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The map label for this gene is treR [H]

Identifier: 56963037

GI number: 56963037

Start: 1386638

End: 1387351

Strand: Direct

Name: treR [H]

Synonym: ABC1265

Alternate gene names: 56963037

Gene position: 1386638-1387351 (Clockwise)

Preceding gene: 56963036

Following gene: 56963038

Centisome position: 32.22

GC content: 44.68

Gene sequence:

>714_bases
GTGAAAAACAAGTTTCAATCGATTTATCAAGCGCTCATACAAGCAATCAATAGCGGTGTTTATGCTCCTGGCGAAACGTT
GCCTTCTGAAAACGAACTGACAGAGATGTTCCAAGCATCGAGGGAAACGATTCGCAAAGCACTGAAAATGTTATCAGAAC
ACGGGTATATTCAAAAGATACAAGGCAGAGGTTCTGTTGTGCTTGATGTCGCACGCCTCGATTTCCCGGTTTCAGGGGTT
GCAAGCTTCCAAGAACTAAATGAAAAGCTTGGTTTGCAAGCTAAGACGGATGTCGTCTGCTTTACAGCTGTTAAAGCAGA
TAAAACAATCGCAAAAAAGTTGGAAATTGAAACAGGTGAGCAAGTTTGGCAAGTGGAGCGAATCCGCTTAATTGATGGGG
AACGAATTATATTGGATAAGGACACGTTTGTTTCCAGTCTTGTCCCTGGTTTAACGAAAGACATTTGTGCGGGCAGCATT
TATGCCTACATTGAGAAGCAACTAGGCCTTGCTATCAGCTTTGCCAAAAAGGAAATTGTCGTTGAAGCGGCGACTGAGGA
AGACCAGGCCATGCTTGACCTCGATGAAAGTGGCCGTGTAGTTGTTGTCAGAAGCTATACGTATTTAGACAATGCTGTGC
CTTTCCAGTACACAGAGTCACGCCATCGTGCGGACCGCTTCCGATTTGTTGATTTTGCCAGACGCAACCCTTAA

Upstream 100 bases:

>100_bases
GTTAATAAGCAACTACAACCAAAAACGAAAACTGGAAAAAACATTTTCGCTCAAGCCTTATGAAACGGTAGCATTCCAGT
TGAAGGAGTAAGAGAAGCAC

Downstream 100 bases:

>100_bases
ATCGATGGCAGTTTTCATAGTGGGGACGATTTAGCTGCTGCTCGACCGGTGAAACAAATCGGTTTTAATTGGTGCCAAAC
CGCAGTATACTTAAAGTGAA

Product: GntR family transcriptional repressor of trehalose operon

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKNKFQSIYQALIQAINSGVYAPGETLPSENELTEMFQASRETIRKALKMLSEHGYIQKIQGRGSVVLDVARLDFPVSGV
ASFQELNEKLGLQAKTDVVCFTAVKADKTIAKKLEIETGEQVWQVERIRLIDGERIILDKDTFVSSLVPGLTKDICAGSI
YAYIEKQLGLAISFAKKEIVVEAATEEDQAMLDLDESGRVVVVRSYTYLDNAVPFQYTESRHRADRFRFVDFARRNP

Sequences:

>Translated_237_residues
MKNKFQSIYQALIQAINSGVYAPGETLPSENELTEMFQASRETIRKALKMLSEHGYIQKIQGRGSVVLDVARLDFPVSGV
ASFQELNEKLGLQAKTDVVCFTAVKADKTIAKKLEIETGEQVWQVERIRLIDGERIILDKDTFVSSLVPGLTKDICAGSI
YAYIEKQLGLAISFAKKEIVVEAATEEDQAMLDLDESGRVVVVRSYTYLDNAVPFQYTESRHRADRFRFVDFARRNP
>Mature_237_residues
MKNKFQSIYQALIQAINSGVYAPGETLPSENELTEMFQASRETIRKALKMLSEHGYIQKIQGRGSVVLDVARLDFPVSGV
ASFQELNEKLGLQAKTDVVCFTAVKADKTIAKKLEIETGEQVWQVERIRLIDGERIILDKDTFVSSLVPGLTKDICAGSI
YAYIEKQLGLAISFAKKEIVVEAATEEDQAMLDLDESGRVVVVRSYTYLDNAVPFQYTESRHRADRFRFVDFARRNP

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=235, Percent_Identity=27.2340425531915, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1790540, Length=229, Percent_Identity=26.6375545851528, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790118, Length=171, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788418, Length=216, Percent_Identity=25.462962962963, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87082252, Length=223, Percent_Identity=26.0089686098655, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26677; Mature: 26677

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKFQSIYQALIQAINSGVYAPGETLPSENELTEMFQASRETIRKALKMLSEHGYIQKI
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
QGRGSVVLDVARLDFPVSGVASFQELNEKLGLQAKTDVVCFTAVKADKTIAKKLEIETGE
CCCCCEEEEEEHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCCH
QVWQVERIRLIDGERIILDKDTFVSSLVPGLTKDICAGSIYAYIEKQLGLAISFAKKEIV
HHHHHHHEEEECCCEEEEECHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHEEHHHEEE
VEAATEEDQAMLDLDESGRVVVVRSYTYLDNAVPFQYTESRHRADRFRFVDFARRNP
EEECCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNKFQSIYQALIQAINSGVYAPGETLPSENELTEMFQASRETIRKALKMLSEHGYIQKI
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
QGRGSVVLDVARLDFPVSGVASFQELNEKLGLQAKTDVVCFTAVKADKTIAKKLEIETGE
CCCCCEEEEEEHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCCCH
QVWQVERIRLIDGERIILDKDTFVSSLVPGLTKDICAGSIYAYIEKQLGLAISFAKKEIV
HHHHHHHEEEECCCEEEEECHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHEEHHHEEE
VEAATEEDQAMLDLDESGRVVVVRSYTYLDNAVPFQYTESRHRADRFRFVDFARRNP
EEECCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]