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The map label for this gene is glpK [H]

Identifier: 56965146

GI number: 56965146

Start: 3511027

End: 3512523

Strand: Direct

Name: glpK [H]

Synonym: ABC3384

Alternate gene names: 56965146

Gene position: 3511027-3512523 (Clockwise)

Preceding gene: 56965145

Following gene: 56965148

Centisome position: 81.58

GC content: 46.63

Gene sequence:

>1497_bases
ATGAAAAACCCATACATTTTATCCATCGATCAAGGAACAACTAGTTCACGCGCGATTTTATTTGACAGCCAAGGAGAAAT
CAAAAAAACGGCGCAACGGGAATTCACCCAATACTTCCCAAATCCAGGCTGGGTAGAGCATAATGCCAATGAAATTTGGA
CATCCGTTCTTGCCGTCATCGCTGAAGTCTTTTCCGAGTCCGATGTTGAGCCAAAAGATGTGGCTGGAATTGGCATTACA
AACCAACGGGAAACAACGGTCGTATGGGATAAACACACAGGAAAACCGATATACAATGCTTTGGTTTGGCAATCACGGCA
AACTGAAAAGATTTGCGCTGATTTGCGGGAAAAAGGGTTGAACGAGACATTCCGTAAAAAAACGGGCTTATTGCTTGATC
CTTATTTCTCTGGCACAAAAGTAAAATGGATTCTTGACCATGTAGATGGCGCAAGAGAAAAAGCTGAAAAAGGCGACCTG
TTGTTTGGCACAATTGATTCATGGCTCATTTGGAAACTAAGCGGCGGCAAAGCTCATGTGACCGATTATACAAATGCAGC
TCGGACGCTTATGTACAATATCCACGAGTTGAAATGGGACGACGAACTGCTCGAACTGCTCGATGTTCCAAAGCAAATGC
TGCCGGAAGTCCGCTCCTCTTCTGAAGTATACGCCACAACCGTTGACTACCATTTCTTTGGGCAAAATGTGCCAATTGCT
GGCGTCGCCGGTGACCAGCATGCGGCTTTATTCGGGCAAGCGTGTTTTGAAAAAGGAATGGTTAAAAACACTTACGGCAC
TGGCTGTTTTATTTTGATGAATACAGGAGAACAAGCGGTTGAGTCGAAAAACGGGCTTTTGACAACACTGGCATGGGGAA
TTGATGGAAAAGTTGAGTACGCCCTTGAAGGCAGTGTATTTGTTGCCGGTTCGGCAATTCAATGGTTACGGGATGGCCTT
AAAATTATTGAAAATGCCCCGCAAAGTGAAGCGTTAGCGACACGAGTAACGTCCGCTGATGGTGTCTACTTAGTCCCTGC
ATTTGTTGGCCTAGGTACCCCATATTGGGACAGCGAAGCAAGAGGCGCCATGTTTGGGTTAACCCGTGGCACAGAGCATG
CTCATATTGTCCGTGCCACGCTGGAATCACTTGCTTATCAGACAAAAGATGTGATGGCAGCAATGGAACAAGACGCTGGC
ATGGAATCGAAAAAGCTCCGTGCCGATGGAGGCGCTGTTGCTAATGACTTTTTAATGCAATTCCAAAGCGATCTCCTTGA
TGCACCCGTTGAAATTCCTTCCGTTACAGAGACGACGGCGCTTGGTGCTGCCTATCTAGCTGGCCTCGCTGTTGGCGTCT
GGAAAAGCAAAGAAGATATCGCCCGCAAATGGAATATGGACCGTTCATTTGAACCAAAAATGAACGCCGATGAGCGAGAT
GCGTTATACAAAGGCTGGAAAAACGCCGTTAACGCAACGATGGCATTCAAGCCGTGA

Upstream 100 bases:

>100_bases
TTGGGCTTATGCATGGGTGCCCATTCTCGGGCCATTTGTTGGCGGTATTGTTGGCGCTGTTCTTTATACCCTTATTTTCT
AAACAAAGGAGACGATATTG

Downstream 100 bases:

