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The map label for this gene is lacC [H]

Identifier: 57233911

GI number: 57233911

Start: 1216894

End: 1217826

Strand: Direct

Name: lacC [H]

Synonym: DET1346

Alternate gene names: 57233911

Gene position: 1216894-1217826 (Clockwise)

Preceding gene: 57233912

Following gene: 57233908

Centisome position: 82.8

GC content: 52.73

Gene sequence:

>933_bases
ATGATTACCACCGTTACCCTAAACCCCTGTCTGGACAAACACATAGACGTGCATGGTCTGGTACTGTACGAAACTAACCG
CTGGCATCTTATGTCCAAATATGCCGGCGGCAAAGGCATAGATGTGTCACGGGCGATACATGAAATGGGAAATGATACCA
TTGCCTGCGGTTTTCTGGGCAGTGAAGAGGGACGGGAGATAGAAACCCTGCTTGCAAAACAGGGGCTTAAATACCGCTTC
ACTCCCATAAGCCAGCCTACCCGAAGCTGTTTTATAATATACGACACTAAAACCCGCCGCCAGACTAATCTTAACGCCCC
CGGCCCGCGGATAACGCCGTCTGAACTGAAACTTTTTCACGAAGACCTGCACAGGGAAAGCGCTTCGTCAAACATTATTG
TTATGTCAGGCAGCGTACCGCCGGGAATACCTTCAAACGTCTATTTCACCCTTATCAAGAGCGCCCATAAACTGGGCAAG
CAAACCATACTGGATACCACCGGCAAATACCTGCGGGCAGGGCTTAAGGCTAAACCCTGTCTGGTAAAGCCTAATATCCG
CGAAGCGGAAGAGCTGCTGGGCAGGAAACTGGAAACCGAGGCTGAAATAATACTGGGGGCTAAGGAAATAGTCCAAATGG
GAGCGGGCATAGCGGTAATCTCCATGGGCAAAAAGGGGCTGATAGCCAGTGACGGCAAGCAGGTTATAAAAGCCAGCTCT
CCCTATGTGCGGGTAAAAAGCGCGGTGGGGGCGGGTGATTCAACGGTGGCCGGCTTGGCCATATCCCTTTGCCGAGGGGA
CAGTCTGGAAGAAGCCTGCCGTTTAGGTGTAGCCATGGGGACAGCCGCCGTGATGACGCCGGGCACCGAACTCTGCCACC
GCGAAGACGTTTTGTACTGGCTGCCCCGCATTAAAATCCGCCGTTTAGCTTAG

Upstream 100 bases:

>100_bases
ATACGGGACGCCCCTGGCATGAAAAACTGGGACTTAAAGCGGGTAATTTTATAAACCCCAGCCCCACCTGGTATGCCAAC
TACCAGCCGGGAGAAAACCC

Downstream 100 bases:

>100_bases
TTATCAGGGGATATCCATAATATTTAATAGCCGCTGGTAAGCCGCAATGGTATTGGCAATTACCCAGGCCATATCCTCAC
GCACATCATCGGAAGCCCTT

Product: carbohydrate kinase

Products: NA

Alternate protein names: Phosphotagatokinase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MITTVTLNPCLDKHIDVHGLVLYETNRWHLMSKYAGGKGIDVSRAIHEMGNDTIACGFLGSEEGREIETLLAKQGLKYRF
TPISQPTRSCFIIYDTKTRRQTNLNAPGPRITPSELKLFHEDLHRESASSNIIVMSGSVPPGIPSNVYFTLIKSAHKLGK
QTILDTTGKYLRAGLKAKPCLVKPNIREAEELLGRKLETEAEIILGAKEIVQMGAGIAVISMGKKGLIASDGKQVIKASS
PYVRVKSAVGAGDSTVAGLAISLCRGDSLEEACRLGVAMGTAAVMTPGTELCHREDVLYWLPRIKIRRLA

Sequences:

>Translated_310_residues
MITTVTLNPCLDKHIDVHGLVLYETNRWHLMSKYAGGKGIDVSRAIHEMGNDTIACGFLGSEEGREIETLLAKQGLKYRF
TPISQPTRSCFIIYDTKTRRQTNLNAPGPRITPSELKLFHEDLHRESASSNIIVMSGSVPPGIPSNVYFTLIKSAHKLGK
QTILDTTGKYLRAGLKAKPCLVKPNIREAEELLGRKLETEAEIILGAKEIVQMGAGIAVISMGKKGLIASDGKQVIKASS
PYVRVKSAVGAGDSTVAGLAISLCRGDSLEEACRLGVAMGTAAVMTPGTELCHREDVLYWLPRIKIRRLA
>Mature_310_residues
MITTVTLNPCLDKHIDVHGLVLYETNRWHLMSKYAGGKGIDVSRAIHEMGNDTIACGFLGSEEGREIETLLAKQGLKYRF
TPISQPTRSCFIIYDTKTRRQTNLNAPGPRITPSELKLFHEDLHRESASSNIIVMSGSVPPGIPSNVYFTLIKSAHKLGK
QTILDTTGKYLRAGLKAKPCLVKPNIREAEELLGRKLETEAEIILGAKEIVQMGAGIAVISMGKKGLIASDGKQVIKASS
PYVRVKSAVGAGDSTVAGLAISLCRGDSLEEACRLGVAMGTAAVMTPGTELCHREDVLYWLPRIKIRRLA

Specific function: Key control step of glycolysis. [C]

COG id: COG1105

COG function: function code G; Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family. LacC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788017, Length=297, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788493, Length=273, Percent_Identity=31.5018315018315, Blast_Score=125, Evalue=4e-30,

Paralogues:

None

Copy number: 496 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR005926
- InterPro:   IPR017583 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: =2.7.1.144 [H]

Molecular weight: Translated: 33709; Mature: 33709

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTVTLNPCLDKHIDVHGLVLYETNRWHLMSKYAGGKGIDVSRAIHEMGNDTIACGFLG
CEEEEEECCHHHCCCCEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECC
SEEGREIETLLAKQGLKYRFTPISQPTRSCFIIYDTKTRRQTNLNAPGPRITPSELKLFH
CCCCHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
EDLHRESASSNIIVMSGSVPPGIPSNVYFTLIKSAHKLGKQTILDTTGKYLRAGLKAKPC
HHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCE
LVKPNIREAEELLGRKLETEAEIILGAKEIVQMGAGIAVISMGKKGLIASDGKQVIKASS
EECCCHHHHHHHHCCCCCCCHHEEECHHHHHHHCCCEEEEECCCCCCEECCCHHHHHCCC
PYVRVKSAVGAGDSTVAGLAISLCRGDSLEEACRLGVAMGTAAVMTPGTELCHREDVLYW
CEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCHHHHHHCCHHHH
LPRIKIRRLA
CCCCEEEECC
>Mature Secondary Structure
MITTVTLNPCLDKHIDVHGLVLYETNRWHLMSKYAGGKGIDVSRAIHEMGNDTIACGFLG
CEEEEEECCHHHCCCCEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECC
SEEGREIETLLAKQGLKYRFTPISQPTRSCFIIYDTKTRRQTNLNAPGPRITPSELKLFH
CCCCHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
EDLHRESASSNIIVMSGSVPPGIPSNVYFTLIKSAHKLGKQTILDTTGKYLRAGLKAKPC
HHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCE
LVKPNIREAEELLGRKLETEAEIILGAKEIVQMGAGIAVISMGKKGLIASDGKQVIKASS
EECCCHHHHHHHHCCCCCCCHHEEECHHHHHHHCCCEEEEECCCCCCEECCCHHHHHCCC
PYVRVKSAVGAGDSTVAGLAISLCRGDSLEEACRLGVAMGTAAVMTPGTELCHREDVLYW
CEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCHHHHHHCCHHHH
LPRIKIRRLA
CCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]