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The map label for this gene is ubiE [C]

Identifier: 55981698

GI number: 55981698

Start: 1621904

End: 1622566

Strand: Reverse

Name: ubiE [C]

Synonym: TTHA1729

Alternate gene names: 55981698

Gene position: 1622566-1621904 (Counterclockwise)

Preceding gene: 55981708

Following gene: 55981683

Centisome position: 87.72

GC content: 68.93

Gene sequence:

>663_bases
GTGCTTTGGCGAAAACGTCTTTTTGCCCACCTTTACCCCGGCCTTTCCGCCCGGCACGAGGCGTTGGTGGCGGAAAGGAA
GCGGGCCCTTTTTCGGGAGGCCCTTAGGCGGGCGCGGCCGGAAAGGGTTCTGGAGATCGGTCCCGGGCCCGGAACCAATC
TGGCCCACCTGCCCGAGGGGGTGGCGTACCTGGCCCTCGAGCCCAACCCTTTCTTCCACCCCCGCCTAAGGGAGGAGGCG
AGGAAGCGGGGCCTCGCCCTTACCCTGCTCCCCGGGCGGGCCGAGGCCATTCCCCTCCCCGGGGGAAGCGTGGACCTGGT
GGTGGCCACCCTGGTCCTCTGCTCCGTGGCGGACCCCGAAAAGGCCATAGAAGAGGTCCACCGGGTCTTGCGGCCGGGCG
GGGCCTACCTCTTCCTGGAGCACGTGGCGGCCCCCAAGCGGACCCCCCTGCGCTTCCTCCAGGAGGTGGCCACACCCTTC
TTCGCCTTCTTCGGGGACGGGTGCCACCCGAACCGCGAGACCCTCGCCCTAATCCAGGCCCGCTTTCCCCGGGTGGAGGC
GGAAGCCTTTCCCCTCCCCCTTCCCGTGGTGGCCCCTCACGTGGCGGGGCTCGCCTTCAAGGAAGGAGGGTCCGGAGGTA
GCCTTCAAGGTCCTTGGGCTTAA

Upstream 100 bases:

>100_bases
TGCCCATCGTTCACCTCCACCTATACCCTAGCCCGGTATTGTTAAGCTTGCGTAAAGCGCGCTTAGTCCGGGCTTACCGG
GGCCGGAGTATGGTGGAGGC

Downstream 100 bases:

>100_bases
GCTCCCCCACGTGACGGGCCTGGACGCGGCCCTCCGGGTCTATGAAAAAGGTTTCGGGAAGGCCGTAGACCCCATAGTCA
ATCCCCACCCGGCCCCTGGG

Product: methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: Methyltransferase; SAM-Dependent Methyltransferase; Methyltransferase UbiE/COQ5 Family; UbiE/COQ5 Family Methlytransferase; Ubiquinone/Menaquinone Biosynthesis Methyltransferase; Methyltransferase Domain Family; Ubiquinone/Menaquinone Biosynthesis Methyltransferase UbiE; Phosphatidylethanolamine N-Methyltransferase; Methylase Involved In Ubiquinone/Menaquinone Biosynthesis; Generic Methyltransferase; SAM-Dependent Methyltransferase UbiE/COQ5 Family; Ubiquinone/Menaquinone Biosynthesis Methyl Transferase; UbiE/COQ5 Methyltransferase; Sam Dependent Methyltransferase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MLWRKRLFAHLYPGLSARHEALVAERKRALFREALRRARPERVLEIGPGPGTNLAHLPEGVAYLALEPNPFFHPRLREEA
RKRGLALTLLPGRAEAIPLPGGSVDLVVATLVLCSVADPEKAIEEVHRVLRPGGAYLFLEHVAAPKRTPLRFLQEVATPF
FAFFGDGCHPNRETLALIQARFPRVEAEAFPLPLPVVAPHVAGLAFKEGGSGGSLQGPWA

Sequences:

>Translated_220_residues
MLWRKRLFAHLYPGLSARHEALVAERKRALFREALRRARPERVLEIGPGPGTNLAHLPEGVAYLALEPNPFFHPRLREEA
RKRGLALTLLPGRAEAIPLPGGSVDLVVATLVLCSVADPEKAIEEVHRVLRPGGAYLFLEHVAAPKRTPLRFLQEVATPF
FAFFGDGCHPNRETLALIQARFPRVEAEAFPLPLPVVAPHVAGLAFKEGGSGGSLQGPWA
>Mature_220_residues
MLWRKRLFAHLYPGLSARHEALVAERKRALFREALRRARPERVLEIGPGPGTNLAHLPEGVAYLALEPNPFFHPRLREEA
RKRGLALTLLPGRAEAIPLPGGSVDLVVATLVLCSVADPEKAIEEVHRVLRPGGAYLFLEHVAAPKRTPLRFLQEVATPF
FAFFGDGCHPNRETLALIQARFPRVEAEAFPLPLPVVAPHVAGLAFKEGGSGGSLQGPWA

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI89145417, Length=212, Percent_Identity=36.3207547169811, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI164663805, Length=213, Percent_Identity=38.4976525821596, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.- [C]

Molecular weight: Translated: 24110; Mature: 24110

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWRKRLFAHLYPGLSARHEALVAERKRALFREALRRARPERVLEIGPGPGTNLAHLPEG
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
VAYLALEPNPFFHPRLREEARKRGLALTLLPGRAEAIPLPGGSVDLVVATLVLCSVADPE
EEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCHH
KAIEEVHRVLRPGGAYLFLEHVAAPKRTPLRFLQEVATPFFAFFGDGCHPNRETLALIQA
HHHHHHHHHHCCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RFPRVEAEAFPLPLPVVAPHVAGLAFKEGGSGGSLQGPWA
HCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MLWRKRLFAHLYPGLSARHEALVAERKRALFREALRRARPERVLEIGPGPGTNLAHLPEG
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
VAYLALEPNPFFHPRLREEARKRGLALTLLPGRAEAIPLPGGSVDLVVATLVLCSVADPE
EEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCHH
KAIEEVHRVLRPGGAYLFLEHVAAPKRTPLRFLQEVATPFFAFFGDGCHPNRETLALIQA
HHHHHHHHHHCCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RFPRVEAEAFPLPLPVVAPHVAGLAFKEGGSGGSLQGPWA
HCCCCCCCCCCCCCCHHHHHHHHEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA