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The map label for this gene is proA [H]

Identifier: 55981897

GI number: 55981897

Start: 1808515

End: 1809756

Strand: Direct

Name: proA [H]

Synonym: TTHA1928

Alternate gene names: 55981897

Gene position: 1808515-1809756 (Clockwise)

Preceding gene: 55981896

Following gene: 55981898

Centisome position: 97.77

GC content: 68.28

Gene sequence:

>1242_bases
ATGACGGCAACAAGCCTTTGGGAACTGGCGGAGCGCGCGCGCAAGAGGCTTTCCGAGATCGCGAAGGGGAACCGGGACCG
GGCCCTTCTCGCCATGGCGGACCTCCTCGAGGCCCGCTGGGAAGAGGTCCTGAGGGCCAACCGGGAAGACCTGGAGGAGG
CGGAAAGAACGGGGCTTCCCAAGGCCAAGCTGGACCGGCTGGCCCTAAAGGAGAAGGACCTCAAGACCCTCACGGAGGGC
CTGAGGCAGATCGCCCGCCTCCCCGACCCCCTGGGGCGGATAGAGGGCCTGGCCAAACGGCCGAACGGCCTGAGGGTGGG
CAGGATGCGGGTGCCCCTGGGCCTCATCGGCTTCATCTACGAGGCGAGGCCCGGGGCCACGGTGGAGGCGGTCTCCGTGG
CCCTGAAGGCGGGGAACGCCATGCTCCTCAGGGGGGGCAAGGAGGCCTTCCGCTCCAACCGGGCCCTGGTGGCCCTCTGG
CACGAGGCCCTGGGAGAGGCGGGCCTTCCCGAGGAGGCGGTCACCCTCGTCCCCACCACCGACCGGGAGGCCGTCTTGGA
GATGTGCCGATTGGAGCTCCTAGACCTCCTTATCCCGAGGGGAGGGGAGGAGCTTATAAGGCTTGTCCAAAGAGAGGCCC
GGGTTCCCGTTTTGGCCCACGCCAAGGGGGTGAACCACCTTTACGTGGACAAGAAGGCGGACCTCTCCATGGCCCTCCGC
CTCGCCCTAAACGGCAAGACCCAGCGCCCCGCGGTGTGCAACGCCCTCGAGACCGTCCTGGTGCACGAGAAGGTGGCGGA
GGCCTTCCTCCCCAGGCTGGAAAAGGCCATGCGGGAAAAAGGGGTGGAGCTCAGGGCCTGCCCTAGGGCCCTTCCCCTCC
TCAAAGAGGCGGTCCCCGCCCGGGAGGACGAGTGGGACCGGGAGTACCTGGACCTCGTCCTCAGGGTCAAGGTGGTCTCG
GGGCTGGAAGAGGCCCTCGCCCACATCGCCCGCTACGGCTCCCGCCACACCGAGGCCATCTGCACCGAGGACCCCAAGGC
GGCTTGGCGCTTCCTGGAGGAGGTGGACGCGAGCCTGGTCCTCTGGAACGCCTCCACCCGCTTCAACGACGGGTTTGAGC
TGGGGCTTGGGGCGGAGATCGGCATCAGCACCTCCAAGCTCCACGCCTACGGCCCCATGGGGCCCATGGAGCTCACCACC
CTCAAGTGGGTGGCCCTAGGGGAGGGCCAGGAGCGCACGTGA

Upstream 100 bases:

>100_bases
GCATCAAGGGGCGGCGGAGCGCGGAGATTGAGGCCGTCCTGGGCTACCGCTACACCGAGGAGGTGGTCCACCGGGACCAC
CTCGCCTTGAAGGAGGAGGC

Downstream 100 bases:

>100_bases
GGCGGGAAGGCTCCGTGGCCCGGGCCTGGGACCCCGAGGGCGCGGAGGGGTAGGGGGCCTTGCTTAGGCGCTTTTACCGC
CTCTACCAGGAGGCCCACGT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTATSLWELAERARKRLSEIAKGNRDRALLAMADLLEARWEEVLRANREDLEEAERTGLPKAKLDRLALKEKDLKTLTEG
LRQIARLPDPLGRIEGLAKRPNGLRVGRMRVPLGLIGFIYEARPGATVEAVSVALKAGNAMLLRGGKEAFRSNRALVALW
HEALGEAGLPEEAVTLVPTTDREAVLEMCRLELLDLLIPRGGEELIRLVQREARVPVLAHAKGVNHLYVDKKADLSMALR
LALNGKTQRPAVCNALETVLVHEKVAEAFLPRLEKAMREKGVELRACPRALPLLKEAVPAREDEWDREYLDLVLRVKVVS
GLEEALAHIARYGSRHTEAICTEDPKAAWRFLEEVDASLVLWNASTRFNDGFELGLGAEIGISTSKLHAYGPMGPMELTT
LKWVALGEGQERT

Sequences:

>Translated_413_residues
MTATSLWELAERARKRLSEIAKGNRDRALLAMADLLEARWEEVLRANREDLEEAERTGLPKAKLDRLALKEKDLKTLTEG
LRQIARLPDPLGRIEGLAKRPNGLRVGRMRVPLGLIGFIYEARPGATVEAVSVALKAGNAMLLRGGKEAFRSNRALVALW
HEALGEAGLPEEAVTLVPTTDREAVLEMCRLELLDLLIPRGGEELIRLVQREARVPVLAHAKGVNHLYVDKKADLSMALR
LALNGKTQRPAVCNALETVLVHEKVAEAFLPRLEKAMREKGVELRACPRALPLLKEAVPAREDEWDREYLDLVLRVKVVS
GLEEALAHIARYGSRHTEAICTEDPKAAWRFLEEVDASLVLWNASTRFNDGFELGLGAEIGISTSKLHAYGPMGPMELTT
LKWVALGEGQERT
>Mature_412_residues
TATSLWELAERARKRLSEIAKGNRDRALLAMADLLEARWEEVLRANREDLEEAERTGLPKAKLDRLALKEKDLKTLTEGL
RQIARLPDPLGRIEGLAKRPNGLRVGRMRVPLGLIGFIYEARPGATVEAVSVALKAGNAMLLRGGKEAFRSNRALVALWH
EALGEAGLPEEAVTLVPTTDREAVLEMCRLELLDLLIPRGGEELIRLVQREARVPVLAHAKGVNHLYVDKKADLSMALRL
ALNGKTQRPAVCNALETVLVHEKVAEAFLPRLEKAMREKGVELRACPRALPLLKEAVPAREDEWDREYLDLVLRVKVVSG
LEEALAHIARYGSRHTEAICTEDPKAAWRFLEEVDASLVLWNASTRFNDGFELGLGAEIGISTSKLHAYGPMGPMELTTL
KWVALGEGQERT

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=406, Percent_Identity=40.8866995073892, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI62912457, Length=406, Percent_Identity=40.8866995073892, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1786438, Length=404, Percent_Identity=46.2871287128713, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569969, Length=413, Percent_Identity=41.4043583535109, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17569967, Length=413, Percent_Identity=41.4043583535109, Blast_Score=289, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6324899, Length=432, Percent_Identity=35.8796296296296, Blast_Score=270, Evalue=4e-73,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=41.3625304136253, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45855; Mature: 45724

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATSLWELAERARKRLSEIAKGNRDRALLAMADLLEARWEEVLRANREDLEEAERTGLP
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
KAKLDRLALKEKDLKTLTEGLRQIARLPDPLGRIEGLAKRPNGLRVGRMRVPLGLIGFIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECEEECCHHHHHHHH
EARPGATVEAVSVALKAGNAMLLRGGKEAFRSNRALVALWHEALGEAGLPEEAVTLVPTT
HCCCCCHHHHHHHHHHCCCEEEEECCHHHHHCCCHHEEHHHHHHCCCCCCCCCEEEECCC
DREAVLEMCRLELLDLLIPRGGEELIRLVQREARVPVLAHAKGVNHLYVDKKADLSMALR
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHH
LALNGKTQRPAVCNALETVLVHEKVAEAFLPRLEKAMREKGVELRACPRALPLLKEAVPA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHCCC
REDEWDREYLDLVLRVKVVSGLEEALAHIARYGSRHTEAICTEDPKAAWRFLEEVDASLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEE
LWNASTRFNDGFELGLGAEIGISTSKLHAYGPMGPMELTTLKWVALGEGQERT
EEECCCCCCCCCEECCCCCCCCCCCCEEECCCCCCCHHHHEEEEEECCCCCCC
>Mature Secondary Structure 
TATSLWELAERARKRLSEIAKGNRDRALLAMADLLEARWEEVLRANREDLEEAERTGLP
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
KAKLDRLALKEKDLKTLTEGLRQIARLPDPLGRIEGLAKRPNGLRVGRMRVPLGLIGFIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECEEECCHHHHHHHH
EARPGATVEAVSVALKAGNAMLLRGGKEAFRSNRALVALWHEALGEAGLPEEAVTLVPTT
HCCCCCHHHHHHHHHHCCCEEEEECCHHHHHCCCHHEEHHHHHHCCCCCCCCCEEEECCC
DREAVLEMCRLELLDLLIPRGGEELIRLVQREARVPVLAHAKGVNHLYVDKKADLSMALR
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHH
LALNGKTQRPAVCNALETVLVHEKVAEAFLPRLEKAMREKGVELRACPRALPLLKEAVPA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHCCC
REDEWDREYLDLVLRVKVVSGLEEALAHIARYGSRHTEAICTEDPKAAWRFLEEVDASLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEE
LWNASTRFNDGFELGLGAEIGISTSKLHAYGPMGPMELTTLKWVALGEGQERT
EEECCCCCCCCCEECCCCCCCCCCCCEEECCCCCCCHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7988899 [H]