Click here to switch to the map view.

The map label for this gene is cssS [H]

Identifier: 56963289

GI number: 56963289

Start: 1646244

End: 1647647

Strand: Direct

Name: cssS [H]

Synonym: ABC1524

Alternate gene names: 56963289

Gene position: 1646244-1647647 (Clockwise)

Preceding gene: 56963288

Following gene: 56963290

Centisome position: 38.25

GC content: 44.37

Gene sequence:

>1404_bases
ATGATTAAAATCAACTTGACGAAACGAATATGGCTAGCATTCGTTTCGTTAATTGTGCTTGTTGTCCTTTCGATTACCAT
TGTTTACCCACTTTCGATCAGAGGAACGCTTACCGAGGAAACGTACCGTTTAATTGAAAACGATGTTAGGCAGCTTCTTT
CTGGGGAGAATGACTACTTTCCGTTCCAGCCAGGGTTTTACCAGGCCAGGGAGCAACGTTCAACGGTTTCTTATTCATTT
CGTTTATCTGAAGCTGGTGTAAGCTATATTGACCCACGGTTAGTTCCCCCTTACGAAGTGAATAATGAAATAGTCCAGAA
TGCTTTAGAACAAAAGGGACAGCATGGCCGTTATGAAACCACAATTGATGAACAAACGCTATTTTATGTAATCACCAAAA
TCTCGGACAGTCAATTCCTTGTCACGTATATGTGGGACACATACCGTGACGAGATGGTAAACCGTTTATGGGAGCGGCTG
CTATACTTATTGTTGTTAGCAAGTGCCTTAAGTTTGTTCCCGGCGATTTGGCTAAAGCATTATTTGCGCCAGCCTCTTGC
CGTGCTTGAGAACCATCTTGAGCAAATTGCCAACCGTAATTGGCAAGAACCATTGCGGTGGGAGGGAGATAAGGATTTCG
AACGCCTATCTTACCAATTTGAACGGATGCGGCAAAACTTAAATAGCTATGACCGAGCGCAAAAGACATTCATCCAACAT
GCATCCCACGAGCTCAAAACGCCAATTATGGTCATTAAAAGCTACTCCCAGTCTGTGAAAGACGGGATTTTGCCAAAAGA
AAATTTGGAGCAAACGATGGACGTCATCACGGAAGAGGCAAACCGGATGGAACGCCGCGTAATTGACATGCTCTATTACA
CAAAGCTCGACCAAATGAAGAAAGATCAGCTTAACGTTGGGCCATTCCCGTTCGGAAAGCTAGCATACCAGATTGAAGAA
CGGTTCCGCTACCAGCGCGATGATGTAACCATTTCCGTTGAAGGGGCAGAAGTCATTGTCGAAGCTGACATTGAACAATG
CGAAGTGTTGTTGGAAAACCTCGTTGAAAACGGGTTGCGTTATGCGAAGCATCGCTTGTATATTCGCGCTGAACAAGATG
AGAGGAACTGTTATCTCATTGTCGAAAATGAAGGAGAACCGATTGACGCTGATTTGACTAAGCTATTTAACCCCTTTTAT
AAAGGCAATAAAGGCAAATTTGGACTCGGGCTGGCAATCGTCAAGCAAATAGCGGAGCTTCATCGGGGGAGTGCACGAGT
GGAAAATATCGATGATGGCGTCCGATTCACCATAACGTTGCCGAAGACAATCAAGCCTAAGCCTATTGAACCAAAACGGA
AAGAACGGCGAAAAGAAGCAAAAGCTGACAAAAAAGAGCGCTAG

Upstream 100 bases:

>100_bases
CAGAACGGGCAGTGGACGATGTAGTCCGCCGCGTCCGTAAAAAAATGCCGCGTATCCACTTAGAAACGCTCTATGGTTAC
GGATACCGCATTTTGTCTTC

Downstream 100 bases:

>100_bases
CCTACGGGTGCGCTCTTTTTGTTTTCAACCCCTTTAAAGCGAATCGTATGCTATACTGAAAGGAAGATTAGAAGCTTAAG
AGGTGAGACGATGGCAAAAG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MIKINLTKRIWLAFVSLIVLVVLSITIVYPLSIRGTLTEETYRLIENDVRQLLSGENDYFPFQPGFYQAREQRSTVSYSF
RLSEAGVSYIDPRLVPPYEVNNEIVQNALEQKGQHGRYETTIDEQTLFYVITKISDSQFLVTYMWDTYRDEMVNRLWERL
LYLLLLASALSLFPAIWLKHYLRQPLAVLENHLEQIANRNWQEPLRWEGDKDFERLSYQFERMRQNLNSYDRAQKTFIQH
ASHELKTPIMVIKSYSQSVKDGILPKENLEQTMDVITEEANRMERRVIDMLYYTKLDQMKKDQLNVGPFPFGKLAYQIEE
RFRYQRDDVTISVEGAEVIVEADIEQCEVLLENLVENGLRYAKHRLYIRAEQDERNCYLIVENEGEPIDADLTKLFNPFY
KGNKGKFGLGLAIVKQIAELHRGSARVENIDDGVRFTITLPKTIKPKPIEPKRKERRKEAKADKKER

Sequences:

>Translated_467_residues
MIKINLTKRIWLAFVSLIVLVVLSITIVYPLSIRGTLTEETYRLIENDVRQLLSGENDYFPFQPGFYQAREQRSTVSYSF
RLSEAGVSYIDPRLVPPYEVNNEIVQNALEQKGQHGRYETTIDEQTLFYVITKISDSQFLVTYMWDTYRDEMVNRLWERL
LYLLLLASALSLFPAIWLKHYLRQPLAVLENHLEQIANRNWQEPLRWEGDKDFERLSYQFERMRQNLNSYDRAQKTFIQH
ASHELKTPIMVIKSYSQSVKDGILPKENLEQTMDVITEEANRMERRVIDMLYYTKLDQMKKDQLNVGPFPFGKLAYQIEE
RFRYQRDDVTISVEGAEVIVEADIEQCEVLLENLVENGLRYAKHRLYIRAEQDERNCYLIVENEGEPIDADLTKLFNPFY
KGNKGKFGLGLAIVKQIAELHRGSARVENIDDGVRFTITLPKTIKPKPIEPKRKERRKEAKADKKER
>Mature_467_residues
MIKINLTKRIWLAFVSLIVLVVLSITIVYPLSIRGTLTEETYRLIENDVRQLLSGENDYFPFQPGFYQAREQRSTVSYSF
RLSEAGVSYIDPRLVPPYEVNNEIVQNALEQKGQHGRYETTIDEQTLFYVITKISDSQFLVTYMWDTYRDEMVNRLWERL
LYLLLLASALSLFPAIWLKHYLRQPLAVLENHLEQIANRNWQEPLRWEGDKDFERLSYQFERMRQNLNSYDRAQKTFIQH
ASHELKTPIMVIKSYSQSVKDGILPKENLEQTMDVITEEANRMERRVIDMLYYTKLDQMKKDQLNVGPFPFGKLAYQIEE
RFRYQRDDVTISVEGAEVIVEADIEQCEVLLENLVENGLRYAKHRLYIRAEQDERNCYLIVENEGEPIDADLTKLFNPFY
KGNKGKFGLGLAIVKQIAELHRGSARVENIDDGVRFTITLPKTIKPKPIEPKRKERRKEAKADKKER

Specific function: Member of the two-component regulatory system CssS/CssR required to control the cellular response to secretion stress. Required for the transcription of htrA. Could detect misfolded proteins at the membrane-cell wall interface and then activate CssR by ph

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790861, Length=343, Percent_Identity=23.6151603498542, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=296, Percent_Identity=26.0135135135135, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=24.9084249084249, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790346, Length=345, Percent_Identity=24.3478260869565, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788279, Length=254, Percent_Identity=28.740157480315, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=298, Percent_Identity=24.496644295302, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=23.6051502145923, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55012; Mature: 55012

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKINLTKRIWLAFVSLIVLVVLSITIVYPLSIRGTLTEETYRLIENDVRQLLSGENDYF
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PFQPGFYQAREQRSTVSYSFRLSEAGVSYIDPRLVPPYEVNNEIVQNALEQKGQHGRYET
CCCCCHHHHHHHHCHHEEEEEECCCCCHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
TIDEQTLFYVITKISDSQFLVTYMWDTYRDEMVNRLWERLLYLLLLASALSLFPAIWLKH
CCCCCEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLRQPLAVLENHLEQIANRNWQEPLRWEGDKDFERLSYQFERMRQNLNSYDRAQKTFIQH
HHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASHELKTPIMVIKSYSQSVKDGILPKENLEQTMDVITEEANRMERRVIDMLYYTKLDQMK
HHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDQLNVGPFPFGKLAYQIEERFRYQRDDVTISVEGAEVIVEADIEQCEVLLENLVENGLR
HHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHH
YAKHRLYIRAEQDERNCYLIVENEGEPIDADLTKLFNPFYKGNKGKFGLGLAIVKQIAEL
HHHHHEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
HRGSARVENIDDGVRFTITLPKTIKPKPIEPKRKERRKEAKADKKER
HCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIKINLTKRIWLAFVSLIVLVVLSITIVYPLSIRGTLTEETYRLIENDVRQLLSGENDYF
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PFQPGFYQAREQRSTVSYSFRLSEAGVSYIDPRLVPPYEVNNEIVQNALEQKGQHGRYET
CCCCCHHHHHHHHCHHEEEEEECCCCCHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
TIDEQTLFYVITKISDSQFLVTYMWDTYRDEMVNRLWERLLYLLLLASALSLFPAIWLKH
CCCCCEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLRQPLAVLENHLEQIANRNWQEPLRWEGDKDFERLSYQFERMRQNLNSYDRAQKTFIQH
HHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASHELKTPIMVIKSYSQSVKDGILPKENLEQTMDVITEEANRMERRVIDMLYYTKLDQMK
HHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDQLNVGPFPFGKLAYQIEERFRYQRDDVTISVEGAEVIVEADIEQCEVLLENLVENGLR
HHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHH
YAKHRLYIRAEQDERNCYLIVENEGEPIDADLTKLFNPFYKGNKGKFGLGLAIVKQIAEL
HHHHHEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
HRGSARVENIDDGVRFTITLPKTIKPKPIEPKRKERRKEAKADKKER
HCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353931; 9639930; 9384377; 11555295 [H]