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The map label for this gene is tdh [H]

Identifier: 56965376

GI number: 56965376

Start: 3767895

End: 3768983

Strand: Direct

Name: tdh [H]

Synonym: ABC3614

Alternate gene names: 56965376

Gene position: 3767895-3768983 (Clockwise)

Preceding gene: 56965375

Following gene: 56965377

Centisome position: 87.55

GC content: 47.84

Gene sequence:

>1089_bases
ATGAACGATTCAATTCCTAAAAAAATGAAAGCGGTTGTCGCTTACGGCCCGAAAGATTATCGATTGGAAGAAGTCGACGT
GCCGGTGATTGAACACGACAAAGAAATCATTGTAAAGGTAGAAGCAACGGGCATATGTGCTGGCGATATTAAAGCATTCG
ACGGGGCGCCAAGTTTTTGGGGCGATGACACACAACCTGCTTATATTAAAGCCCCTATGATTCCAGGCCATGAATTTATC
GGCCATGTGGTCGCTAAAGGCGACGGGGTTGGCGACTTTGAAATCGGTGACCGGATCATTTCCGAACAAATTGTGCCGTG
CTGGGAGTGCCGGTTTTGCAATCGCGGCCAGTACTGGATGTGTGAAAAACATGACTTATACGGATTCCAAAACAATGTCA
ACGGATCGATGGCAGAATATATGAAATTCACAAAAGAGGCGATCAACTACAAAGTGCCGGCAGATTTGCCGATCGAACAA
GCGATTCTAATTGAACCTTATGCGTGCAGCATGCACGCCGTCCAGCGCGCCCGGATTGAATTAGGCGACATCGTTGTTCT
TTCTGGAGCAGGTACTCTCGGCCTCGGCATGATTGGCGCCGTCAAAAAGTCTGGCGCCAAAACGCTGGTTGTTCTCGATT
TGAAGGATGAGCGGCTAGCGCTTGCCCAACAATTTGGCGCAGATGTAGTGTTGAACCCAGCCAAAGACAACGTTGTTGAA
AAGGTCAAAGACATGACAGACGGCTATGGCTGCGATGTGTATATTGAAGCAACTGGCCACCCTGCTTCCGTCGAACAAGG
GCTCAGCATGATCCGCAAACTTGGCCGTTTTGTCGAATTCAGCGTCTTCAAAGATCCTGTCACAGTTGATTGGAGCATTA
TTAGCGACCGAAAAGAACTGGATGTGCTTGGCTCGCATTTAGGCCCATACTGTTATCCGCTAGTGATTGAAGGCATTGCC
AATGGCGACTTGCCGACAGAAGGCGTTGTCACACATGAGCTTCCTCTTGAACGGTTTGCTGAAGGGTTTGAGCTTATGAA
AAATGGTTCAAATTCACTCAAAATTATTTTAAAGCCGCAACAGGCGTAA

Upstream 100 bases:

>100_bases
AGCATCTGACGCATCTAGTTTTACAACTGGCTCCATCATCGTTGTGGATGGCGGCTATACCACATGGTAAACGATAAAGC
ACATACAGGAGGAAAACACG

Downstream 100 bases:

>100_bases
GATGATCGAGGAGGAAGTGCTATGACCCATTTAATAAACAAAGTCGGCTTGCCTTCCCATTTGCTGTGGGGATATGTCGG
TGTCATGCTTTTCATGGTTG

Product: Zn-dependent alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MNDSIPKKMKAVVAYGPKDYRLEEVDVPVIEHDKEIIVKVEATGICAGDIKAFDGAPSFWGDDTQPAYIKAPMIPGHEFI
GHVVAKGDGVGDFEIGDRIISEQIVPCWECRFCNRGQYWMCEKHDLYGFQNNVNGSMAEYMKFTKEAINYKVPADLPIEQ
AILIEPYACSMHAVQRARIELGDIVVLSGAGTLGLGMIGAVKKSGAKTLVVLDLKDERLALAQQFGADVVLNPAKDNVVE
KVKDMTDGYGCDVYIEATGHPASVEQGLSMIRKLGRFVEFSVFKDPVTVDWSIISDRKELDVLGSHLGPYCYPLVIEGIA
NGDLPTEGVVTHELPLERFAEGFELMKNGSNSLKIILKPQQA

Sequences:

>Translated_362_residues
MNDSIPKKMKAVVAYGPKDYRLEEVDVPVIEHDKEIIVKVEATGICAGDIKAFDGAPSFWGDDTQPAYIKAPMIPGHEFI
GHVVAKGDGVGDFEIGDRIISEQIVPCWECRFCNRGQYWMCEKHDLYGFQNNVNGSMAEYMKFTKEAINYKVPADLPIEQ
AILIEPYACSMHAVQRARIELGDIVVLSGAGTLGLGMIGAVKKSGAKTLVVLDLKDERLALAQQFGADVVLNPAKDNVVE
KVKDMTDGYGCDVYIEATGHPASVEQGLSMIRKLGRFVEFSVFKDPVTVDWSIISDRKELDVLGSHLGPYCYPLVIEGIA
NGDLPTEGVVTHELPLERFAEGFELMKNGSNSLKIILKPQQA
>Mature_362_residues
MNDSIPKKMKAVVAYGPKDYRLEEVDVPVIEHDKEIIVKVEATGICAGDIKAFDGAPSFWGDDTQPAYIKAPMIPGHEFI
GHVVAKGDGVGDFEIGDRIISEQIVPCWECRFCNRGQYWMCEKHDLYGFQNNVNGSMAEYMKFTKEAINYKVPADLPIEQ
AILIEPYACSMHAVQRARIELGDIVVLSGAGTLGLGMIGAVKKSGAKTLVVLDLKDERLALAQQFGADVVLNPAKDNVVE
KVKDMTDGYGCDVYIEATGHPASVEQGLSMIRKLGRFVEFSVFKDPVTVDWSIISDRKELDVLGSHLGPYCYPLVIEGIA
NGDLPTEGVVTHELPLERFAEGFELMKNGSNSLKIILKPQQA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=31.0541310541311, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4501929, Length=383, Percent_Identity=26.8929503916449, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI156523966, Length=383, Percent_Identity=27.154046997389, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501939, Length=375, Percent_Identity=27.2, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI71565154, Length=380, Percent_Identity=25.2631578947368, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501933, Length=383, Percent_Identity=25.5874673629243, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI34577061, Length=384, Percent_Identity=25.78125, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71743840, Length=380, Percent_Identity=24.7368421052632, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI262073058, Length=380, Percent_Identity=24.7368421052632, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1788073, Length=353, Percent_Identity=29.7450424929178, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=27.3529411764706, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1788407, Length=361, Percent_Identity=27.1468144044321, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=25.9259259259259, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI226510992, Length=342, Percent_Identity=28.9473684210526, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786825, Length=406, Percent_Identity=26.6009852216749, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=23.4972677595628, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790718, Length=355, Percent_Identity=25.6338028169014, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI87082125, Length=367, Percent_Identity=26.158038147139, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786552, Length=382, Percent_Identity=25.9162303664921, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081918, Length=216, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=338, Percent_Identity=31.9526627218935, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562878, Length=343, Percent_Identity=30.3206997084548, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25146526, Length=384, Percent_Identity=24.4791666666667, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=369, Percent_Identity=23.3062330623306, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=366, Percent_Identity=25.1366120218579, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=320, Percent_Identity=24.6875, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=358, Percent_Identity=28.4916201117318, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322619, Length=358, Percent_Identity=26.536312849162, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319955, Length=358, Percent_Identity=26.536312849162, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=381, Percent_Identity=24.9343832020997, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=392, Percent_Identity=25.2551020408163, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=392, Percent_Identity=26.2755102040816, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323729, Length=315, Percent_Identity=27.9365079365079, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=291, Percent_Identity=25.4295532646048, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=314, Percent_Identity=27.0700636942675, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=283, Percent_Identity=28.9752650176678, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=284, Percent_Identity=27.8169014084507, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137530, Length=354, Percent_Identity=28.2485875706215, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737897, Length=354, Percent_Identity=29.0960451977401, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17737895, Length=381, Percent_Identity=27.5590551181102, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 39767; Mature: 39767

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSIPKKMKAVVAYGPKDYRLEEVDVPVIEHDKEIIVKVEATGICAGDIKAFDGAPSFW
CCCCCCHHHHEEEEECCCCCEEEECCCCEEECCCEEEEEEEECEEEECCCEECCCCCCCC
GDDTQPAYIKAPMIPGHEFIGHVVAKGDGVGDFEIGDRIISEQIVPCWECRFCNRGQYWM
CCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEECEECCCCCEEE
CEKHDLYGFQNNVNGSMAEYMKFTKEAINYKVPADLPIEQAILIEPYACSMHAVQRARIE
EECCCCCCCCCCCCCHHHHHHHHHHHHHCEECCCCCCCCCEEEECCCHHHHHHHHHHHEE
LGDIVVLSGAGTLGLGMIGAVKKSGAKTLVVLDLKDERLALAQQFGADVVLNPAKDNVVE
ECCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCEEEECCHHHHHH
KVKDMTDGYGCDVYIEATGHPASVEQGLSMIRKLGRFVEFSVFKDPVTVDWSIISDRKEL
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCHHH
DVLGSHLGPYCYPLVIEGIANGDLPTEGVVTHELPLERFAEGFELMKNGSNSLKIILKPQ
HHHHHHCCCHHHHHHEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECC
QA
CC
>Mature Secondary Structure
MNDSIPKKMKAVVAYGPKDYRLEEVDVPVIEHDKEIIVKVEATGICAGDIKAFDGAPSFW
CCCCCCHHHHEEEEECCCCCEEEECCCCEEECCCEEEEEEEECEEEECCCEECCCCCCCC
GDDTQPAYIKAPMIPGHEFIGHVVAKGDGVGDFEIGDRIISEQIVPCWECRFCNRGQYWM
CCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEECEECCCCCEEE
CEKHDLYGFQNNVNGSMAEYMKFTKEAINYKVPADLPIEQAILIEPYACSMHAVQRARIE
EECCCCCCCCCCCCCHHHHHHHHHHHHHCEECCCCCCCCCEEEECCCHHHHHHHHHHHEE
LGDIVVLSGAGTLGLGMIGAVKKSGAKTLVVLDLKDERLALAQQFGADVVLNPAKDNVVE
ECCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCEEEECCHHHHHH
KVKDMTDGYGCDVYIEATGHPASVEQGLSMIRKLGRFVEFSVFKDPVTVDWSIISDRKEL
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCHHH
DVLGSHLGPYCYPLVIEGIANGDLPTEGVVTHELPLERFAEGFELMKNGSNSLKIILKPQ
HHHHHHCCCHHHHHHEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECC
QA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]