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The map label for this gene is zwf [H]

Identifier: 56963689

GI number: 56963689

Start: 2037534

End: 2039021

Strand: Direct

Name: zwf [H]

Synonym: ABC1924

Alternate gene names: 56963689

Gene position: 2037534-2039021 (Clockwise)

Preceding gene: 56963687

Following gene: 56963690

Centisome position: 47.34

GC content: 43.62

Gene sequence:

>1488_bases
ATGAACCAGATCGAACAAGCGGAAGCGGTTTTTGTTATTTTTGGCTCTACAGGTGATTTAGCAAAACGAAAATTGTTTCC
TTCTATATACAATTTATACAGAAAAGGCAATTTGAACGAACATTTTGCTGTAGTAGGTTTAGGGCGCCGTGAATGGGATG
ATGAAAAACTAAGAACAGTCGTGATGGAATCGATCCAAGAAGAACTTGGCGAGCAACGTCCTGAAGTGACTGAATCATTT
TTAAAGCATTTTTCCTATCTATCATTTGATGTCACCAACAAAGATTCCTATAGCGAGCTCAATGACAAGTTGCATATTTT
GGATGAGACATTCCAAATTCCTGGGAACCGTATTTTTTATATGGCAATGGCACCTGAATTTTTTGGGCAAATTGCACAGT
CAATACATAACGAAGGGCTAAAGGACACGCAAGGATGGACGCGTCTTGTGATTGAGAAACCGTTTGGCACAGACTTGCAA
TCGGCTATCCGTTTAAATGACGAAATACGCCAGGCATTTTCAGAAGATGAAATTTATCGGATCGACCACTATTTAGGCAA
AGAAATGGTGCAAAACATTCAAGTGATCCGTTTTGCCAATGCCATATTTGGTTCATTGTGGAACAACCGGCATATCGCTA
ATATCCAAGTGACTTCCAGTGAGCAGCTCGGTGTCGAAGGACGGGGCGGCTATTATGAAAAATCAGGAGCCCTTCGTGAT
ATGGTACAAAACCATATGCTGCAAATGGTGTCTCTCTTGGCAATGGATGTACCTCTTCGTTTGTCCACCGATGATATACG
TAGCGAAAAAATTAAAGTGCTACGCGCATTGCGCCCGATTGTCGGCGAGAGCATCAAGGAAAATGTGGTACGCGGGCAAT
ATGGCCGAGGGGAAATCAATGGGCAAGAAGTGATTGGCTATTTAGAAGAAGAAAATGTGAGTGATTCGTCAAAAACAGAG
ACTTACGTTGCGGCAAAGTTAATGATTGACAATCATGTTTGGGCAGGCGTCCCTTTTTATATCCGCACTGGAAAGCGGAT
GGCGGTGAAGTCAACGAAAATCGTTGTTGAATTTAAGGAATTACCTTTAAATCTGTATAGCAAGGAAAACAAACAGACTG
GGCCGAATTTGTTGATCATCCATATCCAGCCTGATGAAGGCATGACGATTGTTTTGAACGGCAAAAAGATTGGCTCCGCA
GATACAACGCCTGTCCATTTGCAATACAGGCATGATAGCGAAGACCGGTTTAACACGCCTGAGGCATATGAGCGGCTCCT
CTTTGATTGCATGATGGGCGATGCCACAAACTTTGCCCATTGGGATGAAGTTAGTTTGTCATGGTCGCTTGTTGATGCGA
TCTCCAAAGCGTGGTCAGAAAGCGGAGAAAAACTGCCAACCTATCGAGCTGGGTCGATGGGGCCGAAAGAAGCGGATGAG
CTTCTTGAAGCAGACGGCTTTTCATGGTGGCCTGTTGAAGAAATGTAA

Upstream 100 bases:

>100_bases
TCTGAGCACCATTTTCGGTATAATGGGGAAGGGCAACAAACACCTATTGCCAATTGCTTATCAAGAGAAGAAAAAGACAG
TCAAGAAAAGAGGTAAAAAG

Downstream 100 bases:

>100_bases
ATAAAAAAGCTTGGCTGAAAAATTGAATAGACTAAACGAATAAGCGGATATTATGTTCTTTATATGAGCATATATCCTCT
TTTTTTGTTAGTTAGATTAG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNQIEQAEAVFVIFGSTGDLAKRKLFPSIYNLYRKGNLNEHFAVVGLGRREWDDEKLRTVVMESIQEELGEQRPEVTESF
LKHFSYLSFDVTNKDSYSELNDKLHILDETFQIPGNRIFYMAMAPEFFGQIAQSIHNEGLKDTQGWTRLVIEKPFGTDLQ
SAIRLNDEIRQAFSEDEIYRIDHYLGKEMVQNIQVIRFANAIFGSLWNNRHIANIQVTSSEQLGVEGRGGYYEKSGALRD
MVQNHMLQMVSLLAMDVPLRLSTDDIRSEKIKVLRALRPIVGESIKENVVRGQYGRGEINGQEVIGYLEEENVSDSSKTE
TYVAAKLMIDNHVWAGVPFYIRTGKRMAVKSTKIVVEFKELPLNLYSKENKQTGPNLLIIHIQPDEGMTIVLNGKKIGSA
DTTPVHLQYRHDSEDRFNTPEAYERLLFDCMMGDATNFAHWDEVSLSWSLVDAISKAWSESGEKLPTYRAGSMGPKEADE
LLEADGFSWWPVEEM

Sequences:

>Translated_495_residues
MNQIEQAEAVFVIFGSTGDLAKRKLFPSIYNLYRKGNLNEHFAVVGLGRREWDDEKLRTVVMESIQEELGEQRPEVTESF
LKHFSYLSFDVTNKDSYSELNDKLHILDETFQIPGNRIFYMAMAPEFFGQIAQSIHNEGLKDTQGWTRLVIEKPFGTDLQ
SAIRLNDEIRQAFSEDEIYRIDHYLGKEMVQNIQVIRFANAIFGSLWNNRHIANIQVTSSEQLGVEGRGGYYEKSGALRD
MVQNHMLQMVSLLAMDVPLRLSTDDIRSEKIKVLRALRPIVGESIKENVVRGQYGRGEINGQEVIGYLEEENVSDSSKTE
TYVAAKLMIDNHVWAGVPFYIRTGKRMAVKSTKIVVEFKELPLNLYSKENKQTGPNLLIIHIQPDEGMTIVLNGKKIGSA
DTTPVHLQYRHDSEDRFNTPEAYERLLFDCMMGDATNFAHWDEVSLSWSLVDAISKAWSESGEKLPTYRAGSMGPKEADE
LLEADGFSWWPVEEM
>Mature_495_residues
MNQIEQAEAVFVIFGSTGDLAKRKLFPSIYNLYRKGNLNEHFAVVGLGRREWDDEKLRTVVMESIQEELGEQRPEVTESF
LKHFSYLSFDVTNKDSYSELNDKLHILDETFQIPGNRIFYMAMAPEFFGQIAQSIHNEGLKDTQGWTRLVIEKPFGTDLQ
SAIRLNDEIRQAFSEDEIYRIDHYLGKEMVQNIQVIRFANAIFGSLWNNRHIANIQVTSSEQLGVEGRGGYYEKSGALRD
MVQNHMLQMVSLLAMDVPLRLSTDDIRSEKIKVLRALRPIVGESIKENVVRGQYGRGEINGQEVIGYLEEENVSDSSKTE
TYVAAKLMIDNHVWAGVPFYIRTGKRMAVKSTKIVVEFKELPLNLYSKENKQTGPNLLIIHIQPDEGMTIVLNGKKIGSA
DTTPVHLQYRHDSEDRFNTPEAYERLLFDCMMGDATNFAHWDEVSLSWSLVDAISKAWSESGEKLPTYRAGSMGPKEADE
LLEADGFSWWPVEEM

