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The map label for this gene is mutS2 [H]

Identifier: 55981614

GI number: 55981614

Start: 1559701

End: 1561935

Strand: Reverse

Name: mutS2 [H]

Synonym: TTHA1645

Alternate gene names: 55981614

Gene position: 1561935-1559701 (Counterclockwise)

Preceding gene: 55981615

Following gene: 55981611

Centisome position: 84.44

GC content: 70.51

Gene sequence:

>2235_bases
GTGCGGGACGTCCTCGAGGTCCTGGAGTTCCCCCGGGTCCGGGCCCTGCTGGCGGAGAGGGCCAAGACCCCCCTGGGCCG
GGAGCTTGCCCTGGCCCTCGCGCCCCTTCCCCGGGAAGAGGCGGAGAAGCGGCACGAGCTCACGGGGGAGGCCCTAAGCT
ACCCCTACGCCCTCCCCGAGGCGGGGACCTTAAGGGAGGCCTACGGGAGGGCCCTCGCGGGGGCGAGGCTTTCCGGCCCC
GAGCTCCTAAAGGCGGCCAAGGCCCTGGAGGAGGCCATGGCCCTGAAGGAGGAGCTCCTTCCCCTGAAAAACGCCTTAAG
CCAGGTGGCGGAGGGCATCGGGGACCACACCCCCTTCCTGGAGCGGGTGAGGAAGGCCCTGGACGAGGAGGGGGCGGTGA
AGGACGAGGCGAGCCCGAGGCTTGCCCAGATCCGAAGGGAGCTTAGGCCCCTCCGCCAGCAGATCCTGGACCGCCTCTAC
GCCCTCATGGACCGCCACAGGGAGGCCTTCCAGGACCGCTTCGTCACCTTAAGGCGGGAGCGCTACTGCGTCCCCGTGAG
GGCGGGGATGGCCCAGAAGGTGCCGGGGATCCTCCTGGACGAGTCCGAGTCGGGGGCGACCCTCTTCATAGAGCCCTTCT
CCGTGGTCAAGCTCAACAACCGCCTCCAGGCCCTGAGGCTAAAGGAGGAGGAGGAGGTGAACCGCATCCTCCGGGACCTC
TCCGAGAGGCTCGCCAAGGACGAGGGGGTGCCGAAGACCCTGGAGGCCCTGGGCCTTTTGGACCTCGTCCAGGCCCAGGC
CGCCTTGGCCCGGGACCTGGGGCTTTCCCGCCCCGCTTTCGGGGAGCGGTACGAGCTCTACCGGGCCTTTCACCCCCTGA
TCCCGGACGCCGTGCGGAACTCCTTCGCCCTGGACGAGAAAAACCGCATCCTCCTCATCTCCGGTCCCAACATGGGGGGA
AAGACCGCCCTCCTCAAGACCCTGGGCCTCGCTGTCCTCATGGCCCAGTCCGGCCTCTTCGTGGCGGCGGAGAAGGCCCT
TTTGGCCTGGCCCGACCGGGTCTATGCCGACATCGGGGACGAGCAGTCCCTTCAGGAGAACCTCTCCACCTTCGCCGGGC
ACTTAAGGCGCCTCAGGGAGATGCTGGAGGAGGCCACCTCCCATAGCCTCGTCCTCATTGACGAGCTCGGAAGCGGCACC
GACCCCGAGGAGGGGGCGGCCCTTTCCCAGGCCATCCTGGAGGCCCTCCTGGAGAGGGGGGTCAAGGGGATGGTCACCAC
CCACCTCTCCCCCCTGAAGGCCTTCGCCCAGGGAAGGGAGGGGATCCAGAACGCCTCCATGCGCTTTGACCTCGAGGCCC
TCCGCCCCACCTACGAGCTCGTCCTCGGGGTGCCGGGGCGGAGCTACGCCTTGGCCATCGCGAGGAGGCTCGCCCTCCCC
GAGGAGGTCCTCAAGCGGGCCGAGGCCCTTCTGCCCGAGGGGGGGAGGCTGGAGGCCCTTCTGGAGAGGCTCGAGGCCGA
GCGCCTGGCCCTGGAGGCGGAGCGGGAGCGCCTGAGGCGGGAGCTTTCCCAGGTGGAGAGGCTGCGCAAGGCCCTGGCCG
AGCGGGAGGCCCGCTTTGAGGAGGAGCGGGCGGAAAGGCTCAAGGCCCTCGAGGAGGAGGTGCGGGCCGAGCTCCTCAAG
GTGGAGGCCGAGCTCAAGGCCCTCAAGGAGAAGGCCCGGACCGAGGGCAAGCGGGACGCCCTCCGGGAGCTCATGGCCCT
CCGGGAGCGCTACGCCAAGAAGGCCCCGCCGCCCCCGCCTCCCCCGGGCCTCGCCCCCGGGGTCTTGGTGGAGGTGCCCT
CCTTGGGCAAACGGGGCCGGGTGGTGGAGCTCAGGGGGGAGGAGGTCCTGGTCCAGGTGGGCCCCCTGAAGATGAGCCTC
AAGCCCCAGGAGGTGAAGCCCCTTCCCGAGGCCGAACCGGGCAAGCCCCTCCTCGCCAAGCCCCGACGGGAGGTGAAGGA
GGTGGACCTCCGGGGCCTCACGGTGGCCGAGGCCCTCCTGGAGGTGGACCAGGCCCTGGAGGAGGCGCGGGCCCTGGGCC
TTTCCACCCTCCGCCTCCTCCACGGCAAGGGGACGGGGGCCTTAAGGCAGGCCATCCGGGAGGCCCTCCGCCGGGACAAG
CGGGTGGAAAGCTTCGCCGACGCCCCGCCCGGCGAGGGGGGGCATGGGGTTACCGTGGTGGCGCTTCGGCCTTGA

Upstream 100 bases:

>100_bases
CTTCTAGCGGCCAAGGGGGCTCAGCTCGCGGCGAAGAAGGAGGTTCTTTCCCTGCTCCTTAAGCTCCTGAAGCGCTAAGC
CCGGGGTATACTCTTTCTTT

Downstream 100 bases:

>100_bases
GGGCCTGGACCACCTCCTCAGGCTCGTCCGTCAGGCGGAAGAGCTGGAGGTCCTCCGGCCCCACGGCCTTTTGGTCCCGG
AGGAAGGCGAGCCAGCGGAC

Product: MutS2 protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 744; Mature: 744

Protein sequence:

>744_residues
MRDVLEVLEFPRVRALLAERAKTPLGRELALALAPLPREEAEKRHELTGEALSYPYALPEAGTLREAYGRALAGARLSGP
ELLKAAKALEEAMALKEELLPLKNALSQVAEGIGDHTPFLERVRKALDEEGAVKDEASPRLAQIRRELRPLRQQILDRLY
ALMDRHREAFQDRFVTLRRERYCVPVRAGMAQKVPGILLDESESGATLFIEPFSVVKLNNRLQALRLKEEEEVNRILRDL
SERLAKDEGVPKTLEALGLLDLVQAQAALARDLGLSRPAFGERYELYRAFHPLIPDAVRNSFALDEKNRILLISGPNMGG
KTALLKTLGLAVLMAQSGLFVAAEKALLAWPDRVYADIGDEQSLQENLSTFAGHLRRLREMLEEATSHSLVLIDELGSGT
DPEEGAALSQAILEALLERGVKGMVTTHLSPLKAFAQGREGIQNASMRFDLEALRPTYELVLGVPGRSYALAIARRLALP
EEVLKRAEALLPEGGRLEALLERLEAERLALEAERERLRRELSQVERLRKALAEREARFEEERAERLKALEEEVRAELLK
VEAELKALKEKARTEGKRDALRELMALRERYAKKAPPPPPPPGLAPGVLVEVPSLGKRGRVVELRGEEVLVQVGPLKMSL
KPQEVKPLPEAEPGKPLLAKPRREVKEVDLRGLTVAEALLEVDQALEEARALGLSTLRLLHGKGTGALRQAIREALRRDK
RVESFADAPPGEGGHGVTVVALRP

Sequences:

>Translated_744_residues
MRDVLEVLEFPRVRALLAERAKTPLGRELALALAPLPREEAEKRHELTGEALSYPYALPEAGTLREAYGRALAGARLSGP
ELLKAAKALEEAMALKEELLPLKNALSQVAEGIGDHTPFLERVRKALDEEGAVKDEASPRLAQIRRELRPLRQQILDRLY
ALMDRHREAFQDRFVTLRRERYCVPVRAGMAQKVPGILLDESESGATLFIEPFSVVKLNNRLQALRLKEEEEVNRILRDL
SERLAKDEGVPKTLEALGLLDLVQAQAALARDLGLSRPAFGERYELYRAFHPLIPDAVRNSFALDEKNRILLISGPNMGG
KTALLKTLGLAVLMAQSGLFVAAEKALLAWPDRVYADIGDEQSLQENLSTFAGHLRRLREMLEEATSHSLVLIDELGSGT
DPEEGAALSQAILEALLERGVKGMVTTHLSPLKAFAQGREGIQNASMRFDLEALRPTYELVLGVPGRSYALAIARRLALP
EEVLKRAEALLPEGGRLEALLERLEAERLALEAERERLRRELSQVERLRKALAEREARFEEERAERLKALEEEVRAELLK
VEAELKALKEKARTEGKRDALRELMALRERYAKKAPPPPPPPGLAPGVLVEVPSLGKRGRVVELRGEEVLVQVGPLKMSL
KPQEVKPLPEAEPGKPLLAKPRREVKEVDLRGLTVAEALLEVDQALEEARALGLSTLRLLHGKGTGALRQAIREALRRDK
RVESFADAPPGEGGHGVTVVALRP
>Mature_744_residues
MRDVLEVLEFPRVRALLAERAKTPLGRELALALAPLPREEAEKRHELTGEALSYPYALPEAGTLREAYGRALAGARLSGP
ELLKAAKALEEAMALKEELLPLKNALSQVAEGIGDHTPFLERVRKALDEEGAVKDEASPRLAQIRRELRPLRQQILDRLY
ALMDRHREAFQDRFVTLRRERYCVPVRAGMAQKVPGILLDESESGATLFIEPFSVVKLNNRLQALRLKEEEEVNRILRDL
SERLAKDEGVPKTLEALGLLDLVQAQAALARDLGLSRPAFGERYELYRAFHPLIPDAVRNSFALDEKNRILLISGPNMGG
KTALLKTLGLAVLMAQSGLFVAAEKALLAWPDRVYADIGDEQSLQENLSTFAGHLRRLREMLEEATSHSLVLIDELGSGT
DPEEGAALSQAILEALLERGVKGMVTTHLSPLKAFAQGREGIQNASMRFDLEALRPTYELVLGVPGRSYALAIARRLALP
EEVLKRAEALLPEGGRLEALLERLEAERLALEAERERLRRELSQVERLRKALAEREARFEEERAERLKALEEEVRAELLK
VEAELKALKEKARTEGKRDALRELMALRERYAKKAPPPPPPPGLAPGVLVEVPSLGKRGRVVELRGEEVLVQVGPLKMSL
KPQEVKPLPEAEPGKPLLAKPRREVKEVDLRGLTVAEALLEVDQALEEARALGLSTLRLLHGKGTGALRQAIREALRRDK
RVESFADAPPGEGGHGVTVVALRP

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=424, Percent_Identity=27.3584905660377, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI36949366, Length=320, Percent_Identity=27.1875, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI4504191, Length=192, Percent_Identity=34.375, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI26638666, Length=265, Percent_Identity=33.2075471698113, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI4505253, Length=265, Percent_Identity=33.2075471698113, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI4557761, Length=199, Percent_Identity=32.1608040201005, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI26638664, Length=266, Percent_Identity=33.0827067669173, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI262231786, Length=192, Percent_Identity=36.4583333333333, Blast_Score=96, Evalue=2e-19,
Organism=Escherichia coli, GI1789089, Length=255, Percent_Identity=30.5882352941176, Blast_Score=109, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17534743, Length=408, Percent_Identity=25, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17508445, Length=222, Percent_Identity=29.2792792792793, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508447, Length=189, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539736, Length=261, Percent_Identity=25.6704980842912, Blast_Score=88, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324482, Length=252, Percent_Identity=27.7777777777778, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321912, Length=499, Percent_Identity=25.250501002004, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319935, Length=404, Percent_Identity=24.2574257425743, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320047, Length=240, Percent_Identity=26.25, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=188, Percent_Identity=27.6595744680851, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321109, Length=279, Percent_Identity=21.1469534050179, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24584320, Length=191, Percent_Identity=31.413612565445, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664545, Length=321, Percent_Identity=27.4143302180685, Blast_Score=106, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 82518; Mature: 82518

