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The map label for this gene is hmeA [H]

Identifier: 55981733

GI number: 55981733

Start: 1651007

End: 1653637

Strand: Reverse

Name: hmeA [H]

Synonym: TTHA1764

Alternate gene names: 55981733

Gene position: 1653637-1651007 (Counterclockwise)

Preceding gene: 55981734

Following gene: 55981732

Centisome position: 89.4

GC content: 71.68

Gene sequence:

>2631_bases
ATGCGCAGAGGACCCCAGGAGGCGTTGGAGCGAGGGCTTTTCCGGGAGGAGTTTCCCTTCGGTCCCGTGACCCGGAGGGG
GTTTCTGGCCCTGGGCCTTGTCTCCTTGGCGGCCTGCACCCCGGTGGTGCGGCGCAAGGGGGTGCCCTACGTGCGCCAGC
CCGAGGGGGTGGTGGAGGGCGGGCGGAGGGAGTTCTTCACCGCCCTGCCCCACGCGGGCTTCGCCGAGCCCGTGCGGGTG
CGCACCTACCAGGGAAGGCCCCTCTTCCTCGTCCCCCAAGGGGAGGCCATGGGGCCCTACCCCCTTGCGGGGCTTTACAG
CCTCTACGACCCGGCCCGCAGGGGCAAAGCCCCGGACTGGGAGGGGTTTTACGCCGCCTGGCGGGAGGCTTTGGCGCAAG
GCGAGACCCTTTTCGTCCTCCCCCGCACCACCTCGCCTAGGCTCGAGGCCCTCCTCCAGAGGGCCCAGGCCCGCTACCCC
AACCTCCGGGTGGCCCGGTTTGAGGCCTGGAGCCTGGAGAACGTCTACCGGGGGGCGGAACTCGCCTTCGGGCAGAGGGC
CTGGCCCGTCTACAGCCCTGAGAAGGCCGAGACCGTGCTCCTCCTGGACGTGGACCTCCACGAGCACCCGGCGGGCTACG
GCTGGTGGGCCGCCCTAAGCCAGAGGCGCCTTCCCCCCATGAACCGCATCTACGCCGTGGAGAGCGGGGCGGGGCTGCTT
GGCGCCATGGCCGACCACCGCCTGGCCCTGAAGCCCAGCGCCCTCGAGGCCTTCCTCCTGGACCTGGCGAAGGCCCTCGG
GGTCCTCCCGGGAAGCCCCGCCTCGGACTACGGGGGCTTCCTCCCCGCCCTGGTGGAGGACCTTGAGCGGGGAGGGCTCC
TCCTCCCCGGGGTCCACCTCACCCCCGCCGCCCAGGCCCTGGCCATGGCGGTGAACGCGAGGCTTAAGGCCCCCGTGGCC
TACGTGCCGCCGCTGGAGGCCGAGCCCGCCACCCCCCGGGCCTTCCTCGAGGCGGAAGCGGCTTCCCGCCTCGTCTGGGC
GGCGGAAGGCCCCCTGCCGGGCCTAGAGGGCAAGGCCTTCGCCGCGGTCCTCTCCCTCTACCCGAAGGAGGCGCCCCATA
GCCTCCCCTTGGCCCACCCCCTGGAGGCGGCAAGCCCCGCCCGGGACGCCTGGGGCCGCCTCTGGCCCGCCCAAGCCCTC
CTCAAGCCCCTCTACGGCGGGAAAAGCCTGGAGGAGGTGCTGGCGGGGCTTTTGGGGGAGGGGCTTCCCGGCCTCACCGA
CGAGGAGAGGCGGGCTCTGGCCGAGGGCCGGCCCCTGGAGGAGGCAAAGCCTTTGGCCCTGGAGCCCCTCCCCGGCCTGG
AGGGCCGCCTTTCCCCCTTGCGGCGGGAGGCCCCCCTGGAGCTCACCCTCCGCCCGGACGCGCGCCTTTTTGACGGCCGC
TACCGGGAAAACCCCTACCTCCAAGAGCTTCCCCGGCCCCTCTCCCTCTTGGTCTGGGACGGGGCCCTCCTCGCCGGGGA
GAGGGAGGCGGAGGCCTGGGGGCTTCTTGAGGGGATCCGCGCCCGGGAGCGGCGCGCCGACCCCAGAAGGCCCCTCCTTC
GGGTGCGGGCTTCCGGAAGGGAGGCCCTCCTCCCCCTCTGGCCCCTCCCCCTCCTCCCCGAGGGAAGCCTTGTGGCCCCC
CTCTCCCACTTCTTCCACCCCGAAGGGACGGTCTTCCCCGCGGAGGTCCTGCCCACGGGCCGCGACTACCCTCTCGTCTC
CACCCAGTACCACGGTTACTTGGGCGAGGTGGAGGCGGTGAAGGTCCTCACCGAGGAGGAGGCGCGCAAGGCCCAGCCCA
AGGAGGAGAAGCGCGTCTCCTTCTACCCCCCCTGGCCCCAGGGGGAGCACGCCTGGGCCATGACCGTGGACCTCGCCCGC
TGCGTGGGGTGCGGGCTTTGCGTCCTCGCCTGCCAGGTGGAGAACAACATCCCCGTGGTGGGGAAGGAGGAGGTAGGGAA
GGGCCGGGAGATGCACTGGATCCGCCTGGACCGCTACTTCGCCGAGGAGGGCGTCTTCCACCAGCCCGTGATGTGCCAGC
ACTGCGAGAAGGCCCCCTGCGAGGCGGTCTGCCCCGTGGCCGCCACGGAGCACTCCCCCGAGGGGCTCAACCTCATGGTC
TACAACCGCTGCGTGGGCACGAAGTACTGCTCCGCCAACTGCCCCTACAAGGCCCGGCGCTTCAACTTCTTCCCCTACGC
CGAGGCCTTCATAGGCCAAGGGGACCCGAGGCGGGCCAAGGAAAGCCCCCTTGCCCTCCTCATGAACCCCGAGGTGACGG
TGAGAAGCCGGGGCGTCATGGAGAAGTGCACCTACTGCGTCCAGCGCATAGAGCTCGCCCGGGCGGAGGCCGCGAGGGAG
GGGCGGAGGATCCGCACCGGGGAGGTGGTCACCGCCTGCCAGGAGGTCTGCCCCGGGCGGGCCATCCACTTCGGGGACCT
CCTGGACCCCGAGGACCCCATCCACGCCCACCGGGAGGAGGGCCGCCACTACGTCCTCTTGGAGGAGGTGAACACCTGGC
CCCGGACCACCTACCTCGCCCACCTGAAGAACCCCAACCCCAGGCTTAGGAAGGAGGGAGGCCATGCCTGA

Upstream 100 bases:

>100_bases
TCCGGACCCCGAGTTGGGACGGGAGCTCCTCAAGCTCTACCACGTCCGGCCCCCCGAGGAGCTCACGAGCTGCAACATCT
GCCACCGCTAGGGAGGAGGT

Downstream 100 bases:

>100_bases
ACGGCACCCGGACCACGACCTCATCCAGGGGGAGTGGACGGAAAGGTCCCTGGTGGAGAAGCTCTTGGAGCCCGTGGAGA
AGCCCCCGCCCAGGCCCTGG

Product: molybdopterin oxidoreductase, iron-sulfur binding subunit

Products: NA

Alternate protein names: Hme subunit A [H]

Number of amino acids: Translated: 876; Mature: 876

Protein sequence:

>876_residues
MRRGPQEALERGLFREEFPFGPVTRRGFLALGLVSLAACTPVVRRKGVPYVRQPEGVVEGGRREFFTALPHAGFAEPVRV
RTYQGRPLFLVPQGEAMGPYPLAGLYSLYDPARRGKAPDWEGFYAAWREALAQGETLFVLPRTTSPRLEALLQRAQARYP
NLRVARFEAWSLENVYRGAELAFGQRAWPVYSPEKAETVLLLDVDLHEHPAGYGWWAALSQRRLPPMNRIYAVESGAGLL
GAMADHRLALKPSALEAFLLDLAKALGVLPGSPASDYGGFLPALVEDLERGGLLLPGVHLTPAAQALAMAVNARLKAPVA
YVPPLEAEPATPRAFLEAEAASRLVWAAEGPLPGLEGKAFAAVLSLYPKEAPHSLPLAHPLEAASPARDAWGRLWPAQAL
LKPLYGGKSLEEVLAGLLGEGLPGLTDEERRALAEGRPLEEAKPLALEPLPGLEGRLSPLRREAPLELTLRPDARLFDGR
YRENPYLQELPRPLSLLVWDGALLAGEREAEAWGLLEGIRARERRADPRRPLLRVRASGREALLPLWPLPLLPEGSLVAP
LSHFFHPEGTVFPAEVLPTGRDYPLVSTQYHGYLGEVEAVKVLTEEEARKAQPKEEKRVSFYPPWPQGEHAWAMTVDLAR
CVGCGLCVLACQVENNIPVVGKEEVGKGREMHWIRLDRYFAEEGVFHQPVMCQHCEKAPCEAVCPVAATEHSPEGLNLMV
YNRCVGTKYCSANCPYKARRFNFFPYAEAFIGQGDPRRAKESPLALLMNPEVTVRSRGVMEKCTYCVQRIELARAEAARE
GRRIRTGEVVTACQEVCPGRAIHFGDLLDPEDPIHAHREEGRHYVLLEEVNTWPRTTYLAHLKNPNPRLRKEGGHA

Sequences:

>Translated_876_residues
MRRGPQEALERGLFREEFPFGPVTRRGFLALGLVSLAACTPVVRRKGVPYVRQPEGVVEGGRREFFTALPHAGFAEPVRV
RTYQGRPLFLVPQGEAMGPYPLAGLYSLYDPARRGKAPDWEGFYAAWREALAQGETLFVLPRTTSPRLEALLQRAQARYP
NLRVARFEAWSLENVYRGAELAFGQRAWPVYSPEKAETVLLLDVDLHEHPAGYGWWAALSQRRLPPMNRIYAVESGAGLL
GAMADHRLALKPSALEAFLLDLAKALGVLPGSPASDYGGFLPALVEDLERGGLLLPGVHLTPAAQALAMAVNARLKAPVA
YVPPLEAEPATPRAFLEAEAASRLVWAAEGPLPGLEGKAFAAVLSLYPKEAPHSLPLAHPLEAASPARDAWGRLWPAQAL
LKPLYGGKSLEEVLAGLLGEGLPGLTDEERRALAEGRPLEEAKPLALEPLPGLEGRLSPLRREAPLELTLRPDARLFDGR
YRENPYLQELPRPLSLLVWDGALLAGEREAEAWGLLEGIRARERRADPRRPLLRVRASGREALLPLWPLPLLPEGSLVAP
LSHFFHPEGTVFPAEVLPTGRDYPLVSTQYHGYLGEVEAVKVLTEEEARKAQPKEEKRVSFYPPWPQGEHAWAMTVDLAR
CVGCGLCVLACQVENNIPVVGKEEVGKGREMHWIRLDRYFAEEGVFHQPVMCQHCEKAPCEAVCPVAATEHSPEGLNLMV
YNRCVGTKYCSANCPYKARRFNFFPYAEAFIGQGDPRRAKESPLALLMNPEVTVRSRGVMEKCTYCVQRIELARAEAARE
GRRIRTGEVVTACQEVCPGRAIHFGDLLDPEDPIHAHREEGRHYVLLEEVNTWPRTTYLAHLKNPNPRLRKEGGHA
>Mature_876_residues
MRRGPQEALERGLFREEFPFGPVTRRGFLALGLVSLAACTPVVRRKGVPYVRQPEGVVEGGRREFFTALPHAGFAEPVRV
RTYQGRPLFLVPQGEAMGPYPLAGLYSLYDPARRGKAPDWEGFYAAWREALAQGETLFVLPRTTSPRLEALLQRAQARYP
NLRVARFEAWSLENVYRGAELAFGQRAWPVYSPEKAETVLLLDVDLHEHPAGYGWWAALSQRRLPPMNRIYAVESGAGLL
GAMADHRLALKPSALEAFLLDLAKALGVLPGSPASDYGGFLPALVEDLERGGLLLPGVHLTPAAQALAMAVNARLKAPVA
YVPPLEAEPATPRAFLEAEAASRLVWAAEGPLPGLEGKAFAAVLSLYPKEAPHSLPLAHPLEAASPARDAWGRLWPAQAL
LKPLYGGKSLEEVLAGLLGEGLPGLTDEERRALAEGRPLEEAKPLALEPLPGLEGRLSPLRREAPLELTLRPDARLFDGR
YRENPYLQELPRPLSLLVWDGALLAGEREAEAWGLLEGIRARERRADPRRPLLRVRASGREALLPLWPLPLLPEGSLVAP
LSHFFHPEGTVFPAEVLPTGRDYPLVSTQYHGYLGEVEAVKVLTEEEARKAQPKEEKRVSFYPPWPQGEHAWAMTVDLAR
CVGCGLCVLACQVENNIPVVGKEEVGKGREMHWIRLDRYFAEEGVFHQPVMCQHCEKAPCEAVCPVAATEHSPEGLNLMV
YNRCVGTKYCSANCPYKARRFNFFPYAEAFIGQGDPRRAKESPLALLMNPEVTVRSRGVMEKCTYCVQRIELARAEAARE
GRRIRTGEVVTACQEVCPGRAIHFGDLLDPEDPIHAHREEGRHYVLLEEVNTWPRTTYLAHLKNPNPRLRKEGGHA

