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The map label for this gene is yngE [H]

Identifier: 56963275

GI number: 56963275

Start: 1635138

End: 1636667

Strand: Direct

Name: yngE [H]

Synonym: ABC1510

Alternate gene names: 56963275

Gene position: 1635138-1636667 (Clockwise)

Preceding gene: 56963274

Following gene: 56963283

Centisome position: 37.99

GC content: 47.84

Gene sequence:

>1530_bases
ATGACATTTGAGCAAACCAAATTGGCGAAGGAAACGGAAATTTTTAAAGGCGGCCATACGAAATACCATCAACAAAATGC
GAAGAAAGGCAAATTGTTTGCCAGGGAGCGTTTGCAGTTGTTGCTTGATGATGGCTTGACTACTGAAGACGGCTTGTTTG
CTAACTGTGAAGCGGACGGTCTGCCAGCAGACGGAGTCATTTGCGGAATGGGTACGATAGACGGCAAGCCTGTTTGTGTG
ATGGCGAATGATTCGACCGTTAAGGCAGGTTCTTGGGGAGCGCGAACGGTTGAGAAAATCATCCGTATTCAAGAAACGGC
AGAAAAATTGTCCGTGCCGCTGTTGTATTTGGTTGACTCAGCTGGTGCAAGAATTACTGACCAAGTTGAGATGTTTCCAG
GGCGGAGAGGGGCAGGCCGTATTTTTAGCAATCAAGTAAAACTGTCAGGAAGAATTCCGCAAGTTTGTATTCTTTTCGGT
CCTTCAGCGGCGGGCGGCGCGTACATTCCTGCATTTTGCGATGTTGTTATTATGGTGGACGGAAATGCTTCCATGTATTT
AGGTTCGCCGCGGATGGCACAAATGGTTATTGGCGAGGATGTCACACTTGAAGAAATGGGCGGCGCCAGCATGCACTGCA
GTGTGTCAGGCTGTGGCGATATTCTAGCCAAAAACGAGGAAGACGCGATTTCCCAGGCGCGTGCTTATTTAAGTTATTTG
CCGCCAAGCTATAAAGAGAAGCCGCCTAGTAAAGAGGCGCGCCCGCCGAAAGATGTGCCAAAAACAATCGAAGACTTGAT
CCCGCAAAATCAAAATGCACCTTTTAATATGTATGACTTGCTCGAGCGCCTTGTCGACAACGACAGTTTTTTTGAAATCA
AGCGAAACTTTGCTCCAGAACTCATCACTGGCTTTGCCCGGTTAAACGGACAGGCGATCGGCATTGTCGCCAATCAACCA
AAGGCAAAAGGCGGAGTATTGTTTCCAGACTCAGCTGACAAAGCCGCTCGCTTCATTACTCTTTGTGATGCTTTTCATCT
GCCGCTTTTGTTTTTAGCGGACATTCCAGGTTTTATGATCGGCACCAAAGTCGAACGTGCTGGCATTATTCGCCATGGCG
CAAAAATGATTGCCGCTATGGCTGAAGCGACTGTACCGAAAATTTCCGTCATCGTTCGAAAAGCATACGGGGCCGGACTG
TATGCAATGGCCGGGCCTGCTTTTGACCCAGATTGTTGCCTTGCCCTTCCGCAAGCACAAATTGCGGTGATGGGGCCAGA
AGCTGCGGTCAACGCCGTATATGCAAACAAAATTGCTGAACTTGGGGAACAGGAGCGGAAAGCATTTATAGAGGAAAAAC
GTGAAGCATATAAACGAGATATCGATGTTTATCGCCTTGCTTCAGAGCTAGTCATCGACGGGGTTGTCAACGGCAATGAC
TTACGACAAGAATTGGGACAGCGCTTTGCTTTTTATGAAAGCAAGCGGATGGTGTTTAGCGAACGAAAACATCCTGTTTA
TCCCGTTTAA

Upstream 100 bases:

>100_bases
ATTTGCAGACATTGCAAACCGAAGATCGTTTAGAAGGGCTTGCTTCATTCAAAGAAAAGCGCCCTCCCGTTTACAAAGGC
AAATAGGAGTTGAGAGCGAG

Downstream 100 bases:

>100_bases
GACGGAGCGCTTGAACAATAATAAATCCCCTTGTGCCCGATAAGGCCAGTGACGGTCTTATGGGCCTTTTTCGTATGGAT
AGATGATCACGAAACAATCG

Product: propionyl-CoA carboxylase beta chain

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTFEQTKLAKETEIFKGGHTKYHQQNAKKGKLFARERLQLLLDDGLTTEDGLFANCEADGLPADGVICGMGTIDGKPVCV
MANDSTVKAGSWGARTVEKIIRIQETAEKLSVPLLYLVDSAGARITDQVEMFPGRRGAGRIFSNQVKLSGRIPQVCILFG
PSAAGGAYIPAFCDVVIMVDGNASMYLGSPRMAQMVIGEDVTLEEMGGASMHCSVSGCGDILAKNEEDAISQARAYLSYL
PPSYKEKPPSKEARPPKDVPKTIEDLIPQNQNAPFNMYDLLERLVDNDSFFEIKRNFAPELITGFARLNGQAIGIVANQP
KAKGGVLFPDSADKAARFITLCDAFHLPLLFLADIPGFMIGTKVERAGIIRHGAKMIAAMAEATVPKISVIVRKAYGAGL
YAMAGPAFDPDCCLALPQAQIAVMGPEAAVNAVYANKIAELGEQERKAFIEEKREAYKRDIDVYRLASELVIDGVVNGND
LRQELGQRFAFYESKRMVFSERKHPVYPV

Sequences:

>Translated_509_residues
MTFEQTKLAKETEIFKGGHTKYHQQNAKKGKLFARERLQLLLDDGLTTEDGLFANCEADGLPADGVICGMGTIDGKPVCV
MANDSTVKAGSWGARTVEKIIRIQETAEKLSVPLLYLVDSAGARITDQVEMFPGRRGAGRIFSNQVKLSGRIPQVCILFG
PSAAGGAYIPAFCDVVIMVDGNASMYLGSPRMAQMVIGEDVTLEEMGGASMHCSVSGCGDILAKNEEDAISQARAYLSYL
PPSYKEKPPSKEARPPKDVPKTIEDLIPQNQNAPFNMYDLLERLVDNDSFFEIKRNFAPELITGFARLNGQAIGIVANQP
KAKGGVLFPDSADKAARFITLCDAFHLPLLFLADIPGFMIGTKVERAGIIRHGAKMIAAMAEATVPKISVIVRKAYGAGL
YAMAGPAFDPDCCLALPQAQIAVMGPEAAVNAVYANKIAELGEQERKAFIEEKREAYKRDIDVYRLASELVIDGVVNGND
LRQELGQRFAFYESKRMVFSERKHPVYPV
>Mature_508_residues
TFEQTKLAKETEIFKGGHTKYHQQNAKKGKLFARERLQLLLDDGLTTEDGLFANCEADGLPADGVICGMGTIDGKPVCVM
ANDSTVKAGSWGARTVEKIIRIQETAEKLSVPLLYLVDSAGARITDQVEMFPGRRGAGRIFSNQVKLSGRIPQVCILFGP
SAAGGAYIPAFCDVVIMVDGNASMYLGSPRMAQMVIGEDVTLEEMGGASMHCSVSGCGDILAKNEEDAISQARAYLSYLP
PSYKEKPPSKEARPPKDVPKTIEDLIPQNQNAPFNMYDLLERLVDNDSFFEIKRNFAPELITGFARLNGQAIGIVANQPK
AKGGVLFPDSADKAARFITLCDAFHLPLLFLADIPGFMIGTKVERAGIIRHGAKMIAAMAEATVPKISVIVRKAYGAGLY
AMAGPAFDPDCCLALPQAQIAVMGPEAAVNAVYANKIAELGEQERKAFIEEKREAYKRDIDVYRLASELVIDGVVNGNDL
RQELGQRFAFYESKRMVFSERKHPVYPV

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=517, Percent_Identity=36.5570599613153, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI295821216, Length=537, Percent_Identity=35.3817504655494, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI11545863, Length=507, Percent_Identity=36.4891518737673, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI25147362, Length=510, Percent_Identity=36.6666666666667, Blast_Score=320, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI25147359, Length=510, Percent_Identity=36.6666666666667, Blast_Score=319, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17552936, Length=493, Percent_Identity=36.105476673428, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI133931226, Length=283, Percent_Identity=23.6749116607774, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997163, Length=295, Percent_Identity=23.0508474576271, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323863, Length=432, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586065, Length=509, Percent_Identity=36.9351669941061, Blast_Score=307, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 55442; Mature: 55310

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFEQTKLAKETEIFKGGHTKYHQQNAKKGKLFARERLQLLLDDGLTTEDGLFANCEADG
CCCCHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
LPADGVICGMGTIDGKPVCVMANDSTVKAGSWGARTVEKIIRIQETAEKLSVPLLYLVDS
CCCCCEEEECCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
AGARITDQVEMFPGRRGAGRIFSNQVKLSGRIPQVCILFGPSAAGGAYIPAFCDVVIMVD
CCCCCCHHHHHCCCCCCCCCEECCCEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
GNASMYLGSPRMAQMVIGEDVTLEEMGGASMHCSVSGCGDILAKNEEDAISQARAYLSYL
CCCEEEECCCCHHHHHHCCCCCHHHCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHC
PPSYKEKPPSKEARPPKDVPKTIEDLIPQNQNAPFNMYDLLERLVDNDSFFEIKRNFAPE
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHH
LITGFARLNGQAIGIVANQPKAKGGVLFPDSADKAARFITLCDAFHLPLLFLADIPGFMI
HHHHHHHHCCCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
GTKVERAGIIRHGAKMIAAMAEATVPKISVIVRKAYGAGLYAMAGPAFDPDCCLALPQAQ
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCHHHEECCCCE
IAVMGPEAAVNAVYANKIAELGEQERKAFIEEKREAYKRDIDVYRLASELVIDGVVNGND
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHH
LRQELGQRFAFYESKRMVFSERKHPVYPV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TFEQTKLAKETEIFKGGHTKYHQQNAKKGKLFARERLQLLLDDGLTTEDGLFANCEADG
CCCHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
LPADGVICGMGTIDGKPVCVMANDSTVKAGSWGARTVEKIIRIQETAEKLSVPLLYLVDS
CCCCCEEEECCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEC
AGARITDQVEMFPGRRGAGRIFSNQVKLSGRIPQVCILFGPSAAGGAYIPAFCDVVIMVD
CCCCCCHHHHHCCCCCCCCCEECCCEEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
GNASMYLGSPRMAQMVIGEDVTLEEMGGASMHCSVSGCGDILAKNEEDAISQARAYLSYL
CCCEEEECCCCHHHHHHCCCCCHHHCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHC
PPSYKEKPPSKEARPPKDVPKTIEDLIPQNQNAPFNMYDLLERLVDNDSFFEIKRNFAPE
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHH
LITGFARLNGQAIGIVANQPKAKGGVLFPDSADKAARFITLCDAFHLPLLFLADIPGFMI
HHHHHHHHCCCEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
GTKVERAGIIRHGAKMIAAMAEATVPKISVIVRKAYGAGLYAMAGPAFDPDCCLALPQAQ
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCHHHEECCCCE
IAVMGPEAAVNAVYANKIAELGEQERKAFIEEKREAYKRDIDVYRLASELVIDGVVNGND
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHH
LRQELGQRFAFYESKRMVFSERKHPVYPV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]