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The map label for this gene is mthA

Identifier: 56963368

GI number: 56963368

Start: 1727700

End: 1728395

Strand: Direct

Name: mthA

Synonym: ABC1603

Alternate gene names: 56963368

Gene position: 1727700-1728395 (Clockwise)

Preceding gene: 56963367

Following gene: 56963376

Centisome position: 40.14

GC content: 44.83

Gene sequence:

>696_bases
GTGAAAATCGGTATCATTGGCGCAATGGAAGAAGAAGTTAACTTTTTACGAGATAAAATGGAAAACCGTGTAGCGACAAC
GATTGCCAATTGTGAATTTACAGAAGGCCAAATTGGCGCTGTGCAAGTAGTCTTAACACGATGTGGAATTGGAAAAGTGA
ACGCTGCACTGGCAACAACGCTATTAAATGATCGGTTTCAACCTGATGCCATTATCAACACTGGCGTAGCAGGTGGCCTT
AACGCAAGTATGGCTGTTGGCGATCTTGTCATTTCAACGGAGGTGCGTTACCACGATGTTGACGCAACTGTGTTTGGCTA
TGAATATGGACAAGTTCCAGGAATGGTGCCAGCGTATTTGCCAGATGCAACCTTAATCGCAGCGGCGAAGACAGCCGCGC
AAAAAGTAGGTTTCCATTCAGAAGAGGGGCTGATTGTGACAGGTGATTCCTTTATGGGGGAAGAAACGCGTGTAAATGAA
GTCAAAACGCTATTTCCTGCTGCTTATTGTGCAGAAATGGAAGCTGGCGCGATCGCTCAAGTATGCCACCAATTCCAGAC
TCCATTTGTCATTATTCGAGCCTTGTCTGACGTGGCTGGCCAAGACGCAAAGATGTCATACGATACATTTTTAGAAAAAT
CAGCTGTCAATTCTGCTAAACAAGTGATGTTGATGCTCGACCATTTATCAGCATAA

Upstream 100 bases:

>100_bases
CCGGCATTGCCAGCTGGTTTTTTCAGTTTTAAGTCGTGAAATCTTCCTTAAAGGTGTGTATACTGGAAAAGAAATTGTCC
AATAGAAGGGAAGAGTGGCT

Downstream 100 bases:

>100_bases
TTTTCCTCTATTAGCAAAAGTCTTCGCCTTTCGAACTTCTTTTGATCTGTTAAGATAGAAAAGGAGAGCAGTAGGAGAGG
AGGCAGTCTAATGGACGAAA

Product: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKIGIIGAMEEEVNFLRDKMENRVATTIANCEFTEGQIGAVQVVLTRCGIGKVNAALATTLLNDRFQPDAIINTGVAGGL
NASMAVGDLVISTEVRYHDVDATVFGYEYGQVPGMVPAYLPDATLIAAAKTAAQKVGFHSEEGLIVTGDSFMGEETRVNE
VKTLFPAAYCAEMEAGAIAQVCHQFQTPFVIIRALSDVAGQDAKMSYDTFLEKSAVNSAKQVMLMLDHLSA

Sequences:

>Translated_231_residues
MKIGIIGAMEEEVNFLRDKMENRVATTIANCEFTEGQIGAVQVVLTRCGIGKVNAALATTLLNDRFQPDAIINTGVAGGL
NASMAVGDLVISTEVRYHDVDATVFGYEYGQVPGMVPAYLPDATLIAAAKTAAQKVGFHSEEGLIVTGDSFMGEETRVNE
VKTLFPAAYCAEMEAGAIAQVCHQFQTPFVIIRALSDVAGQDAKMSYDTFLEKSAVNSAKQVMLMLDHLSA
>Mature_231_residues
MKIGIIGAMEEEVNFLRDKMENRVATTIANCEFTEGQIGAVQVVLTRCGIGKVNAALATTLLNDRFQPDAIINTGVAGGL
NASMAVGDLVISTEVRYHDVDATVFGYEYGQVPGMVPAYLPDATLIAAAKTAAQKVGFHSEEGLIVTGDSFMGEETRVNE
VKTLFPAAYCAEMEAGAIAQVCHQFQTPFVIIRALSDVAGQDAKMSYDTFLEKSAVNSAKQVMLMLDHLSA

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily

Homologues:

Organism=Escherichia coli, GI1786354, Length=229, Percent_Identity=51.528384279476, Blast_Score=211, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNN_BACSK (Q5WHL7)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175099.1
- HSSP:   P0AF12
- ProteinModelPortal:   Q5WHL7
- SMR:   Q5WHL7
- STRING:   Q5WHL7
- EnsemblBacteria:   EBBACT00000046980
- GeneID:   3204484
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC1603
- NMPDR:   fig|66692.3.peg.1565
- eggNOG:   COG0775
- GeneTree:   EBGT00050000000478
- HOGENOM:   HBG367723
- OMA:   AMEQEVT
- ProtClustDB:   CLSK248008
- BioCyc:   BCLA66692:ABC1603-MONOMER
- HAMAP:   MF_01684
- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845
- PANTHER:   PTHR21234
- TIGRFAMs:   TIGR01704

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =3.2.2.9

Molecular weight: Translated: 24691; Mature: 24691

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: ACT_SITE 12-12 BINDING 78-78 BINDING 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIIGAMEEEVNFLRDKMENRVATTIANCEFTEGQIGAVQVVLTRCGIGKVNAALATT
CEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHH
LLNDRFQPDAIINTGVAGGLNASMAVGDLVISTEVRYHDVDATVFGYEYGQVPGMVPAYL
HHHCCCCCCHHEECCCCCCCCCHHHHCEEEEECEEEEEECCEEEEECCCCCCCCCCCCCC
PDATLIAAAKTAAQKVGFHSEEGLIVTGDSFMGEETRVNEVKTLFPAAYCAEMEAGAIAQ
CCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
VCHQFQTPFVIIRALSDVAGQDAKMSYDTFLEKSAVNSAKQVMLMLDHLSA
HHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIGIIGAMEEEVNFLRDKMENRVATTIANCEFTEGQIGAVQVVLTRCGIGKVNAALATT
CEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHH
LLNDRFQPDAIINTGVAGGLNASMAVGDLVISTEVRYHDVDATVFGYEYGQVPGMVPAYL
HHHCCCCCCHHEECCCCCCCCCHHHHCEEEEECEEEEEECCEEEEECCCCCCCCCCCCCC
PDATLIAAAKTAAQKVGFHSEEGLIVTGDSFMGEETRVNEVKTLFPAAYCAEMEAGAIAQ
CCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
VCHQFQTPFVIIRALSDVAGQDAKMSYDTFLEKSAVNSAKQVMLMLDHLSA
HHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA