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The map label for this gene is gpsA

Identifier: 55981709

GI number: 55981709

Start: 1629623

End: 1630591

Strand: Reverse

Name: gpsA

Synonym: TTHA1740

Alternate gene names: 55981709

Gene position: 1630591-1629623 (Counterclockwise)

Preceding gene: 55981710

Following gene: 55981708

Centisome position: 88.15

GC content: 73.79

Gene sequence:

>969_bases
ATGAGGGTGGCGGTCCTGGGCGCGGGGGCCTGGGGGACGGCCTTGGCCGTCCTCCTCGCCAGCAAAGGGGTGCCCACCCG
GCTTTGGGCCCGGCGGAAGGCGCAGGCGGAGGCCTTGAAGGCCATGCGGGAGAACCGGGACTACCTCCCTGGGGTGGCCC
TCCCGGCCTACCTCTACCCCACCCATGACCCTGAGGAGGCCTTGGAGGGGGCGGAGCTCGCCGTGCTGGCGGTGCCCTCC
AAGGCCCTCCGGGAGACCGTGGCCGGCCTTCCCCCGGCTCCCTGGTACGTCTCCGCCACCAAGGGCCTCTTTTACGGGGA
GGAGGGGGTCCGGACGCCCGCGGAGGTGGTGGAGGCCCTGACCCAAAGGCCCGTGGTGGCCCTTTCCGGGCCCAACCACG
CCGAGGAGGTGGCCCGCTTCCTCCCCACGGCGAGCGTGGCCGCGGGGCCGGAAGACCTCGCCCGGCGGGTCCAGGCCCTC
TTCTCCGGGCCCACCTTCCGGGTCTACACCAGCCGGGACCGGCGGGGGGTGGAGCTTGGGGGGGCGGTGAAGAACGTCCT
GGCCCTGGCGGCGGGCATGGTGGACGGGCTTAGGCTCGGGGACAACGCCAAGGCCGCCCTCCTCACCCGGGGCCTTAAGG
AGATGGTCCGCTTCGGCACCGCGCTTGGGGGGGAGGAGGCCACCTTCTACGGGCTTGCGGGCCTCGGGGACCTCCTGGCC
ACGGCCTACAGCCTCCACTCCCGCAACCGCATGGCGGGGGAGAGCCTGGTGCGGGGGGTGGACCGGGAGGCCCTCGAGGC
CCGGGGGGTGGTGGAGGGGCTTTACGCGGTGAAGGCCATGGTGGCCTGGGGGAAGGAGCAGGGGGTGGAGCTCCCCGTGG
CCGAGGCGGTCCACCGGGTGGCCCACGAGGGCCTGGACCCCCTGGCGGCCCTAAAGGCCCTCATGGCCCGGGAGCCCAAG
GAGGAGTGA

Upstream 100 bases:

>100_bases
ACCGGGAGGGGCTTAAGGGACTTCTCCTGGCCTTTTACTTGGGGGCCCTCTTCCTCCTCGCCGCCGCCTGGTACGAGGCC
TGGGAGGTGGTCTTCCTCCT

Downstream 100 bases:

>100_bases
GGCCACCCCATGCCGGCGCAAGCCGGCATGGGGGCCCCGGCAAAGGGTTTTCAAGGGGCTTCCTCGGGCCAGCCGGGCGA
AGGAAGCGAAAGGGGAGGGG

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MRVAVLGAGAWGTALAVLLASKGVPTRLWARRKAQAEALKAMRENRDYLPGVALPAYLYPTHDPEEALEGAELAVLAVPS
KALRETVAGLPPAPWYVSATKGLFYGEEGVRTPAEVVEALTQRPVVALSGPNHAEEVARFLPTASVAAGPEDLARRVQAL
FSGPTFRVYTSRDRRGVELGGAVKNVLALAAGMVDGLRLGDNAKAALLTRGLKEMVRFGTALGGEEATFYGLAGLGDLLA
TAYSLHSRNRMAGESLVRGVDREALEARGVVEGLYAVKAMVAWGKEQGVELPVAEAVHRVAHEGLDPLAALKALMAREPK
EE

Sequences:

