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The map label for this gene is thyX [H]

Identifier: 57233818

GI number: 57233818

Start: 1346944

End: 1347531

Strand: Direct

Name: thyX [H]

Synonym: DET1489

Alternate gene names: 57233818

Gene position: 1346944-1347531 (Clockwise)

Preceding gene: 57233819

Following gene: 57233804

Centisome position: 91.65

GC content: 50.85

Gene sequence:

>588_bases
ATGGAATATAACGTAGAAGTAAAACTGCTGGCCATTACTCCGGATGCCGAAAATCTGGCAGAACAAGCCGGACGGCTTTG
TTACGCCAGCGGCAATAAACTTGGCAGCAGCCAGGACTGGCTTCAGACACGCATCAAACAAGGGCACGAAAGCCTGCTTG
AGCATGTTTCGGCCACTTTTTATATAAAGGCCTCACGGGTGGTTACCCATGAGCTGGTCAGACACCGTATTGGCAGTTAC
TCCCAGCGAAGCCAGCGTTACGTTAAGGAAAATCAGGCCGAGTTTATCACCCCGCCTGAAATTACCGAAGGAGATAGTGC
CAAACTGGCGCTGTTCAATCAGGCTATGGAAAGCGCTTGGGATTCCTACCGCAAACTGCTGGAAGCGGGTATAAAGCCTG
AAATAGCCCGTTACGTACTGCCCAATGCCTGTGCCACCGAGATTATCTGCACCTGGAATTTCCGCGAACTGCGGCATATT
TTGAAACTGCGCACTGCCCCGTCCGCCCAGCCGGAAATGAGGGTAGTAGCTAACCTAATCCAAGAGATACTGAAAAAAGA
AGCCCCCAAGATATTCGGAGACCTCTAA

Upstream 100 bases:

>100_bases
ATTTGAAGTGAACGGTACACCCAAATGCTCTACCATGGCTGTTTCCGCTTGTGAAAATACTTCTGAATTGGTATCCTTTC
GGCATAAGGAGACGCCTTTT

Downstream 100 bases:

>100_bases
GCCACAGGCAATGAGATTTCGCCCCCGCTTAATTCAGGCTAAATGACAGGCGCAGAGATGATTTTCAGACACCTCTTTCA
AAAATGGAGTTTCCTGGTGG

Product: thymidylate synthase, flavin-dependent

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MEYNVEVKLLAITPDAENLAEQAGRLCYASGNKLGSSQDWLQTRIKQGHESLLEHVSATFYIKASRVVTHELVRHRIGSY
SQRSQRYVKENQAEFITPPEITEGDSAKLALFNQAMESAWDSYRKLLEAGIKPEIARYVLPNACATEIICTWNFRELRHI
LKLRTAPSAQPEMRVVANLIQEILKKEAPKIFGDL

Sequences:

>Translated_195_residues
MEYNVEVKLLAITPDAENLAEQAGRLCYASGNKLGSSQDWLQTRIKQGHESLLEHVSATFYIKASRVVTHELVRHRIGSY
SQRSQRYVKENQAEFITPPEITEGDSAKLALFNQAMESAWDSYRKLLEAGIKPEIARYVLPNACATEIICTWNFRELRHI
LKLRTAPSAQPEMRVVANLIQEILKKEAPKIFGDL
>Mature_195_residues
MEYNVEVKLLAITPDAENLAEQAGRLCYASGNKLGSSQDWLQTRIKQGHESLLEHVSATFYIKASRVVTHELVRHRIGSY
SQRSQRYVKENQAEFITPPEITEGDSAKLALFNQAMESAWDSYRKLLEAGIKPEIARYVLPNACATEIICTWNFRELRHI
LKLRTAPSAQPEMRVVANLIQEILKKEAPKIFGDL

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 22171; Mature: 22171

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNVEVKLLAITPDAENLAEQAGRLCYASGNKLGSSQDWLQTRIKQGHESLLEHVSATF
CCCCEEEEEEEECCCHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YIKASRVVTHELVRHRIGSYSQRSQRYVKENQAEFITPPEITEGDSAKLALFNQAMESAW
EEEHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DSYRKLLEAGIKPEIARYVLPNACATEIICTWNFRELRHILKLRTAPSAQPEMRVVANLI
HHHHHHHHCCCCHHHHHHHCCCHHHHHEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QEILKKEAPKIFGDL
HHHHHHHCHHHHCCC
>Mature Secondary Structure
MEYNVEVKLLAITPDAENLAEQAGRLCYASGNKLGSSQDWLQTRIKQGHESLLEHVSATF
CCCCEEEEEEEECCCHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YIKASRVVTHELVRHRIGSYSQRSQRYVKENQAEFITPPEITEGDSAKLALFNQAMESAW
EEEHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DSYRKLLEAGIKPEIARYVLPNACATEIICTWNFRELRHILKLRTAPSAQPEMRVVANLI
HHHHHHHHCCCCHHHHHHHCCCHHHHHEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHH
QEILKKEAPKIFGDL
HHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]