Click here to switch to the map view.

The map label for this gene is ytkP [H]

Identifier: 56964556

GI number: 56964556

Start: 2926431

End: 2927363

Strand: Direct

Name: ytkP [H]

Synonym: ABC2792

Alternate gene names: 56964556

Gene position: 2926431-2927363 (Clockwise)

Preceding gene: 56964545

Following gene: 56964561

Centisome position: 68.0

GC content: 49.41

Gene sequence:

>933_bases
ATGCGAGTAGTAGACAATATCGCTGACTTAATTGGACAGACGCCTTTGGTCCGTTTAAACAAGCTGCCTGATAGTGAAGG
CGCATCTGTCTATTTAAAATTAGAAATGAATAACCCGAGCGGCAGCGTGAAAGACCGTGCTGCCTTTTCCATGATTATTC
AAGCAGAAAAGGATGGCCATTTGCAACCTGGTTCCACCATTATTGAGCCAACGAGTGGAAATACTGGGATTGGCTTGGCT
ATGAACGCTGCGGCCCGCGGCTATCGCGCTATTCTCGTCATGCCTGATACAATGAGCCAAGAACGGATTAATTTACTAAA
GGCGTATGGCGCTGAAGTCGTGCTAACGGAAGGCGATAAAAAAATGCCTGGGGCCATCGAAAAAGCCAAGGAGCTTGCCG
AAAGCATTCCTGGCTCTTTCATGCCAATGCAGTTTGAAAATGAAGCAAACCCTGATGCCCACCGCCGTACCACTGCCATA
GAAATTAAACAAGACTTAGATGCAATTGGCGCCACACTTTCAGGGTTTGTCGCAGCCTCTGGTACGGGCGGCACGATCAC
CGGCACAGGAGAAGTGCTTAAAACCTATTACCCTGATGCCCTTATTCATGTGGTGGAGCCAGCTGGATCACCTGTTTTGT
CAGGTGGCAAGCCTGGCCCGCATAAGCTTGTCGGTACAAGCCCTGGATTTGTACCGCCTATACTAAATACAGCTATCTAT
GACCAGATTAGGCGGATCGAAGATGAAGATGCATACAAGACAGCAAAAGACTTGGCACGGCTTGAAGGCATTCTTGTCGG
CCCTTCTTCTGGAGCGGCTTGCTTTGCGGCACTGGAAATGGCCAAGACGCTTGACAAAGGCGATCACGTCGTTGCCATCG
CCTGTGATACAGGCGAGCGCTATTTATCGACCGACCTGTATCAATCCGAATAG

Upstream 100 bases:

>100_bases
TAGTGTAGTTCGTTCATGTTGTCCTCCTAAGCGTTCAATAAGCTGGCTTGCCTTATTTATGTTAAACTAAATAAATGGAA
CTTTAAAGAGGTGATTACTG

Downstream 100 bases:

>100_bases
GTTCTTATCAACTAGAGTGTTCCCACTTTCCGGAGTTTAATCAGTTACGTACACTTCACTCATGTTGTTGCACCTGCTTA
GGATAACTAAAAAGACTGCC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRVVDNIADLIGQTPLVRLNKLPDSEGASVYLKLEMNNPSGSVKDRAAFSMIIQAEKDGHLQPGSTIIEPTSGNTGIGLA
MNAAARGYRAILVMPDTMSQERINLLKAYGAEVVLTEGDKKMPGAIEKAKELAESIPGSFMPMQFENEANPDAHRRTTAI
EIKQDLDAIGATLSGFVAASGTGGTITGTGEVLKTYYPDALIHVVEPAGSPVLSGGKPGPHKLVGTSPGFVPPILNTAIY
DQIRRIEDEDAYKTAKDLARLEGILVGPSSGAACFAALEMAKTLDKGDHVVAIACDTGERYLSTDLYQSE

Sequences:

