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The map label for this gene is speA [H]

Identifier: 55981609

GI number: 55981609

Start: 1553871

End: 1555757

Strand: Direct

Name: speA [H]

Synonym: TTHA1640

Alternate gene names: 55981609

Gene position: 1553871-1555757 (Clockwise)

Preceding gene: 55981608

Following gene: 55981610

Centisome position: 84.0

GC content: 68.31

Gene sequence:

>1887_bases
GTGGCCAAGCGCTTCACCCTTAAGGACGCGGAGGAGCTTTACCTGGTGCCCCACTGGAGCGGGGGCTTCTTCCGGGTGGG
GGAGAAGGGGGATCTGGAGGTCACCCCCTTGGGCCCCAAGGGCCCCGCGGCCTCCCTCCTGGAGATCGTGGAGGCCTTGA
GGGACGAGGGTAGGCCCCTGCCCCTCGTGCTCCGCTTTCCCCAGATCCTCGAGGCCCGGGTCCGGGACCTCAACGAGGCC
TTCCTGGAGGCCATGGCGAAGTACGGCTACCAGGGCACCTACCGGGGGGTCTACCCGGTGAAGGTGAACCAGCGCCGCCT
GGTCCTGGAGACCGTGGCCCGGGCGGGGAGGCCCTACCACCTCGGCCTCGAGGCGGGGAGCAAGCCCGAGCTCGCCCTCA
TCCTGGCCCAGGACCTCTCCGAGGAGGCCCTCATCACCACCAACGGCTTCAAGGACGACGACTTCGTCCGCCTCGCCCTC
ATGGGGAGGAAGCTTGGCCGCAACGTGGTGATCACCCTGGAAAAGTTCGCCGAGCTCTTTCGGGTCCTCCGCCTCTCCAA
GGAGCTCGGCGTGAAGCCCCTTTTGGGCATCCGCTACAAGCTCAAGGCCAAGGGGGCGGGGCAGTGGGAGGCCTCCGGGG
GCGAGAACGCCAAGTTCGGCCTCACCACCCCGGAGATCGTGCGGGCGGTGGAGGTCCTCCAAGAGGAGGGCCTCCTGGAC
GCCCTGGTGATGCTCCACGCCCACATCGGCAGCCAGGTCACGGACATCCGCCGGATCAAGGCCGCGGTGCGGGAGGCGGC
CCAGACCTACGTCCAGCTCCGGAAGCTCGGGGCCCCCCTCCGCTACCTCAACCTGGGCGGGGGCCTGGCCGTGGACTACG
ACGGCTCCAAGACCAACTTCTACGCCTCGGCCAACTACACCCTCTCCGAGTACGCCGAGAACCTGGTCTACGTCACCAAG
GAGGTGGTGGAGGCCCAGGGCGAGCCCCACCCCATCCTGGTCACCGAAAGCGGGCGGGCCATCACCGCCTACCACGAGGT
CCTGGTCCTCCAGGTCATTGACGTCATCGCCCCGCCCGGGGAGGCGCGGCCAAGCCCCCCGCCCCCCGAGGCCCACCCCC
TGGTGAAGGAGCTCTGGGAGAGCCTGCAAAGCCTCTCCCCCAAGAACTTCCAGGAGGTCTACCACGACGCCTTCGCCGAC
AAGGAGACCCTCCAGACCCTCTACGACCTGGGCCTGGTCTCCCTGCGGGACCGGGCCCTGGCGGAGGAGATCTTCTACCA
CATCGCCCGCCGGGTCCAGACCATCGCCCAGAACCTCCCCTACGTTCCCGACGAGCTGGAAGACCTGGAAAAGCTCCTCG
CCGACAAGCTGGTCTGCAACTTCTCCGTCTTTCAGAGCCTCCCCGACGCCTGGGCCATCCACCAGCTCTTCCCCGTGGTG
CCCCTCTCCCGCCTGCTGGAGCCCCCGACCCGGAGGGCCACCCTGGTGGACATCTCCTGCGACTCGGACGGCAAGATGGA
CCGCTTCATTGACCTCCACGACGTACGCCAGACCCTGCCTGTCCACCCCGTCCGCCCCGGGGAGCCCTACTACCTGGGGG
TCTTCCTGGTGGGGGCGTACCAGGACGTCCTGGGGAGCAACCACAACCTCTTCGGCCAGGTGGGGGAGGCCCACGTGCGG
GTGGAGGAGGAGGGCTTCGCCATAGAGCGCTTCGTGGGGGGGGAGACGGCGGAGCGGGTGATAGAGAAGATGGGCTTCAC
CGCCCGGGAGCTGATGCTCGGGGTGGAGCGCCTGGTGCGGCAAAGCCGCCTCTCCCCCGTGGAGAAGGGCGCCTTCCTGG
AGCGCTACGCCCGGGAGCTTCAGGGGTACACCTACCTGGAGGACTAA

Upstream 100 bases:

>100_bases
TCCCCCCGGGGAAGGGGTACGCCTACTTCGCCCCGGAGCGGGTCTTCCCAAACCCACCTCCTGGGCCTACACTCGGGGAG
GAGGTTGAGGGGCGTTGAAG

Downstream 100 bases:

>100_bases
GCCCCCGCCCTAACCCGTTAAGGCCCGGTTAAGGGGGGGCGTGGCAGGATGGGGCCATGGCCTCCTTGAAGGGCCGTTAT
ACTGGTCTTAACTTGTCCCC

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MAKRFTLKDAEELYLVPHWSGGFFRVGEKGDLEVTPLGPKGPAASLLEIVEALRDEGRPLPLVLRFPQILEARVRDLNEA
FLEAMAKYGYQGTYRGVYPVKVNQRRLVLETVARAGRPYHLGLEAGSKPELALILAQDLSEEALITTNGFKDDDFVRLAL
MGRKLGRNVVITLEKFAELFRVLRLSKELGVKPLLGIRYKLKAKGAGQWEASGGENAKFGLTTPEIVRAVEVLQEEGLLD
ALVMLHAHIGSQVTDIRRIKAAVREAAQTYVQLRKLGAPLRYLNLGGGLAVDYDGSKTNFYASANYTLSEYAENLVYVTK
EVVEAQGEPHPILVTESGRAITAYHEVLVLQVIDVIAPPGEARPSPPPPEAHPLVKELWESLQSLSPKNFQEVYHDAFAD
KETLQTLYDLGLVSLRDRALAEEIFYHIARRVQTIAQNLPYVPDELEDLEKLLADKLVCNFSVFQSLPDAWAIHQLFPVV
PLSRLLEPPTRRATLVDISCDSDGKMDRFIDLHDVRQTLPVHPVRPGEPYYLGVFLVGAYQDVLGSNHNLFGQVGEAHVR
VEEEGFAIERFVGGETAERVIEKMGFTARELMLGVERLVRQSRLSPVEKGAFLERYARELQGYTYLED

Sequences:

>Translated_628_residues
MAKRFTLKDAEELYLVPHWSGGFFRVGEKGDLEVTPLGPKGPAASLLEIVEALRDEGRPLPLVLRFPQILEARVRDLNEA
FLEAMAKYGYQGTYRGVYPVKVNQRRLVLETVARAGRPYHLGLEAGSKPELALILAQDLSEEALITTNGFKDDDFVRLAL
MGRKLGRNVVITLEKFAELFRVLRLSKELGVKPLLGIRYKLKAKGAGQWEASGGENAKFGLTTPEIVRAVEVLQEEGLLD
ALVMLHAHIGSQVTDIRRIKAAVREAAQTYVQLRKLGAPLRYLNLGGGLAVDYDGSKTNFYASANYTLSEYAENLVYVTK
EVVEAQGEPHPILVTESGRAITAYHEVLVLQVIDVIAPPGEARPSPPPPEAHPLVKELWESLQSLSPKNFQEVYHDAFAD
KETLQTLYDLGLVSLRDRALAEEIFYHIARRVQTIAQNLPYVPDELEDLEKLLADKLVCNFSVFQSLPDAWAIHQLFPVV
PLSRLLEPPTRRATLVDISCDSDGKMDRFIDLHDVRQTLPVHPVRPGEPYYLGVFLVGAYQDVLGSNHNLFGQVGEAHVR
VEEEGFAIERFVGGETAERVIEKMGFTARELMLGVERLVRQSRLSPVEKGAFLERYARELQGYTYLED
>Mature_627_residues
AKRFTLKDAEELYLVPHWSGGFFRVGEKGDLEVTPLGPKGPAASLLEIVEALRDEGRPLPLVLRFPQILEARVRDLNEAF
LEAMAKYGYQGTYRGVYPVKVNQRRLVLETVARAGRPYHLGLEAGSKPELALILAQDLSEEALITTNGFKDDDFVRLALM
GRKLGRNVVITLEKFAELFRVLRLSKELGVKPLLGIRYKLKAKGAGQWEASGGENAKFGLTTPEIVRAVEVLQEEGLLDA
LVMLHAHIGSQVTDIRRIKAAVREAAQTYVQLRKLGAPLRYLNLGGGLAVDYDGSKTNFYASANYTLSEYAENLVYVTKE
VVEAQGEPHPILVTESGRAITAYHEVLVLQVIDVIAPPGEARPSPPPPEAHPLVKELWESLQSLSPKNFQEVYHDAFADK
ETLQTLYDLGLVSLRDRALAEEIFYHIARRVQTIAQNLPYVPDELEDLEKLLADKLVCNFSVFQSLPDAWAIHQLFPVVP
LSRLLEPPTRRATLVDISCDSDGKMDRFIDLHDVRQTLPVHPVRPGEPYYLGVFLVGAYQDVLGSNHNLFGQVGEAHVRV
EEEGFAIERFVGGETAERVIEKMGFTARELMLGVERLVRQSRLSPVEKGAFLERYARELQGYTYLED

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=624, Percent_Identity=40.5448717948718, Blast_Score=476, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 70242; Mature: 70110

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRFTLKDAEELYLVPHWSGGFFRVGEKGDLEVTPLGPKGPAASLLEIVEALRDEGRPL
CCCCCCCCCCCCEEEEEECCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
PLVLRFPQILEARVRDLNEAFLEAMAKYGYQGTYRGVYPVKVNQRRLVLETVARAGRPYH
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCEE
LGLEAGSKPELALILAQDLSEEALITTNGFKDDDFVRLALMGRKLGRNVVITLEKFAELF
EECCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHH
RVLRLSKELGVKPLLGIRYKLKAKGAGQWEASGGENAKFGLTTPEIVRAVEVLQEEGLLD
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHH
ALVMLHAHIGSQVTDIRRIKAAVREAAQTYVQLRKLGAPLRYLNLGGGLAVDYDGSKTNF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEE
YASANYTLSEYAENLVYVTKEVVEAQGEPHPILVTESGRAITAYHEVLVLQVIDVIAPPG
EEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHCCCC
EARPSPPPPEAHPLVKELWESLQSLSPKNFQEVYHDAFADKETLQTLYDLGLVSLRDRAL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AEEIFYHIARRVQTIAQNLPYVPDELEDLEKLLADKLVCNFSVFQSLPDAWAIHQLFPVV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
PLSRLLEPPTRRATLVDISCDSDGKMDRFIDLHDVRQTLPVHPVRPGEPYYLGVFLVGAY
HHHHHCCCCCCCEEEEEEECCCCCCHHHHEEHHHHHHHCCCCCCCCCCCEEEEEEHHHHH
QDVLGSNHNLFGQVGEAHVRVEEEGFAIERFVGGETAERVIEKMGFTARELMLGVERLVR
HHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHH
QSRLSPVEKGAFLERYARELQGYTYLED
HHHCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKRFTLKDAEELYLVPHWSGGFFRVGEKGDLEVTPLGPKGPAASLLEIVEALRDEGRPL
CCCCCCCCCCCEEEEEECCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
PLVLRFPQILEARVRDLNEAFLEAMAKYGYQGTYRGVYPVKVNQRRLVLETVARAGRPYH
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCEE
LGLEAGSKPELALILAQDLSEEALITTNGFKDDDFVRLALMGRKLGRNVVITLEKFAELF
EECCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHH
RVLRLSKELGVKPLLGIRYKLKAKGAGQWEASGGENAKFGLTTPEIVRAVEVLQEEGLLD
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHH
ALVMLHAHIGSQVTDIRRIKAAVREAAQTYVQLRKLGAPLRYLNLGGGLAVDYDGSKTNF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEE
YASANYTLSEYAENLVYVTKEVVEAQGEPHPILVTESGRAITAYHEVLVLQVIDVIAPPG
EEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHCCCC
EARPSPPPPEAHPLVKELWESLQSLSPKNFQEVYHDAFADKETLQTLYDLGLVSLRDRAL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AEEIFYHIARRVQTIAQNLPYVPDELEDLEKLLADKLVCNFSVFQSLPDAWAIHQLFPVV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
PLSRLLEPPTRRATLVDISCDSDGKMDRFIDLHDVRQTLPVHPVRPGEPYYLGVFLVGAY
HHHHHCCCCCCCEEEEEEECCCCCCHHHHEEHHHHHHHCCCCCCCCCCCEEEEEEHHHHH
QDVLGSNHNLFGQVGEAHVRVEEEGFAIERFVGGETAERVIEKMGFTARELMLGVERLVR
HHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHH
QSRLSPVEKGAFLERYARELQGYTYLED
HHHCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]