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The map label for this gene is tmk

Identifier: 55981576

GI number: 55981576

Start: 1527505

End: 1528101

Strand: Direct

Name: tmk

Synonym: TTHA1607

Alternate gene names: 55981576

Gene position: 1527505-1528101 (Clockwise)

Preceding gene: 55981575

Following gene: 55981577

Centisome position: 82.58

GC content: 73.53

Gene sequence:

>597_bases
ATGCCGGGGCTCTTCCTCACCCTCGAGGGCCTGGACGGCAGCGGCAAGACCACCCAGGCGAGGCGGCTCGCCGCCTTCCT
GGAGGCCCAGGGCCGCCCCGTCCTCCTCACCCGGGAACCCGGGGGAGGGCTTCCCGAGGTGCGGAGCCTCCTCCTCACCC
AAGAGCTTTCCCCCGAGGCGGAGTACCTCCTCTTCAGCGCCGACCGGGCAGAGCACGTGCGCAAGGTGATCCTCCCCGGC
CTCGCCGCGGGGAAGGTGGTGATCTCCGACCGCTACCTGGACTCCAGCCTGGCCTACCAAGGCTATGGCCGGGGCCTCCC
CCTCCCCTGGCTGCGGGAGGTGGCCCGGGAGGCGACCCGGGGGCTTAAGCCCCGGCTCACCTTCCTCCTGGACCTGCCCC
CGGAGGCCGCCCTCCGCCGGGTGCGCCGCCCGGACCGCCTGGAAGGACTCGGCCTGGAGTTCTTCCGCAGGGTGCGGGAG
GGGTACCTGGCCCTCGCCCGGGCCGAGCCCGGGCGCTTCGTGGTCCTGGACGCCACCCTCCCCGAGGAGGAGATCGCGAG
GGCGATCCAGGCCCACCTCCGGCCCCTTCTGCCATAA

Upstream 100 bases:

>100_bases
CTACGACACGGAGACCTTCGGGGTGAAGGCCCTCGCCGCCCACCTCGAGGCCCGCTTCGGCCTCCCCTGGGTCTTCCTGG
ACCACCCCACGGGGCTTTAG

Downstream 100 bases:

>100_bases
TGGGCCCATGCGCCACCGGCTTTGGGGACTCTTGGGCCTTTTAGGGCTCGCCCTGGCCCTCACCTTCCCCAAGAGCACCC
TCTACGTGGAGGGGAACGGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MPGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLLLTQELSPEAEYLLFSADRAEHVRKVILPG
LAAGKVVISDRYLDSSLAYQGYGRGLPLPWLREVAREATRGLKPRLTFLLDLPPEAALRRVRRPDRLEGLGLEFFRRVRE
GYLALARAEPGRFVVLDATLPEEEIARAIQAHLRPLLP

Sequences:

>Translated_198_residues
MPGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLLLTQELSPEAEYLLFSADRAEHVRKVILPG
LAAGKVVISDRYLDSSLAYQGYGRGLPLPWLREVAREATRGLKPRLTFLLDLPPEAALRRVRRPDRLEGLGLEFFRRVRE
GYLALARAEPGRFVVLDATLPEEEIARAIQAHLRPLLP
>Mature_197_residues
PGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLLLTQELSPEAEYLLFSADRAEHVRKVILPGL
AAGKVVISDRYLDSSLAYQGYGRGLPLPWLREVAREATRGLKPRLTFLLDLPPEAALRRVRRPDRLEGLGLEFFRRVREG
YLALARAEPGRFVVLDATLPEEEIARAIQAHLRPLLP

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=204, Percent_Identity=39.7058823529412, Blast_Score=111, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28573735, Length=202, Percent_Identity=33.1683168316832, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_THET2 (Q72I89)

Other databases:

- EMBL:   AE017221
- RefSeq:   YP_005212.1
- ProteinModelPortal:   Q72I89
- SMR:   Q72I89
- STRING:   Q72I89
- GeneID:   2774590
- GenomeReviews:   AE017221_GR
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q72I89
- ProtClustDB:   CLSK738777
- BioCyc:   TTHE262724:TT_C1243-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 21979; Mature: 21848

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLLLTQELSPEA
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCC
EYLLFSADRAEHVRKVILPGLAAGKVVISDRYLDSSLAYQGYGRGLPLPWLREVAREATR
CEEEEECCHHHHHHHHHHCCCCCCEEEEECCHHCCHHHHCCCCCCCCCHHHHHHHHHHHC
GLKPRLTFLLDLPPEAALRRVRRPDRLEGLGLEFFRRVREGYLALARAEPGRFVVLDATL
CCCCEEEEEEECCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCEEEEECCC
PEEEIARAIQAHLRPLLP
CHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PGLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLLLTQELSPEA
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCC
EYLLFSADRAEHVRKVILPGLAAGKVVISDRYLDSSLAYQGYGRGLPLPWLREVAREATR
CEEEEECCHHHHHHHHHHCCCCCCEEEEECCHHCCHHHHCCCCCCCCCHHHHHHHHHHHC
GLKPRLTFLLDLPPEAALRRVRRPDRLEGLGLEFFRRVREGYLALARAEPGRFVVLDATL
CCCCEEEEEEECCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCEEEEECCC
PEEEIARAIQAHLRPLLP
CHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA