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The map label for this gene is dtd

Identifier: 57233644

GI number: 57233644

Start: 18528

End: 18989

Strand: Direct

Name: dtd

Synonym: DET0019

Alternate gene names: 57233644

Gene position: 18528-18989 (Clockwise)

Preceding gene: 57233655

Following gene: 57233643

Centisome position: 1.26

GC content: 54.76

Gene sequence:

>462_bases
ATGAAAGCGGTAATCCAGAGGGTTAGCCGGGCATCTGTAATGGTAGGCGGAGATACTGTGGGCGAAATAGGGCCGGGTCT
GGCGGTGCTGCTGGGCGTGGCCGAAGGGGATACGCAGGCAGATGCCGAATACCTGGTATCCAAGATAATAAACCTGCGGA
TATTTGCTGATGGCGAAGGCAAGTTTAATCTGTCTTTAAAAGACCTTTGCCGTGAGCTGCTGGTGGTCAGCCAGTTTACC
CTTATTGCCGATACCCGGAAGGGCCGCCGCCCCAGTTTTGTTGAGGCCGCCCAGCCAGAGGAAGCCGACCGTTTATATAA
CTTGTTTATCCGCCTTTGCCGTGGAGAAGGTGTGCAGGCGGCAACCGGGAAATTCGGGGCTATGATGATGCTGGAAATCC
ATAATGACGGCCCGGTGACTATTATTCTGGACAGCCGTGACCGTTTGAACCCCCGCCAGTAG

Upstream 100 bases:

>100_bases
TGCCTGATATCTCTCTGTAAGTGGTTATTTCTCCATTATACCTATTATTTCGTTTTGCAGCTGGATAGTTTAAAATAAGG
CGGCATGGAGGCAGGCAAAT

Downstream 100 bases:

>100_bases
AGGCAGTTGCAAACAGTTGCAATAATAAGCTCTAACTGCTAGACTAGCTGTATGCATAAACAAAATTCTATAGCCGGTGA
ACTGGCAAATGACGGTTTTC

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKAVIQRVSRASVMVGGDTVGEIGPGLAVLLGVAEGDTQADAEYLVSKIINLRIFADGEGKFNLSLKDLCRELLVVSQFT
LIADTRKGRRPSFVEAAQPEEADRLYNLFIRLCRGEGVQAATGKFGAMMMLEIHNDGPVTIILDSRDRLNPRQ

Sequences:

>Translated_153_residues
MKAVIQRVSRASVMVGGDTVGEIGPGLAVLLGVAEGDTQADAEYLVSKIINLRIFADGEGKFNLSLKDLCRELLVVSQFT
LIADTRKGRRPSFVEAAQPEEADRLYNLFIRLCRGEGVQAATGKFGAMMMLEIHNDGPVTIILDSRDRLNPRQ
>Mature_153_residues
MKAVIQRVSRASVMVGGDTVGEIGPGLAVLLGVAEGDTQADAEYLVSKIINLRIFADGEGKFNLSLKDLCRELLVVSQFT
LIADTRKGRRPSFVEAAQPEEADRLYNLFIRLCRGEGVQAATGKFGAMMMLEIHNDGPVTIILDSRDRLNPRQ

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=150, Percent_Identity=48.6666666666667, Blast_Score=126, Evalue=8e-30,
Organism=Escherichia coli, GI1790320, Length=143, Percent_Identity=49.6503496503497, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115533292, Length=153, Percent_Identity=45.0980392156863, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=41.2162162162162, Blast_Score=110, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281361569, Length=147, Percent_Identity=50.3401360544218, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_DEHE1 (Q3ZAH5)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_180774.1
- HSSP:   O66742
- ProteinModelPortal:   Q3ZAH5
- SMR:   Q3ZAH5
- STRING:   Q3ZAH5
- GeneID:   3229107
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0019
- NMPDR:   fig|243164.3.peg.31
- TIGR:   DET0019
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q3ZAH5
- ProtClustDB:   PRK05273
- BioCyc:   DETH243164:DET_0019-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16705; Mature: 16705

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVIQRVSRASVMVGGDTVGEIGPGLAVLLGVAEGDTQADAEYLVSKIINLRIFADGEG
CHHHHHHHHHCEEEECCCCCCHHCCCCEEEEEECCCCCCHHHHHHHHHHHEEEEEECCCC
KFNLSLKDLCRELLVVSQFTLIADTRKGRRPSFVEAAQPEEADRLYNLFIRLCRGEGVQA
EEEECHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
ATGKFGAMMMLEIHNDGPVTIILDSRDRLNPRQ
CCCCCCEEEEEEEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MKAVIQRVSRASVMVGGDTVGEIGPGLAVLLGVAEGDTQADAEYLVSKIINLRIFADGEG
CHHHHHHHHHCEEEECCCCCCHHCCCCEEEEEECCCCCCHHHHHHHHHHHEEEEEECCCC
KFNLSLKDLCRELLVVSQFTLIADTRKGRRPSFVEAAQPEEADRLYNLFIRLCRGEGVQA
EEEECHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
ATGKFGAMMMLEIHNDGPVTIILDSRDRLNPRQ
CCCCCCEEEEEEEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA