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The map label for this gene is gdh [H]

Identifier: 56965154

GI number: 56965154

Start: 3519100

End: 3520482

Strand: Direct

Name: gdh [H]

Synonym: ABC3392

Alternate gene names: 56965154

Gene position: 3519100-3520482 (Clockwise)

Preceding gene: 56965149

Following gene: 56965168

Centisome position: 81.77

GC content: 46.28

Gene sequence:

>1383_bases
ATGAACGTATTGGAAAAAGAGAAAGGAACGTATACGAGTGACGTGCACGAATATGTTCAACACGTCTACGAAACAGTAAA
ACAGCGGAACCCATATGAAAACGAGTTTCATCAAGCAGTCAAGGAAGTGTTGGACTCGTTATTGCCTGTCCTTGCTAAGC
GCCCACAGTATATTAGACAAGCTATACTTGAACGAATCGTGGAGCCAGAAAGAATGATCTCTTTTCGCGTTCCGTGGGTC
GATGACCAAGGAAATGTCCAAGTAAATCGTGGTTTCCGAGTACAGTTCAACAGTGCTTTAGGCCCGTATAAAGGCGGGTT
GCGGTTTCACCCTTCCGTCAATACAAGCATCATTAAATTCCTCGGGTTTGAACAAATCTTCAAAAATGCACTGACAGGCC
AACCGATCGGTGGCGGAAAAGGCGGTTCAGACTTCGATCCAAAAGGAAAAAGCGATGGCGAAATCATGCGCTTTACGCAA
AGTTTCATGTCTGAACTGAGCAAATACATCGGACCAGATACCGATGTTCCGGCAGGAGACATTGGTGTAGGTGCCAAGGA
AATTGGTTATATGTTTGGTCAATATAAAAAAATGCGCGGTCGTTTTGAAGCAGGCGTCCTGACCGGAAAAGACATCGCTT
ACGGCGGAAGTCTTGCCAGAAAAGAAGCGACAGGTTATGGAACGGTTTATTTCGTCGAAGAGATGCTTAAAGAAAAAGGC
CATAGTTTCGCAGGAAGCACCGTTGTCGTGTCAGGGTCAGGGAATGTATCGATCTATGCGATGGAAAAAGCCATGCATCT
TGGCGCGAAAGTGGTCGCCTGTAGCGACTCAGAAGGCTATATTTACGACAAACGCGGCATTAACTTGGAAACGGTCAAAC
GTTTGAAGGAAAGCGAGAAAAAACGGATTAGCGAATACGTAAACGAACACCCACAAGCTCACTTTTTCCAAGGTTGCTCA
GACATTTGGTCTGTGCCTTGTGATATTGCTCTTCCTTGTGCCACGCAAAATGAAATTGACGAAAACACGGCGACCGTTTT
AGTCTCCAACGGCGTAAAAGCAATTGGCGAAGGAGCCAATATGCCTTCAACGCTAGAAGCGGTAAACGTGTTTCACGAAC
ATGGTGTTCTGTTTGCTCCAGCAAAAGCGGCGAACGCAGGCGGCGTTTCTGTCTCTGCTTTAGAAATGGCGCAAAACAGC
GCCCGGCTTTCTTGGACGTTCGAAGAAGTCGACGCGAAGCTCCAAGACATTATGAAGACCATTTACAGAGATTGTATAGA
AGCGGCAAAAGAGAACGATGCTCCTGGCAACCTAGTAGTGGGCGCTAATATTGCTGGCTTTGTTAAAGTAGCCGATGCGA
TGATCGCACAAGGAGTAATATAA

Upstream 100 bases:

>100_bases
TAGCGAATCCTGTTTCAAAAGGGCAGTCTTCTATGCCAAGACCTTGAAAACGATTTCATTTCCATAGATTGGATTCAGAC
TGAATGGGGAGGCCATATCA

Downstream 100 bases:

>100_bases
ACACATAAACGCCCAACGAAACAAGCAGCTTGTTTTGATTAAAAACGAGCTGCTTGTTGGTTTTAAACTTTGGACGTTTT
TCTCTTTGTGTGATAGACCC

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNVLEKEKGTYTSDVHEYVQHVYETVKQRNPYENEFHQAVKEVLDSLLPVLAKRPQYIRQAILERIVEPERMISFRVPWV
DDQGNVQVNRGFRVQFNSALGPYKGGLRFHPSVNTSIIKFLGFEQIFKNALTGQPIGGGKGGSDFDPKGKSDGEIMRFTQ
SFMSELSKYIGPDTDVPAGDIGVGAKEIGYMFGQYKKMRGRFEAGVLTGKDIAYGGSLARKEATGYGTVYFVEEMLKEKG
HSFAGSTVVVSGSGNVSIYAMEKAMHLGAKVVACSDSEGYIYDKRGINLETVKRLKESEKKRISEYVNEHPQAHFFQGCS
DIWSVPCDIALPCATQNEIDENTATVLVSNGVKAIGEGANMPSTLEAVNVFHEHGVLFAPAKAANAGGVSVSALEMAQNS
ARLSWTFEEVDAKLQDIMKTIYRDCIEAAKENDAPGNLVVGANIAGFVKVADAMIAQGVI

Sequences:

>Translated_460_residues
MNVLEKEKGTYTSDVHEYVQHVYETVKQRNPYENEFHQAVKEVLDSLLPVLAKRPQYIRQAILERIVEPERMISFRVPWV
DDQGNVQVNRGFRVQFNSALGPYKGGLRFHPSVNTSIIKFLGFEQIFKNALTGQPIGGGKGGSDFDPKGKSDGEIMRFTQ
SFMSELSKYIGPDTDVPAGDIGVGAKEIGYMFGQYKKMRGRFEAGVLTGKDIAYGGSLARKEATGYGTVYFVEEMLKEKG
HSFAGSTVVVSGSGNVSIYAMEKAMHLGAKVVACSDSEGYIYDKRGINLETVKRLKESEKKRISEYVNEHPQAHFFQGCS
DIWSVPCDIALPCATQNEIDENTATVLVSNGVKAIGEGANMPSTLEAVNVFHEHGVLFAPAKAANAGGVSVSALEMAQNS
ARLSWTFEEVDAKLQDIMKTIYRDCIEAAKENDAPGNLVVGANIAGFVKVADAMIAQGVI
>Mature_460_residues
MNVLEKEKGTYTSDVHEYVQHVYETVKQRNPYENEFHQAVKEVLDSLLPVLAKRPQYIRQAILERIVEPERMISFRVPWV
DDQGNVQVNRGFRVQFNSALGPYKGGLRFHPSVNTSIIKFLGFEQIFKNALTGQPIGGGKGGSDFDPKGKSDGEIMRFTQ
SFMSELSKYIGPDTDVPAGDIGVGAKEIGYMFGQYKKMRGRFEAGVLTGKDIAYGGSLARKEATGYGTVYFVEEMLKEKG
HSFAGSTVVVSGSGNVSIYAMEKAMHLGAKVVACSDSEGYIYDKRGINLETVKRLKESEKKRISEYVNEHPQAHFFQGCS
DIWSVPCDIALPCATQNEIDENTATVLVSNGVKAIGEGANMPSTLEAVNVFHEHGVLFAPAKAANAGGVSVSALEMAQNS
ARLSWTFEEVDAKLQDIMKTIYRDCIEAAKENDAPGNLVVGANIAGFVKVADAMIAQGVI

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=355, Percent_Identity=32.112676056338, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4885281, Length=372, Percent_Identity=31.4516129032258, Blast_Score=175, Evalue=1e-43,
Organism=Escherichia coli, GI1788059, Length=452, Percent_Identity=57.9646017699115, Blast_Score=529, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17544676, Length=389, Percent_Identity=28.0205655526992, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319256, Length=454, Percent_Identity=51.1013215859031, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6324951, Length=452, Percent_Identity=50.2212389380531, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24649283, Length=426, Percent_Identity=30.5164319248826, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45549226, Length=359, Percent_Identity=30.6406685236769, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45553475, Length=359, Percent_Identity=30.6406685236769, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24649460, Length=292, Percent_Identity=31.1643835616438, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 50326; Mature: 50326

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLEKEKGTYTSDVHEYVQHVYETVKQRNPYENEFHQAVKEVLDSLLPVLAKRPQYIRQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AILERIVEPERMISFRVPWVDDQGNVQVNRGFRVQFNSALGPYKGGLRFHPSVNTSIIKF
HHHHHHCCHHHHEEEECCEECCCCCEEECCCEEEEECCCCCCCCCCEEECCCCCHHHHHH
LGFEQIFKNALTGQPIGGGKGGSDFDPKGKSDGEIMRFTQSFMSELSKYIGPDTDVPAGD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
IGVGAKEIGYMFGQYKKMRGRFEAGVLTGKDIAYGGSLARKEATGYGTVYFVEEMLKEKG
CCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCC
HSFAGSTVVVSGSGNVSIYAMEKAMHLGAKVVACSDSEGYIYDKRGINLETVKRLKESEK
CCCCCCEEEEECCCCEEEEEEHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHH
KRISEYVNEHPQAHFFQGCSDIWSVPCDIALPCATQNEIDENTATVLVSNGVKAIGEGAN
HHHHHHHHCCCCHHHHHCCHHHHCCCCCEEECCCCCCCCCCCCEEEEEECCCHHHCCCCC
MPSTLEAVNVFHEHGVLFAPAKAANAGGVSVSALEMAQNSARLSWTFEEVDAKLQDIMKT
CCHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHH
IYRDCIEAAKENDAPGNLVVGANIAGFVKVADAMIAQGVI
HHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNVLEKEKGTYTSDVHEYVQHVYETVKQRNPYENEFHQAVKEVLDSLLPVLAKRPQYIRQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AILERIVEPERMISFRVPWVDDQGNVQVNRGFRVQFNSALGPYKGGLRFHPSVNTSIIKF
HHHHHHCCHHHHEEEECCEECCCCCEEECCCEEEEECCCCCCCCCCEEECCCCCHHHHHH
LGFEQIFKNALTGQPIGGGKGGSDFDPKGKSDGEIMRFTQSFMSELSKYIGPDTDVPAGD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
IGVGAKEIGYMFGQYKKMRGRFEAGVLTGKDIAYGGSLARKEATGYGTVYFVEEMLKEKG
CCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCC
HSFAGSTVVVSGSGNVSIYAMEKAMHLGAKVVACSDSEGYIYDKRGINLETVKRLKESEK
CCCCCCEEEEECCCCEEEEEEHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHH
KRISEYVNEHPQAHFFQGCSDIWSVPCDIALPCATQNEIDENTATVLVSNGVKAIGEGAN
HHHHHHHHCCCCHHHHHCCHHHHCCCCCEEECCCCCCCCCCCCEEEEEECCCHHHCCCCC
MPSTLEAVNVFHEHGVLFAPAKAANAGGVSVSALEMAQNSARLSWTFEEVDAKLQDIMKT
CCHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHH
IYRDCIEAAKENDAPGNLVVGANIAGFVKVADAMIAQGVI
HHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]