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The map label for this gene is ygcA [C]

Identifier: 56963072

GI number: 56963072

Start: 1421755

End: 1423170

Strand: Direct

Name: ygcA [C]

Synonym: ABC1300

Alternate gene names: 56963072

Gene position: 1421755-1423170 (Clockwise)

Preceding gene: 56963068

Following gene: 56963073

Centisome position: 33.03

GC content: 45.83

Gene sequence:

>1416_bases
ATGAAAACGAACAATAAACAAAAAACGTCTTCTCGATCAAGCCAAGGCGTGTCTGTAGTCAAAGGGCAAAAGTTTCCGTT
GACGATCAAACGTATCGGCATTAATGGAGAAGGCGTTGGTTATTATAAACGCCATGTTGTTTTTGTAAAAGGCGCCTTGC
CAGGGGAAGAAGTTGTCGCTGAAGTGACAAAGGCAGGGCGCTCTTTTTCAGAAGCGAAAATCAAGAAAATCCGCAAGCGA
TCAAATGACCGTGTTAAAGCGCCGTGCCCCATCTATGAAGAGTGTGGCGGCTGCCAGCTTCAACATATGAATTATGAGGC
GACATTGGAAGGCAAGAAGGACATTGTGCGCCAAGCGTTTGTCCGCTACACAAATGTGCCAGAATCAACGCTGCCGCTAA
AAAATACGATAGGCATGGACAACCCTTGGTATTATCGTAATAAAAGCCAGCTGCAAACGCGCAAGCAAAAAGACGGCAGA
GTGGCAGCAGGGCTGTATCGGGAAAATAGCCATGATTTAATTGATTTGTCCGCTTGCATGGTGCAGCATAAGCAGCTGAA
CCGGGTGGCACAAATTGTTAAGCAGCTGCTCGGAGATTTGCAAATTCCTATTTATAATGAGAAAACGCATAGCGGTGACA
TTCGGACGATCGTGACTCGAATTGGCTTTGAAACAAAGCAAATCCAACTTGTGTTTATTACAAGAACCGAAGCACTCCCG
AAAAAAGAGCTGCTTATTAAACAAGTGCGGGAAAAACTGCCTGAAGTGACGTCCGTTATGCAAAACGTCAACCATGAGAA
AACGTCGCTTATATTCGGCGAGAAAATGGTTCATTTGTACGGTGAAAAGACGATCCATGAGCGTCTTGGAGAATACAGCT
TTGACCTATCGGCACGGGCCTTTTTCCAATTAAACCCGAGCCAAACGGTTAAATTGTACAATGAAGCGAAAAAGGCAGCC
CACTTAACGGGAAAAGAAAAGCTCGTTGACGCGTATTGCGGTGTCGGTACAATTGGCCAATGGCTTGGCGATCAAGCCGA
AGAAGTCCGTGGCATGGATATTACCGAAGAAGCCATTGAAAATGCACGCAGCAATGCCAAAAAGCATGGAATCGCTGCTG
TATATGAAGTGGGTCCGGCAGAAAAATGGCTGCCGTTGTGGCTTAAGCAAGGATTTAAACCAGACGTTATTTTAGTAGAC
CCTCCACGCAGCGGCTGTGACCGCCAATTGTTAAAAAGCATGCTAAAAGCCAAGCCGAAACGAATTGTTTACGTCTCATG
CAATCCATCTACTCTTGCCAAAGACGTACAACATCTGATCGAAGCTGGCGGCTATGCGATTCAATCCATTCAGCCTGTCG
ATATGTTCCCATGGACGGCACAGGTGGAAAGTGTGACTGAGCTAATTCTCAAATAA

Upstream 100 bases:

>100_bases
TAGAAAGTTTAGGAAAGCAGTCGATTTTGTTATACTAAGGGAAGAAGCGAGTTGGCCAATCAACAAAAGTGCGACCGCCT
CCACTAACAGGAGTGAGACG

Downstream 100 bases:

>100_bases
AAAACGTTAAAATCTTGTTTGCTTCCAATAGAAAAATGAAAAGAGGCCCACGAAAAAGGGAGGGGAATGGTGTGCTTAAA
CTTTTACAGCCTGCTAGACT

Product: S-adenosylmethionine (SAM)-dependent methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKTNNKQKTSSRSSQGVSVVKGQKFPLTIKRIGINGEGVGYYKRHVVFVKGALPGEEVVAEVTKAGRSFSEAKIKKIRKR
SNDRVKAPCPIYEECGGCQLQHMNYEATLEGKKDIVRQAFVRYTNVPESTLPLKNTIGMDNPWYYRNKSQLQTRKQKDGR
VAAGLYRENSHDLIDLSACMVQHKQLNRVAQIVKQLLGDLQIPIYNEKTHSGDIRTIVTRIGFETKQIQLVFITRTEALP
KKELLIKQVREKLPEVTSVMQNVNHEKTSLIFGEKMVHLYGEKTIHERLGEYSFDLSARAFFQLNPSQTVKLYNEAKKAA
HLTGKEKLVDAYCGVGTIGQWLGDQAEEVRGMDITEEAIENARSNAKKHGIAAVYEVGPAEKWLPLWLKQGFKPDVILVD
PPRSGCDRQLLKSMLKAKPKRIVYVSCNPSTLAKDVQHLIEAGGYAIQSIQPVDMFPWTAQVESVTELILK

Sequences:

