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The map label for this gene is xlyA [H]

Identifier: 56963123

GI number: 56963123

Start: 1476923

End: 1477828

Strand: Direct

Name: xlyA [H]

Synonym: ABC1351

Alternate gene names: 56963123

Gene position: 1476923-1477828 (Clockwise)

Preceding gene: 56963122

Following gene: 56963124

Centisome position: 34.32

GC content: 45.81

Gene sequence:

>906_bases
ATGAAAATCGTACAAGATTTAATCAGCAAATCAGCGTCTAACCGTCCTGGTGATCGCCTTAACCCAACCCATATTACTGT
CCATGAGACGGGGAATACGTCAAAAGGCGCCGACGCTGCTATGCATGCGCGTTACATCAAAGGCGCCGACGCTCGTGCTC
GTAAAGTGTCCTGGCATTATACTGTAGACGATAAACAAATTATTCAACATGTACCAGATAACGAACGTGCCTGGCACGCC
GGAAGTGGAAATGCAAAATCAATCGGCGTTGAAATTTGTGTTAACAGTGACGGTAATTTTGAAAAAGCAAAGTCTAATGC
AGCTTGGCTTTTGCGGAACCTAATGTCTAAACACAACATTTCTCTGTCCAATGTCGTAACCCACAAGTATTGGACAGGCA
AAAACTGCCCTGCACGATTGCTAAAGGAATGGAATGCTTTTAAACAACTAATTAGCAATGAAGATGCACCGCAAGTAGGT
GGAATCATTGTTGAAGATAAACCGAAGGCCAAGCCGTCTGGTGATGCTTATATTCGCAGTATCCAGCAGTGGGTTGTTAA
CTACGGTTATAAAATCGCTGTTGACGGTCTGAAAGGGCCCGAAACTAAGCGAGGGCTTATTCGTGTCTACCAAAATGAAT
TAAACAAACAGTTTGGCGCTGGTTTGTCTGTGGATGGCATCCCGGGGGCAAAGACTTATAACGCTGCTCGTAATGTCCGC
AAAGGTGCTAAAGGTAATTTAACCCGTGTTCTGCAAGCGCTGCTGTATATGGCAGGCCACAATCCAGGGCCGTTCGATGG
AGTTTTCGGCAACGGCACAGAAAAGGCTGTGCGGGCTTTTCAACGTGACAAGGGATTAGGAGTAGACGGTATTGCCGGTA
AAAATACTTGGCGTGCATTGTTGTAA

Upstream 100 bases:

>100_bases
CAAGCAGAATTGGGCTGAAAGTTCCGCCAGTAATTATGGAAAAACTACGTGGCTTTGATGAACACGGCCCTGAAGAAAAT
AAAAAGGAGAGTGAATAAGC

Downstream 100 bases:

>100_bases
ATAAAAATTGGCCCTACGTGTATAAACGTGGGGTCCGTGATAATTTTATTGGAATTTTTAATTTAAGGATATATTATAAA
ACTAATATGTTTAAATTTAG

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Autolysin; Cell wall hydrolase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKIVQDLISKSASNRPGDRLNPTHITVHETGNTSKGADAAMHARYIKGADARARKVSWHYTVDDKQIIQHVPDNERAWHA
GSGNAKSIGVEICVNSDGNFEKAKSNAAWLLRNLMSKHNISLSNVVTHKYWTGKNCPARLLKEWNAFKQLISNEDAPQVG
GIIVEDKPKAKPSGDAYIRSIQQWVVNYGYKIAVDGLKGPETKRGLIRVYQNELNKQFGAGLSVDGIPGAKTYNAARNVR
KGAKGNLTRVLQALLYMAGHNPGPFDGVFGNGTEKAVRAFQRDKGLGVDGIAGKNTWRALL

Sequences:

>Translated_301_residues
MKIVQDLISKSASNRPGDRLNPTHITVHETGNTSKGADAAMHARYIKGADARARKVSWHYTVDDKQIIQHVPDNERAWHA
GSGNAKSIGVEICVNSDGNFEKAKSNAAWLLRNLMSKHNISLSNVVTHKYWTGKNCPARLLKEWNAFKQLISNEDAPQVG
GIIVEDKPKAKPSGDAYIRSIQQWVVNYGYKIAVDGLKGPETKRGLIRVYQNELNKQFGAGLSVDGIPGAKTYNAARNVR
KGAKGNLTRVLQALLYMAGHNPGPFDGVFGNGTEKAVRAFQRDKGLGVDGIAGKNTWRALL
>Mature_301_residues
MKIVQDLISKSASNRPGDRLNPTHITVHETGNTSKGADAAMHARYIKGADARARKVSWHYTVDDKQIIQHVPDNERAWHA
GSGNAKSIGVEICVNSDGNFEKAKSNAAWLLRNLMSKHNISLSNVVTHKYWTGKNCPARLLKEWNAFKQLISNEDAPQVG
GIIVEDKPKAKPSGDAYIRSIQQWVVNYGYKIAVDGLKGPETKRGLIRVYQNELNKQFGAGLSVDGIPGAKTYNAARNVR
KGAKGNLTRVLQALLYMAGHNPGPFDGVFGNGTEKAVRAFQRDKGLGVDGIAGKNTWRALL

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Could play a role in mother cell lysis with CwlC [H]

COG id: COG5632

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002502
- InterPro:   IPR002477 [H]

Pfam domain/function: PF01510 Amidase_2; PF01471 PG_binding_1 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 32950; Mature: 32950

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVQDLISKSASNRPGDRLNPTHITVHETGNTSKGADAAMHARYIKGADARARKVSWHY
CCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHEEEEEE
TVDDKQIIQHVPDNERAWHAGSGNAKSIGVEICVNSDGNFEKAKSNAAWLLRNLMSKHNI
ECCHHHHHHHCCCCCCEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
SLSNVVTHKYWTGKNCPARLLKEWNAFKQLISNEDAPQVGGIIVEDKPKAKPSGDAYIRS
CHHHHHEECEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHH
IQQWVVNYGYKIAVDGLKGPETKRGLIRVYQNELNKQFGAGLSVDGIPGAKTYNAARNVR
HHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
KGAKGNLTRVLQALLYMAGHNPGPFDGVFGNGTEKAVRAFQRDKGLGVDGIAGKNTWRAL
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHC
L
C
>Mature Secondary Structure
MKIVQDLISKSASNRPGDRLNPTHITVHETGNTSKGADAAMHARYIKGADARARKVSWHY
CCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHEEEEEE
TVDDKQIIQHVPDNERAWHAGSGNAKSIGVEICVNSDGNFEKAKSNAAWLLRNLMSKHNI
ECCHHHHHHHCCCCCCEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
SLSNVVTHKYWTGKNCPARLLKEWNAFKQLISNEDAPQVGGIIVEDKPKAKPSGDAYIRS
CHHHHHEECEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHH
IQQWVVNYGYKIAVDGLKGPETKRGLIRVYQNELNKQFGAGLSVDGIPGAKTYNAARNVR
HHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
KGAKGNLTRVLQALLYMAGHNPGPFDGVFGNGTEKAVRAFQRDKGLGVDGIAGKNTWRAL
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]