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=487, Percent_Identity=37.3716632443532, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=37.3716632443532, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI52145310, Length=409, Percent_Identity=29.3398533007335, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1788158, Length=496, Percent_Identity=40.3225806451613, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=35.2577319587629, Blast_Score=310, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6324088, Length=500, Percent_Identity=34, Blast_Score=306, Evalue=5e-84,
Organism=Drosophila melanogaster, GI24643350, Length=485, Percent_Identity=35.6701030927835, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24643352, Length=485, Percent_Identity=35.6701030927835, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI221513548, Length=499, Percent_Identity=28.2565130260521, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56529; Mature: 56529

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQIEQAEAVFVIFGSTGDLAKRKLFPSIYNLYRKGNLNEHFAVVGLGRREWDDEKLRTV
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHH
VMESIQEELGEQRPEVTESFLKHFSYLSFDVTNKDSYSELNDKLHILDETFQIPGNRIFY
HHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCCHHHHCCCEEEEHHHHCCCCCEEEE
MAMAPEFFGQIAQSIHNEGLKDTQGWTRLVIEKPFGTDLQSAIRLNDEIRQAFSEDEIYR
EEECHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHCHHHHHHCCCCCEEH
IDHYLGKEMVQNIQVIRFANAIFGSLWNNRHIANIQVTSSEQLGVEGRGGYYEKSGALRD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEECCCCHHHH
MVQNHMLQMVSLLAMDVPLRLSTDDIRSEKIKVLRALRPIVGESIKENVVRGQYGRGEIN
HHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GQEVIGYLEEENVSDSSKTETYVAAKLMIDNHVWAGVPFYIRTGKRMAVKSTKIVVEFKE
HHHHEEEHHCCCCCCCCCCHHEEEEEEEECCCEECCCCEEEECCCEEEEECEEEEEEEEC
LPLNLYSKENKQTGPNLLIIHIQPDEGMTIVLNGKKIGSADTTPVHLQYRHDSEDRFNTP
CCCCHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCH
EAYERLLFDCMMGDATNFAHWDEVSLSWSLVDAISKAWSESGEKLPTYRAGSMGPKEADE
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
LLEADGFSWWPVEEM
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MNQIEQAEAVFVIFGSTGDLAKRKLFPSIYNLYRKGNLNEHFAVVGLGRREWDDEKLRTV
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHH
VMESIQEELGEQRPEVTESFLKHFSYLSFDVTNKDSYSELNDKLHILDETFQIPGNRIFY
HHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCCHHHHCCCEEEEHHHHCCCCCEEEE
MAMAPEFFGQIAQSIHNEGLKDTQGWTRLVIEKPFGTDLQSAIRLNDEIRQAFSEDEIYR
EEECHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHCHHHHHHCCCCCEEH
IDHYLGKEMVQNIQVIRFANAIFGSLWNNRHIANIQVTSSEQLGVEGRGGYYEKSGALRD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEECCCCHHHH
MVQNHMLQMVSLLAMDVPLRLSTDDIRSEKIKVLRALRPIVGESIKENVVRGQYGRGEIN
HHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GQEVIGYLEEENVSDSSKTETYVAAKLMIDNHVWAGVPFYIRTGKRMAVKSTKIVVEFKE
HHHHEEEHHCCCCCCCCCCHHEEEEEEEECCCEECCCCEEEECCCEEEEECEEEEEEEEC
LPLNLYSKENKQTGPNLLIIHIQPDEGMTIVLNGKKIGSADTTPVHLQYRHDSEDRFNTP
CCCCHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCH
EAYERLLFDCMMGDATNFAHWDEVSLSWSLVDAISKAWSESGEKLPTYRAGSMGPKEADE
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
LLEADGFSWWPVEEM
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]