>Translated_471_residues
MKTNNKQKTSSRSSQGVSVVKGQKFPLTIKRIGINGEGVGYYKRHVVFVKGALPGEEVVAEVTKAGRSFSEAKIKKIRKR
SNDRVKAPCPIYEECGGCQLQHMNYEATLEGKKDIVRQAFVRYTNVPESTLPLKNTIGMDNPWYYRNKSQLQTRKQKDGR
VAAGLYRENSHDLIDLSACMVQHKQLNRVAQIVKQLLGDLQIPIYNEKTHSGDIRTIVTRIGFETKQIQLVFITRTEALP
KKELLIKQVREKLPEVTSVMQNVNHEKTSLIFGEKMVHLYGEKTIHERLGEYSFDLSARAFFQLNPSQTVKLYNEAKKAA
HLTGKEKLVDAYCGVGTIGQWLGDQAEEVRGMDITEEAIENARSNAKKHGIAAVYEVGPAEKWLPLWLKQGFKPDVILVD
PPRSGCDRQLLKSMLKAKPKRIVYVSCNPSTLAKDVQHLIEAGGYAIQSIQPVDMFPWTAQVESVTELILK
>Mature_471_residues
MKTNNKQKTSSRSSQGVSVVKGQKFPLTIKRIGINGEGVGYYKRHVVFVKGALPGEEVVAEVTKAGRSFSEAKIKKIRKR
SNDRVKAPCPIYEECGGCQLQHMNYEATLEGKKDIVRQAFVRYTNVPESTLPLKNTIGMDNPWYYRNKSQLQTRKQKDGR
VAAGLYRENSHDLIDLSACMVQHKQLNRVAQIVKQLLGDLQIPIYNEKTHSGDIRTIVTRIGFETKQIQLVFITRTEALP
KKELLIKQVREKLPEVTSVMQNVNHEKTSLIFGEKMVHLYGEKTIHERLGEYSFDLSARAFFQLNPSQTVKLYNEAKKAA
HLTGKEKLVDAYCGVGTIGQWLGDQAEEVRGMDITEEAIENARSNAKKHGIAAVYEVGPAEKWLPLWLKQGFKPDVILVD
PPRSGCDRQLLKSMLKAKPKRIVYVSCNPSTLAKDVQHLIEAGGYAIQSIQPVDMFPWTAQVESVTELILK

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=201, Percent_Identity=32.3383084577114, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI51173878, Length=201, Percent_Identity=32.3383084577114, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI269784680, Length=205, Percent_Identity=30.2439024390244, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI269784676, Length=205, Percent_Identity=30.2439024390244, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI20149688, Length=205, Percent_Identity=30.2439024390244, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI269784678, Length=205, Percent_Identity=30.2439024390244, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1789148, Length=467, Percent_Identity=27.4089935760171, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1787083, Length=327, Percent_Identity=25.0764525993884, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1790403, Length=214, Percent_Identity=26.6355140186916, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71997438, Length=163, Percent_Identity=29.4478527607362, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24666579, Length=442, Percent_Identity=24.6606334841629, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 53105; Mature: 53105

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNNKQKTSSRSSQGVSVVKGQKFPLTIKRIGINGEGVGYYKRHVVFVKGALPGEEVVA
CCCCCCCHHCCCCCCCCEEECCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCCHHHHHH
EVTKAGRSFSEAKIKKIRKRSNDRVKAPCPIYEECGGCQLQHMNYEATLEGKKDIVRQAF
HHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEECCCEEEECCHHHHHHHHH
VRYTNVPESTLPLKNTIGMDNPWYYRNKSQLQTRKQKDGRVAAGLYRENSHDLIDLSACM
HHHCCCCCCCCCCHHCCCCCCCEEECCHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHH
VQHKQLNRVAQIVKQLLGDLQIPIYNEKTHSGDIRTIVTRIGFETKQIQLVFITRTEALP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCC
KKELLIKQVREKLPEVTSVMQNVNHEKTSLIFGEKMVHLYGEKTIHERLGEYSFDLSARA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
FFQLNPSQTVKLYNEAKKAAHLTGKEKLVDAYCGVGTIGQWLGDQAEEVRGMDITEEAIE
EEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHCCHHHHHCCCCCHHHHHH
NARSNAKKHGIAAVYEVGPAEKWLPLWLKQGFKPDVILVDPPRSGCDRQLLKSMLKAKPK
HHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCC
RIVYVSCNPSTLAKDVQHLIEAGGYAIQSIQPVDMFPWTAQVESVTELILK
EEEEEECCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKTNNKQKTSSRSSQGVSVVKGQKFPLTIKRIGINGEGVGYYKRHVVFVKGALPGEEVVA
CCCCCCCHHCCCCCCCCEEECCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCCHHHHHH
EVTKAGRSFSEAKIKKIRKRSNDRVKAPCPIYEECGGCQLQHMNYEATLEGKKDIVRQAF
HHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEECCCEEEECCHHHHHHHHH
VRYTNVPESTLPLKNTIGMDNPWYYRNKSQLQTRKQKDGRVAAGLYRENSHDLIDLSACM
HHHCCCCCCCCCCHHCCCCCCCEEECCHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHH
VQHKQLNRVAQIVKQLLGDLQIPIYNEKTHSGDIRTIVTRIGFETKQIQLVFITRTEALP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCC
KKELLIKQVREKLPEVTSVMQNVNHEKTSLIFGEKMVHLYGEKTIHERLGEYSFDLSARA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
FFQLNPSQTVKLYNEAKKAAHLTGKEKLVDAYCGVGTIGQWLGDQAEEVRGMDITEEAIE
EEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHCCHHHHHCCCCCHHHHHH
NARSNAKKHGIAAVYEVGPAEKWLPLWLKQGFKPDVILVDPPRSGCDRQLLKSMLKAKPK
HHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCC
RIVYVSCNPSTLAKDVQHLIEAGGYAIQSIQPVDMFPWTAQVESVTELILK
EEEEEECCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]