Specific function: Has menaquinol-oxidizing activity. HmeA, hmeB and hmeE subunits may together catalyze electron transfer from menaquinol to cytochrome c [H]

COG id: COG0437

COG function: function code C; Fe-S-cluster-containing hydrogenase components 1

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Extracellular side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Escherichia coli, GI226510944, Length=125, Percent_Identity=30.4, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787122, Length=242, Percent_Identity=26.4462809917355, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1787872, Length=247, Percent_Identity=25.5060728744939, Blast_Score=73, Evalue=9e-14,
Organism=Escherichia coli, GI2367345, Length=211, Percent_Identity=25.5924170616114, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR006311 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 97001; Mature: 97001

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRGPQEALERGLFREEFPFGPVTRRGFLALGLVSLAACTPVVRRKGVPYVRQPEGVVEG
CCCCHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
GRREFFTALPHAGFAEPVRVRTYQGRPLFLVPQGEAMGPYPLAGLYSLYDPARRGKAPDW
CHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHCHHHCCCCCCC
EGFYAAWREALAQGETLFVLPRTTSPRLEALLQRAQARYPNLRVARFEAWSLENVYRGAE
CHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCH
LAFGQRAWPVYSPEKAETVLLLDVDLHEHPAGYGWWAALSQRRLPPMNRIYAVESGAGLL
HCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCHHEEEECCCCCHH
GAMADHRLALKPSALEAFLLDLAKALGVLPGSPASDYGGFLPALVEDLERGGLLLPGVHL
HHHHCCCEEECHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHCCEECCCCCC
TPAAQALAMAVNARLKAPVAYVPPLEAEPATPRAFLEAEAASRLVWAAEGPLPGLEGKAF
CHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCHHH
AAVLSLYPKEAPHSLPLAHPLEAASPARDAWGRLWPAQALLKPLYGGKSLEEVLAGLLGE
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCC
GLPGLTDEERRALAEGRPLEEAKPLALEPLPGLEGRLSPLRREAPLELTLRPDARLFDGR
CCCCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCHHHCCCCEEEEECCCCHHHCCC
YRENPYLQELPRPLSLLVWDGALLAGEREAEAWGLLEGIRARERRADPRRPLLRVRASGR
CCCCCCHHHCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCCC
EALLPLWPLPLLPEGSLVAPLSHFFHPEGTVFPAEVLPTGRDYPLVSTQYHGYLGEVEAV
CEECEECCCCCCCCCCCHHHHHHHHCCCCCEECHHHCCCCCCCCEEECCCCCCCCCHHHH
KVLTEEEARKAQPKEEKRVSFYPPWPQGEHAWAMTVDLARCVGCGLCVLACQVENNIPVV
HHHHHHHHHHCCCCHHCCEEECCCCCCCCCCEEEHHHHHHHHHCCEEEEEEEECCCCCEE
GKEEVGKGREMHWIRLDRYFAEEGVFHQPVMCQHCEKAPCEAVCPVAATEHSPEGLNLMV
CHHHCCCCCCEEEEEHHHHHHHCCCCCCCHHHHHHCCCCCHHCCCCCCCCCCCCCCEEEE
YNRCVGTKYCSANCPYKARRFNFFPYAEAFIGQGDPRRAKESPLALLMNPEVTVRSRGVM
EECCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCCCCCCCCEEEEECCCEEECCCCHH
EKCTYCVQRIELARAEAAREGRRIRTGEVVTACQEVCPGRAIHFGDLLDPEDPIHAHREE
HHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHC
GRHYVLLEEVNTWPRTTYLAHLKNPNPRLRKEGGHA
CCEEEEEECCCCCCCEEEEEEECCCCHHHCCCCCCC
>Mature Secondary Structure
MRRGPQEALERGLFREEFPFGPVTRRGFLALGLVSLAACTPVVRRKGVPYVRQPEGVVEG
CCCCHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
GRREFFTALPHAGFAEPVRVRTYQGRPLFLVPQGEAMGPYPLAGLYSLYDPARRGKAPDW
CHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHCHHHCCCCCCC
EGFYAAWREALAQGETLFVLPRTTSPRLEALLQRAQARYPNLRVARFEAWSLENVYRGAE
CHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCH
LAFGQRAWPVYSPEKAETVLLLDVDLHEHPAGYGWWAALSQRRLPPMNRIYAVESGAGLL
HCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCHHEEEECCCCCHH
GAMADHRLALKPSALEAFLLDLAKALGVLPGSPASDYGGFLPALVEDLERGGLLLPGVHL
HHHHCCCEEECHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHCCEECCCCCC
TPAAQALAMAVNARLKAPVAYVPPLEAEPATPRAFLEAEAASRLVWAAEGPLPGLEGKAF
CHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCHHH
AAVLSLYPKEAPHSLPLAHPLEAASPARDAWGRLWPAQALLKPLYGGKSLEEVLAGLLGE
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCC
GLPGLTDEERRALAEGRPLEEAKPLALEPLPGLEGRLSPLRREAPLELTLRPDARLFDGR
CCCCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCHHHCCCCEEEEECCCCHHHCCC
YRENPYLQELPRPLSLLVWDGALLAGEREAEAWGLLEGIRARERRADPRRPLLRVRASGR
CCCCCCHHHCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCCC
EALLPLWPLPLLPEGSLVAPLSHFFHPEGTVFPAEVLPTGRDYPLVSTQYHGYLGEVEAV
CEECEECCCCCCCCCCCHHHHHHHHCCCCCEECHHHCCCCCCCCEEECCCCCCCCCHHHH
KVLTEEEARKAQPKEEKRVSFYPPWPQGEHAWAMTVDLARCVGCGLCVLACQVENNIPVV
HHHHHHHHHHCCCCHHCCEEECCCCCCCCCCEEEHHHHHHHHHCCEEEEEEEECCCCCEE
GKEEVGKGREMHWIRLDRYFAEEGVFHQPVMCQHCEKAPCEAVCPVAATEHSPEGLNLMV
CHHHCCCCCCEEEEEHHHHHHHCCCCCCCHHHHHHCCCCCHHCCCCCCCCCCCCCCEEEE
YNRCVGTKYCSANCPYKARRFNFFPYAEAFIGQGDPRRAKESPLALLMNPEVTVRSRGVM
EECCCCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCCCCCCCCEEEEECCCEEECCCCHH
EKCTYCVQRIELARAEAAREGRRIRTGEVVTACQEVCPGRAIHFGDLLDPEDPIHAHREE
HHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHC
GRHYVLLEEVNTWPRTTYLAHLKNPNPRLRKEGGHA
CCEEEEEECCCCCCCEEEEEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9389475; 11952791 [H]