>Translated_310_residues
MRVVDNIADLIGQTPLVRLNKLPDSEGASVYLKLEMNNPSGSVKDRAAFSMIIQAEKDGHLQPGSTIIEPTSGNTGIGLA
MNAAARGYRAILVMPDTMSQERINLLKAYGAEVVLTEGDKKMPGAIEKAKELAESIPGSFMPMQFENEANPDAHRRTTAI
EIKQDLDAIGATLSGFVAASGTGGTITGTGEVLKTYYPDALIHVVEPAGSPVLSGGKPGPHKLVGTSPGFVPPILNTAIY
DQIRRIEDEDAYKTAKDLARLEGILVGPSSGAACFAALEMAKTLDKGDHVVAIACDTGERYLSTDLYQSE
>Mature_310_residues
MRVVDNIADLIGQTPLVRLNKLPDSEGASVYLKLEMNNPSGSVKDRAAFSMIIQAEKDGHLQPGSTIIEPTSGNTGIGLA
MNAAARGYRAILVMPDTMSQERINLLKAYGAEVVLTEGDKKMPGAIEKAKELAESIPGSFMPMQFENEANPDAHRRTTAI
EIKQDLDAIGATLSGFVAASGTGGTITGTGEVLKTYYPDALIHVVEPAGSPVLSGGKPGPHKLVGTSPGFVPPILNTAIY
DQIRRIEDEDAYKTAKDLARLEGILVGPSSGAACFAALEMAKTLDKGDHVVAIACDTGERYLSTDLYQSE

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=40.3174603174603, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=40.3174603174603, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=40.3174603174603, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=44.3333333333333, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=46.5189873417722, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=308, Percent_Identity=46.1038961038961, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI115535073, Length=305, Percent_Identity=47.8688524590164, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17562970, Length=307, Percent_Identity=43.3224755700326, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=43.3774834437086, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=40.453074433657, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=39.1849529780564, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=40.9302325581395, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=294, Percent_Identity=38.7755102040816, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71996324, Length=330, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561716, Length=109, Percent_Identity=39.4495412844037, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539800, Length=339, Percent_Identity=23.3038348082596, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=39.4904458598726, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=35.0453172205438, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=40.0641025641026, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=40.0641025641026, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32799; Mature: 32799

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVDNIADLIGQTPLVRLNKLPDSEGASVYLKLEMNNPSGSVKDRAAFSMIIQAEKDGH
CCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHEEEEEEECCCCC
LQPGSTIIEPTSGNTGIGLAMNAAARGYRAILVMPDTMSQERINLLKAYGAEVVLTEGDK
CCCCCEEEECCCCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECCCC
KMPGAIEKAKELAESIPGSFMPMQFENEANPDAHRRTTAIEIKQDLDAIGATLSGFVAAS
CCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHEEEEEHHHHHHHHHHHHHCEEEEC
GTGGTITGTGEVLKTYYPDALIHVVEPAGSPVLSGGKPGPHKLVGTSPGFVPPILNTAIY
CCCCEEECCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHH
DQIRRIEDEDAYKTAKDLARLEGILVGPSSGAACFAALEMAKTLDKGDHVVAIACDTGER
HHHHHCCCCHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCH
YLSTDLYQSE
HHHCCCCCCC
>Mature Secondary Structure
MRVVDNIADLIGQTPLVRLNKLPDSEGASVYLKLEMNNPSGSVKDRAAFSMIIQAEKDGH
CCHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHEEEEEEECCCCC
LQPGSTIIEPTSGNTGIGLAMNAAARGYRAILVMPDTMSQERINLLKAYGAEVVLTEGDK
CCCCCEEEECCCCCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECCCC
KMPGAIEKAKELAESIPGSFMPMQFENEANPDAHRRTTAIEIKQDLDAIGATLSGFVAAS
CCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHEEEEEHHHHHHHHHHHHHCEEEEC
GTGGTITGTGEVLKTYYPDALIHVVEPAGSPVLSGGKPGPHKLVGTSPGFVPPILNTAIY
CCCCEEECCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHH
DQIRRIEDEDAYKTAKDLARLEGILVGPSSGAACFAALEMAKTLDKGDHVVAIACDTGER
HHHHHCCCCHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCH
YLSTDLYQSE
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]