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The map label for this gene is prs [H]

Identifier: 55981606

GI number: 55981606

Start: 1551652

End: 1552584

Strand: Direct

Name: prs [H]

Synonym: TTHA1637

Alternate gene names: 55981606

Gene position: 1551652-1552584 (Clockwise)

Preceding gene: 55981605

Following gene: 55981607

Centisome position: 83.88

GC content: 68.06

Gene sequence:

>933_bases
ATGGACCGCCCCCTCTTGATCTTCTCCGGCCAGTCCAACCGGCCCCTGGCCCAGGCCATCGCCGAGGCTTTAGGCCTCCC
CTTGGGCAAGAGCACCACCTTGCGCTTCGCCAACGACAACCTCTTCGTCCGCTACGAGGAAAGCCTGAGGGAGGGGGACG
TCTTCATCGTCCAGTCCTTTGTCCCCCCGGTGCAGGACCACCTGATGGAGCTCCTCATGATGGTGGACGCCGCCAAGGGG
GCGAGCGCCGCCCGGGTCACCGCCGTCATCCCCTACTTCTCCTACGCCCGGAGCGACAAGAAGGACGCCCCCAGGATCTC
CATCACCGCGCGGCTCATCGCCGACCTCCTGCAGACGGCGGGGGCCGACCGGGTCCTCACCATGACCCTCCACTCCCCTC
AGGTCCACGGCTTCTTCAAGATCCCCGTGGACCACCTCTCCGCCGAGCCCGTGATCGCCAACTACTTCGCCACCCGGGTG
GACCTGGAAAACGCCGTGGTGGTGGCCCCGGACGCCGGGGACCTCAAACGGGCAAGCGCCCTCGCCCGCAGGCTCGGCCT
TCCCCTGGCCTTCATTGATAAGGAACGGGTTTCCGACACCGAGGTGCGGGTCCGGATGCTGGTGGGGGAGGTGGAGGGAA
AGACGGCCCTCATCGTGGACGACGAGATCTCCACGGCGGGGAGCCTGGTGGAGGCGGTGGAGGCCCTCATGCAGGCCGGG
GCCAAGGAGGTGTACGCCGCCGCCACCCACGGGGTCTACGTGGGCCCGGCCCTGGACCGGATCGCCAAAAGCCCCGTGAA
GGAGGTGGCCGCCACGGACACCTGCCCCCCCAAGGAAGGCCCCAAGCTCAGGACCCTCACCGTGGCCCCCCTGTTCGCCG
AGGCCATCTGGCGGATCCATAGGGGGGAGTCGGTGTCCAGCCTCTTCACATGA

Upstream 100 bases:

>100_bases
AGGTGGACGTCTACCTCCACCCCACGGGCCCCGAGGTCACCACCCCCCTCCAGGAGGCCATTACCCCGCTTTAGGGGGGC
GTGGTATCTTGGGGGACGGC

Downstream 100 bases:

>100_bases
GGGTGCGGACCGAGCGGCTCACCTTGGCGGGGCTTTCCGTCCTCGCCCGGATCCCCGAGGCGCCCAAGGCCCTCCTCCTC
GCCCTCCACGGGCTCCAGGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MDRPLLIFSGQSNRPLAQAIAEALGLPLGKSTTLRFANDNLFVRYEESLREGDVFIVQSFVPPVQDHLMELLMMVDAAKG
ASAARVTAVIPYFSYARSDKKDAPRISITARLIADLLQTAGADRVLTMTLHSPQVHGFFKIPVDHLSAEPVIANYFATRV
DLENAVVVAPDAGDLKRASALARRLGLPLAFIDKERVSDTEVRVRMLVGEVEGKTALIVDDEISTAGSLVEAVEALMQAG
AKEVYAAATHGVYVGPALDRIAKSPVKEVAATDTCPPKEGPKLRTLTVAPLFAEAIWRIHRGESVSSLFT

Sequences:

>Translated_310_residues
MDRPLLIFSGQSNRPLAQAIAEALGLPLGKSTTLRFANDNLFVRYEESLREGDVFIVQSFVPPVQDHLMELLMMVDAAKG
ASAARVTAVIPYFSYARSDKKDAPRISITARLIADLLQTAGADRVLTMTLHSPQVHGFFKIPVDHLSAEPVIANYFATRV
DLENAVVVAPDAGDLKRASALARRLGLPLAFIDKERVSDTEVRVRMLVGEVEGKTALIVDDEISTAGSLVEAVEALMQAG
AKEVYAAATHGVYVGPALDRIAKSPVKEVAATDTCPPKEGPKLRTLTVAPLFAEAIWRIHRGESVSSLFT
>Mature_310_residues
MDRPLLIFSGQSNRPLAQAIAEALGLPLGKSTTLRFANDNLFVRYEESLREGDVFIVQSFVPPVQDHLMELLMMVDAAKG
ASAARVTAVIPYFSYARSDKKDAPRISITARLIADLLQTAGADRVLTMTLHSPQVHGFFKIPVDHLSAEPVIANYFATRV
DLENAVVVAPDAGDLKRASALARRLGLPLAFIDKERVSDTEVRVRMLVGEVEGKTALIVDDEISTAGSLVEAVEALMQAG
AKEVYAAATHGVYVGPALDRIAKSPVKEVAATDTCPPKEGPKLRTLTVAPLFAEAIWRIHRGESVSSLFT