>100_bases
ATTAAAAAGAGACACCCAGCACATGCAATCGCTGCATGTGCTGTTTTTTAGCTTCCAATATACAACCTAATTGGGCGGCC
TTCCACGTCTAACGGTTTCA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKNPYILSIDQGTTSSRAILFDSQGEIKKTAQREFTQYFPNPGWVEHNANEIWTSVLAVIAEVFSESDVEPKDVAGIGIT
NQRETTVVWDKHTGKPIYNALVWQSRQTEKICADLREKGLNETFRKKTGLLLDPYFSGTKVKWILDHVDGAREKAEKGDL
LFGTIDSWLIWKLSGGKAHVTDYTNAARTLMYNIHELKWDDELLELLDVPKQMLPEVRSSSEVYATTVDYHFFGQNVPIA
GVAGDQHAALFGQACFEKGMVKNTYGTGCFILMNTGEQAVESKNGLLTTLAWGIDGKVEYALEGSVFVAGSAIQWLRDGL
KIIENAPQSEALATRVTSADGVYLVPAFVGLGTPYWDSEARGAMFGLTRGTEHAHIVRATLESLAYQTKDVMAAMEQDAG
MESKKLRADGGAVANDFLMQFQSDLLDAPVEIPSVTETTALGAAYLAGLAVGVWKSKEDIARKWNMDRSFEPKMNADERD
ALYKGWKNAVNATMAFKP

Sequences:

>Translated_498_residues
MKNPYILSIDQGTTSSRAILFDSQGEIKKTAQREFTQYFPNPGWVEHNANEIWTSVLAVIAEVFSESDVEPKDVAGIGIT
NQRETTVVWDKHTGKPIYNALVWQSRQTEKICADLREKGLNETFRKKTGLLLDPYFSGTKVKWILDHVDGAREKAEKGDL
LFGTIDSWLIWKLSGGKAHVTDYTNAARTLMYNIHELKWDDELLELLDVPKQMLPEVRSSSEVYATTVDYHFFGQNVPIA
GVAGDQHAALFGQACFEKGMVKNTYGTGCFILMNTGEQAVESKNGLLTTLAWGIDGKVEYALEGSVFVAGSAIQWLRDGL
KIIENAPQSEALATRVTSADGVYLVPAFVGLGTPYWDSEARGAMFGLTRGTEHAHIVRATLESLAYQTKDVMAAMEQDAG
MESKKLRADGGAVANDFLMQFQSDLLDAPVEIPSVTETTALGAAYLAGLAVGVWKSKEDIARKWNMDRSFEPKMNADERD
ALYKGWKNAVNATMAFKP
>Mature_498_residues
MKNPYILSIDQGTTSSRAILFDSQGEIKKTAQREFTQYFPNPGWVEHNANEIWTSVLAVIAEVFSESDVEPKDVAGIGIT
NQRETTVVWDKHTGKPIYNALVWQSRQTEKICADLREKGLNETFRKKTGLLLDPYFSGTKVKWILDHVDGAREKAEKGDL
LFGTIDSWLIWKLSGGKAHVTDYTNAARTLMYNIHELKWDDELLELLDVPKQMLPEVRSSSEVYATTVDYHFFGQNVPIA
GVAGDQHAALFGQACFEKGMVKNTYGTGCFILMNTGEQAVESKNGLLTTLAWGIDGKVEYALEGSVFVAGSAIQWLRDGL
KIIENAPQSEALATRVTSADGVYLVPAFVGLGTPYWDSEARGAMFGLTRGTEHAHIVRATLESLAYQTKDVMAAMEQDAG
MESKKLRADGGAVANDFLMQFQSDLLDAPVEIPSVTETTALGAAYLAGLAVGVWKSKEDIARKWNMDRSFEPKMNADERD
ALYKGWKNAVNATMAFKP

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=510, Percent_Identity=45.4901960784314, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI189409120, Length=504, Percent_Identity=46.2301587301587, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI4504007, Length=506, Percent_Identity=45.8498023715415, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI41393575, Length=504, Percent_Identity=45.2380952380952, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI88196792, Length=508, Percent_Identity=30.511811023622, Blast_Score=301, Evalue=9e-82,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=60.0405679513185, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=523, Percent_Identity=23.3269598470363, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789987, Length=481, Percent_Identity=23.7006237006237, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789168, Length=489, Percent_Identity=22.6993865030675, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787789, Length=517, Percent_Identity=21.6634429400387, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=499, Percent_Identity=40.4809619238477, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71986140, Length=520, Percent_Identity=25, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71986147, Length=301, Percent_Identity=29.5681063122924, Blast_Score=138, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6321755, Length=509, Percent_Identity=37.1316306483301, Blast_Score=305, Evalue=1e-83,
Organism=Drosophila melanogaster, GI17864214, Length=508, Percent_Identity=41.3385826771654, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24654573, Length=433, Percent_Identity=43.64896073903, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655555, Length=499, Percent_Identity=37.6753507014028, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24655560, Length=499, Percent_Identity=37.6753507014028, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24655570, Length=499, Percent_Identity=37.6753507014028, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24655574, Length=499, Percent_Identity=37.6753507014028, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24655565, Length=499, Percent_Identity=37.6753507014028, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI19922058, Length=524, Percent_Identity=30.1526717557252, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24652871, Length=491, Percent_Identity=30.9572301425662, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24656367, Length=491, Percent_Identity=28.1059063136456, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI21357867, Length=505, Percent_Identity=26.9306930693069, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24656372, Length=325, Percent_Identity=30.4615384615385, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=27.2413793103448, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55051; Mature: 55051

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPYILSIDQGTTSSRAILFDSQGEIKKTAQREFTQYFPNPGWVEHNANEIWTSVLAVI
CCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AEVFSESDVEPKDVAGIGITNQRETTVVWDKHTGKPIYNALVWQSRQTEKICADLREKGL
HHHHCCCCCCHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCC
NETFRKKTGLLLDPYFSGTKVKWILDHVDGAREKAEKGDLLFGTIDSWLIWKLSGGKAHV
CHHHHHHCCCEECCCCCCCEEEEEEECCCCHHHHHHCCCEEEEECCCEEEEEECCCEEEE
TDYTNAARTLMYNIHELKWDDELLELLDVPKQMLPEVRSSSEVYATTVDYHFFGQNVPIA
CCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHCCCCCEEEEEEEEEEECCCCCEE
GVAGDQHAALFGQACFEKGMVKNTYGTGCFILMNTGEQAVESKNGLLTTLAWGIDGKVEY
EECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHCCCCEEEEEEECCCCEEEE
ALEGSVFVAGSAIQWLRDGLKIIENAPQSEALATRVTSADGVYLVPAFVGLGTPYWDSEA
EECCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCC
RGAMFGLTRGTEHAHIVRATLESLAYQTKDVMAAMEQDAGMESKKLRADGGAVANDFLMQ
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCHHHHHHHHH
FQSDLLDAPVEIPSVTETTALGAAYLAGLAVGVWKSKEDIARKWNMDRSFEPKMNADERD
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHH
ALYKGWKNAVNATMAFKP
HHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MKNPYILSIDQGTTSSRAILFDSQGEIKKTAQREFTQYFPNPGWVEHNANEIWTSVLAVI
CCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AEVFSESDVEPKDVAGIGITNQRETTVVWDKHTGKPIYNALVWQSRQTEKICADLREKGL
HHHHCCCCCCHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCC
NETFRKKTGLLLDPYFSGTKVKWILDHVDGAREKAEKGDLLFGTIDSWLIWKLSGGKAHV
CHHHHHHCCCEECCCCCCCEEEEEEECCCCHHHHHHCCCEEEEECCCEEEEEECCCEEEE
TDYTNAARTLMYNIHELKWDDELLELLDVPKQMLPEVRSSSEVYATTVDYHFFGQNVPIA
CCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHCCCCCEEEEEEEEEEECCCCCEE
GVAGDQHAALFGQACFEKGMVKNTYGTGCFILMNTGEQAVESKNGLLTTLAWGIDGKVEY
EECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHCCCCEEEEEEECCCCEEEE
ALEGSVFVAGSAIQWLRDGLKIIENAPQSEALATRVTSADGVYLVPAFVGLGTPYWDSEA
EECCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCC
RGAMFGLTRGTEHAHIVRATLESLAYQTKDVMAAMEQDAGMESKKLRADGGAVANDFLMQ
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCHHHHHHHHH
FQSDLLDAPVEIPSVTETTALGAAYLAGLAVGVWKSKEDIARKWNMDRSFEPKMNADERD
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHH
ALYKGWKNAVNATMAFKP
HHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA