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The map label for this gene is comC [H]

Identifier: 57233881

GI number: 57233881

Start: 1231704

End: 1232471

Strand: Direct

Name: comC [H]

Synonym: DET1362

Alternate gene names: 57233881

Gene position: 1231704-1232471 (Clockwise)

Preceding gene: 57233890

Following gene: 57233880

Centisome position: 83.81

GC content: 52.47

Gene sequence:

>768_bases
ATGTTTACGGGTTGGGTTATATTTTTCTTCGTTTTAGGAGCGGAGCTGGGCAGCTTTATAAATATGCTGTCTGACCGCCT
GCCGGCCAATAAATCCATCGTCACCCCCGGCTCTGTATGTGATGCCTGCGGCAAAAGGCTGGGCGCAGCTGAGCTGATAC
CTGTTTTCAGTTATATTTTCCTAAAGGGACGCTGCCGTTCCTGCGGGGCCAAGATACCCGCCAGAGCTTTGTGGGTGGAG
ATAGCCACCGCCAGTTTGTTTGCCATTTTCTACGTGATAATAGGCCCAAGCGCGGAGCTGGCCATAAGCCTGGTATACCT
GTGCGTATTTATCACTCTGTTTGTGATAGACCTGGAAAAAGGGCTTATCCTGAACGTGATTATTTACCCCTGTATGCTGC
TGGCACTGGCGCTTTCACCCCTGTACCTTCAGGCAGACGGGATACTGGCGAACCTGTCTTCTTCGTTTTTCGGCGGGCTG
AGCGGTTTCGGGCTGTTTCTGCTTATTTATATTGCTTCACGCGGGGGTATAGGTGAAGGCGATATAAAAATGGCCGGATT
TATCGGGCTGGTGTGCGGTTTCCCCAATATTTTTGTAGCTATATTTACCGGCATAGTGCTGGGCGGCCTGGCAGCCGCCG
CTCTGATGCTTTCAGGCAAACGCCGCAAGGGGCAGACTATGCCCTTCGGCCCTTTTCTGGCAGTAGGGGCTGTAACCGCC
ATGCTGTTTGGCAGCCAGATTATGGACTGGTATCTGGGTCTCGCCTGA

Upstream 100 bases:

>100_bases
GTGATTATAATACACTCTATGCCCATTTGTATACAACCCGGCAGTACTTTAGTATGCAAATCACTTGACGGTTCGGCAAA
AAAAAGCCACAATATAGTTC

Downstream 100 bases:

>100_bases
GCCTTTCTGCCAAAACCATTTCCCAAACCTTAAACCTTGATACCTGCCCGGTTTCAGCCTAAAATAAGGCTGTACGCCGT
ACCGGCGCACTTAGACCTGT

Product: type IV prepilin leader peptidase family protein

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MFTGWVIFFFVLGAELGSFINMLSDRLPANKSIVTPGSVCDACGKRLGAAELIPVFSYIFLKGRCRSCGAKIPARALWVE
IATASLFAIFYVIIGPSAELAISLVYLCVFITLFVIDLEKGLILNVIIYPCMLLALALSPLYLQADGILANLSSSFFGGL
SGFGLFLLIYIASRGGIGEGDIKMAGFIGLVCGFPNIFVAIFTGIVLGGLAAAALMLSGKRRKGQTMPFGPFLAVGAVTA
MLFGSQIMDWYLGLA

Sequences:

>Translated_255_residues
MFTGWVIFFFVLGAELGSFINMLSDRLPANKSIVTPGSVCDACGKRLGAAELIPVFSYIFLKGRCRSCGAKIPARALWVE
IATASLFAIFYVIIGPSAELAISLVYLCVFITLFVIDLEKGLILNVIIYPCMLLALALSPLYLQADGILANLSSSFFGGL
SGFGLFLLIYIASRGGIGEGDIKMAGFIGLVCGFPNIFVAIFTGIVLGGLAAAALMLSGKRRKGQTMPFGPFLAVGAVTA
MLFGSQIMDWYLGLA
>Mature_255_residues
MFTGWVIFFFVLGAELGSFINMLSDRLPANKSIVTPGSVCDACGKRLGAAELIPVFSYIFLKGRCRSCGAKIPARALWVE
IATASLFAIFYVIIGPSAELAISLVYLCVFITLFVIDLEKGLILNVIIYPCMLLALALSPLYLQADGILANLSSSFFGGL
SGFGLFLLIYIASRGGIGEGDIKMAGFIGLVCGFPNIFVAIFTGIVLGGLAAAALMLSGKRRKGQTMPFGPFLAVGAVTA
MLFGSQIMDWYLGLA

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=260, Percent_Identity=27.3076923076923, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27057; Mature: 27057

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]