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The map label for this gene is mtnV [H]

Identifier: 56963257

GI number: 56963257

Start: 1612462

End: 1613634

Strand: Direct

Name: mtnV [H]

Synonym: ABC1492

Alternate gene names: 56963257

Gene position: 1612462-1613634 (Clockwise)

Preceding gene: 56963256

Following gene: 56963258

Centisome position: 37.47

GC content: 48.25

Gene sequence:

>1173_bases
ATGGCGATGGACATACAGCAAGCAAAAATGATGGAACAGCTGCCAAGTCAATTTTTTGCGAAATTAGTAAACAAAGCACA
ACGATTGGCTCAAGAACATAATGATCTCATAAATTTAGGCCAAGGCAACCACGATCAGCCGACTCCTGCCTTTATTGTTG
AGGCGCTGCGTGAGGCAAGCAGCGAGCCGCAGTTTCATCGATACGGCCCTTTTCGTGGGTATCCGTTTTTAAAGGAAGCA
ATCGCTGCTTATTACAAACAGCAGTATGGCGTGGAGTTGGACCCTGAAACCGAGGTCGCCATTGTGCCAGGAACAAAAAC
GGCCATTGTTGAGTTATGCCAATGTTTATTAAATAAGGGGGACATGGCGCTCGTACCTGATCCAGGCTATCCAGACTATT
TGTCAGGCATCGCGATAACGGGAGCAATAGCGAAACCAATGCCGTTGTTAAGGAACAACCGATTTCTGCCAGATTATCAT
GAGCTAAGCTCTGATGTGTTGGATAAAGCAAAAATGATGTTTCTAAATTATCCTAACAACCCAACTGGCGCGACAGCCGA
CGCGCGCTTTTTTGCCGATACGGTCGCTGTTGCCCGTTCGCACTGTATTCCGGTCATTCATGACTTTGCTTACGGTGCAA
TCGGGTTTAATGGCACGCCACGCAGCTTTTTGCAGCAAGAGGGGGCAAAGGATGTAGGCGTAGAGCTTTTTACTATGTCG
AAATTGTACAATATGGCAGGCTGGCGTGTCGGTTTCGTGCTTGGCAATAAGGAAATCGTTGCGATGCTAGAAGAGTTGCA
AGATCATTACCATTGTAGTCTCTTCGGCGGCCTTCAAGCAGCTTCTGCTTGCGCGTTGCAATCCGATCAATCCAGTGTAC
ACGAGCTGGTTGGTCTGTACAAAGAACGGAGCGAAGCCCTTTGGGAGGCAGCCCAGGAAATTGGCTGGCAAGTTGAACAA
CCATCAGGTTCGTTTTTTGCCTGGTTCCCTGTACCAAAAGGCTATACGTCCGAGGAATTTAGTGAACTGCTTCTTGACAA
AGCCCATCTCGTCGTCGCTCCAGGAAACGGGTTTGGCCAGTATGGAGAAGGATATGTGCGTATCGGGCTTCTCGCTGACA
AAACGACATTGCGTGAGGCGATCGCACGAGTGGGCAACTTAAATCTGTTTTAA

Upstream 100 bases:

>100_bases
GATGGCGGCTTACACAAAAGAACGGAAGCGGCCTCATTTGGATGCTTTCTTGAAAGAAAAGGGCTTTTTGCAACAGGAAT
AACAGACAGTGAGTGGGGGG

Downstream 100 bases:

>100_bases
TAAAACAATGAAACCGTGTCGTCCGTGTAATGACACAGAGGGGGATGGAATGGAGGAAATTGCGAGCATTTATTGCATTG
GCCGTAACTATGCCAACCAT

Product: transaminase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MAMDIQQAKMMEQLPSQFFAKLVNKAQRLAQEHNDLINLGQGNHDQPTPAFIVEALREASSEPQFHRYGPFRGYPFLKEA
IAAYYKQQYGVELDPETEVAIVPGTKTAIVELCQCLLNKGDMALVPDPGYPDYLSGIAITGAIAKPMPLLRNNRFLPDYH
ELSSDVLDKAKMMFLNYPNNPTGATADARFFADTVAVARSHCIPVIHDFAYGAIGFNGTPRSFLQQEGAKDVGVELFTMS
KLYNMAGWRVGFVLGNKEIVAMLEELQDHYHCSLFGGLQAASACALQSDQSSVHELVGLYKERSEALWEAAQEIGWQVEQ
PSGSFFAWFPVPKGYTSEEFSELLLDKAHLVVAPGNGFGQYGEGYVRIGLLADKTTLREAIARVGNLNLF

Sequences:

>Translated_390_residues
MAMDIQQAKMMEQLPSQFFAKLVNKAQRLAQEHNDLINLGQGNHDQPTPAFIVEALREASSEPQFHRYGPFRGYPFLKEA
IAAYYKQQYGVELDPETEVAIVPGTKTAIVELCQCLLNKGDMALVPDPGYPDYLSGIAITGAIAKPMPLLRNNRFLPDYH
ELSSDVLDKAKMMFLNYPNNPTGATADARFFADTVAVARSHCIPVIHDFAYGAIGFNGTPRSFLQQEGAKDVGVELFTMS
KLYNMAGWRVGFVLGNKEIVAMLEELQDHYHCSLFGGLQAASACALQSDQSSVHELVGLYKERSEALWEAAQEIGWQVEQ
PSGSFFAWFPVPKGYTSEEFSELLLDKAHLVVAPGNGFGQYGEGYVRIGLLADKTTLREAIARVGNLNLF
>Mature_389_residues
AMDIQQAKMMEQLPSQFFAKLVNKAQRLAQEHNDLINLGQGNHDQPTPAFIVEALREASSEPQFHRYGPFRGYPFLKEAI
AAYYKQQYGVELDPETEVAIVPGTKTAIVELCQCLLNKGDMALVPDPGYPDYLSGIAITGAIAKPMPLLRNNRFLPDYHE
LSSDVLDKAKMMFLNYPNNPTGATADARFFADTVAVARSHCIPVIHDFAYGAIGFNGTPRSFLQQEGAKDVGVELFTMSK
LYNMAGWRVGFVLGNKEIVAMLEELQDHYHCSLFGGLQAASACALQSDQSSVHELVGLYKERSEALWEAAQEIGWQVEQP
SGSFFAWFPVPKGYTSEEFSELLLDKAHLVVAPGNGFGQYGEGYVRIGLLADKTTLREAIARVGNLNLF

Specific function: Catalyzes the formation of methionine from 2-keto-4- methylthiobutyrate (KMTB) (Probable) [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. MtnE subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=390, Percent_Identity=25.1282051282051, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169881279, Length=390, Percent_Identity=25.1282051282051, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4507369, Length=383, Percent_Identity=21.9321148825065, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI56713254, Length=302, Percent_Identity=23.5099337748344, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI56713256, Length=302, Percent_Identity=23.5099337748344, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788722, Length=378, Percent_Identity=38.0952380952381, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786816, Length=388, Percent_Identity=25.7731958762887, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788627, Length=389, Percent_Identity=23.9074550128535, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994476, Length=265, Percent_Identity=26.7924528301887, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71994472, Length=249, Percent_Identity=27.3092369477912, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17567369, Length=399, Percent_Identity=23.8095238095238, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17567663, Length=353, Percent_Identity=23.2294617563739, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322401, Length=385, Percent_Identity=22.5974025974026, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573069, Length=379, Percent_Identity=21.8997361477573, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646114, Length=379, Percent_Identity=21.8997361477573, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573067, Length=379, Percent_Identity=21.8997361477573, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573065, Length=379, Percent_Identity=21.8997361477573, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859735, Length=340, Percent_Identity=20.5882352941176, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 43143; Mature: 43011

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMDIQQAKMMEQLPSQFFAKLVNKAQRLAQEHNDLINLGQGNHDQPTPAFIVEALREAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHC
SEPQFHRYGPFRGYPFLKEAIAAYYKQQYGVELDPETEVAIVPGTKTAIVELCQCLLNKG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCC
DMALVPDPGYPDYLSGIAITGAIAKPMPLLRNNRFLPDYHELSSDVLDKAKMMFLNYPNN
CEEEECCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHEEEEECCCC
PTGATADARFFADTVAVARSHCIPVIHDFAYGAIGFNGTPRSFLQQEGAKDVGVELFTMS
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHCHHHHHHH
KLYNMAGWRVGFVLGNKEIVAMLEELQDHYHCSLFGGLQAASACALQSDQSSVHELVGLY
HHHHHCCCEEEEEECCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KERSEALWEAAQEIGWQVEQPSGSFFAWFPVPKGYTSEEFSELLLDKAHLVVAPGNGFGQ
HHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCC
YGEGYVRIGLLADKTTLREAIARVGNLNLF
CCCCEEEEEEEECHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AMDIQQAKMMEQLPSQFFAKLVNKAQRLAQEHNDLINLGQGNHDQPTPAFIVEALREAS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHC
SEPQFHRYGPFRGYPFLKEAIAAYYKQQYGVELDPETEVAIVPGTKTAIVELCQCLLNKG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCC
DMALVPDPGYPDYLSGIAITGAIAKPMPLLRNNRFLPDYHELSSDVLDKAKMMFLNYPNN
CEEEECCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHEEEEECCCC
PTGATADARFFADTVAVARSHCIPVIHDFAYGAIGFNGTPRSFLQQEGAKDVGVELFTMS
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHCHHHHHHH
KLYNMAGWRVGFVLGNKEIVAMLEELQDHYHCSLFGGLQAASACALQSDQSSVHELVGLY
HHHHHCCCEEEEEECCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KERSEALWEAAQEIGWQVEQPSGSFFAWFPVPKGYTSEEFSELLLDKAHLVVAPGNGFGQ
HHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCC
YGEGYVRIGLLADKTTLREAIARVGNLNLF
CCCCEEEEEEEECHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 12022921 [H]