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The map label for this gene is mazG [H]

Identifier: 55981915

GI number: 55981915

Start: 1823527

End: 1824123

Strand: Direct

Name: mazG [H]

Synonym: TTHA1946

Alternate gene names: 55981915

Gene position: 1823527-1824123 (Clockwise)

Preceding gene: 55981914

Following gene: 55981916

Centisome position: 98.58

GC content: 68.17

Gene sequence:

>597_bases
ATGGAGAGCATGGAGCGGCTTCTTGAGGTGATGCGCCGCCTGAGGGGGCCCGGAGGATGCCCCTGGGACCGGGCCCAGAC
CCACGAGAGCCTCGTCCCCTACCTCTTGGAGGAGGCCAGCGAGGCGGCGGACGCCCTCCTCGAGGGAAACCCCCAGGAGA
TGGCCGAGGAGCTCGGGGACGTCCTCCTGCAGGTGGCCTTCCACAGCGTCATCGCCGAAGAGGAGGGGCGCTTCACCTAC
GGGGACGTGGAGCGCGCCATCGTGGAGAAGCTCATCCGCCGCCATCCCCACGTCTTTGGGGAGGCCGAGGCCAGGACCCC
GGAGGAGGTGAAGGCCCGCTGGGAGGACCTGAAGGCCAAGGAGGGCAAGAAGGAGGACCCCTGCGGCCTGCTCAAGGGGC
TTCCCACCTTGCTCCGAGCCTACGAGCTCCAGCGGAAGGGGATAGACCCGGGAAGCGAGGAAGGCCTGAGGAAGGCCCTG
GAAGAGGGCGACCTGGAGGAAGCGCTTTGGCACCTGGTGGGGCTTTTCGCCGCCAAGGGGATGGACCCCGAGAGCGCCTT
AAGGAAGCGCTCCCTCAAAGCCTGCCGGCAGGGCTAG

Upstream 100 bases:

>100_bases
CCGGGCCCCGGGGGCTGGACCCTGGAACCCGCCCCCCTAGACCCCCTCTCCCTCCTCCTCGTGGGGCTTTCCCTGGCGGG
GGGATTGCTTCTTAAGGAGA

Downstream 100 bases:

>100_bases
AGCCCCCGCCCGGCTTCCGCCTGGCGGCGGTGGCCGTGCCCCTTCTGGGGGAGCACCTCCTCTTCACCTTAAGGAGCCCC
CGCCTCCCCACCCACGCCGG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MESMERLLEVMRRLRGPGGCPWDRAQTHESLVPYLLEEASEAADALLEGNPQEMAEELGDVLLQVAFHSVIAEEEGRFTY
GDVERAIVEKLIRRHPHVFGEAEARTPEEVKARWEDLKAKEGKKEDPCGLLKGLPTLLRAYELQRKGIDPGSEEGLRKAL
EEGDLEEALWHLVGLFAAKGMDPESALRKRSLKACRQG

Sequences:

>Translated_198_residues
MESMERLLEVMRRLRGPGGCPWDRAQTHESLVPYLLEEASEAADALLEGNPQEMAEELGDVLLQVAFHSVIAEEEGRFTY
GDVERAIVEKLIRRHPHVFGEAEARTPEEVKARWEDLKAKEGKKEDPCGLLKGLPTLLRAYELQRKGIDPGSEEGLRKAL
EEGDLEEALWHLVGLFAAKGMDPESALRKRSLKACRQG
>Mature_198_residues
MESMERLLEVMRRLRGPGGCPWDRAQTHESLVPYLLEEASEAADALLEGNPQEMAEELGDVLLQVAFHSVIAEEEGRFTY
GDVERAIVEKLIRRHPHVFGEAEARTPEEVKARWEDLKAKEGKKEDPCGLLKGLPTLLRAYELQRKGIDPGSEEGLRKAL
EEGDLEEALWHLVGLFAAKGMDPESALRKRSLKACRQG

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=156, Percent_Identity=42.9487179487179, Blast_Score=137, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 22226; Mature: 22226

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESMERLLEVMRRLRGPGGCPWDRAQTHESLVPYLLEEASEAADALLEGNPQEMAEELGD
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VLLQVAFHSVIAEEEGRFTYGDVERAIVEKLIRRHPHVFGEAEARTPEEVKARWEDLKAK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
EGKKEDPCGLLKGLPTLLRAYELQRKGIDPGSEEGLRKALEEGDLEEALWHLVGLFAAKG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
MDPESALRKRSLKACRQG
CCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESMERLLEVMRRLRGPGGCPWDRAQTHESLVPYLLEEASEAADALLEGNPQEMAEELGD
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VLLQVAFHSVIAEEEGRFTYGDVERAIVEKLIRRHPHVFGEAEARTPEEVKARWEDLKAK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
EGKKEDPCGLLKGLPTLLRAYELQRKGIDPGSEEGLRKALEEGDLEEALWHLVGLFAAKG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
MDPESALRKRSLKACRQG
CCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]