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=309, Percent_Identity=46.6019417475728, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=45.016077170418, Blast_Score=282, Evalue=2e-76,
Organism=Homo sapiens, GI28557709, Length=309, Percent_Identity=46.2783171521036, Blast_Score=280, Evalue=9e-76,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=44.5859872611465, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4506133, Length=344, Percent_Identity=37.2093023255814, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI194018537, Length=341, Percent_Identity=36.3636363636364, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=30.6122448979592, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=30.6122448979592, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=30.6122448979592, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=30.6122448979592, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1787458, Length=309, Percent_Identity=43.042071197411, Blast_Score=250, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.9838187702265, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI25149168, Length=309, Percent_Identity=44.9838187702265, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17554702, Length=309, Percent_Identity=44.9838187702265, Blast_Score=268, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71989924, Length=309, Percent_Identity=44.9838187702265, Blast_Score=266, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=31.7507418397626, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319403, Length=308, Percent_Identity=47.4025974025974, Blast_Score=281, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6320946, Length=307, Percent_Identity=45.928338762215, Blast_Score=276, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6321776, Length=302, Percent_Identity=44.7019867549669, Blast_Score=251, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=195, Percent_Identity=41.5384615384615, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=88, Percent_Identity=55.6818181818182, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21355239, Length=309, Percent_Identity=46.9255663430421, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI45551540, Length=332, Percent_Identity=43.6746987951807, Blast_Score=272, Evalue=2e-73,
Organism=Drosophila melanogaster, GI281362873, Length=353, Percent_Identity=32.0113314447592, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24651454, Length=353, Percent_Identity=32.0113314447592, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24651458, Length=353, Percent_Identity=32.0113314447592, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24651456, Length=353, Percent_Identity=32.0113314447592, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24651462, Length=372, Percent_Identity=29.3010752688172, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24651464, Length=372, Percent_Identity=29.3010752688172, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45552010, Length=193, Percent_Identity=35.2331606217617, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33500; Mature: 33500

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRPLLIFSGQSNRPLAQAIAEALGLPLGKSTTLRFANDNLFVRYEESLREGDVFIVQSF
CCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEECCCEEEEEHHHCCCCCEEEEECC
VPPVQDHLMELLMMVDAAKGASAARVTAVIPYFSYARSDKKDAPRISITARLIADLLQTA
CCCHHHHHHHHHHHHHCCCCCCCHHHEEEHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHC
GADRVLTMTLHSPQVHGFFKIPVDHLSAEPVIANYFATRVDLENAVVVAPDAGDLKRASA
CCCEEEEEEECCCCCCEEEECCHHHCCCCCHHHHHHHHHEECCCCEEECCCCCCHHHHHH
LARRLGLPLAFIDKERVSDTEVRVRMLVGEVEGKTALIVDDEISTAGSLVEAVEALMQAG
HHHHHCCCEEEECHHHCCHHHHEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCC
AKEVYAAATHGVYVGPALDRIAKSPVKEVAATDTCPPKEGPKLRTLTVAPLFAEAIWRIH
HHHHHHHHCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHH
RGESVSSLFT
CCCCHHHHCC
>Mature Secondary Structure
MDRPLLIFSGQSNRPLAQAIAEALGLPLGKSTTLRFANDNLFVRYEESLREGDVFIVQSF
CCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEECCCEEEEEHHHCCCCCEEEEECC
VPPVQDHLMELLMMVDAAKGASAARVTAVIPYFSYARSDKKDAPRISITARLIADLLQTA
CCCHHHHHHHHHHHHHCCCCCCCHHHEEEHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHC
GADRVLTMTLHSPQVHGFFKIPVDHLSAEPVIANYFATRVDLENAVVVAPDAGDLKRASA
CCCEEEEEEECCCCCCEEEECCHHHCCCCCHHHHHHHHHEECCCCEEECCCCCCHHHHHH
LARRLGLPLAFIDKERVSDTEVRVRMLVGEVEGKTALIVDDEISTAGSLVEAVEALMQAG
HHHHHCCCEEEECHHHCCHHHHEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCC
AKEVYAAATHGVYVGPALDRIAKSPVKEVAATDTCPPKEGPKLRTLTVAPLFAEAIWRIH
HHHHHHHHCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHH
RGESVSSLFT
CCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]