>Translated_322_residues
MRVAVLGAGAWGTALAVLLASKGVPTRLWARRKAQAEALKAMRENRDYLPGVALPAYLYPTHDPEEALEGAELAVLAVPS
KALRETVAGLPPAPWYVSATKGLFYGEEGVRTPAEVVEALTQRPVVALSGPNHAEEVARFLPTASVAAGPEDLARRVQAL
FSGPTFRVYTSRDRRGVELGGAVKNVLALAAGMVDGLRLGDNAKAALLTRGLKEMVRFGTALGGEEATFYGLAGLGDLLA
TAYSLHSRNRMAGESLVRGVDREALEARGVVEGLYAVKAMVAWGKEQGVELPVAEAVHRVAHEGLDPLAALKALMAREPK
EE
>Mature_322_residues
MRVAVLGAGAWGTALAVLLASKGVPTRLWARRKAQAEALKAMRENRDYLPGVALPAYLYPTHDPEEALEGAELAVLAVPS
KALRETVAGLPPAPWYVSATKGLFYGEEGVRTPAEVVEALTQRPVVALSGPNHAEEVARFLPTASVAAGPEDLARRVQAL
FSGPTFRVYTSRDRRGVELGGAVKNVLALAAGMVDGLRLGDNAKAALLTRGLKEMVRFGTALGGEEATFYGLAGLGDLLA
TAYSLHSRNRMAGESLVRGVDREALEARGVVEGLYAVKAMVAWGKEQGVELPVAEAVHRVAHEGLDPLAALKALMAREPK
EE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI24307999, Length=350, Percent_Identity=26.2857142857143, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI33695088, Length=348, Percent_Identity=29.0229885057471, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI1790037, Length=329, Percent_Identity=40.4255319148936, Blast_Score=194, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI32564403, Length=352, Percent_Identity=29.5454545454545, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI193210136, Length=352, Percent_Identity=29.5454545454545, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32564399, Length=343, Percent_Identity=29.7376093294461, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17507425, Length=348, Percent_Identity=27.0114942528736, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193210134, Length=338, Percent_Identity=27.5147928994083, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320181, Length=353, Percent_Identity=28.6118980169972, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6324513, Length=343, Percent_Identity=27.6967930029155, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17136204, Length=336, Percent_Identity=28.2738095238095, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17136202, Length=336, Percent_Identity=28.2738095238095, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17136200, Length=336, Percent_Identity=28.2738095238095, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI22026922, Length=278, Percent_Identity=25.8992805755396, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551945, Length=341, Percent_Identity=27.2727272727273, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281362270, Length=287, Percent_Identity=27.8745644599303, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648969, Length=300, Percent_Identity=28.6666666666667, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_THET2 (P61747)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005347.1
- ProteinModelPortal:   P61747
- STRING:   P61747
- GeneID:   2775037
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   P61747
- ProtClustDB:   PRK14618
- BioCyc:   TTHE262724:TT_C1378-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34103; Mature: 34103

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 184-184 BINDING 101-101 BINDING 101-101 BINDING 134-134 BINDING 248-248 BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAVLGAGAWGTALAVLLASKGVPTRLWARRKAQAEALKAMRENRDYLPGVALPAYLYP
CEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECC
THDPEEALEGAELAVLAVPSKALRETVAGLPPAPWYVSATKGLFYGEEGVRTPAEVVEAL
CCCHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCCHHHHHHHH
TQRPVVALSGPNHAEEVARFLPTASVAAGPEDLARRVQALFSGPTFRVYTSRDRRGVELG
HHCCEEEECCCCHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
GAVKNVLALAAGMVDGLRLGDNAKAALLTRGLKEMVRFGTALGGEEATFYGLAGLGDLLA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TAYSLHSRNRMAGESLVRGVDREALEARGVVEGLYAVKAMVAWGKEQGVELPVAEAVHRV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AHEGLDPLAALKALMAREPKEE
HHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRVAVLGAGAWGTALAVLLASKGVPTRLWARRKAQAEALKAMRENRDYLPGVALPAYLYP
CEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECC
THDPEEALEGAELAVLAVPSKALRETVAGLPPAPWYVSATKGLFYGEEGVRTPAEVVEAL
CCCHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCEEECCCCCEECCCCCCCHHHHHHHH
TQRPVVALSGPNHAEEVARFLPTASVAAGPEDLARRVQALFSGPTFRVYTSRDRRGVELG
HHCCEEEECCCCHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
GAVKNVLALAAGMVDGLRLGDNAKAALLTRGLKEMVRFGTALGGEEATFYGLAGLGDLLA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TAYSLHSRNRMAGESLVRGVDREALEARGVVEGLYAVKAMVAWGKEQGVELPVAEAVHRV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AHEGLDPLAALKALMAREPKEE
HHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA