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The map label for this gene is trpE [H]

Identifier: 56963660

GI number: 56963660

Start: 2011767

End: 2013263

Strand: Direct

Name: trpE [H]

Synonym: ABC1895

Alternate gene names: 56963660

Gene position: 2011767-2013263 (Clockwise)

Preceding gene: 56963659

Following gene: 56963661

Centisome position: 46.74

GC content: 45.82

Gene sequence:

>1497_bases
ATGAAGAAAACCCCTTTTGCATCTTTTCAGCAAGCCTACAACCGTTACGGTACATGCTTTTATAGCGAAACGGTATTTGC
CGATGGCTTGACCCCTATTCAAATGTTTCAAGCATTGCAAGAAGAAGCGACCTATTTGCTCGAGAGCAATGACGTGCAGT
CGGAATGGTCCAATTACTCCTTTATTGGGTTGAGCCCAATTTATGAGTGTGTAGAAGAGAACGGTTCATATAAAACCATT
CACTTGCAGACTGGTAACGTAGTTGCCAGTGCGGTAAATTTCGAAGCGTGTTATCAGAAAACCGTTTCACATATCGACCC
GCAACCGAGCGAAATGGAGATTCCTTTCCAAGGAGGCGCCGTTGGCTACGTCAGCTATGACGCGGTCGAAGAAATAGAGC
CTGTCATCAAGCGGAGCGATCAACGCAGCTGCCCGTATTATCATTTCATTTTTTGTGAACAGTTGTTAAGCTTTCATGAG
CAAACAAAGCAATTGACGCTGATTCAATTAGTCAAAAGTGGCTTGCAGCCAGCAGAACAAGCTTTTGCTGAAGCGCAAGC
GAAAATTCGTACACTAATCGGTAAATTGGAAAGTGCGAAAGCGCCTGTTTTGCCACATATGGTCACGAAAAAGCAGCTGC
CGATCGAGGTTCGCTCCAACTATTCGAAACAAGGCTTTATAAACGATGTAAACCGGATTAAAGCTTATATTCAGGCAGGG
GACATTTTCCAAGCTGTTTTGTCACAACGTCTAGAAATGACCGTTTCTGTTGGCGGGCTCGATTTGTACCGTGTGTTGCG
CTATGTTAACCCTTCGCCGTATTTGTACTATATTAAAATTGGAAAAAAAGAAATCATTGGAAGTTCGCCAGAAAAGCTTG
TCCAAGTACGCGGTGACCATGTCGAAATACATCCAATTGCAGGCACGCGCAAGCGTGGGCAAACGGCGGCCGAAGACGAA
GCATTAGCCCGCGAGTTGCTAGCCGACGACAAAGAACGGGCGGAGCACCATATGCTTGTTGACTTGGCGCGCAATGATGT
TGGCAAGGTTTCAGTTTATGGAAGCGTAGAAGTTCCATCCTTGTTGGAAATCGGGAAATTTTCCCATGTGATGCATCTCG
TCTCCAAAGTAACAGGCAAATTGAAGCCTGAAGCAACGCCTTATGACGCGTTAAAAGCGGCATTTCCTGCTGGGACTCTT
TCTGGTGCACCGAAAATTCGCGCCATGCAAATTTTAAATGAGCTAGAACCGACTAGACGGGGCATCTACGGAGGCGCCAT
TTGCTATATGGATTTCAACGGCAATATCGATTCTTGCATTGCGATTCGTACGATTGTTCTGGAAGGCAATTGCGCCACCA
TCCAAGCAGGAGCAGGCATTGTCGCAGATTCAGACCCGGAAAAAGAATACGAAGAAACATTAAACAAAGCAAAGGCACTT
ATTCATGCGATTGAACAGACAGAAGCATTGTTTGCAAAGGCGGTGCGTTTGTCATGA

Upstream 100 bases:

>100_bases
AACATGCTTTTATATGTTTTTTTCCATACCTTCACCAGAGGCGAATCCCCTTTTTTCGCCACCCCCGCTCTTCATTTTCA
CATCACAAGGAGTGAGTGAG

Downstream 100 bases:

>100_bases
TGAAGCACGTGCTGAACAAATGTTTAATGGGCGAATCCTTGTCTGTACAAGAAGCAGAGCAAGTGATGGAACAAATCATG
TCAGGGCGCGCAACCGCCAG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKKTPFASFQQAYNRYGTCFYSETVFADGLTPIQMFQALQEEATYLLESNDVQSEWSNYSFIGLSPIYECVEENGSYKTI
HLQTGNVVASAVNFEACYQKTVSHIDPQPSEMEIPFQGGAVGYVSYDAVEEIEPVIKRSDQRSCPYYHFIFCEQLLSFHE
QTKQLTLIQLVKSGLQPAEQAFAEAQAKIRTLIGKLESAKAPVLPHMVTKKQLPIEVRSNYSKQGFINDVNRIKAYIQAG
DIFQAVLSQRLEMTVSVGGLDLYRVLRYVNPSPYLYYIKIGKKEIIGSSPEKLVQVRGDHVEIHPIAGTRKRGQTAAEDE
ALARELLADDKERAEHHMLVDLARNDVGKVSVYGSVEVPSLLEIGKFSHVMHLVSKVTGKLKPEATPYDALKAAFPAGTL
SGAPKIRAMQILNELEPTRRGIYGGAICYMDFNGNIDSCIAIRTIVLEGNCATIQAGAGIVADSDPEKEYEETLNKAKAL
IHAIEQTEALFAKAVRLS

Sequences:

>Translated_498_residues
MKKTPFASFQQAYNRYGTCFYSETVFADGLTPIQMFQALQEEATYLLESNDVQSEWSNYSFIGLSPIYECVEENGSYKTI
HLQTGNVVASAVNFEACYQKTVSHIDPQPSEMEIPFQGGAVGYVSYDAVEEIEPVIKRSDQRSCPYYHFIFCEQLLSFHE
QTKQLTLIQLVKSGLQPAEQAFAEAQAKIRTLIGKLESAKAPVLPHMVTKKQLPIEVRSNYSKQGFINDVNRIKAYIQAG
DIFQAVLSQRLEMTVSVGGLDLYRVLRYVNPSPYLYYIKIGKKEIIGSSPEKLVQVRGDHVEIHPIAGTRKRGQTAAEDE
ALARELLADDKERAEHHMLVDLARNDVGKVSVYGSVEVPSLLEIGKFSHVMHLVSKVTGKLKPEATPYDALKAAFPAGTL
SGAPKIRAMQILNELEPTRRGIYGGAICYMDFNGNIDSCIAIRTIVLEGNCATIQAGAGIVADSDPEKEYEETLNKAKAL
IHAIEQTEALFAKAVRLS
>Mature_498_residues
MKKTPFASFQQAYNRYGTCFYSETVFADGLTPIQMFQALQEEATYLLESNDVQSEWSNYSFIGLSPIYECVEENGSYKTI
HLQTGNVVASAVNFEACYQKTVSHIDPQPSEMEIPFQGGAVGYVSYDAVEEIEPVIKRSDQRSCPYYHFIFCEQLLSFHE
QTKQLTLIQLVKSGLQPAEQAFAEAQAKIRTLIGKLESAKAPVLPHMVTKKQLPIEVRSNYSKQGFINDVNRIKAYIQAG
DIFQAVLSQRLEMTVSVGGLDLYRVLRYVNPSPYLYYIKIGKKEIIGSSPEKLVQVRGDHVEIHPIAGTRKRGQTAAEDE
ALARELLADDKERAEHHMLVDLARNDVGKVSVYGSVEVPSLLEIGKFSHVMHLVSKVTGKLKPEATPYDALKAAFPAGTL
SGAPKIRAMQILNELEPTRRGIYGGAICYMDFNGNIDSCIAIRTIVLEGNCATIQAGAGIVADSDPEKEYEETLNKAKAL
IHAIEQTEALFAKAVRLS

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=377, Percent_Identity=39.2572944297082, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788114, Length=444, Percent_Identity=30.8558558558559, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1786809, Length=257, Percent_Identity=28.0155642023346, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082077, Length=262, Percent_Identity=26.7175572519084, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320935, Length=461, Percent_Identity=40.997830802603, Blast_Score=319, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6324361, Length=403, Percent_Identity=25.0620347394541, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55294; Mature: 55294

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTPFASFQQAYNRYGTCFYSETVFADGLTPIQMFQALQEEATYLLESNDVQSEWSNYS
CCCCCHHHHHHHHHHHCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCE
FIGLSPIYECVEENGSYKTIHLQTGNVVASAVNFEACYQKTVSHIDPQPSEMEIPFQGGA
EEEHHHHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCCCCEECCCCCCE
VGYVSYDAVEEIEPVIKRSDQRSCPYYHFIFCEQLLSFHEQTKQLTLIQLVKSGLQPAEQ
EEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AFAEAQAKIRTLIGKLESAKAPVLPHMVTKKQLPIEVRSNYSKQGFINDVNRIKAYIQAG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHH
DIFQAVLSQRLEMTVSVGGLDLYRVLRYVNPSPYLYYIKIGKKEIIGSSPEKLVQVRGDH
HHHHHHHHHHHHEEEEECCHHHHHHHHHCCCCCEEEEEEECCHHHCCCCHHHHHHHCCCE
VEIHPIAGTRKRGQTAAEDEALARELLADDKERAEHHMLVDLARNDVGKVSVYGSVEVPS
EEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
LLEIGKFSHVMHLVSKVTGKLKPEATPYDALKAAFPAGTLSGAPKIRAMQILNELEPTRR
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHC
GIYGGAICYMDFNGNIDSCIAIRTIVLEGNCATIQAGAGIVADSDPEKEYEETLNKAKAL
CCCCCEEEEEEECCCCCCEEEEEEEEEECCCEEEECCCCEECCCCCHHHHHHHHHHHHHH
IHAIEQTEALFAKAVRLS
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKTPFASFQQAYNRYGTCFYSETVFADGLTPIQMFQALQEEATYLLESNDVQSEWSNYS
CCCCCHHHHHHHHHHHCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCE
FIGLSPIYECVEENGSYKTIHLQTGNVVASAVNFEACYQKTVSHIDPQPSEMEIPFQGGA
EEEHHHHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCCCCEECCCCCCE
VGYVSYDAVEEIEPVIKRSDQRSCPYYHFIFCEQLLSFHEQTKQLTLIQLVKSGLQPAEQ
EEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AFAEAQAKIRTLIGKLESAKAPVLPHMVTKKQLPIEVRSNYSKQGFINDVNRIKAYIQAG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHH
DIFQAVLSQRLEMTVSVGGLDLYRVLRYVNPSPYLYYIKIGKKEIIGSSPEKLVQVRGDH
HHHHHHHHHHHHEEEEECCHHHHHHHHHCCCCCEEEEEEECCHHHCCCCHHHHHHHCCCE
VEIHPIAGTRKRGQTAAEDEALARELLADDKERAEHHMLVDLARNDVGKVSVYGSVEVPS
EEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
LLEIGKFSHVMHLVSKVTGKLKPEATPYDALKAAFPAGTLSGAPKIRAMQILNELEPTRR
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHC
GIYGGAICYMDFNGNIDSCIAIRTIVLEGNCATIQAGAGIVADSDPEKEYEETLNKAKAL
CCCCCEEEEEEECCCCCCEEEEEEEEEECCCEEEECCCCEECCCCCHHHHHHHHHHHHHH
IHAIEQTEALFAKAVRLS
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10369778 [H]