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDVLEVLEFPRVRALLAERAKTPLGRELALALAPLPREEAEKRHELTGEALSYPYALPE
CHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCC
AGTLREAYGRALAGARLSGPELLKAAKALEEAMALKEELLPLKNALSQVAEGIGDHTPFL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ERVRKALDEEGAVKDEASPRLAQIRRELRPLRQQILDRLYALMDRHREAFQDRFVTLRRE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYCVPVRAGMAQKVPGILLDESESGATLFIEPFSVVKLNNRLQALRLKEEEEVNRILRDL
CCEEEHHCCHHHHCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SERLAKDEGVPKTLEALGLLDLVQAQAALARDLGLSRPAFGERYELYRAFHPLIPDAVRN
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHH
SFALDEKNRILLISGPNMGGKTALLKTLGLAVLMAQSGLFVAAEKALLAWPDRVYADIGD
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCC
EQSLQENLSTFAGHLRRLREMLEEATSHSLVLIDELGSGTDPEEGAALSQAILEALLERG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
VKGMVTTHLSPLKAFAQGREGIQNASMRFDLEALRPTYELVLGVPGRSYALAIARRLALP
CCHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHCCHHHHHCCCCCCHHHHHHHHHHCCH
EEVLKRAEALLPEGGRLEALLERLEAERLALEAERERLRRELSQVERLRKALAEREARFE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EERAERLKALEEEVRAELLKVEAELKALKEKARTEGKRDALRELMALRERYAKKAPPPPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
PPGLAPGVLVEVPSLGKRGRVVELRGEEVLVQVGPLKMSLKPQEVKPLPEAEPGKPLLAK
CCCCCCCCEEECCCCCCCCCEEEECCCEEEEEECCEEECCCHHHCCCCCCCCCCCCCCCC
PRREVKEVDLRGLTVAEALLEVDQALEEARALGLSTLRLLHGKGTGALRQAIREALRRDK
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RVESFADAPPGEGGHGVTVVALRP
HHHHHCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRDVLEVLEFPRVRALLAERAKTPLGRELALALAPLPREEAEKRHELTGEALSYPYALPE
CHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCC
AGTLREAYGRALAGARLSGPELLKAAKALEEAMALKEELLPLKNALSQVAEGIGDHTPFL
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ERVRKALDEEGAVKDEASPRLAQIRRELRPLRQQILDRLYALMDRHREAFQDRFVTLRRE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYCVPVRAGMAQKVPGILLDESESGATLFIEPFSVVKLNNRLQALRLKEEEEVNRILRDL
CCEEEHHCCHHHHCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SERLAKDEGVPKTLEALGLLDLVQAQAALARDLGLSRPAFGERYELYRAFHPLIPDAVRN
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHH
SFALDEKNRILLISGPNMGGKTALLKTLGLAVLMAQSGLFVAAEKALLAWPDRVYADIGD
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCC
EQSLQENLSTFAGHLRRLREMLEEATSHSLVLIDELGSGTDPEEGAALSQAILEALLERG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
VKGMVTTHLSPLKAFAQGREGIQNASMRFDLEALRPTYELVLGVPGRSYALAIARRLALP
CCHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHCCHHHHHCCCCCCHHHHHHHHHHCCH
EEVLKRAEALLPEGGRLEALLERLEAERLALEAERERLRRELSQVERLRKALAEREARFE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EERAERLKALEEEVRAELLKVEAELKALKEKARTEGKRDALRELMALRERYAKKAPPPPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
PPGLAPGVLVEVPSLGKRGRVVELRGEEVLVQVGPLKMSLKPQEVKPLPEAEPGKPLLAK
CCCCCCCCEEECCCCCCCCCEEEECCCEEEEEECCEEECCCHHHCCCCCCCCCCCCCCCC
PRREVKEVDLRGLTVAEALLEVDQALEEARALGLSTLRLLHGKGTGALRQAIREALRRDK
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RVESFADAPPGEGGHGVTVVALRP
HHHHHCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA