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The map label for this gene is gyrB [H]

Identifier: 55981555

GI number: 55981555

Start: 1508748

End: 1510652

Strand: Direct

Name: gyrB [H]

Synonym: TTHA1586

Alternate gene names: 55981555

Gene position: 1508748-1510652 (Clockwise)

Preceding gene: 55981553

Following gene: 55981565

Centisome position: 81.57

GC content: 67.35

Gene sequence:

>1905_bases
GTGAGCTACGACGCTTCTGCCATTCGGGTGCTCAAGGGCCTGGAGGGGGTCCGCCACCGCCCGGCCATGTACATCGGCGG
CACGGGGGTGGAAGGGTACCACCACCTCTTCAAGGAGATCCTGGACAACGCCGTGGACGAGGCCCTGGCGGGCTACGCCA
CGGAGATCCTGGTGCGCCTCAACGAGGACGGCTCCCTCACCGTGGAGGACAACGGCCGCGGCATCCCCGTGGACCTCATG
CCCGAGGAGGGAAAGCCCGCCGTGGAGGTCATCTACACCACCCTCCACTCCGGGGGCAAGTTTGAGCAGGGCGCCTACAA
GGTCTCCGGGGGGCTCCACGGGGTGGGGGCGAGCGTGGTGAACGCCCTTTCCGAGTGGACCGTGGTGGAGGTCTTCCGGG
AGGGGAAGCACCACCGGATCGCCTTCAGCCGGGGCGAGGTCACGGAGCCCCTCCGGGTGGTGGGCGAGGCCCCCAGGGGG
AAGACCGGGACCCGGGTCACCTTCAAGCCCGACCCCGAGATCTTCGGGAACCTCCGCTTTGACCCGAGCAAGATCCGGGC
CCGCCTCCGGGAGGTGGCCTACCTGGTGGCCGGGCTCAAGCTCGTCTTCCAGGACCGCCAGCACGGAAAGGAGGAGGTCT
TCCTGGACAAGGGGGGCGTGGCCTCCTTCGCCAAGGCCTTGGCCGAGGGGGAGGACCTCCTCTACGAGAAGCCCTTCCTC
ATCCGGGGCACCCACGGGGAGGTGGAGGTGGAGGTGGGCTTCCTCCACACCCAGGGGTACAACGCCGAGATCCTCACCTA
CGCCAACATGATCCCCACCCGGGACGGGGGTACCCACCTCACCGCCTTCAAGTCCGCCTACAGCCGCGCCCTGAACCAGT
ACGCCAAGAAGGCGGGCCTCAACAAGGAAAAAGGCCCCCAGCCCACGGGGGACGACCTCCTGGAGGGGCTCTACGCCGTG
GTCTCGGTGAAGCTCCCCAACCCCCAGTTTGAGGGGCAGACCAAGGGGAAGCTCCTAAACCCCGAGGCCGGGACCGCCGT
GGGCCAGGTGGTTTACGAGCGGCTTCTGGAGATCCTGGAGGAGAACCCCCGCATCGCCAAGGCCGTCTACGAGAAGGCCC
TGAGGGCCGCCCAGGCCCGGGAGGCGGCGAGGAAGGCGAGGGAGCTCGTCCGCAGGCAGAACCCCCTGGAGTCCGACGAG
CTTCCCGGAAAGCTCGCCGACTGCCAGACGGAAAACCCCGAGGAGGCGGAGCTTTTCATCGTGGAGGGGGACTCGGCAGG
GGGGAGCGCCAAGCAGGGCCGGGACCGCCGCTTCCAGGCCATCCTGCCCCTCCGGGGGAAGATCCTCAACGTGGAGAAGG
CGGGGCTCTCCAAGGCCCTGAAGAACGCCGAGGTGCGGGCCATGGTCTCGGCCATCGGCGTGGGCATCGGGGGGGATGGG
GAGGCCCACTTTGACCTCGAGGGCCTCCGCTACCACAAGATCATCATCATGACCGACGCCGACGTGGACGGAAGCCACAT
CCGCACCCTCCTCCTCACCTTCTTCTACCGCTACATGCGCCCCCTCATTGAACGGGGCCACGTCTACATCGCCCAGCCTC
CCCTCTACCGCCTCCAGGTGGGGAAGAAGGTGGAGTACCTCTACTCCGACGAGGAGCTCCAGGCCCGGCTCAAGGAGCTG
GAAGGCAAGCACTACGAGGTCCAGCGCTTCAAGGGCCTGGGGGAGATGAACCCGGAGCAGCTTTGGGAGACCACCATGAA
CCCGGAGAAGCGGGTCCTCAAGCGGGTGGAGCTCCAGGACGCCCTCGAGGCCAGCGAGCTCTTTGAGAAGCTCATGGGCC
AGGAGGTGGCCCCGAGGCGCGAGTTCATAGAGGAGCACGCCCGCTACGCCGAGCTGGACATCTAA

Upstream 100 bases:

>100_bases
CAATACACTGGCCTCAGTCCGATAAACTTTCCGGCCCCAGGCAAGGAGAGCTCCCTTTACAAGGGGAAAAACCCCGCTCC
GGTTGTGGTATACTGAAGGG

Downstream 100 bases:

>100_bases
TACCGCCCCAGGCCGGCTTGCGCCAGCCTGGGAGGCCCGAGGGGCGCTTAGGTGAGGGCGAGCTCCACCAGGCGCCTGAG
AAGCTCCGGGTAGGCCACCC

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: Topoisomerase II subunit B [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MSYDASAIRVLKGLEGVRHRPAMYIGGTGVEGYHHLFKEILDNAVDEALAGYATEILVRLNEDGSLTVEDNGRGIPVDLM
PEEGKPAVEVIYTTLHSGGKFEQGAYKVSGGLHGVGASVVNALSEWTVVEVFREGKHHRIAFSRGEVTEPLRVVGEAPRG
KTGTRVTFKPDPEIFGNLRFDPSKIRARLREVAYLVAGLKLVFQDRQHGKEEVFLDKGGVASFAKALAEGEDLLYEKPFL
IRGTHGEVEVEVGFLHTQGYNAEILTYANMIPTRDGGTHLTAFKSAYSRALNQYAKKAGLNKEKGPQPTGDDLLEGLYAV
VSVKLPNPQFEGQTKGKLLNPEAGTAVGQVVYERLLEILEENPRIAKAVYEKALRAAQAREAARKARELVRRQNPLESDE
LPGKLADCQTENPEEAELFIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKAGLSKALKNAEVRAMVSAIGVGIGGDG
EAHFDLEGLRYHKIIIMTDADVDGSHIRTLLLTFFYRYMRPLIERGHVYIAQPPLYRLQVGKKVEYLYSDEELQARLKEL
EGKHYEVQRFKGLGEMNPEQLWETTMNPEKRVLKRVELQDALEASELFEKLMGQEVAPRREFIEEHARYAELDI

Sequences:

>Translated_634_residues
MSYDASAIRVLKGLEGVRHRPAMYIGGTGVEGYHHLFKEILDNAVDEALAGYATEILVRLNEDGSLTVEDNGRGIPVDLM
PEEGKPAVEVIYTTLHSGGKFEQGAYKVSGGLHGVGASVVNALSEWTVVEVFREGKHHRIAFSRGEVTEPLRVVGEAPRG
KTGTRVTFKPDPEIFGNLRFDPSKIRARLREVAYLVAGLKLVFQDRQHGKEEVFLDKGGVASFAKALAEGEDLLYEKPFL
IRGTHGEVEVEVGFLHTQGYNAEILTYANMIPTRDGGTHLTAFKSAYSRALNQYAKKAGLNKEKGPQPTGDDLLEGLYAV
VSVKLPNPQFEGQTKGKLLNPEAGTAVGQVVYERLLEILEENPRIAKAVYEKALRAAQAREAARKARELVRRQNPLESDE
LPGKLADCQTENPEEAELFIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKAGLSKALKNAEVRAMVSAIGVGIGGDG
EAHFDLEGLRYHKIIIMTDADVDGSHIRTLLLTFFYRYMRPLIERGHVYIAQPPLYRLQVGKKVEYLYSDEELQARLKEL
EGKHYEVQRFKGLGEMNPEQLWETTMNPEKRVLKRVELQDALEASELFEKLMGQEVAPRREFIEEHARYAELDI
>Mature_633_residues
SYDASAIRVLKGLEGVRHRPAMYIGGTGVEGYHHLFKEILDNAVDEALAGYATEILVRLNEDGSLTVEDNGRGIPVDLMP
EEGKPAVEVIYTTLHSGGKFEQGAYKVSGGLHGVGASVVNALSEWTVVEVFREGKHHRIAFSRGEVTEPLRVVGEAPRGK
TGTRVTFKPDPEIFGNLRFDPSKIRARLREVAYLVAGLKLVFQDRQHGKEEVFLDKGGVASFAKALAEGEDLLYEKPFLI
RGTHGEVEVEVGFLHTQGYNAEILTYANMIPTRDGGTHLTAFKSAYSRALNQYAKKAGLNKEKGPQPTGDDLLEGLYAVV
SVKLPNPQFEGQTKGKLLNPEAGTAVGQVVYERLLEILEENPRIAKAVYEKALRAAQAREAARKARELVRRQNPLESDEL
PGKLADCQTENPEEAELFIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKAGLSKALKNAEVRAMVSAIGVGIGGDGE
AHFDLEGLRYHKIIIMTDADVDGSHIRTLLLTFFYRYMRPLIERGHVYIAQPPLYRLQVGKKVEYLYSDEELQARLKELE
GKHYEVQRFKGLGEMNPEQLWETTMNPEKRVLKRVELQDALEASELFEKLMGQEVAPRREFIEEHARYAELDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=609, Percent_Identity=26.7651888341544, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI19913406, Length=604, Percent_Identity=25.8278145695364, Blast_Score=134, Evalue=3e-31,
Organism=Escherichia coli, GI48994957, Length=554, Percent_Identity=52.1660649819495, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1789408, Length=642, Percent_Identity=41.9003115264797, Blast_Score=456, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17535065, Length=568, Percent_Identity=26.5845070422535, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI212645845, Length=532, Percent_Identity=24.812030075188, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI212645657, Length=180, Percent_Identity=31.6666666666667, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324241, Length=626, Percent_Identity=25.8785942492013, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17136538, Length=561, Percent_Identity=26.3814616755793, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 70525; Mature: 70394

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDASAIRVLKGLEGVRHRPAMYIGGTGVEGYHHLFKEILDNAVDEALAGYATEILVRL
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
NEDGSLTVEDNGRGIPVDLMPEEGKPAVEVIYTTLHSGGKFEQGAYKVSGGLHGVGASVV
CCCCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHH
NALSEWTVVEVFREGKHHRIAFSRGEVTEPLRVVGEAPRGKTGTRVTFKPDPEIFGNLRF
HHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCCCCCCCCEEEECCCHHHHCCCCC
DPSKIRARLREVAYLVAGLKLVFQDRQHGKEEVFLDKGGVASFAKALAEGEDLLYEKPFL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCHHHCCCCEE
IRGTHGEVEVEVGFLHTQGYNAEILTYANMIPTRDGGTHLTAFKSAYSRALNQYAKKAGL
EECCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
NKEKGPQPTGDDLLEGLYAVVSVKLPNPQFEGQTKGKLLNPEAGTAVGQVVYERLLEILE
CCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHH
ENPRIAKAVYEKALRAAQAREAARKARELVRRQNPLESDELPGKLADCQTENPEEAELFI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCEEEE
VEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKAGLSKALKNAEVRAMVSAIGVGIGGDG
EECCCCCCCCCCCCCCHHEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EAHFDLEGLRYHKIIIMTDADVDGSHIRTLLLTFFYRYMRPLIERGHVYIAQPPLYRLQV
CEEEEECCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEC
GKKVEYLYSDEELQARLKELEGKHYEVQRFKGLGEMNPEQLWETTMNPEKRVLKRVELQD
CCEEEEEECCHHHHHHHHHHCCCCEEHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
ALEASELFEKLMGQEVAPRREFIEEHARYAELDI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SYDASAIRVLKGLEGVRHRPAMYIGGTGVEGYHHLFKEILDNAVDEALAGYATEILVRL
CCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
NEDGSLTVEDNGRGIPVDLMPEEGKPAVEVIYTTLHSGGKFEQGAYKVSGGLHGVGASVV
CCCCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHH
NALSEWTVVEVFREGKHHRIAFSRGEVTEPLRVVGEAPRGKTGTRVTFKPDPEIFGNLRF
HHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCCCCCCCCEEEECCCHHHHCCCCC
DPSKIRARLREVAYLVAGLKLVFQDRQHGKEEVFLDKGGVASFAKALAEGEDLLYEKPFL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCHHHCCCCEE
IRGTHGEVEVEVGFLHTQGYNAEILTYANMIPTRDGGTHLTAFKSAYSRALNQYAKKAGL
EECCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
NKEKGPQPTGDDLLEGLYAVVSVKLPNPQFEGQTKGKLLNPEAGTAVGQVVYERLLEILE
CCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHH
ENPRIAKAVYEKALRAAQAREAARKARELVRRQNPLESDELPGKLADCQTENPEEAELFI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCEEEE
VEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKAGLSKALKNAEVRAMVSAIGVGIGGDG
EECCCCCCCCCCCCCCHHEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EAHFDLEGLRYHKIIIMTDADVDGSHIRTLLLTFFYRYMRPLIERGHVYIAQPPLYRLQV
CEEEEECCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEC
GKKVEYLYSDEELQARLKELEGKHYEVQRFKGLGEMNPEQLWETTMNPEKRVLKRVELQD
CCEEEEEECCHHHHHHHHHHCCCCEEHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
ALEASELFEKLMGQEVAPRREFIEEHARYAELDI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8863738; 10360571 [H]