEALDLVMRATLNP
HHHCCCEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCHHHHHHHHHCCCC
GDEVLMTDPAYVAYPSCVFMAYGNPVQIPTFEANNFEISAADIAPRITPKTRSILLGYPS
CCCEEEECCCHHCCCCEEEEECCCEEECEEEECCCEEEEHHHCCCCCCCCCCEEEEECCC
NPTGAVMPKAKLAEIAKLACEKNLLVVSDEIYDKIIYSGFEHTCFATLPGMRERSVIING
CCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEC
FSKTYAMTGWRIGYAAGPADIIQAMTKIHQHTMLCAPIAAQKAALEALKNGHDDVRLMVE
CCHHHEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHH
EYDRRRRFIVKSFNDMGLSCFEPKGAFYTFPSVKKTGLSSAEFAEKLLLEETVAAVPGTA
HHHHHHHHHHHHHHHCCCEEECCCCCEEECCCHHHCCCCHHHHHHHHHHHHHHHHCCCCC
FGDSGEGYLRCCYATSMKDLEEAMKRFRHFLKHNCPGM
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSQVETDKGFISDRAKELKPSGIRKFFDLAAKMGSGAISLGVGEPDFTTPWHIRESAIY
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHH
ALEKGYTMYTSNAGLLELRQEIAKYLYQTYKLEYNPETEILITVGSSEALDLVMRATLNP
HHHCCCEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCHHHHHHHHHCCCC
GDEVLMTDPAYVAYPSCVFMAYGNPVQIPTFEANNFEISAADIAPRITPKTRSILLGYPS
CCCEEEECCCHHCCCCEEEEECCCEEECEEEECCCEEEEHHHCCCCCCCCCCEEEEECCC
NPTGAVMPKAKLAEIAKLACEKNLLVVSDEIYDKIIYSGFEHTCFATLPGMRERSVIING
CCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEC
FSKTYAMTGWRIGYAAGPADIIQAMTKIHQHTMLCAPIAAQKAALEALKNGHDDVRLMVE
CCHHHEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHH
EYDRRRRFIVKSFNDMGLSCFEPKGAFYTFPSVKKTGLSSAEFAEKLLLEETVAAVPGTA
HHHHHHHHHHHHHHHCCCEEECCCCCEEECCCHHHCCCCHHHHHHHHHHHHHHHHCCCCC
FGDSGEGYLRCCYATSMKDLEEAMKRFRHFLKHNCPGM
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]