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The map label for this gene is fba [H]

Identifier: 56965267

GI number: 56965267

Start: 3642365

End: 3643219

Strand: Direct

Name: fba [H]

Synonym: ABC3505

Alternate gene names: 56965267

Gene position: 3642365-3643219 (Clockwise)

Preceding gene: 56965266

Following gene: 56965269

Centisome position: 84.63

GC content: 46.2

Gene sequence:

>855_bases
ATGTATGCGAATTTAAAAGAAACGCTTGCTTACGCGAAAGAACGAGGCATTGCTGTCGGCGCCTTTAATGCCCATTGTCT
AGAAATGGTTCCAGCTATGCTCCATGCAGCAAAGGAAACAAACTTGCCGATCATTATCCAAACAACAGCGGGCACAGCCG
ATTATGTAGGCTATGACGTATTTGTCGCCGTTGTCAAAACCCTTGCTGAGCAACTTCCTGTACCGGTTACATTGCATCTT
GACCATGCAACAGATTTTGCGAAAATCAAACAGGCAGTCGATGCAGGCTATTCATCTGTGATGTTCGACGGTTCAACGCT
CCCGATAGCAGAAAATATTGAAAAAACATTAGAAGTTAGTGCCTATGCCCACCCTCGCAACGTCTCCGTCGAAGCGGAAC
TCGGCATAATCGGCGGCGCCGAAGACGGGGTCATGATCGATTCTACGCAAGTAAGCTTCACTCAACCAGAAGAGGTCAGC
CAGTTCTTACAACACGTGACTGTCGATGCACTCGCTTTGTCTATTGGGACAACACACGGCCAATACAAATCAAAAGCCAA
TTTGCAGTTTGATTTGCTAGAGACGATCGCCAACAACCATGCACGCCCTTTAGTTCTCCATGGCGGCACAGGCGTCAAGG
ATGAAGATATCCAAAAATGTGTAACGAGAGGGATTGTAAAGATTAACGTCGGCACTGAATTGCTAATCGCTTGGACGCGC
ACAGCCAAACACCAATTTGCAAAAGCCGATTTGACAGACTCATTGCGTAACCATTTAATTCCTTGCAATGAACAAATCAA
ACAAGTGATCAAAGCGAAAATGGCGGTTTTCGCACTGGAAAAAGCTTCGGTCTAA

Upstream 100 bases:

>100_bases
CCTTGAAAATGTCACGTTTAGTGACTCCGATGTCATTACGATTGGCATTTTGCTTGGGTATGTGTTGGAATGGTTTAATT
AATAAAGGAGTGGAAATATC

Downstream 100 bases:

>100_bases
AACAAGTCTTCATGCTTAAATAGGAAAGGGATGAGGCTATCTCCGCACAGAGATGGCCTCAAACTGTTAACGCGATGACT
TTACCGCGTCAGCTTAAGAA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MYANLKETLAYAKERGIAVGAFNAHCLEMVPAMLHAAKETNLPIIIQTTAGTADYVGYDVFVAVVKTLAEQLPVPVTLHL
DHATDFAKIKQAVDAGYSSVMFDGSTLPIAENIEKTLEVSAYAHPRNVSVEAELGIIGGAEDGVMIDSTQVSFTQPEEVS
QFLQHVTVDALALSIGTTHGQYKSKANLQFDLLETIANNHARPLVLHGGTGVKDEDIQKCVTRGIVKINVGTELLIAWTR
TAKHQFAKADLTDSLRNHLIPCNEQIKQVIKAKMAVFALEKASV

Sequences:

>Translated_284_residues
MYANLKETLAYAKERGIAVGAFNAHCLEMVPAMLHAAKETNLPIIIQTTAGTADYVGYDVFVAVVKTLAEQLPVPVTLHL
DHATDFAKIKQAVDAGYSSVMFDGSTLPIAENIEKTLEVSAYAHPRNVSVEAELGIIGGAEDGVMIDSTQVSFTQPEEVS
QFLQHVTVDALALSIGTTHGQYKSKANLQFDLLETIANNHARPLVLHGGTGVKDEDIQKCVTRGIVKINVGTELLIAWTR
TAKHQFAKADLTDSLRNHLIPCNEQIKQVIKAKMAVFALEKASV
>Mature_284_residues
MYANLKETLAYAKERGIAVGAFNAHCLEMVPAMLHAAKETNLPIIIQTTAGTADYVGYDVFVAVVKTLAEQLPVPVTLHL
DHATDFAKIKQAVDAGYSSVMFDGSTLPIAENIEKTLEVSAYAHPRNVSVEAELGIIGGAEDGVMIDSTQVSFTQPEEVS
QFLQHVTVDALALSIGTTHGQYKSKANLQFDLLETIANNHARPLVLHGGTGVKDEDIQKCVTRGIVKINVGTELLIAWTR
TAKHQFAKADLTDSLRNHLIPCNEQIKQVIKAKMAVFALEKASV

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=270, Percent_Identity=38.5185185185185, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1789526, Length=271, Percent_Identity=35.4243542435424, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1788072, Length=240, Percent_Identity=32.5, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1789293, Length=275, Percent_Identity=28.3636363636364, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322790, Length=274, Percent_Identity=27.007299270073, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30747; Mature: 30747

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYANLKETLAYAKERGIAVGAFNAHCLEMVPAMLHAAKETNLPIIIQTTAGTADYVGYDV
CCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHH
FVAVVKTLAEQLPVPVTLHLDHATDFAKIKQAVDAGYSSVMFDGSTLPIAENIEKTLEVS
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCHHEEECCCCCCHHHHHHHHHHHH
AYAHPRNVSVEAELGIIGGAEDGVMIDSTQVSFTQPEEVSQFLQHVTVDALALSIGTTHG
EECCCCCCEEEEEEEEEECCCCCEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QYKSKANLQFDLLETIANNHARPLVLHGGTGVKDEDIQKCVTRGIVKINVGTELLIAWTR
CCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEECCCEEEEEEHH
TAKHQFAKADLTDSLRNHLIPCNEQIKQVIKAKMAVFALEKASV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYANLKETLAYAKERGIAVGAFNAHCLEMVPAMLHAAKETNLPIIIQTTAGTADYVGYDV
CCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHH
FVAVVKTLAEQLPVPVTLHLDHATDFAKIKQAVDAGYSSVMFDGSTLPIAENIEKTLEVS
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCHHEEECCCCCCHHHHHHHHHHHH
AYAHPRNVSVEAELGIIGGAEDGVMIDSTQVSFTQPEEVSQFLQHVTVDALALSIGTTHG
EECCCCCCEEEEEEEEEECCCCCEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QYKSKANLQFDLLETIANNHARPLVLHGGTGVKDEDIQKCVTRGIVKINVGTELLIAWTR
CCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEECCCEEEEEEHH
TAKHQFAKADLTDSLRNHLIPCNEQIKQVIKAKMAVFALEKASV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA