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The map label for this gene is hom [H]

Identifier: 56963343

GI number: 56963343

Start: 1701819

End: 1703018

Strand: Direct

Name: hom [H]

Synonym: ABC1578

Alternate gene names: 56963343

Gene position: 1701819-1703018 (Clockwise)

Preceding gene: 56963342

Following gene: 56963346

Centisome position: 39.54

GC content: 47.58

Gene sequence:

>1200_bases
GTGAAAATAGGCATTATTGGATTTGGGACAGTAGGGACTGGCATTTACGAGCGCATCACCAGTACACAAAGAGCGCTCCA
ACAGATGGTAAGTGATCGGATTGAACTTGTCTCCATTTTAGTAAAAGATCAGTCTAAGCAAAGGCAAAGCGAAGGGGCCA
AACTCGTTACGTCATCATGGGATCTTTTCAGGGAGGCTGCTACATATGATGTTGTGTTTGAAGTAACAAATGTTGTCGAA
CCGGCCAGAACATATACGGAAAGCTTGCTAGCAGAAGGCGTATCTGTAGTGACCGCCAATAAAAAGCTTGTCGCCTTACA
CGGTAAAGAACTAGAGGCGGTCGCCCTTTCATCTGGTGCCTATTACGGCTACGACGCTGCGGTTTGTGGAGCGATCCCGA
TTGTGAATGTGTTGCAAAGTGCATTGGCGACAACTGCGATTAATGGGATATCAGGCATTTTAAACGGCACAACCAATTTT
ATTCTCACTGAAATGGACAGTGGCAAAACCTACCAACAAGCTCTAGATGAAGCGCAGCGGCTTGGCTATGCAGAAACAGA
CCCGACGTCCGATGTAGAAGGCTATGACGCCCTGTATAAGTTGACTTTGCTGGCGCGCCTTTGTTTTGGCCAATGGGTCG
ACATATCGGCATTTGAACGCCAAGGAATCGGCGGGATTGAACCATGGCATGTACGGGTGGCAAAAGAAAACCAGTTTGCC
TTAAAACTTGTTGGCACCTCTTTTTTACAACAAGACGGCAGCATAACTGGTTCTGTGAAGCCTGCTTTTGTAGAGGAAAC
ACATCTATTAGCGGGCGTAAACGGTGTGGCCAATGGGGTTCTGTTACAAGGCAAAGACATTCAGCAATTGTTTTTTGCTG
GCCCAGGAGCAGGGCAAGAGGCAACAGCCAATAGCGCTGTCGAAGACTTTATTCTACATGAGAAAGGCAAGCGTCTGCGT
AGGACCGTCCTTTCCCAGCCTGCATCGAATATGCCTCAACTGCAAAAGCAGCTTTGGTTTGTACCTACTGGGGCAGATGT
CAGTGACGTTTCCAGCAATATTCATGTGTGGGAGCGCCGCCGCGAAAAAGAAGGCGATGTCCTTTTAGTGACGGCGCCAC
TTTTGGAAGTTCCTTTTCAGTCGTATCAAGTAATTGGTGGGGAGCATGTATTTAAACAGGAACAGGCACATGCTTTATGA

Upstream 100 bases:

>100_bases
GCTACATTCAGCAGAGCAGCTTTTGTTCTGAAAGATAAGTGAGGCGAACCCCTTTTCTTATCTGAAAAGGGGTTTTTTCA
ATGGAGAAAGGGTGAAGACG

Downstream 100 bases:

>100_bases
GCGGAATTTTGTTTCAGGGACAAGTTTTTTGAACGCTTTAATAAAGGATTCGGGATTTTGCTTAATTTTATACGTAACAA
CGCCTTGGCTTGTATGCAAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKIGIIGFGTVGTGIYERITSTQRALQQMVSDRIELVSILVKDQSKQRQSEGAKLVTSSWDLFREAATYDVVFEVTNVVE
PARTYTESLLAEGVSVVTANKKLVALHGKELEAVALSSGAYYGYDAAVCGAIPIVNVLQSALATTAINGISGILNGTTNF
ILTEMDSGKTYQQALDEAQRLGYAETDPTSDVEGYDALYKLTLLARLCFGQWVDISAFERQGIGGIEPWHVRVAKENQFA
LKLVGTSFLQQDGSITGSVKPAFVEETHLLAGVNGVANGVLLQGKDIQQLFFAGPGAGQEATANSAVEDFILHEKGKRLR
RTVLSQPASNMPQLQKQLWFVPTGADVSDVSSNIHVWERRREKEGDVLLVTAPLLEVPFQSYQVIGGEHVFKQEQAHAL

Sequences:

>Translated_399_residues
MKIGIIGFGTVGTGIYERITSTQRALQQMVSDRIELVSILVKDQSKQRQSEGAKLVTSSWDLFREAATYDVVFEVTNVVE
PARTYTESLLAEGVSVVTANKKLVALHGKELEAVALSSGAYYGYDAAVCGAIPIVNVLQSALATTAINGISGILNGTTNF
ILTEMDSGKTYQQALDEAQRLGYAETDPTSDVEGYDALYKLTLLARLCFGQWVDISAFERQGIGGIEPWHVRVAKENQFA
LKLVGTSFLQQDGSITGSVKPAFVEETHLLAGVNGVANGVLLQGKDIQQLFFAGPGAGQEATANSAVEDFILHEKGKRLR
RTVLSQPASNMPQLQKQLWFVPTGADVSDVSSNIHVWERRREKEGDVLLVTAPLLEVPFQSYQVIGGEHVFKQEQAHAL
>Mature_399_residues
MKIGIIGFGTVGTGIYERITSTQRALQQMVSDRIELVSILVKDQSKQRQSEGAKLVTSSWDLFREAATYDVVFEVTNVVE
PARTYTESLLAEGVSVVTANKKLVALHGKELEAVALSSGAYYGYDAAVCGAIPIVNVLQSALATTAINGISGILNGTTNF
ILTEMDSGKTYQQALDEAQRLGYAETDPTSDVEGYDALYKLTLLARLCFGQWVDISAFERQGIGGIEPWHVRVAKENQFA
LKLVGTSFLQQDGSITGSVKPAFVEETHLLAGVNGVANGVLLQGKDIQQLFFAGPGAGQEATANSAVEDFILHEKGKRLR
RTVLSQPASNMPQLQKQLWFVPTGADVSDVSSNIHVWERRREKEGDVLLVTAPLLEVPFQSYQVIGGEHVFKQEQAHAL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=140, Percent_Identity=33.5714285714286, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790376, Length=351, Percent_Identity=25.0712250712251, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 43335; Mature: 43335

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIIGFGTVGTGIYERITSTQRALQQMVSDRIELVSILVKDQSKQRQSEGAKLVTSSW
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEEHHH
DLFREAATYDVVFEVTNVVEPARTYTESLLAEGVSVVTANKKLVALHGKELEAVALSSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCEEEEEECCCC
YYGYDAAVCGAIPIVNVLQSALATTAINGISGILNGTTNFILTEMDSGKTYQQALDEAQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
LGYAETDPTSDVEGYDALYKLTLLARLCFGQWVDISAFERQGIGGIEPWHVRVAKENQFA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEECCCCEE
LKLVGTSFLQQDGSITGSVKPAFVEETHLLAGVNGVANGVLLQGKDIQQLFFAGPGAGQE
EEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHCCCEEECCCCHHHHHCCCCCCCCC
ATANSAVEDFILHEKGKRLRRTVLSQPASNMPQLQKQLWFVPTGADVSDVSSNIHVWERR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEECCCCCHHHHCCCHHHHHHH
REKEGDVLLVTAPLLEVPFQSYQVIGGEHVFKQEQAHAL
HCCCCCEEEEECCHHHCCCHHHEECCCHHHHHHHHHCCC
>Mature Secondary Structure
MKIGIIGFGTVGTGIYERITSTQRALQQMVSDRIELVSILVKDQSKQRQSEGAKLVTSSW
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEEHHH
DLFREAATYDVVFEVTNVVEPARTYTESLLAEGVSVVTANKKLVALHGKELEAVALSSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCEEEEEECCCC
YYGYDAAVCGAIPIVNVLQSALATTAINGISGILNGTTNFILTEMDSGKTYQQALDEAQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
LGYAETDPTSDVEGYDALYKLTLLARLCFGQWVDISAFERQGIGGIEPWHVRVAKENQFA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEECCCCEE
LKLVGTSFLQQDGSITGSVKPAFVEETHLLAGVNGVANGVLLQGKDIQQLFFAGPGAGQE
EEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHCCCEEECCCCHHHHHCCCCCCCCC
ATANSAVEDFILHEKGKRLRRTVLSQPASNMPQLQKQLWFVPTGADVSDVSSNIHVWERR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEECCCCCHHHHCCCHHHHHHH
REKEGDVLLVTAPLLEVPFQSYQVIGGEHVFKQEQAHAL
HCCCCCEEEEECCHHHCCCHHHEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]