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The map label for this gene is yqgN [H]

Identifier: 56963487

GI number: 56963487

Start: 1849632

End: 1850195

Strand: Direct

Name: yqgN [H]

Synonym: ABC1722

Alternate gene names: 56963487

Gene position: 1849632-1850195 (Clockwise)

Preceding gene: 56963486

Following gene: 56963488

Centisome position: 42.98

GC content: 45.92

Gene sequence:

>564_bases
ATGCGTAGTAAACAGAACATTCGAAATGACGTCTCTAAACAGTTGAACATGTTGCCAGCGCATGTGTATAAGCAACGATC
AACCAGGCTTGCTGATTTGCTTATGCAACAGGATGTTTGGAATCAGGCAACAACCATTGCGCTAACGGTCTCTCGCTTTC
CGGAAGTAGAGACAGCGCCTTTGATTGCTGGCGCATTAGCTGAGAATAAAAAAGTGGTCTTGCCGCGTATTAACATGAAA
GAGCGGACAATGGCGTTCTTTTACATAACCTCTACTGAGGAATTGGTAGAAAACAAGTATGGCCTGTTTGAACCAAAACA
AGAGGAAGCGTGCCTCGTTCGCCCTGACGAGCTAGAGCTCATTGTTGTCCCAGGTGTGGCATTTACAAAGGCGGGAAAAC
GACTCGGTTTAGGCGGCGGTTTTTATGATCGTTTTTTGCCAAGCTGTTCAGGCTTAACCGTTGCGTTATGTTTCCGTGAA
CAACTGTTTTCTGATTTGCCAACAGAACCCCATGATGTTCTGATTGACAAGGTCATCTCTGACGACAGGGTCGATGCTTC
ATGA

Upstream 100 bases:

>100_bases
CGTTTAAAGCGCCACACACTTCATCGCGAAACAAAGTAAGCAGCCGGTCATCCGCTGCTTATTTTTTTGCCGTGACCATG
ATACTTGGAGTGATGCCGAT

Downstream 100 bases:

>100_bases
TCTCCCTTTTGGCTTATATTGGGATTGGGATAGCGGCACTCCTTTTATACAAGCTGGACAAGCTGACTGCTTCTGGTATG
TGGGCCGCGTGTGTTGTTGG

Product: 5-formyltetrahydrofolate cyclo-ligase

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MRSKQNIRNDVSKQLNMLPAHVYKQRSTRLADLLMQQDVWNQATTIALTVSRFPEVETAPLIAGALAENKKVVLPRINMK
ERTMAFFYITSTEELVENKYGLFEPKQEEACLVRPDELELIVVPGVAFTKAGKRLGLGGGFYDRFLPSCSGLTVALCFRE
QLFSDLPTEPHDVLIDKVISDDRVDAS

Sequences:

>Translated_187_residues
MRSKQNIRNDVSKQLNMLPAHVYKQRSTRLADLLMQQDVWNQATTIALTVSRFPEVETAPLIAGALAENKKVVLPRINMK
ERTMAFFYITSTEELVENKYGLFEPKQEEACLVRPDELELIVVPGVAFTKAGKRLGLGGGFYDRFLPSCSGLTVALCFRE
QLFSDLPTEPHDVLIDKVISDDRVDAS
>Mature_187_residues
MRSKQNIRNDVSKQLNMLPAHVYKQRSTRLADLLMQQDVWNQATTIALTVSRFPEVETAPLIAGALAENKKVVLPRINMK
ERTMAFFYITSTEELVENKYGLFEPKQEEACLVRPDELELIVVPGVAFTKAGKRLGLGGGFYDRFLPSCSGLTVALCFRE
QLFSDLPTEPHDVLIDKVISDDRVDAS

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=197, Percent_Identity=27.4111675126904, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI1789278, Length=146, Percent_Identity=32.1917808219178, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17510857, Length=197, Percent_Identity=26.3959390862944, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321031, Length=204, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077430, Length=192, Percent_Identity=27.6041666666667, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 21047; Mature: 21047

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSKQNIRNDVSKQLNMLPAHVYKQRSTRLADLLMQQDVWNQATTIALTVSRFPEVETAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCH
LIAGALAENKKVVLPRINMKERTMAFFYITSTEELVENKYGLFEPKQEEACLVRPDELEL
HHHHHHCCCCEEEEECCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCCCEEEECCCCEEE
IVVPGVAFTKAGKRLGLGGGFYDRFLPSCSGLTVALCFREQLFSDLPTEPHDVLIDKVIS
EEECCCHHHHCCCEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
DDRVDAS
CCCCCCC
>Mature Secondary Structure
MRSKQNIRNDVSKQLNMLPAHVYKQRSTRLADLLMQQDVWNQATTIALTVSRFPEVETAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCH
LIAGALAENKKVVLPRINMKERTMAFFYITSTEELVENKYGLFEPKQEEACLVRPDELEL
HHHHHHCCCCEEEEECCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCCCEEEECCCCEEE
IVVPGVAFTKAGKRLGLGGGFYDRFLPSCSGLTVALCFREQLFSDLPTEPHDVLIDKVIS
EEECCCHHHHCCCEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
DDRVDAS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]